GREMLIN Database
Q9HSR9 - Type I restriction modification enzyme, M subunit
UniProt: Q9HSR9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 499 (453)
Sequences: 6850 (4439)
Seq/√Len: 208.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
351_Q355_E5.6971.00
319_L332_A4.3331.00
179_C333_A3.8621.00
270_D320_K3.6691.00
348_R351_Q3.5251.00
315_I332_A3.4061.00
420_D424_E3.2561.00
75_G80_D3.2431.00
415_T418_G3.1841.00
181_R209_Y3.0721.00
442_E445_E3.0211.00
437_R443_E3.0191.00
312_I336_I2.9291.00
352_P356_N2.8121.00
179_C273_L2.7821.00
442_E446_E2.6591.00
477_E481_E2.6331.00
333_A381_V2.6241.00
192_F206_A2.5701.00
440_G443_E2.5491.00
445_E449_F2.5341.00
315_I334_I2.4481.00
197_V236_A2.4251.00
480_A484_E2.3931.00
441_I445_E2.3361.00
394_V444_I2.3041.00
360_E383_N2.2391.00
177_Q205_E2.1681.00
14_K17_D2.1121.00
347_Q351_Q2.1041.00
197_V225_G2.0821.00
474_E478_L1.9841.00
481_E484_E1.9451.00
190_M271_R1.9301.00
193_H318_Q1.9231.00
474_E477_E1.9191.00
417_D420_D1.9161.00
196_T311_F1.8931.00
482_R485_I1.8881.00
90_E94_N1.8861.00
320_K329_G1.8701.00
216_G220_K1.8631.00
196_T274_A1.8591.00
467_D470_E1.8551.00
478_L481_E1.8511.00
393_E440_G1.8491.00
479_Q482_R1.8321.00
476_R480_A1.8311.00
200_G236_A1.8241.00
190_M331_K1.8041.00
468_V472_L1.8041.00
316_A357_D1.8011.00
423_V426_F1.7891.00
131_H134_T1.7701.00
333_A379_I1.7691.00
425_N435_V1.7491.00
478_L482_R1.7461.00
441_I449_F1.7431.00
368_N374_S1.7411.00
341_L362_I1.7401.00
89_D93_N1.7211.00
197_V249_I1.7181.00
39_K43_D1.7181.00
453_I457_V1.6911.00
338_H364_G1.6631.00
354_L394_V1.6611.00
418_G421_H1.6581.00
168_Q229_N1.6551.00
473_A477_E1.6461.00
181_R423_V1.6421.00
319_L330_G1.6391.00
367_E374_S1.6251.00
177_Q416_D1.6141.00
471_E475_L1.6131.00
419_L423_V1.6111.00
429_W432_E1.6101.00
355_E445_E1.6041.00
373_N376_P1.5961.00
183_V271_R1.5831.00
331_K383_N1.5781.00
48_E51_E1.5741.00
404_F407_E1.5611.00
279_S307_G1.5581.00
103_N106_L1.5511.00
274_A315_I1.5441.00
316_A353_M1.5411.00
367_E376_P1.5331.00
454_A458_D1.5271.00
443_E446_E1.5261.00
335_V379_I1.5201.00
421_H424_E1.5131.00
10_S14_K1.5091.00
479_Q483_E1.5081.00
227_E233_A1.5051.00
193_H272_V1.5011.00
368_N373_N1.4961.00
466_I470_E1.4911.00
405_Y408_L1.4821.00
472_L476_R1.4741.00
183_V333_A1.4651.00
453_I456_Y1.4631.00
355_E449_F1.4611.00
399_A422_I1.4581.00
177_Q181_R1.4551.00
421_H425_N1.4501.00
78_W82_R1.4491.00
316_A358_L1.4411.00
450_N453_I1.4361.00
184_D209_Y1.4361.00
74_E77_R1.4281.00
453_I458_D1.4231.00
236_A249_I1.4151.00
233_A249_I1.4051.00
468_V471_E1.3971.00
27_D30_E1.3971.00
309_Y346_E1.3821.00
361_A381_V1.3801.00
87_N92_I1.3751.00
321_E384_T1.3751.00
205_E208_K1.3691.00
471_E474_E1.3621.00
126_I130_E1.3571.00
347_Q448_D1.3561.00
338_H376_P1.3501.00
178_L182_L1.3501.00
451_L457_V1.3431.00
423_V427_D1.3401.00
227_E232_I1.3381.00
180_V209_Y1.3321.00
449_F453_I1.3271.00
180_V273_L1.3251.00
184_D427_D1.3221.00
284_K288_Q1.3151.00
363_V379_I1.3111.00
457_V460_T1.3081.00
444_I448_D1.2911.00
452_N456_Y1.2821.00
362_I380_L1.2821.00
452_N455_L1.2731.00
343_R346_E1.2721.00
468_V479_Q1.2711.00
451_L456_Y1.2611.00
291_Q310_A1.2601.00
73_P78_W1.2471.00
179_C379_I1.2401.00
477_E480_A1.2301.00
451_L454_A1.2271.00
424_E427_D1.2271.00
87_N91_A1.2251.00
79_N83_Q1.2171.00
339_G343_R1.2131.00
353_M358_L1.2101.00
271_R331_K1.2101.00
98_E101_Q1.2071.00
46_E79_N1.2051.00
458_D461_E1.1941.00
62_D65_N1.1931.00
332_A382_L1.1901.00
331_K360_E1.1881.00
480_A483_E1.1821.00
253_D256_A1.1801.00
475_L479_Q1.1781.00
193_H269_F1.1701.00
193_H254_S1.1691.00
123_D127_K1.1681.00
186_F190_M1.1661.00
176_V202_M1.1641.00
11_H134_T1.1641.00
78_W81_L1.1631.00
455_L458_D1.1611.00
441_I444_I1.1601.00
89_D96_F1.1591.00
444_I456_Y1.1591.00
454_A457_V1.1561.00
190_M270_D1.1401.00
329_G385_D1.1371.00
94_N97_T1.1371.00
466_I474_E1.1301.00
336_I380_L1.1291.00
338_H342_F1.1281.00
285_D289_D1.1281.00
92_I95_A1.1241.00
437_R440_G1.1201.00
62_D66_L1.1121.00
462_P465_D1.1101.00
439_V443_E1.1071.00
312_I334_I1.1051.00
195_P274_A1.1001.00
87_N95_A1.0981.00
466_I471_E1.0901.00
24_D29_K1.0891.00
91_A94_N1.0871.00
431_T437_R1.0851.00
451_L458_D1.0781.00
452_N457_V1.0761.00
250_E259_G1.0751.00
73_P76_H1.0741.00
448_D452_N1.0711.00
449_F456_Y1.0621.00
339_G346_E1.0621.00
456_Y461_E1.0601.00
93_N96_F1.0591.00
195_P315_I1.0581.00
366_P377_S1.0571.00
450_N454_A1.0551.00
96_F100_T1.0541.00
55_E58_E1.0531.00
368_N376_P1.0491.00
393_E438_T1.0491.00
95_A99_F1.0441.00
447_N450_N1.0401.00
449_F455_L1.0361.00
118_G121_T1.0361.00
444_I449_F1.0301.00
471_E478_L1.0291.00
339_G376_P1.0271.00
467_D471_E1.0231.00
475_L482_R1.0221.00
431_T436_S1.0211.00
308_D337_P1.0181.00
357_D386_K1.0181.00
359_V382_L1.0151.00
336_I378_A1.0151.00
447_N455_L1.0141.00
91_A95_A1.0141.00
226_Q252_G1.0091.00
127_K131_H1.0071.00
473_A480_A1.0071.00
439_V444_I1.0061.00
73_P77_R1.0061.00
180_V206_A1.0021.00
255_L311_F0.9991.00
203_L225_G0.9991.00
275_N370_F0.9981.00
312_I380_L0.9981.00
476_R479_Q0.9941.00
470_E474_E0.9911.00
414_L418_G0.9901.00
424_E428_D0.9851.00
74_E80_D0.9851.00
77_R82_R0.9821.00
339_G345_H0.9791.00
209_Y212_E0.9781.00
359_V362_I0.9751.00
87_N90_E0.9731.00
89_D95_A0.9721.00
353_M359_V0.9681.00
272_V319_L0.9681.00
428_D432_E0.9671.00
478_L485_I0.9671.00
404_F408_L0.9591.00
395_Q399_A0.9571.00
446_E452_N0.9530.99
152_M170_F0.9530.99
338_H373_N0.9480.99
88_V91_A0.9470.99
444_I453_I0.9450.99
369_L373_N0.9430.99
461_E465_D0.9430.99
82_R133_S0.9400.99
438_T441_I0.9390.99
469_N473_A0.9380.99
357_D384_T0.9340.99
357_D392_G0.9340.99
18_I127_K0.9330.99
466_I472_L0.9290.99
468_V475_L0.9280.99
440_G445_E0.9240.99
314_H317_E0.9240.99
450_N457_V0.9240.99
431_T438_T0.9190.99
207_A223_F0.9180.99
447_N453_I0.9170.99
473_A483_E0.9170.99
475_L478_L0.9160.99
50_E54_E0.9140.99
96_F99_F0.9120.99
368_N375_I0.9110.99
338_H375_I0.9100.99
88_V93_N0.9080.99
65_N68_D0.9050.99
30_E231_D0.9040.99
85_S91_A0.9030.99
53_V56_Y0.9020.99
191_T224_T0.9000.99
106_L110_F0.9000.99
472_L479_Q0.8990.99
365_L369_L0.8980.99
278_F375_I0.8970.99
416_D420_D0.8950.99
93_N97_T0.8930.99
159_A162_E0.8920.99
477_E483_E0.8910.99
109_I112_A0.8900.99
252_G257_S0.8880.99
473_A476_R0.8870.99
77_R81_L0.8870.99
373_N377_S0.8870.99
200_G203_L0.8870.99
303_R310_A0.8860.99
472_L482_R0.8860.99
280_A283_A0.8850.99
449_F457_V0.8840.99
432_E436_S0.8840.99
191_T267_E0.8830.99
316_A382_L0.8830.99
14_K131_H0.8790.99
446_E451_L0.8760.99
439_V445_E0.8760.99
458_D465_D0.8740.99
173_P201_G0.8710.99
268_R321_E0.8680.99
439_V457_V0.8650.99
224_T269_F0.8640.99
16_A20_R0.8610.99
49_R53_V0.8600.99
363_V381_V0.8590.99
113_N116_E0.8560.99
274_A334_I0.8530.99
272_V315_I0.8520.99
402_E418_G0.8520.99
398_H401_D0.8510.99
359_V394_V0.8510.99
313_M317_E0.8500.99
243_H247_G0.8480.99
176_V205_E0.8470.99
80_D83_Q0.8460.99
102_A105_D0.8450.99
186_F189_G0.8450.99
439_V455_L0.8420.99
109_I115_M0.8410.99
192_F210_Y0.8410.99
439_V456_Y0.8410.99
176_V201_G0.8400.99
402_E421_H0.8400.99
210_Y221_L0.8390.99
440_G444_I0.8380.99
450_N456_Y0.8370.99
448_D451_L0.8370.99
394_V397_I0.8370.99
461_E464_E0.8360.99
170_F232_I0.8350.99
481_E485_I0.8320.99
303_R313_M0.8300.99
184_D213_A0.8290.99
233_A251_R0.8250.99
449_F452_N0.8230.99
444_I452_N0.8220.99
422_I426_F0.8220.99
77_R80_D0.8210.98
456_Y459_T0.8200.98
285_D288_Q0.8190.98
135_Y139_R0.8170.98
270_D329_G0.8160.98
87_N94_N0.8150.98
308_D336_I0.8140.98
458_D462_P0.8130.98
445_E454_A0.8130.98
286_D289_D0.8120.98
321_E329_G0.8090.98
437_R457_V0.8040.98
54_E57_G0.8020.98
367_E373_N0.8020.98
450_N455_L0.8010.98
440_G456_Y0.7970.98
95_A100_T0.7960.98
145_D239_N0.7960.98
95_A98_E0.7960.98
181_R420_D0.7920.98
460_T463_E0.7900.98
437_R445_E0.7900.98
448_D458_D0.7900.98
182_L363_V0.7870.98
339_G342_F0.7860.98
479_Q485_I0.7850.98
394_V399_A0.7850.98
396_F399_A0.7840.98
454_A460_T0.7830.98
361_A426_F0.7810.98
52_I56_Y0.7810.98
206_A273_L0.7790.98
284_K289_D0.7750.98
171_T275_N0.7740.98
419_L424_E0.7740.98
471_E482_R0.7730.98
438_T446_E0.7720.98
469_N472_L0.7690.98
466_I469_N0.7680.98
37_F238_M0.7680.98
197_V200_G0.7680.98
472_L478_L0.7680.98
476_R483_E0.7670.98
438_T444_I0.7670.98
352_P355_E0.7660.98
153_D157_H0.7660.98
338_H366_P0.7640.98
456_Y460_T0.7610.98
11_H14_K0.7600.98
291_Q295_F0.7590.97
279_S338_H0.7590.97
455_L462_P0.7590.97
365_L368_N0.7580.97
364_G453_I0.7560.97
88_V95_A0.7540.97
14_K18_I0.7540.97
301_L305_D0.7530.97
451_L455_L0.7520.97
91_A99_F0.7500.97
254_S314_H0.7480.97
336_I340_V0.7470.97
454_A459_T0.7470.97
439_V442_E0.7460.97
240_L249_I0.7460.97
111_N118_G0.7400.97
394_V398_H0.7390.97
444_I447_N0.7390.97
340_V380_L0.7380.97
329_G383_N0.7370.97
372_N375_I0.7350.97
24_D229_N0.7330.97
446_E450_N0.7300.97
183_V273_L0.7280.97
312_I349_Y0.7280.97
183_V331_K0.7270.97
278_F377_S0.7250.97
177_Q208_K0.7240.97
46_E49_R0.7210.97
43_D46_E0.7210.97
452_N465_D0.7210.97
110_F115_M0.7200.97
182_L381_V0.7190.97
445_E456_Y0.7180.96
74_E78_W0.7150.96
444_I450_N0.7120.96
191_T270_D0.7100.96
455_L460_T0.7060.96
17_D20_R0.7060.96
369_L375_I0.7040.96
428_D431_T0.7040.96
392_G396_F0.7040.96
89_D92_I0.7020.96
362_I394_V0.7010.96
175_I369_L0.7000.96
359_V380_L0.7000.96
437_R444_I0.6990.96
287_L290_D0.6990.96
422_I427_D0.6990.96
439_V452_N0.6980.96
364_G396_F0.6980.96
360_E381_V0.6980.96
474_E485_I0.6980.96
449_F454_A0.6940.96
53_V57_G0.6890.96
471_E479_Q0.6880.96
337_P376_P0.6880.96
368_N372_N0.6870.96
448_D455_L0.6870.96
293_G296_D0.6860.95
13_F157_H0.6860.95
425_N432_E0.6830.95
18_I131_H0.6820.95
448_D456_Y0.6820.95
365_L377_S0.6810.95
40_A44_E0.6800.95
24_D27_D0.6800.95
446_E454_A0.6780.95
63_N67_Y0.6780.95
460_T465_D0.6750.95
452_N458_D0.6720.95
456_Y462_P0.6720.95
456_Y465_D0.6710.95
156_R160_E0.6710.95
437_R441_I0.6700.95
477_E485_I0.6700.95
97_T100_T0.6700.95
62_D68_D0.6690.95
445_E448_D0.6680.95
407_E411_Q0.6670.95
395_Q398_H0.6670.95
440_G446_E0.6660.95
393_E429_W0.6660.95
193_H226_Q0.6650.95
340_V378_A0.6570.94
179_C202_M0.6570.94
339_G354_L0.6570.94
438_T452_N0.6550.94
87_N93_N0.6540.94
296_D300_K0.6500.94
84_E91_A0.6480.94
406_E415_T0.6480.94
191_T320_K0.6460.94
207_A218_P0.6460.94
474_E481_E0.6450.94
351_Q445_E0.6450.94
444_I451_L0.6440.94
419_L426_F0.6440.94
443_E447_N0.6440.94
252_G259_G0.6440.94
334_I382_L0.6420.94
393_E396_F0.6400.93
143_P146_M0.6400.93
13_F16_A0.6400.93
13_F20_R0.6370.93
421_H435_V0.6370.93
459_T464_E0.6360.93
439_V450_N0.6350.93
63_N66_L0.6350.93
76_H98_E0.6340.93
474_E479_Q0.6320.93
12_L150_A0.6320.93
185_D190_M0.6300.93
474_E482_R0.6300.93
408_L411_Q0.6300.93
312_I353_M0.6300.93
84_E87_N0.6300.93
178_L423_V0.6300.93
365_L370_F0.6270.93
42_S46_E0.6260.93
441_I452_N0.6260.93
71_I78_W0.6250.93
416_D419_L0.6190.92
16_A19_I0.6190.92
450_N458_D0.6180.92
471_E477_E0.6170.92
202_M273_L0.6150.92
338_H374_S0.6120.92
177_Q212_E0.6100.92
416_D423_V0.6100.92
437_R452_N0.6080.92
21_D25_P0.6040.91
416_D424_E0.6040.91
313_M352_P0.6040.91
166_G229_N0.6030.91
366_P373_N0.6030.91
338_H367_E0.6020.91
94_N98_E0.6010.91
474_E483_E0.6000.91
69_V77_R0.5990.91
313_M316_A0.5990.91
456_Y464_E0.5970.91
181_R427_D0.5950.91
335_V374_S0.5950.91
38_Y81_L0.5950.91
69_V73_P0.5940.91
106_L116_E0.5920.91
457_V479_Q0.5890.90
15_C128_L0.5880.90
144_P149_E0.5880.90
338_H346_E0.5870.90
66_L70_P0.5860.90
208_K211_R0.5860.90
290_D294_R0.5860.90
337_P343_R0.5850.90
313_M349_Y0.5830.90
279_S308_D0.5830.90
71_I74_E0.5830.90
288_Q291_Q0.5820.90
56_Y66_L0.5810.90
181_R212_E0.5810.90
70_P74_E0.5800.90
448_D457_V0.5800.90
308_D339_G0.5780.90
76_H80_D0.5780.90
397_I402_E0.5760.89
429_W434_R0.5760.89
104_P107_S0.5760.89
165_S229_N0.5750.89
316_A384_T0.5750.89
467_D474_E0.5750.89
364_G376_P0.5750.89
203_L223_F0.5750.89
238_M242_L0.5740.89
459_T465_D0.5740.89
455_L463_E0.5730.89
366_P376_P0.5730.89
436_S439_V0.5720.89
302_P305_D0.5710.89
219_S222_T0.5710.89
230_P251_R0.5700.89
313_M334_I0.5700.89
47_Q51_E0.5700.89
475_L483_E0.5690.89
463_E467_D0.5690.89
421_H426_F0.5680.89
437_R454_A0.5670.89
70_P76_H0.5670.89
416_D421_H0.5650.88
372_N376_P0.5640.88
191_T222_T0.5640.88
371_Q374_S0.5620.88
439_V449_F0.5620.88
75_G79_N0.5620.88
164_K169_F0.5610.88
362_I378_A0.5590.88
43_D170_F0.5580.88
51_E54_E0.5580.88
70_P78_W0.5560.88
439_V458_D0.5550.88
441_I446_E0.5550.88
443_E451_L0.5540.87
450_N460_T0.5530.87
455_L459_T0.5530.87
50_E53_V0.5520.87
466_I479_Q0.5480.87
106_L115_M0.5480.87
250_E253_D0.5480.87
68_D72_V0.5480.87
189_G270_D0.5470.87
38_Y42_S0.5470.87
452_N462_P0.5470.87
360_E429_W0.5440.87
446_E458_D0.5440.87
437_R456_Y0.5440.87
272_V332_A0.5440.87
315_I319_L0.5430.86
176_V180_V0.5420.86
420_D423_V0.5410.86
306_R337_P0.5410.86
48_E52_I0.5410.86
99_F102_A0.5400.86
51_E56_Y0.5390.86
448_D454_A0.5380.86
473_A484_E0.5370.86
84_E126_I0.5360.86
155_V235_I0.5360.86
39_K133_S0.5350.86
465_D468_V0.5350.86
112_A115_M0.5350.86
319_L384_T0.5350.86
156_R166_G0.5350.86
464_E467_D0.5340.86
282_W307_G0.5330.85
338_H368_N0.5320.85
27_D116_E0.5310.85
280_A310_A0.5310.85
306_R340_V0.5290.85
440_G457_V0.5280.85
51_E55_E0.5260.85
16_A28_Y0.5250.85
439_V447_N0.5250.85
70_P73_P0.5240.84
339_G373_N0.5240.84
107_S110_F0.5230.84
465_D471_E0.5230.84
173_P205_E0.5220.84
31_Y34_P0.5210.84
195_P272_V0.5210.84
472_L475_L0.5190.84
440_G447_N0.5180.84
191_T268_R0.5180.84
53_V58_E0.5170.84
460_T466_I0.5160.84
425_N436_S0.5160.84
460_T464_E0.5160.84
244_T247_G0.5150.83
437_R453_I0.5150.83
371_Q375_I0.5140.83
471_E485_I0.5140.83
170_F274_A0.5140.83
447_N458_D0.5110.83
309_Y345_H0.5100.83
308_D346_E0.5100.83
173_P208_K0.5100.83
232_I235_I0.5090.83
339_G374_S0.5090.83
337_P373_N0.5060.82
364_G378_A0.5050.82
443_E450_N0.5050.82
337_P377_S0.5040.82
337_P372_N0.5040.82
437_R442_E0.5030.82
209_Y213_A0.5030.82
225_G249_I0.5030.82
470_E473_A0.5030.82
458_D468_V0.5020.82
373_N378_A0.5020.82
34_P42_S0.5010.82
339_G366_P0.5010.82
393_E398_H0.5000.82
191_T221_L0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lkdA 1 0.8677 100 0.261 Contact Map
3khkA 1 0.8597 100 0.304 Contact Map
2ar0A 1 0.8196 100 0.305 Contact Map
3ufbA 1 0.8737 100 0.323 Contact Map
2okcA 1 0.8176 100 0.373 Contact Map
3s1sA 1 0.9118 100 0.531 Contact Map
2f8lA 1 0.6353 100 0.555 Contact Map
2ih2A 1 0.5511 100 0.672 Contact Map
3v97A 1 0.8016 99.9 0.758 Contact Map
3lduA 1 0.6152 99.8 0.808 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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