Q9HSS1 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HSS1 - Phosphoglycerate dehydrogenase

UniProt:	Q9HSS1	Sequences: MFTVLVSDGMGMLGALPDAVADRATRDVAFEHRRVETGEGLVAAVDDTGADAVVGGPETPVPAETIAEIDGDVAAIVRAGVGVDAIDCAAAADHGVAVANAPSYCTREVGEHALSLVFGAARRLHEYDRQTRRGGWAWNDAPAPLRLADATVGFVGFGEIARGVADTATTVAESVIAYDPYVDAATAERHGVAMAEFEAVCAQSDVLVVFAPLTEETRGLVDEAACNRLPEGAVVVNVGRGAVVDDAALAGALEDGPVSAAALDVLPTEPPVESPLVGRSDVLVTPHCGWYSEAAAESLVASLAGTVAAVADGDGVPERTRVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	323 (281)
Sequences:	19344 (13227)
Seq/√Len:	789.0

ECOLI - SERA GHRB LDHD GHRA PDXB
BACSU - SERA YOAD TKRA
HALSA - Q9HSS1 Q9HMR0 Q9HPW9
SULSO - Q97ZK1 Q97U35

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
222_D	225_A	4.146	1.00
223_E	251_G	3.173	1.00
245_D	248_A	3.065	1.00
152_V	168_A	2.638	1.00
254_E	279_R	2.536	1.00
151_T	174_S	2.507	1.00
213_L	242_A	2.428	1.00
198_E	228_R	2.392	1.00
51_D	74_A	2.315	1.00
151_T	176_I	2.184	1.00
176_I	203_Q	2.158	1.00
201_C	225_A	2.141	1.00
231_E	257_P	2.082	1.00
219_G	267_P	2.077	1.00
153_G	200_V	2.065	1.00
202_A	228_R	2.062	1.00
128_D	132_R	2.039	1.00
157_F	177_A	2.033	1.00
196_E	199_A	2.028	1.00
114_L	168_A	1.957	1.00
309_A	314_D	1.947	1.00
63_A	93_D	1.926	1.00
121_A	206_V	1.922	1.00
227_N	257_P	1.920	1.00
123_R	126_E	1.903	1.00
75_A	99_A	1.856	1.00
251_G	255_D	1.855	1.00
163_G	166_D	1.827	1.00
219_G	245_D	1.799	1.00
115_S	124_L	1.782	1.00
153_G	204_S	1.780	1.00
63_A	67_A	1.779	1.00
198_E	225_A	1.748	1.00
49_G	72_D	1.748	1.00
234_V	260_A	1.715	1.00
117_V	206_V	1.713	1.00
221_V	226_C	1.709	1.00
233_A	258_V	1.701	1.00
226_C	252_A	1.697	1.00
223_E	227_N	1.688	1.00
97_A	319_R	1.685	1.00
114_L	171_V	1.661	1.00
250_A	279_R	1.656	1.00
116_L	262_A	1.644	1.00
90_A	93_D	1.639	1.00
107_R	148_A	1.617	1.00
119_G	125_H	1.613	1.00
235_V	244_V	1.612	1.00
199_A	203_Q	1.611	1.00
254_E	275_P	1.587	1.00
279_R	282_V	1.587	1.00
154_F	161_A	1.586	1.00
174_S	193_A	1.568	1.00
213_L	218_R	1.564	1.00
250_A	254_E	1.549	1.00
152_V	173_E	1.533	1.00
308_A	312_D	1.522	1.00
221_V	225_A	1.521	1.00
246_D	267_P	1.514	1.00
38_G	64_E	1.509	1.00
145_L	150_A	1.498	1.00
215_E	218_R	1.491	1.00
67_A	94_H	1.491	1.00
229_L	233_A	1.484	1.00
150_A	294_A	1.473	1.00
112_H	289_G	1.469	1.00
224_A	228_R	1.466	1.00
249_L	261_A	1.454	1.00
201_C	221_V	1.452	1.00
120_A	260_A	1.451	1.00
113_A	164_V	1.445	1.00
129_R	132_R	1.440	1.00
37_T	40_G	1.438	1.00
218_R	242_A	1.420	1.00
209_V	243_V	1.416	1.00
168_A	173_E	1.414	1.00
225_A	228_R	1.406	1.00
205_D	230_P	1.406	1.00
164_V	210_F	1.382	1.00
62_P	65_T	1.380	1.00
111_E	167_T	1.380	1.00
234_V	259_S	1.378	1.00
163_G	167_T	1.378	1.00
223_E	248_A	1.367	1.00
38_G	62_P	1.362	1.00
51_D	72_D	1.360	1.00
107_R	163_G	1.347	1.00
309_A	317_P	1.342	1.00
146_R	298_S	1.336	1.00
130_Q	135_G	1.333	1.00
239_G	243_V	1.330	1.00
176_I	195_A	1.321	1.00
268_T	271_P	1.313	1.00
63_A	90_A	1.298	1.00
210_F	238_V	1.294	1.00
52_A	75_A	1.285	1.00
42_V	68_E	1.280	1.00
113_A	238_V	1.263	1.00
91_A	98_V	1.256	1.00
120_A	234_V	1.255	1.00
129_R	133_R	1.234	1.00
209_V	235_V	1.233	1.00
125_H	128_D	1.224	1.00
154_F	208_V	1.223	1.00
166_D	172_A	1.219	1.00
305_G	309_A	1.215	1.00
154_F	165_A	1.208	1.00
174_S	203_Q	1.206	1.00
301_A	305_G	1.198	1.00
211_A	243_V	1.193	1.00
112_H	116_L	1.192	1.00
200_V	204_S	1.190	1.00
89_A	93_D	1.182	1.00
155_V	211_A	1.175	1.00
66_I	94_H	1.175	1.00
155_V	220_L	1.169	1.00
266_L	284_V	1.160	1.00
90_A	94_H	1.155	1.00
157_F	162_R	1.152	1.00
134_G	278_G	1.143	1.00
207_L	229_L	1.141	1.00
197_F	225_A	1.134	1.00
176_I	204_S	1.134	1.00
224_A	227_N	1.133	1.00
305_G	317_P	1.133	1.00
118_F	171_V	1.131	1.00
67_A	90_A	1.130	1.00
75_A	310_V	1.129	1.00
198_E	224_A	1.129	1.00
155_V	221_V	1.124	1.00
164_V	208_V	1.117	1.00
302_S	318_E	1.116	1.00
46_D	49_G	1.114	1.00
310_V	316_V	1.110	1.00
193_A	203_Q	1.109	1.00
110_G	167_T	1.106	1.00
66_I	91_A	1.105	1.00
151_T	203_Q	1.098	1.00
120_A	262_A	1.094	1.00
45_V	69_I	1.090	1.00
220_L	243_V	1.087	1.00
115_S	118_F	1.084	1.00
206_V	234_V	1.080	1.00
230_P	233_A	1.078	1.00
117_V	152_V	1.078	1.00
107_R	167_T	1.077	1.00
120_A	283_L	1.072	1.00
78_R	86_I	1.070	1.00
247_A	275_P	1.045	1.00
40_G	43_A	1.040	1.00
117_V	168_A	1.038	1.00
77_V	306_T	1.035	1.00
182_V	194_M	1.030	1.00
250_A	275_P	1.027	1.00
89_A	92_A	1.025	1.00
155_V	207_L	1.023	1.00
226_C	235_V	1.017	1.00
253_L	282_V	1.011	1.00
112_H	285_T	1.005	1.00
222_D	248_A	1.003	1.00
208_V	238_V	1.002	1.00
252_A	257_P	1.002	1.00
232_G	257_P	0.999	1.00
184_A	188_E	0.995	1.00
86_I	91_A	0.995	1.00
180_P	216_E	0.995	1.00
77_V	303_L	0.989	1.00
197_F	201_C	0.984	1.00
121_A	145_L	0.978	1.00
166_D	169_T	0.975	1.00
38_G	42_V	0.974	1.00
105_C	290_W	0.955	1.00
254_E	278_G	0.955	1.00
121_A	150_A	0.945	1.00
169_T	191_G	0.939	1.00
155_V	197_F	0.938	1.00
297_E	301_A	0.936	1.00
87_D	90_A	0.935	1.00
246_D	268_T	0.927	1.00
97_A	316_V	0.919	1.00
116_L	283_L	0.916	1.00
43_A	46_D	0.916	1.00
88_C	92_A	0.915	1.00
112_H	262_A	0.913	1.00
211_A	220_L	0.912	1.00
148_A	172_A	0.912	1.00
114_L	167_T	0.910	1.00
52_A	307_V	0.910	1.00
252_A	258_V	0.900	1.00
222_D	245_D	0.899	1.00
86_I	98_V	0.897	1.00
246_D	274_S	0.894	1.00
42_V	65_T	0.893	1.00
164_V	168_A	0.889	1.00
52_A	311_A	0.888	1.00
78_R	85_A	0.887	1.00
204_S	207_L	0.886	1.00
195_A	199_A	0.886	1.00
155_V	209_V	0.885	1.00
162_R	186_T	0.881	1.00
129_R	280_S	0.881	1.00
179_D	183_D	0.880	1.00
40_G	44_A	0.878	1.00
152_V	208_V	0.875	1.00
77_V	99_A	0.871	1.00
195_A	200_V	0.869	1.00
195_A	203_Q	0.868	1.00
221_V	235_V	0.866	1.00
177_A	192_V	0.853	1.00
119_G	124_L	0.850	1.00
46_D	68_E	0.846	1.00
125_H	129_R	0.846	1.00
162_R	183_D	0.845	1.00
198_E	202_A	0.844	1.00
226_C	229_L	0.840	1.00
306_T	309_A	0.838	1.00
108_E	146_R	0.837	1.00
154_F	164_V	0.836	1.00
146_R	292_S	0.835	1.00
66_I	76_I	0.831	1.00
165_A	175_V	0.828	1.00
212_P	217_T	0.827	1.00
119_G	283_L	0.825	1.00
157_F	165_A	0.817	1.00
244_V	249_L	0.817	1.00
145_L	293_E	0.816	1.00
183_D	186_T	0.814	1.00
121_A	234_V	0.813	1.00
209_V	221_V	0.809	1.00
201_C	207_L	0.809	1.00
114_L	164_V	0.806	1.00
147_L	173_E	0.794	1.00
76_I	91_A	0.793	1.00
226_C	257_P	0.792	1.00
75_A	307_V	0.791	1.00
263_L	282_V	0.790	1.00
106_T	159_E	0.787	1.00
106_T	163_G	0.786	1.00
177_A	194_M	0.784	1.00
232_G	259_S	0.782	1.00
145_L	294_A	0.782	1.00
80_G	85_A	0.780	1.00
83_V	88_C	0.776	1.00
113_A	208_V	0.773	1.00
260_A	283_L	0.771	1.00
199_A	202_A	0.768	1.00
249_L	258_V	0.764	1.00
53_V	61_V	0.762	1.00
115_S	119_G	0.762	1.00
113_A	210_F	0.756	1.00
64_E	67_A	0.754	1.00
223_E	257_P	0.753	1.00
127_Y	288_C	0.753	1.00
247_A	251_G	0.752	1.00
261_A	282_V	0.750	1.00
107_R	111_E	0.746	1.00
101_A	302_S	0.745	1.00
63_A	94_H	0.745	1.00
251_G	254_E	0.741	1.00
227_N	255_D	0.739	1.00
298_S	301_A	0.739	1.00
42_V	64_E	0.739	1.00
246_D	276_L	0.736	1.00
197_F	220_L	0.733	1.00
121_A	125_H	0.732	1.00
109_V	289_G	0.729	1.00
207_L	233_A	0.727	1.00
178_Y	197_F	0.726	1.00
201_C	228_R	0.725	1.00
107_R	146_R	0.722	1.00
117_V	164_V	0.714	1.00
63_A	87_D	0.712	1.00
114_L	117_V	0.712	1.00
247_A	267_P	0.707	1.00
110_G	163_G	0.707	1.00
213_L	217_T	0.705	1.00
111_E	122_R	0.704	1.00
108_E	295_A	0.703	1.00
103_S	159_E	0.703	1.00
54_V	303_L	0.700	1.00
78_R	83_V	0.698	1.00
148_A	298_S	0.696	1.00
151_T	204_S	0.693	1.00
253_L	281_D	0.692	1.00
304_A	308_A	0.687	1.00
207_L	230_P	0.687	1.00
167_T	171_V	0.686	1.00
192_V	195_A	0.682	1.00
251_G	257_P	0.681	1.00
305_G	308_A	0.680	1.00
145_L	232_G	0.676	1.00
117_V	147_L	0.670	1.00
274_S	278_G	0.670	1.00
49_G	70_D	0.669	1.00
244_V	261_A	0.668	1.00
130_Q	133_R	0.666	1.00
201_C	229_L	0.666	1.00
150_A	206_V	0.666	1.00
315_G	319_R	0.664	1.00
64_E	68_E	0.663	1.00
293_E	297_E	0.663	1.00
70_D	73_V	0.656	1.00
232_G	258_V	0.653	1.00
209_V	239_G	0.652	1.00
179_D	182_V	0.650	1.00
234_V	262_A	0.648	1.00
151_T	205_D	0.646	1.00
77_V	307_V	0.645	1.00
218_R	267_P	0.645	1.00
128_D	131_T	0.643	1.00
151_T	230_P	0.641	1.00
69_I	73_V	0.639	1.00
271_P	274_S	0.637	1.00
103_S	302_S	0.637	1.00
103_S	106_T	0.636	1.00
249_L	263_L	0.633	1.00
131_T	277_V	0.626	1.00
253_L	261_A	0.626	1.00
223_E	255_D	0.626	1.00
39_E	43_A	0.625	1.00
185_A	189_R	0.624	1.00
127_Y	286_P	0.621	1.00
83_V	100_N	0.620	1.00
277_V	284_V	0.619	1.00
101_A	299_L	0.618	1.00
107_R	172_A	0.618	1.00
309_A	315_G	0.618	1.00
117_V	236_V	0.617	1.00
214_T	217_T	0.615	1.00
262_A	283_L	0.614	1.00
173_E	206_V	0.613	1.00
113_A	116_L	0.610	1.00
116_L	119_G	0.610	1.00
252_A	255_D	0.609	1.00
117_V	208_V	0.609	1.00
162_R	166_D	0.607	1.00
77_V	101_A	0.607	1.00
45_V	53_V	0.602	1.00
84_D	213_L	0.602	1.00
157_F	194_M	0.601	1.00
242_A	267_P	0.600	1.00
186_T	189_R	0.599	1.00
211_A	239_G	0.598	1.00
130_Q	137_A	0.597	1.00
153_G	178_Y	0.596	1.00
246_D	250_A	0.596	1.00
74_A	310_V	0.596	1.00
55_G	61_V	0.591	1.00
46_D	70_D	0.590	1.00
176_I	200_V	0.587	1.00
191_G	195_A	0.585	1.00
167_T	170_T	0.585	1.00
309_A	316_V	0.582	1.00
152_V	164_V	0.581	1.00
223_E	252_A	0.578	1.00
126_E	130_Q	0.578	1.00
219_G	242_A	0.578	1.00
219_G	222_D	0.577	1.00
70_D	94_H	0.576	1.00
33_R	36_E	0.576	1.00
108_E	111_E	0.576	1.00
291_Y	296_A	0.575	1.00
39_E	64_E	0.574	1.00
131_T	266_L	0.571	1.00
316_V	319_R	0.570	1.00
145_L	259_S	0.569	1.00
137_A	140_D	0.569	1.00
150_A	173_E	0.563	1.00
112_H	122_R	0.561	1.00
94_H	97_A	0.559	1.00
147_L	171_V	0.559	1.00
41_L	45_V	0.559	1.00
274_S	277_V	0.557	1.00
188_E	191_G	0.556	1.00
128_D	284_V	0.554	1.00
42_V	69_I	0.554	1.00
268_T	274_S	0.552	1.00
108_E	292_S	0.550	1.00
134_G	273_E	0.549	1.00
169_T	175_V	0.549	1.00
157_F	179_D	0.549	1.00
39_E	42_V	0.548	1.00
250_A	282_V	0.546	1.00
61_V	66_I	0.546	1.00
112_H	115_S	0.545	1.00
119_G	128_D	0.543	1.00
79_A	299_L	0.541	1.00
121_A	173_E	0.541	1.00
211_A	217_T	0.540	1.00
116_L	120_A	0.539	1.00
99_A	306_T	0.538	1.00
69_I	72_D	0.537	1.00
121_A	147_L	0.535	1.00
104_Y	302_S	0.531	1.00
150_A	205_D	0.530	1.00
155_V	200_V	0.530	1.00
207_L	221_V	0.528	1.00
176_I	193_A	0.526	1.00
135_G	138_W	0.526	1.00
105_C	108_E	0.526	1.00
104_Y	299_L	0.524	1.00
302_S	306_T	0.523	1.00
256_G	281_D	0.520	1.00
52_A	77_V	0.520	1.00
52_A	55_G	0.520	1.00
201_C	220_L	0.519	1.00
165_A	177_A	0.518	1.00
42_V	45_V	0.518	1.00
186_T	190_H	0.517	1.00
301_A	304_A	0.516	1.00
184_A	194_M	0.515	1.00
254_E	280_S	0.512	1.00
302_S	305_G	0.512	1.00
42_V	46_D	0.512	1.00
207_L	235_V	0.511	1.00
276_L	282_V	0.506	1.00
308_A	314_D	0.505	1.00
101_A	104_Y	0.504	1.00
56_G	59_T	0.503	1.00
125_H	283_L	0.502	1.00
273_E	277_V	0.501	1.00
217_T	243_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ygyA	4	0.969	100	0.189	Contact Map
2g76A	2	0.935	100	0.194	Contact Map
2yq5A	4	0.9721	100	0.202	Contact Map
1sc6A	4	0.9319	100	0.204	Contact Map
2d0iA	2	0.969	100	0.205	Contact Map
3wwyA	4	0.9752	100	0.207	Contact Map
1dxyA	5	0.9752	100	0.209	Contact Map
4g2nA	3	0.9628	100	0.211	Contact Map
3ba1A	2	0.9598	100	0.212	Contact Map
3k5pA	3	0.9536	100	0.213	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.