GREMLIN Database
Q9HSS3 - Cold shock protein
UniProt: Q9HSS3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 74 (61)
Sequences: 1134 (570)
Seq/√Len: 73.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_F71_L4.1441.00
58_D70_N2.5881.00
31_E54_E2.4661.00
60_E69_T2.4521.00
56_E72_T2.2201.00
17_D36_D2.1961.00
14_G68_A2.0301.00
14_G28_I1.8611.00
15_E54_E1.7891.00
21_D50_E1.6791.00
30_T34_D1.6270.99
39_F49_L1.6250.99
50_E53_Q1.5710.99
27_F40_H1.4820.99
17_D23_G1.4360.99
62_A67_R1.4160.99
13_T56_E1.3760.98
18_F23_G1.3650.98
28_I57_F1.3440.98
19_F41_M1.2720.97
49_L55_V1.2580.97
16_V49_L1.2390.97
28_I55_V1.2250.96
62_A65_G1.2210.96
30_T33_A1.1430.95
19_F23_G1.1250.94
57_F68_A1.0650.92
15_E33_A1.0430.92
41_M47_P1.0240.91
20_N38_F1.0230.91
18_F36_D1.0160.90
31_E71_L0.9970.90
44_V47_P0.9730.88
12_A30_T0.9400.87
30_T57_F0.9330.86
46_G52_G0.8670.82
45_G56_E0.8640.82
37_V43_D0.8610.81
37_V44_V0.8570.81
21_D48_D0.8270.79
24_G65_G0.8230.78
13_T54_E0.7990.76
43_D70_N0.7870.75
19_F39_F0.7810.75
61_Q66_P0.7790.75
15_E29_E0.7700.74
43_D57_F0.7660.73
59_I66_P0.7620.73
28_I68_A0.7560.72
17_D71_L0.7460.71
12_A33_A0.7460.71
14_G41_M0.7360.70
13_T32_D0.7310.70
14_G55_V0.7210.69
39_F53_Q0.7190.69
27_F36_D0.7170.68
30_T37_V0.7160.68
38_F53_Q0.7140.68
60_E68_A0.7050.67
27_F38_F0.6930.66
53_Q57_F0.6880.65
42_E58_D0.6740.64
25_Y37_V0.6720.63
15_E34_D0.6660.63
24_G44_V0.6560.61
37_V68_A0.6490.61
21_D57_F0.6490.61
60_E70_N0.6310.58
12_A35_E0.6090.56
16_V43_D0.6030.55
15_E59_I0.5920.54
19_F44_V0.5920.54
43_D47_P0.5910.54
42_E57_F0.5900.53
25_Y40_H0.5860.53
33_A67_R0.5830.53
22_T54_E0.5760.52
35_E67_R0.5630.50
23_G36_D0.5620.50
63_D69_T0.5510.49
22_T51_E0.5490.48
32_D70_N0.5460.48
38_F62_A0.5400.47
18_F39_F0.5370.47
24_G36_D0.5370.47
62_A66_P0.5280.46
18_F24_G0.5270.46
19_F24_G0.5170.44
37_V63_D0.5170.44
21_D35_E0.5100.44
22_T50_E0.5060.43
64_K67_R0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i2zB 2 0.9189 99.6 0.247 Contact Map
3aqqA 4 1 99.6 0.254 Contact Map
3camA 2 0.8649 99.6 0.264 Contact Map
1h95A 1 0.9595 99.6 0.27 Contact Map
2lssA 1 0.9054 99.6 0.272 Contact Map
2k5nA 1 0.8649 99.6 0.278 Contact Map
1x65A 1 0.9324 99.6 0.28 Contact Map
1c9oA 2 0.8514 99.6 0.281 Contact Map
1g6pA 1 0.8378 99.6 0.283 Contact Map
2lxjA 1 0.8514 99.6 0.285 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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