GREMLIN Database
Q9HSS1 - Phosphoglycerate dehydrogenase
UniProt: Q9HSS1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (281)
Sequences: 19344 (13227)
Seq/√Len: 789.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_D225_A4.1461.00
223_E251_G3.1731.00
245_D248_A3.0651.00
152_V168_A2.6381.00
254_E279_R2.5361.00
151_T174_S2.5071.00
213_L242_A2.4281.00
198_E228_R2.3921.00
51_D74_A2.3151.00
151_T176_I2.1841.00
176_I203_Q2.1581.00
201_C225_A2.1411.00
231_E257_P2.0821.00
219_G267_P2.0771.00
153_G200_V2.0651.00
202_A228_R2.0621.00
128_D132_R2.0391.00
157_F177_A2.0331.00
196_E199_A2.0281.00
114_L168_A1.9571.00
309_A314_D1.9471.00
63_A93_D1.9261.00
121_A206_V1.9221.00
227_N257_P1.9201.00
123_R126_E1.9031.00
75_A99_A1.8561.00
251_G255_D1.8551.00
163_G166_D1.8271.00
219_G245_D1.7991.00
115_S124_L1.7821.00
153_G204_S1.7801.00
63_A67_A1.7791.00
198_E225_A1.7481.00
49_G72_D1.7481.00
234_V260_A1.7151.00
117_V206_V1.7131.00
221_V226_C1.7091.00
233_A258_V1.7011.00
226_C252_A1.6971.00
223_E227_N1.6881.00
97_A319_R1.6851.00
114_L171_V1.6611.00
250_A279_R1.6561.00
116_L262_A1.6441.00
90_A93_D1.6391.00
107_R148_A1.6171.00
119_G125_H1.6131.00
235_V244_V1.6121.00
199_A203_Q1.6111.00
254_E275_P1.5871.00
279_R282_V1.5871.00
154_F161_A1.5861.00
174_S193_A1.5681.00
213_L218_R1.5641.00
250_A254_E1.5491.00
152_V173_E1.5331.00
308_A312_D1.5221.00
221_V225_A1.5211.00
246_D267_P1.5141.00
38_G64_E1.5091.00
145_L150_A1.4981.00
215_E218_R1.4911.00
67_A94_H1.4911.00
229_L233_A1.4841.00
150_A294_A1.4731.00
112_H289_G1.4691.00
224_A228_R1.4661.00
249_L261_A1.4541.00
201_C221_V1.4521.00
120_A260_A1.4511.00
113_A164_V1.4451.00
129_R132_R1.4401.00
37_T40_G1.4381.00
218_R242_A1.4201.00
209_V243_V1.4161.00
168_A173_E1.4141.00
225_A228_R1.4061.00
205_D230_P1.4061.00
164_V210_F1.3821.00
62_P65_T1.3801.00
111_E167_T1.3801.00
234_V259_S1.3781.00
163_G167_T1.3781.00
223_E248_A1.3671.00
38_G62_P1.3621.00
51_D72_D1.3601.00
107_R163_G1.3471.00
309_A317_P1.3421.00
146_R298_S1.3361.00
130_Q135_G1.3331.00
239_G243_V1.3301.00
176_I195_A1.3211.00
268_T271_P1.3131.00
63_A90_A1.2981.00
210_F238_V1.2941.00
52_A75_A1.2851.00
42_V68_E1.2801.00
113_A238_V1.2631.00
91_A98_V1.2561.00
120_A234_V1.2551.00
129_R133_R1.2341.00
209_V235_V1.2331.00
125_H128_D1.2241.00
154_F208_V1.2231.00
166_D172_A1.2191.00
305_G309_A1.2151.00
154_F165_A1.2081.00
174_S203_Q1.2061.00
301_A305_G1.1981.00
211_A243_V1.1931.00
112_H116_L1.1921.00
200_V204_S1.1901.00
89_A93_D1.1821.00
155_V211_A1.1751.00
66_I94_H1.1751.00
155_V220_L1.1691.00
266_L284_V1.1601.00
90_A94_H1.1551.00
157_F162_R1.1521.00
134_G278_G1.1431.00
207_L229_L1.1411.00
197_F225_A1.1341.00
176_I204_S1.1341.00
224_A227_N1.1331.00
305_G317_P1.1331.00
118_F171_V1.1311.00
67_A90_A1.1301.00
75_A310_V1.1291.00
198_E224_A1.1291.00
155_V221_V1.1241.00
164_V208_V1.1171.00
302_S318_E1.1161.00
46_D49_G1.1141.00
310_V316_V1.1101.00
193_A203_Q1.1091.00
110_G167_T1.1061.00
66_I91_A1.1051.00
151_T203_Q1.0981.00
120_A262_A1.0941.00
45_V69_I1.0901.00
220_L243_V1.0871.00
115_S118_F1.0841.00
206_V234_V1.0801.00
230_P233_A1.0781.00
117_V152_V1.0781.00
107_R167_T1.0771.00
120_A283_L1.0721.00
78_R86_I1.0701.00
247_A275_P1.0451.00
40_G43_A1.0401.00
117_V168_A1.0381.00
77_V306_T1.0351.00
182_V194_M1.0301.00
250_A275_P1.0271.00
89_A92_A1.0251.00
155_V207_L1.0231.00
226_C235_V1.0171.00
253_L282_V1.0111.00
112_H285_T1.0051.00
222_D248_A1.0031.00
208_V238_V1.0021.00
252_A257_P1.0021.00
232_G257_P0.9991.00
184_A188_E0.9951.00
86_I91_A0.9951.00
180_P216_E0.9951.00
77_V303_L0.9891.00
197_F201_C0.9841.00
121_A145_L0.9781.00
166_D169_T0.9751.00
38_G42_V0.9741.00
105_C290_W0.9551.00
254_E278_G0.9551.00
121_A150_A0.9451.00
169_T191_G0.9391.00
155_V197_F0.9381.00
297_E301_A0.9361.00
87_D90_A0.9351.00
246_D268_T0.9271.00
97_A316_V0.9191.00
116_L283_L0.9161.00
43_A46_D0.9161.00
88_C92_A0.9151.00
112_H262_A0.9131.00
211_A220_L0.9121.00
148_A172_A0.9121.00
114_L167_T0.9101.00
52_A307_V0.9101.00
252_A258_V0.9001.00
222_D245_D0.8991.00
86_I98_V0.8971.00
246_D274_S0.8941.00
42_V65_T0.8931.00
164_V168_A0.8891.00
52_A311_A0.8881.00
78_R85_A0.8871.00
204_S207_L0.8861.00
195_A199_A0.8861.00
155_V209_V0.8851.00
162_R186_T0.8811.00
129_R280_S0.8811.00
179_D183_D0.8801.00
40_G44_A0.8781.00
152_V208_V0.8751.00
77_V99_A0.8711.00
195_A200_V0.8691.00
195_A203_Q0.8681.00
221_V235_V0.8661.00
177_A192_V0.8531.00
119_G124_L0.8501.00
46_D68_E0.8461.00
125_H129_R0.8461.00
162_R183_D0.8451.00
198_E202_A0.8441.00
226_C229_L0.8401.00
306_T309_A0.8381.00
108_E146_R0.8371.00
154_F164_V0.8361.00
146_R292_S0.8351.00
66_I76_I0.8311.00
165_A175_V0.8281.00
212_P217_T0.8271.00
119_G283_L0.8251.00
157_F165_A0.8171.00
244_V249_L0.8171.00
145_L293_E0.8161.00
183_D186_T0.8141.00
121_A234_V0.8131.00
209_V221_V0.8091.00
201_C207_L0.8091.00
114_L164_V0.8061.00
147_L173_E0.7941.00
76_I91_A0.7931.00
226_C257_P0.7921.00
75_A307_V0.7911.00
263_L282_V0.7901.00
106_T159_E0.7871.00
106_T163_G0.7861.00
177_A194_M0.7841.00
232_G259_S0.7821.00
145_L294_A0.7821.00
80_G85_A0.7801.00
83_V88_C0.7761.00
113_A208_V0.7731.00
260_A283_L0.7711.00
199_A202_A0.7681.00
249_L258_V0.7641.00
53_V61_V0.7621.00
115_S119_G0.7621.00
113_A210_F0.7561.00
64_E67_A0.7541.00
223_E257_P0.7531.00
127_Y288_C0.7531.00
247_A251_G0.7521.00
261_A282_V0.7501.00
107_R111_E0.7461.00
101_A302_S0.7451.00
63_A94_H0.7451.00
251_G254_E0.7411.00
227_N255_D0.7391.00
298_S301_A0.7391.00
42_V64_E0.7391.00
246_D276_L0.7361.00
197_F220_L0.7331.00
121_A125_H0.7321.00
109_V289_G0.7291.00
207_L233_A0.7271.00
178_Y197_F0.7261.00
201_C228_R0.7251.00
107_R146_R0.7221.00
117_V164_V0.7141.00
63_A87_D0.7121.00
114_L117_V0.7121.00
247_A267_P0.7071.00
110_G163_G0.7071.00
213_L217_T0.7051.00
111_E122_R0.7041.00
108_E295_A0.7031.00
103_S159_E0.7031.00
54_V303_L0.7001.00
78_R83_V0.6981.00
148_A298_S0.6961.00
151_T204_S0.6931.00
253_L281_D0.6921.00
304_A308_A0.6871.00
207_L230_P0.6871.00
167_T171_V0.6861.00
192_V195_A0.6821.00
251_G257_P0.6811.00
305_G308_A0.6801.00
145_L232_G0.6761.00
117_V147_L0.6701.00
274_S278_G0.6701.00
49_G70_D0.6691.00
244_V261_A0.6681.00
130_Q133_R0.6661.00
201_C229_L0.6661.00
150_A206_V0.6661.00
315_G319_R0.6641.00
64_E68_E0.6631.00
293_E297_E0.6631.00
70_D73_V0.6561.00
232_G258_V0.6531.00
209_V239_G0.6521.00
179_D182_V0.6501.00
234_V262_A0.6481.00
151_T205_D0.6461.00
77_V307_V0.6451.00
218_R267_P0.6451.00
128_D131_T0.6431.00
151_T230_P0.6411.00
69_I73_V0.6391.00
271_P274_S0.6371.00
103_S302_S0.6371.00
103_S106_T0.6361.00
249_L263_L0.6331.00
131_T277_V0.6261.00
253_L261_A0.6261.00
223_E255_D0.6261.00
39_E43_A0.6251.00
185_A189_R0.6241.00
127_Y286_P0.6211.00
83_V100_N0.6201.00
277_V284_V0.6191.00
101_A299_L0.6181.00
107_R172_A0.6181.00
309_A315_G0.6181.00
117_V236_V0.6171.00
214_T217_T0.6151.00
262_A283_L0.6141.00
173_E206_V0.6131.00
113_A116_L0.6101.00
116_L119_G0.6101.00
252_A255_D0.6091.00
117_V208_V0.6091.00
162_R166_D0.6071.00
77_V101_A0.6071.00
45_V53_V0.6021.00
84_D213_L0.6021.00
157_F194_M0.6011.00
242_A267_P0.6001.00
186_T189_R0.5991.00
211_A239_G0.5981.00
130_Q137_A0.5971.00
153_G178_Y0.5961.00
246_D250_A0.5961.00
74_A310_V0.5961.00
55_G61_V0.5911.00
46_D70_D0.5901.00
176_I200_V0.5871.00
191_G195_A0.5851.00
167_T170_T0.5851.00
309_A316_V0.5821.00
152_V164_V0.5811.00
223_E252_A0.5781.00
126_E130_Q0.5781.00
219_G242_A0.5781.00
219_G222_D0.5771.00
70_D94_H0.5761.00
33_R36_E0.5761.00
108_E111_E0.5761.00
291_Y296_A0.5751.00
39_E64_E0.5741.00
131_T266_L0.5711.00
316_V319_R0.5701.00
145_L259_S0.5691.00
137_A140_D0.5691.00
150_A173_E0.5631.00
112_H122_R0.5611.00
94_H97_A0.5591.00
147_L171_V0.5591.00
41_L45_V0.5591.00
274_S277_V0.5571.00
188_E191_G0.5561.00
128_D284_V0.5541.00
42_V69_I0.5541.00
268_T274_S0.5521.00
108_E292_S0.5501.00
134_G273_E0.5491.00
169_T175_V0.5491.00
157_F179_D0.5491.00
39_E42_V0.5481.00
250_A282_V0.5461.00
61_V66_I0.5461.00
112_H115_S0.5451.00
119_G128_D0.5431.00
79_A299_L0.5411.00
121_A173_E0.5411.00
211_A217_T0.5401.00
116_L120_A0.5391.00
99_A306_T0.5381.00
69_I72_D0.5371.00
121_A147_L0.5351.00
104_Y302_S0.5311.00
150_A205_D0.5301.00
155_V200_V0.5301.00
207_L221_V0.5281.00
176_I193_A0.5261.00
135_G138_W0.5261.00
105_C108_E0.5261.00
104_Y299_L0.5241.00
302_S306_T0.5231.00
256_G281_D0.5201.00
52_A77_V0.5201.00
52_A55_G0.5201.00
201_C220_L0.5191.00
165_A177_A0.5181.00
42_V45_V0.5181.00
186_T190_H0.5171.00
301_A304_A0.5161.00
184_A194_M0.5151.00
254_E280_S0.5121.00
302_S305_G0.5121.00
42_V46_D0.5121.00
207_L235_V0.5111.00
276_L282_V0.5061.00
308_A314_D0.5051.00
101_A104_Y0.5041.00
56_G59_T0.5031.00
125_H283_L0.5021.00
273_E277_V0.5011.00
217_T243_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ygyA 4 0.969 100 0.189 Contact Map
2g76A 2 0.935 100 0.194 Contact Map
2yq5A 4 0.9721 100 0.202 Contact Map
1sc6A 4 0.9319 100 0.204 Contact Map
2d0iA 2 0.969 100 0.205 Contact Map
3wwyA 4 0.9752 100 0.207 Contact Map
1dxyA 5 0.9752 100 0.209 Contact Map
4g2nA 3 0.9628 100 0.211 Contact Map
3ba1A 2 0.9598 100 0.212 Contact Map
3k5pA 3 0.9536 100 0.213 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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