GREMLIN Database
Q9HSS2 - Uncharacterized protein
UniProt: Q9HSS2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (201)
Sequences: 28176 (21989)
Seq/√Len: 1551.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_D165_T4.0821.00
123_D128_R3.1001.00
146_R150_N2.8591.00
156_R160_D2.8431.00
115_Q119_D2.7011.00
179_A186_S2.5771.00
170_G175_D2.5201.00
5_T163_A2.4501.00
98_D130_L2.4461.00
94_Y98_D2.3271.00
156_R159_A2.2501.00
108_G133_A2.2371.00
106_N132_G2.2371.00
8_F107_M2.1891.00
111_S118_V2.1091.00
115_Q139_P2.0951.00
110_V153_Y2.0901.00
146_R152_H2.0781.00
158_L166_A2.0541.00
133_A160_D2.0481.00
176_I186_S2.0471.00
180_E204_T2.0271.00
208_D212_D1.9711.00
33_R73_E1.9551.00
185_D204_T1.9211.00
40_D43_D1.9191.00
99_T103_L1.9001.00
177_R181_N1.8971.00
29_E77_A1.7971.00
101_H130_L1.7721.00
6_V105_V1.7591.00
168_F179_A1.7461.00
158_L184_I1.7231.00
93_L210_L1.6771.00
119_D128_R1.6761.00
101_H132_G1.6451.00
167_L187_A1.6291.00
190_R208_D1.5791.00
107_M131_F1.5661.00
5_T161_L1.5531.00
7_V157_A1.5291.00
163_A166_A1.5011.00
7_V168_F1.5011.00
77_A80_E1.4921.00
7_V110_V1.4741.00
34_F73_E1.4511.00
6_V100_L1.4211.00
90_R191_R1.4181.00
33_R77_A1.4131.00
6_V169_V1.4131.00
187_A207_I1.3821.00
173_E177_R1.3581.00
29_E33_R1.3541.00
108_G161_L1.3511.00
14_L93_L1.3261.00
54_K57_G1.3251.00
10_N118_V1.3141.00
190_R206_D1.3101.00
96_D210_L1.2941.00
99_T102_D1.2901.00
13_V169_V1.2851.00
10_N15_V1.2701.00
187_A205_W1.2661.00
29_E81_A1.2631.00
209_C212_D1.2541.00
119_D123_D1.2391.00
77_A81_A1.2371.00
10_N109_I1.2171.00
92_T95_D1.2171.00
11_D17_R1.2041.00
69_D73_E1.1991.00
89_G127_V1.1901.00
73_E76_R1.1741.00
166_A184_I1.1721.00
135_Y160_D1.1651.00
151_S155_D1.1631.00
154_I168_F1.1611.00
154_I178_A1.1551.00
118_V136_G1.1361.00
30_T34_F1.1091.00
5_T166_A1.1091.00
154_I184_I1.0941.00
74_R78_L1.0891.00
25_R29_E1.0831.00
5_T106_N1.0811.00
7_V166_A1.0781.00
72_P76_R1.0771.00
135_Y157_A1.0721.00
97_L131_F1.0671.00
50_G54_K1.0661.00
73_E77_A1.0651.00
152_H156_R1.0601.00
95_D211_S1.0491.00
126_G129_D1.0481.00
25_R81_A1.0461.00
110_V157_A1.0411.00
98_D102_D1.0401.00
109_I131_F1.0401.00
133_A161_L1.0371.00
53_P57_G1.0241.00
29_E32_R1.0111.00
101_H107_M1.0081.00
168_F184_I1.0031.00
94_Y130_L1.0021.00
155_D182_A0.9961.00
57_G67_P0.9931.00
10_N113_N0.9921.00
157_A161_L0.9881.00
115_Q136_G0.9831.00
78_L82_Q0.9821.00
120_F124_H0.9801.00
180_E186_S0.9791.00
155_D159_A0.9781.00
25_R28_E0.9441.00
76_R80_E0.9411.00
28_E32_R0.9411.00
185_D205_W0.9401.00
83_R120_F0.9381.00
95_D98_D0.9331.00
152_H155_D0.9331.00
92_T209_C0.9321.00
67_P70_F0.9301.00
5_T108_G0.9301.00
176_I203_P0.9251.00
81_A85_E0.9241.00
174_S177_R0.9201.00
11_D113_N0.9171.00
154_I170_G0.9111.00
57_G61_S0.9091.00
167_L185_D0.9081.00
89_G94_Y0.9051.00
41_P45_E0.9001.00
120_F123_D0.8951.00
61_S64_G0.8941.00
58_D61_S0.8881.00
180_E202_W0.8821.00
92_T211_S0.8801.00
98_D129_D0.8761.00
71_W75_D0.8671.00
25_R85_E0.8621.00
43_D46_A0.8601.00
7_V161_L0.8551.00
115_Q138_E0.8521.00
54_K58_D0.8501.00
31_F36_V0.8471.00
4_D105_V0.8471.00
50_G58_D0.8381.00
10_N121_V0.8381.00
7_V184_I0.8321.00
28_E41_P0.8281.00
90_R189_I0.8261.00
24_E28_E0.8251.00
100_L107_M0.8251.00
53_P68_K0.8231.00
68_K72_P0.8221.00
111_S136_G0.8211.00
145_E152_H0.8211.00
169_V187_A0.8131.00
107_M130_L0.8091.00
135_Y156_R0.8061.00
186_S204_T0.8041.00
100_L105_V0.8021.00
178_A182_A0.7951.00
90_R93_L0.7931.00
136_G139_P0.7911.00
15_V121_V0.7881.00
70_F73_E0.7881.00
187_A213_L0.7851.00
169_V213_L0.7851.00
70_F74_R0.7811.00
118_V121_V0.7791.00
11_D111_S0.7781.00
108_G157_A0.7781.00
207_I213_L0.7761.00
6_V167_L0.7741.00
113_N118_V0.7651.00
176_I188_F0.7631.00
15_V125_F0.7631.00
11_D171_D0.7571.00
52_T55_T0.7571.00
97_L130_L0.7501.00
188_F206_D0.7491.00
4_D106_N0.7481.00
94_Y129_D0.7451.00
75_D79_T0.7431.00
196_S208_D0.7431.00
138_E144_L0.7301.00
94_Y126_G0.7241.00
118_V134_A0.7241.00
191_R210_L0.7231.00
144_L156_R0.7211.00
39_P43_D0.7191.00
89_G125_F0.7121.00
119_D134_A0.7111.00
154_I175_D0.6891.00
122_L128_R0.6861.00
151_S181_N0.6861.00
24_E44_V0.6851.00
39_P44_V0.6831.00
51_A55_T0.6801.00
133_A157_A0.6791.00
42_E46_A0.6781.00
153_Y157_A0.6721.00
46_A58_D0.6701.00
16_G88_E0.6691.00
72_P75_D0.6681.00
92_T96_D0.6681.00
42_E45_E0.6641.00
51_A54_K0.6631.00
26_A30_T0.6611.00
177_R180_E0.6601.00
21_D88_E0.6591.00
207_I210_L0.6591.00
58_D62_R0.6581.00
112_S147_R0.6571.00
95_D99_T0.6571.00
23_L27_T0.6551.00
7_V108_G0.6511.00
12_G20_Y0.6481.00
155_D158_L0.6441.00
11_D121_V0.6431.00
110_V168_F0.6421.00
168_F175_D0.6411.00
153_Y178_A0.6411.00
67_P71_W0.6391.00
106_N163_A0.6321.00
23_L113_N0.6311.00
96_D169_V0.6301.00
158_L163_A0.6291.00
79_T116_A0.6271.00
69_D72_P0.6271.00
118_V122_L0.6261.00
107_M132_G0.6191.00
52_T56_V0.6191.00
189_I210_L0.6171.00
168_F178_A0.6171.00
144_L153_Y0.6121.00
45_E48_T0.6061.00
116_A120_F0.6051.00
24_E41_P0.6031.00
21_D41_P0.6021.00
131_F134_A0.6001.00
79_T83_R0.5991.00
139_P160_D0.5961.00
13_V175_D0.5961.00
98_D101_H0.5951.00
75_D78_L0.5911.00
139_P144_L0.5901.00
197_W200_N0.5841.00
8_F96_D0.5811.00
101_H129_D0.5811.00
4_D163_A0.5791.00
112_S137_R0.5741.00
17_R113_N0.5721.00
91_K211_S0.5721.00
76_R79_T0.5701.00
71_W74_R0.5661.00
113_N117_T0.5601.00
93_L96_D0.5591.00
113_N170_G0.5591.00
188_F203_P0.5581.00
50_G55_T0.5561.00
112_S149_P0.5561.00
93_L97_L0.5541.00
80_E83_R0.5521.00
194_R197_W0.5511.00
174_S178_A0.5511.00
17_R23_L0.5501.00
34_F69_D0.5501.00
122_L127_V0.5491.00
43_D47_M0.5471.00
32_R37_D0.5461.00
135_Y153_Y0.5441.00
21_D25_R0.5421.00
96_D99_T0.5421.00
137_R153_Y0.5401.00
53_P71_W0.5371.00
177_R201_A0.5361.00
13_V189_I0.5351.00
16_G21_D0.5321.00
133_A136_G0.5311.00
112_S174_S0.5311.00
123_D129_D0.5291.00
110_V135_Y0.5211.00
96_D100_L0.5211.00
16_G90_R0.5181.00
114_Q117_T0.5171.00
91_K209_C0.5161.00
89_G93_L0.5151.00
74_R77_A0.5151.00
30_T73_E0.5141.00
96_D207_I0.5091.00
30_T33_R0.5091.00
22_V87_R0.5081.00
53_P67_P0.5061.00
26_A77_A0.5051.00
60_C63_Y0.5031.00
188_F199_L0.5031.00
173_E188_F0.5021.00
154_I179_A0.5011.00
176_I180_E0.5011.00
109_I122_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1te2A 2 0.9679 100 0.277 Contact Map
1swvA 2 0.9587 100 0.279 Contact Map
4eekA 2 0.9633 100 0.279 Contact Map
4uw9A 1 0.8991 100 0.281 Contact Map
3l5kA 1 0.9541 100 0.281 Contact Map
2zg6A 2 0.8853 100 0.285 Contact Map
3mc1A 2 0.9633 100 0.285 Contact Map
2hdoA 1 0.9266 100 0.287 Contact Map
3iruA 4 0.9633 100 0.287 Contact Map
3sd7A 1 0.9633 100 0.288 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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