Q9HSS2 - HALSA - GREMLIN Contacts

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Q9HSS2 - Uncharacterized protein

UniProt:	Q9HSS2	Sequences: MTYDTVVFDNDGVLVGRTRYDVLERATEETFRRFNVDDPDPEDVEAMTIGATPKTVGDVCSRYGISPKDFWPERDRALTEAQRDEVREGRKTLYDDLDTLHDLNVNMGIVSSNQQATVDFVLDHFGVRDLFGAAYGREPTIQSLERRKPNSHYIDRALADLDADTALFVGDNESDIRAAENAGIDSAFIRRPHRESWELNAWPTWDIDCLSDLHDICE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	218 (201)
Sequences:	28176 (21989)
Seq/√Len:	1551.0

ECOLI - YNIC YFBT YJJG GPH YIEH PGMB YRFG YIGB YQAB YIHX
BACSU - PPAX YHCW PGMB YSAA YFNB
HALSA - Q9HSS2 Q9HQE2 Q9HP74 Q9HMC4
SULSO - Q7LXL6 Q97ZU6 Q7LX46 Q97WT6 Q97X58 Q97YZ1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_D	165_T	4.082	1.00
123_D	128_R	3.100	1.00
146_R	150_N	2.859	1.00
156_R	160_D	2.843	1.00
115_Q	119_D	2.701	1.00
179_A	186_S	2.577	1.00
170_G	175_D	2.520	1.00
5_T	163_A	2.450	1.00
98_D	130_L	2.446	1.00
94_Y	98_D	2.327	1.00
156_R	159_A	2.250	1.00
108_G	133_A	2.237	1.00
106_N	132_G	2.237	1.00
8_F	107_M	2.189	1.00
111_S	118_V	2.109	1.00
115_Q	139_P	2.095	1.00
110_V	153_Y	2.090	1.00
146_R	152_H	2.078	1.00
158_L	166_A	2.054	1.00
133_A	160_D	2.048	1.00
176_I	186_S	2.047	1.00
180_E	204_T	2.027	1.00
208_D	212_D	1.971	1.00
33_R	73_E	1.955	1.00
185_D	204_T	1.921	1.00
40_D	43_D	1.919	1.00
99_T	103_L	1.900	1.00
177_R	181_N	1.897	1.00
29_E	77_A	1.797	1.00
101_H	130_L	1.772	1.00
6_V	105_V	1.759	1.00
168_F	179_A	1.746	1.00
158_L	184_I	1.723	1.00
93_L	210_L	1.677	1.00
119_D	128_R	1.676	1.00
101_H	132_G	1.645	1.00
167_L	187_A	1.629	1.00
190_R	208_D	1.579	1.00
107_M	131_F	1.566	1.00
5_T	161_L	1.553	1.00
7_V	157_A	1.529	1.00
163_A	166_A	1.501	1.00
7_V	168_F	1.501	1.00
77_A	80_E	1.492	1.00
7_V	110_V	1.474	1.00
34_F	73_E	1.451	1.00
6_V	100_L	1.421	1.00
90_R	191_R	1.418	1.00
33_R	77_A	1.413	1.00
6_V	169_V	1.413	1.00
187_A	207_I	1.382	1.00
173_E	177_R	1.358	1.00
29_E	33_R	1.354	1.00
108_G	161_L	1.351	1.00
14_L	93_L	1.326	1.00
54_K	57_G	1.325	1.00
10_N	118_V	1.314	1.00
190_R	206_D	1.310	1.00
96_D	210_L	1.294	1.00
99_T	102_D	1.290	1.00
13_V	169_V	1.285	1.00
10_N	15_V	1.270	1.00
187_A	205_W	1.266	1.00
29_E	81_A	1.263	1.00
209_C	212_D	1.254	1.00
119_D	123_D	1.239	1.00
77_A	81_A	1.237	1.00
10_N	109_I	1.217	1.00
92_T	95_D	1.217	1.00
11_D	17_R	1.204	1.00
69_D	73_E	1.199	1.00
89_G	127_V	1.190	1.00
73_E	76_R	1.174	1.00
166_A	184_I	1.172	1.00
135_Y	160_D	1.165	1.00
151_S	155_D	1.163	1.00
154_I	168_F	1.161	1.00
154_I	178_A	1.155	1.00
118_V	136_G	1.136	1.00
30_T	34_F	1.109	1.00
5_T	166_A	1.109	1.00
154_I	184_I	1.094	1.00
74_R	78_L	1.089	1.00
25_R	29_E	1.083	1.00
5_T	106_N	1.081	1.00
7_V	166_A	1.078	1.00
72_P	76_R	1.077	1.00
135_Y	157_A	1.072	1.00
97_L	131_F	1.067	1.00
50_G	54_K	1.066	1.00
73_E	77_A	1.065	1.00
152_H	156_R	1.060	1.00
95_D	211_S	1.049	1.00
126_G	129_D	1.048	1.00
25_R	81_A	1.046	1.00
110_V	157_A	1.041	1.00
98_D	102_D	1.040	1.00
109_I	131_F	1.040	1.00
133_A	161_L	1.037	1.00
53_P	57_G	1.024	1.00
29_E	32_R	1.011	1.00
101_H	107_M	1.008	1.00
168_F	184_I	1.003	1.00
94_Y	130_L	1.002	1.00
155_D	182_A	0.996	1.00
57_G	67_P	0.993	1.00
10_N	113_N	0.992	1.00
157_A	161_L	0.988	1.00
115_Q	136_G	0.983	1.00
78_L	82_Q	0.982	1.00
120_F	124_H	0.980	1.00
180_E	186_S	0.979	1.00
155_D	159_A	0.978	1.00
25_R	28_E	0.944	1.00
76_R	80_E	0.941	1.00
28_E	32_R	0.941	1.00
185_D	205_W	0.940	1.00
83_R	120_F	0.938	1.00
95_D	98_D	0.933	1.00
152_H	155_D	0.933	1.00
92_T	209_C	0.932	1.00
67_P	70_F	0.930	1.00
5_T	108_G	0.930	1.00
176_I	203_P	0.925	1.00
81_A	85_E	0.924	1.00
174_S	177_R	0.920	1.00
11_D	113_N	0.917	1.00
154_I	170_G	0.911	1.00
57_G	61_S	0.909	1.00
167_L	185_D	0.908	1.00
89_G	94_Y	0.905	1.00
41_P	45_E	0.900	1.00
120_F	123_D	0.895	1.00
61_S	64_G	0.894	1.00
58_D	61_S	0.888	1.00
180_E	202_W	0.882	1.00
92_T	211_S	0.880	1.00
98_D	129_D	0.876	1.00
71_W	75_D	0.867	1.00
25_R	85_E	0.862	1.00
43_D	46_A	0.860	1.00
7_V	161_L	0.855	1.00
115_Q	138_E	0.852	1.00
54_K	58_D	0.850	1.00
31_F	36_V	0.847	1.00
4_D	105_V	0.847	1.00
50_G	58_D	0.838	1.00
10_N	121_V	0.838	1.00
7_V	184_I	0.832	1.00
28_E	41_P	0.828	1.00
90_R	189_I	0.826	1.00
24_E	28_E	0.825	1.00
100_L	107_M	0.825	1.00
53_P	68_K	0.823	1.00
68_K	72_P	0.822	1.00
111_S	136_G	0.821	1.00
145_E	152_H	0.821	1.00
169_V	187_A	0.813	1.00
107_M	130_L	0.809	1.00
135_Y	156_R	0.806	1.00
186_S	204_T	0.804	1.00
100_L	105_V	0.802	1.00
178_A	182_A	0.795	1.00
90_R	93_L	0.793	1.00
136_G	139_P	0.791	1.00
15_V	121_V	0.788	1.00
70_F	73_E	0.788	1.00
187_A	213_L	0.785	1.00
169_V	213_L	0.785	1.00
70_F	74_R	0.781	1.00
118_V	121_V	0.779	1.00
11_D	111_S	0.778	1.00
108_G	157_A	0.778	1.00
207_I	213_L	0.776	1.00
6_V	167_L	0.774	1.00
113_N	118_V	0.765	1.00
176_I	188_F	0.763	1.00
15_V	125_F	0.763	1.00
11_D	171_D	0.757	1.00
52_T	55_T	0.757	1.00
97_L	130_L	0.750	1.00
188_F	206_D	0.749	1.00
4_D	106_N	0.748	1.00
94_Y	129_D	0.745	1.00
75_D	79_T	0.743	1.00
196_S	208_D	0.743	1.00
138_E	144_L	0.730	1.00
94_Y	126_G	0.724	1.00
118_V	134_A	0.724	1.00
191_R	210_L	0.723	1.00
144_L	156_R	0.721	1.00
39_P	43_D	0.719	1.00
89_G	125_F	0.712	1.00
119_D	134_A	0.711	1.00
154_I	175_D	0.689	1.00
122_L	128_R	0.686	1.00
151_S	181_N	0.686	1.00
24_E	44_V	0.685	1.00
39_P	44_V	0.683	1.00
51_A	55_T	0.680	1.00
133_A	157_A	0.679	1.00
42_E	46_A	0.678	1.00
153_Y	157_A	0.672	1.00
46_A	58_D	0.670	1.00
16_G	88_E	0.669	1.00
72_P	75_D	0.668	1.00
92_T	96_D	0.668	1.00
42_E	45_E	0.664	1.00
51_A	54_K	0.663	1.00
26_A	30_T	0.661	1.00
177_R	180_E	0.660	1.00
21_D	88_E	0.659	1.00
207_I	210_L	0.659	1.00
58_D	62_R	0.658	1.00
112_S	147_R	0.657	1.00
95_D	99_T	0.657	1.00
23_L	27_T	0.655	1.00
7_V	108_G	0.651	1.00
12_G	20_Y	0.648	1.00
155_D	158_L	0.644	1.00
11_D	121_V	0.643	1.00
110_V	168_F	0.642	1.00
168_F	175_D	0.641	1.00
153_Y	178_A	0.641	1.00
67_P	71_W	0.639	1.00
106_N	163_A	0.632	1.00
23_L	113_N	0.631	1.00
96_D	169_V	0.630	1.00
158_L	163_A	0.629	1.00
79_T	116_A	0.627	1.00
69_D	72_P	0.627	1.00
118_V	122_L	0.626	1.00
107_M	132_G	0.619	1.00
52_T	56_V	0.619	1.00
189_I	210_L	0.617	1.00
168_F	178_A	0.617	1.00
144_L	153_Y	0.612	1.00
45_E	48_T	0.606	1.00
116_A	120_F	0.605	1.00
24_E	41_P	0.603	1.00
21_D	41_P	0.602	1.00
131_F	134_A	0.600	1.00
79_T	83_R	0.599	1.00
139_P	160_D	0.596	1.00
13_V	175_D	0.596	1.00
98_D	101_H	0.595	1.00
75_D	78_L	0.591	1.00
139_P	144_L	0.590	1.00
197_W	200_N	0.584	1.00
8_F	96_D	0.581	1.00
101_H	129_D	0.581	1.00
4_D	163_A	0.579	1.00
112_S	137_R	0.574	1.00
17_R	113_N	0.572	1.00
91_K	211_S	0.572	1.00
76_R	79_T	0.570	1.00
71_W	74_R	0.566	1.00
113_N	117_T	0.560	1.00
93_L	96_D	0.559	1.00
113_N	170_G	0.559	1.00
188_F	203_P	0.558	1.00
50_G	55_T	0.556	1.00
112_S	149_P	0.556	1.00
93_L	97_L	0.554	1.00
80_E	83_R	0.552	1.00
194_R	197_W	0.551	1.00
174_S	178_A	0.551	1.00
17_R	23_L	0.550	1.00
34_F	69_D	0.550	1.00
122_L	127_V	0.549	1.00
43_D	47_M	0.547	1.00
32_R	37_D	0.546	1.00
135_Y	153_Y	0.544	1.00
21_D	25_R	0.542	1.00
96_D	99_T	0.542	1.00
137_R	153_Y	0.540	1.00
53_P	71_W	0.537	1.00
177_R	201_A	0.536	1.00
13_V	189_I	0.535	1.00
16_G	21_D	0.532	1.00
133_A	136_G	0.531	1.00
112_S	174_S	0.531	1.00
123_D	129_D	0.529	1.00
110_V	135_Y	0.521	1.00
96_D	100_L	0.521	1.00
16_G	90_R	0.518	1.00
114_Q	117_T	0.517	1.00
91_K	209_C	0.516	1.00
89_G	93_L	0.515	1.00
74_R	77_A	0.515	1.00
30_T	73_E	0.514	1.00
96_D	207_I	0.509	1.00
30_T	33_R	0.509	1.00
22_V	87_R	0.508	1.00
53_P	67_P	0.506	1.00
26_A	77_A	0.505	1.00
60_C	63_Y	0.503	1.00
188_F	199_L	0.503	1.00
173_E	188_F	0.502	1.00
154_I	179_A	0.501	1.00
176_I	180_E	0.501	1.00
109_I	122_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1te2A	2	0.9679	100	0.277	Contact Map
1swvA	2	0.9587	100	0.279	Contact Map
4eekA	2	0.9633	100	0.279	Contact Map
4uw9A	1	0.8991	100	0.281	Contact Map
3l5kA	1	0.9541	100	0.281	Contact Map
2zg6A	2	0.8853	100	0.285	Contact Map
3mc1A	2	0.9633	100	0.285	Contact Map
2hdoA	1	0.9266	100	0.287	Contact Map
3iruA	4	0.9633	100	0.287	Contact Map
3sd7A	1	0.9633	100	0.288	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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