GREMLIN Database
Q9HSR8 - Type I restriction modification enzyme, S subunit
UniProt: Q9HSR8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 475 (385)
Sequences: 3366 (3347)
Seq/√Len: 170.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
339_R360_G4.2561.00
360_G399_E4.1561.00
138_H179_E4.0151.00
339_R399_E3.8541.00
116_T179_E3.8211.00
110_D143_R3.3081.00
116_T138_H3.1601.00
149_C199_R3.0781.00
221_K441_Q3.0351.00
339_R397_F2.9811.00
117_G120_T2.9341.00
333_E365_V2.8631.00
338_I359_R2.7761.00
338_I360_G2.6361.00
228_G448_G2.5941.00
360_G397_F2.4151.00
331_A351_E2.4151.00
373_T426_S2.4051.00
117_G178_I2.3911.00
126_V151_H2.3591.00
338_I362_A2.3481.00
357_L363_R2.3281.00
282_Y285_V2.3241.00
116_T177_Q2.3191.00
115_S138_H2.3171.00
452_D457_E2.3051.00
115_S137_S2.2981.00
138_H177_Q2.1801.00
402_L406_G2.1721.00
330_H365_V2.1171.00
285_V359_R2.1121.00
371_D419_D2.0551.00
55_K142_L2.0421.00
231_D451_Q2.0301.00
216_E443_K2.0221.00
300_T337_T2.0021.00
115_S140_T2.0001.00
338_I399_E1.9781.00
273_Q406_G1.9371.00
339_R359_R1.9241.00
338_I358_T1.8741.00
340_A397_F1.8541.00
270_E274_N1.8381.00
57_L60_R1.8361.00
340_A398_D1.8271.00
282_Y358_T1.8111.00
445_L448_G1.7701.00
300_T339_R1.7661.00
225_L445_L1.7621.00
116_T137_S1.7591.00
107_E143_R1.6841.00
299_N314_S1.6571.00
214_K217_A1.6331.00
362_A402_L1.6321.00
431_R435_E1.6311.00
116_T136_D1.6281.00
300_T340_A1.6191.00
357_L361_T1.5961.00
299_N358_T1.5931.00
366_P375_L1.5871.00
75_N138_H1.5851.00
335_V361_T1.5831.00
118_Q178_I1.5661.00
135_I141_L1.5651.00
114_N123_R1.5541.00
50_R187_L1.5511.00
340_A396_T1.5501.00
441_Q445_L1.5481.00
299_N360_G1.5401.00
333_E363_R1.5401.00
148_L153_H1.5301.00
52_G186_D1.5271.00
115_S177_Q1.5251.00
276_C364_V1.5171.00
75_N78_C1.4971.00
136_D139_V1.4941.00
115_S179_E1.4931.00
56_Q145_D1.4781.00
75_N137_S1.4741.00
270_E412_H1.4691.00
282_Y338_I1.4661.00
118_Q177_Q1.4651.00
112_I139_V1.4641.00
182_K186_D1.4621.00
76_Q114_N1.4571.00
224_R444_R1.4501.00
282_Y360_G1.4361.00
285_V358_T1.4321.00
151_H206_Y1.4281.00
117_G177_Q1.4281.00
155_Y205_L1.4191.00
338_I361_T1.4151.00
359_R399_E1.4121.00
348_V355_A1.4021.00
330_H333_E1.4021.00
362_A405_L1.3891.00
300_T399_E1.3881.00
338_I397_F1.3821.00
297_Y359_R1.3801.00
327_S356_N1.3741.00
76_Q115_S1.3651.00
357_L360_G1.3621.00
202_A206_Y1.3561.00
50_R189_P1.3551.00
450_M454_L1.3511.00
299_N359_R1.3491.00
140_T182_K1.3331.00
48_A191_P1.3291.00
282_Y359_R1.3281.00
117_G136_D1.3211.00
118_Q138_H1.3201.00
338_I402_L1.3081.00
144_T150_P1.3071.00
361_T399_E1.3021.00
370_V375_L1.2991.00
232_D452_D1.2901.00
300_T358_T1.2871.00
340_A360_G1.2851.00
136_D177_Q1.2821.00
218_V438_Y1.2761.00
359_R362_A1.2731.00
299_N399_E1.2721.00
339_R362_A1.2611.00
297_Y358_T1.2591.00
215_T218_V1.2581.00
225_L229_L1.2541.00
115_S136_D1.2531.00
300_T360_G1.2511.00
221_K225_L1.2501.00
271_S409_P1.2471.00
347_Q376_L1.2411.00
137_S140_T1.2381.00
271_S407_K1.2371.00
149_C202_A1.2291.00
366_P372_N1.2261.00
300_T361_T1.2251.00
219_I435_E1.2211.00
211_A215_T1.2151.00
282_Y339_R1.2151.00
117_G121_L1.2101.00
126_V154_R1.2001.00
285_V297_Y1.1921.00
300_T397_F1.1811.00
286_Q359_R1.1811.00
76_Q118_Q1.1751.00
195_L199_R1.1701.00
415_I419_D1.1661.00
215_T439_L1.1581.00
258_E261_Q1.1571.00
120_T178_I1.1571.00
286_Q360_G1.1551.00
116_T135_I1.1521.00
304_T344_A1.1501.00
223_E436_E1.1481.00
318_P322_E1.1471.00
76_Q116_T1.1471.00
117_G138_H1.1441.00
214_K434_N1.1441.00
202_A205_L1.1441.00
337_T397_F1.1391.00
362_A397_F1.1311.00
339_R361_T1.1211.00
136_D179_E1.1211.00
76_Q138_H1.1171.00
300_T338_I1.1151.00
75_N179_E1.1141.00
282_Y399_E1.1061.00
415_I418_Q1.1031.00
358_T361_T1.1001.00
50_R53_D1.0991.00
337_T344_A1.0951.00
58_I61_G1.0931.00
159_S162_G1.0901.00
339_R357_L1.0861.00
421_I425_L1.0851.00
371_D422_V1.0831.00
339_R358_T1.0811.00
144_T153_H1.0811.00
139_V179_E1.0741.00
392_V398_D1.0691.00
396_T399_E1.0681.00
115_S139_V1.0581.00
327_S363_R1.0581.00
55_K153_H1.0570.99
120_T138_H1.0540.99
139_V177_Q1.0520.99
454_L458_V1.0480.99
338_I401_N1.0450.99
217_A221_K1.0410.99
116_T120_T1.0390.99
114_N118_Q1.0380.99
394_G398_D1.0350.99
336_V405_L1.0340.99
358_T399_E1.0330.99
420_R423_D1.0240.99
285_V360_G1.0240.99
211_A431_R1.0230.99
337_T340_A1.0220.99
236_K239_S1.0210.99
282_Y362_A1.0090.99
302_D312_G1.0090.99
329_I348_V1.0040.99
338_I357_L0.9970.99
285_V338_I0.9970.99
284_I359_R0.9880.99
112_I127_Y0.9870.99
232_D238_L0.9830.99
228_G231_D0.9800.99
273_Q407_K0.9800.99
299_N302_D0.9790.99
137_S179_E0.9780.99
216_E439_L0.9720.99
229_L449_L0.9660.99
49_K53_D0.9630.99
169_M184_R0.9610.99
135_I138_H0.9600.99
284_I339_R0.9600.99
76_Q179_E0.9550.99
330_H351_E0.9540.99
107_E132_R0.9500.99
60_R179_E0.9480.99
200_K203_S0.9410.99
59_T136_D0.9400.99
114_N177_Q0.9390.99
377_W425_L0.9360.99
61_G138_H0.9350.99
300_T304_T0.9340.99
226_K446_K0.9330.99
285_V357_L0.9290.99
282_Y402_L0.9210.99
60_R138_H0.9090.98
114_N179_E0.9050.98
258_E263_I0.9040.98
335_V348_V0.9010.98
217_A220_E0.9010.98
118_Q137_S0.8980.98
115_S181_S0.8970.98
216_E220_E0.8970.98
448_G452_D0.8950.98
341_T344_A0.8930.98
285_V339_R0.8920.98
114_N120_T0.8900.98
118_Q121_L0.8840.98
76_Q120_T0.8830.98
437_S441_Q0.8800.98
215_T438_Y0.8770.98
231_D236_K0.8770.98
285_V399_E0.8770.98
453_L458_V0.8760.98
362_A399_E0.8740.98
154_R158_E0.8680.98
105_F132_R0.8680.98
341_T396_T0.8640.98
282_Y363_R0.8570.98
165_L188_L0.8570.98
108_S132_R0.8560.98
209_D446_K0.8540.98
104_Y115_S0.8540.98
136_D141_L0.8500.98
337_T341_T0.8500.98
75_N136_D0.8480.98
117_G163_Q0.8460.98
337_T362_A0.8430.98
48_A189_P0.8400.97
115_S135_I0.8400.97
452_D458_V0.8360.97
226_K230_L0.8340.97
297_Y338_I0.8330.97
114_N117_G0.8310.97
340_A343_G0.8300.97
303_M337_T0.8300.97
337_T360_G0.8290.97
336_V364_V0.8280.97
76_Q177_Q0.8270.97
235_T238_L0.8270.97
347_Q373_T0.8230.97
300_T359_R0.8220.97
361_T397_F0.8210.97
108_S129_G0.8210.97
283_G286_Q0.8210.97
162_G166_L0.8170.97
327_S360_G0.8140.97
282_Y286_Q0.8090.97
235_T239_S0.8080.97
117_G137_S0.8010.97
78_C88_N0.7990.97
120_T177_Q0.7990.97
271_S274_N0.7970.97
345_V379_I0.7960.96
281_T327_S0.7960.96
199_R203_S0.7940.96
358_T362_A0.7940.96
208_V211_A0.7910.96
284_I360_G0.7900.96
215_T435_E0.7900.96
360_G394_G0.7890.96
117_G123_R0.7890.96
72_P78_C0.7880.96
435_E438_Y0.7880.96
140_T179_E0.7860.96
73_V120_T0.7850.96
202_A209_D0.7840.96
162_G188_L0.7830.96
358_T397_F0.7820.96
286_Q358_T0.7810.96
76_Q104_Y0.7790.96
75_N116_T0.7780.96
136_D140_T0.7780.96
118_Q175_T0.7770.96
284_I324_Y0.7750.96
337_T342_I0.7730.96
451_Q454_L0.7690.96
282_Y300_T0.7690.96
269_V411_P0.7660.96
339_R402_L0.7650.96
299_N339_R0.7650.96
73_V137_S0.7640.96
258_E262_T0.7630.96
286_Q297_Y0.7620.96
345_V376_L0.7590.95
106_P179_E0.7570.95
320_I324_Y0.7550.95
321_A356_N0.7550.95
232_D237_G0.7520.95
206_Y210_Q0.7510.95
173_G178_I0.7480.95
116_T139_V0.7470.95
286_Q338_I0.7450.95
74_I78_C0.7430.95
339_R394_G0.7430.95
387_E391_R0.7420.95
329_I355_A0.7410.95
232_D236_K0.7410.95
171_V179_E0.7370.95
340_A344_A0.7370.95
114_N121_L0.7360.95
221_K224_R0.7360.95
116_T121_L0.7340.95
422_V426_S0.7340.95
297_Y361_T0.7330.94
124_A157_F0.7330.94
115_S134_A0.7320.94
77_E118_Q0.7320.94
181_S184_R0.7300.94
276_C375_L0.7270.94
220_E223_E0.7260.94
49_K192_L0.7260.94
76_Q137_S0.7250.94
387_E409_P0.7220.94
77_E117_G0.7220.94
118_Q139_V0.7210.94
326_R356_N0.7190.94
341_T398_D0.7190.94
300_T342_I0.7190.94
121_L179_E0.7180.94
116_T140_T0.7180.94
339_R396_T0.7170.94
227_Q231_D0.7150.94
417_E421_I0.7150.94
356_N359_R0.7130.94
360_G396_T0.7130.94
221_K445_L0.7130.94
269_V409_P0.7120.94
121_L139_V0.7110.94
299_N312_G0.7110.94
328_Q356_N0.7090.93
219_I225_L0.7090.93
394_G399_E0.7020.93
441_Q444_R0.7020.93
148_L192_L0.6940.93
360_G401_N0.6940.93
399_E402_L0.6930.93
300_T398_D0.6900.93
76_Q125_Q0.6890.92
137_S181_S0.6880.92
211_A438_Y0.6870.92
259_R262_T0.6870.92
339_R401_N0.6860.92
359_R397_F0.6860.92
329_I333_E0.6830.92
338_I355_A0.6830.92
401_N404_Q0.6830.92
115_S182_K0.6810.92
338_I405_L0.6810.92
297_Y356_N0.6800.92
76_Q117_G0.6780.92
392_V399_E0.6780.92
298_I355_A0.6770.92
340_A358_T0.6740.92
121_L138_H0.6730.92
230_L233_L0.6730.92
284_I338_I0.6730.92
229_L233_L0.6720.91
75_N117_G0.6720.91
59_T115_S0.6700.91
138_H141_L0.6700.91
211_A218_V0.6700.91
282_Y299_N0.6690.91
76_Q80_Y0.6680.91
341_T360_G0.6680.91
414_D417_E0.6670.91
230_L234_F0.6660.91
362_A401_N0.6650.91
284_I326_R0.6640.91
297_Y360_G0.6640.91
233_L238_L0.6620.91
195_L198_Q0.6610.91
286_Q399_E0.6590.91
60_R115_S0.6580.91
282_Y397_F0.6550.90
73_V179_E0.6550.90
179_E182_K0.6540.90
73_V76_Q0.6530.90
173_G179_E0.6530.90
285_V300_T0.6510.90
72_P76_Q0.6510.90
299_N337_T0.6480.90
56_Q143_R0.6480.90
104_Y117_G0.6460.90
59_T182_K0.6450.90
75_N114_N0.6450.90
60_R136_D0.6430.90
116_T178_I0.6420.90
286_Q362_A0.6410.89
60_R137_S0.6400.89
120_T125_Q0.6400.89
376_L380_R0.6390.89
114_N138_H0.6380.89
194_P197_E0.6380.89
115_S121_L0.6370.89
285_V356_N0.6360.89
358_T402_L0.6360.89
218_V222_I0.6350.89
197_E200_K0.6340.89
264_P267_W0.6340.89
135_I139_V0.6340.89
286_Q320_I0.6340.89
284_I356_N0.6320.89
222_I227_Q0.6320.89
175_T178_I0.6310.89
342_I400_I0.6290.89
76_Q136_D0.6260.88
275_L370_V0.6220.88
101_K106_P0.6190.88
327_S338_I0.6190.88
77_E116_T0.6190.88
165_L169_M0.6180.88
355_A358_T0.6170.88
138_H178_I0.6150.87
385_Q389_D0.6130.87
118_Q122_G0.6120.87
77_E115_S0.6110.87
337_T359_R0.6110.87
300_T401_N0.6110.87
80_Y123_R0.6080.87
418_Q422_V0.6070.87
317_S320_I0.6030.86
77_E177_Q0.6020.86
78_C136_D0.6010.86
61_G115_S0.6000.86
137_S177_Q0.6000.86
128_P151_H0.6000.86
300_T329_I0.5990.86
340_A359_R0.5990.86
120_T123_R0.5970.86
419_D423_D0.5970.86
117_G175_T0.5960.86
151_H155_Y0.5950.86
300_T402_L0.5950.86
59_T179_E0.5940.86
341_T397_F0.5930.86
282_Y401_N0.5930.86
54_I148_L0.5930.86
57_L140_T0.5930.86
297_Y300_T0.5910.85
204_V453_L0.5910.85
127_Y133_R0.5910.85
121_L177_Q0.5900.85
211_A214_K0.5900.85
76_Q139_V0.5890.85
101_K138_H0.5870.85
75_N118_Q0.5860.85
334_L372_N0.5850.85
229_L445_L0.5840.85
281_T285_V0.5820.84
339_R363_R0.5810.84
301_E399_E0.5810.84
342_I397_F0.5790.84
339_R344_A0.5790.84
165_L189_P0.5780.84
226_K233_L0.5770.84
447_Q451_Q0.5760.84
104_Y141_L0.5750.84
275_L410_V0.5700.83
223_E229_L0.5690.83
80_Y83_G0.5690.83
136_D175_T0.5680.83
218_V221_K0.5680.83
74_I139_V0.5640.83
156_F190_T0.5640.83
384_F388_L0.5620.82
329_I363_R0.5610.82
285_V362_A0.5600.82
208_V445_L0.5600.82
76_Q79_I0.5590.82
113_V177_Q0.5580.82
429_E433_E0.5580.82
137_S141_L0.5580.82
224_R227_Q0.5570.82
140_T180_L0.5570.82
104_Y136_D0.5550.82
78_C138_H0.5550.82
345_V380_R0.5550.82
303_M361_T0.5540.81
282_Y327_S0.5530.81
106_P133_R0.5530.81
281_T363_R0.5520.81
211_A225_L0.5520.81
342_I355_A0.5510.81
302_D358_T0.5510.81
61_G137_S0.5500.81
226_K229_L0.5480.81
337_T399_E0.5470.81
329_I357_L0.5470.81
213_Q217_A0.5460.81
214_K218_V0.5460.81
281_T284_I0.5440.80
140_T177_Q0.5440.80
116_T141_L0.5440.80
238_L258_E0.5430.80
284_I358_T0.5420.80
387_E408_I0.5420.80
285_V327_S0.5410.80
339_R398_D0.5410.80
165_L168_S0.5410.80
114_N122_G0.5410.80
101_K177_Q0.5400.80
124_A154_R0.5390.80
134_A138_H0.5390.80
203_S207_N0.5380.80
117_G134_A0.5330.79
387_E390_A0.5320.79
301_E341_T0.5320.79
60_R141_L0.5310.79
232_D239_S0.5300.79
233_L236_K0.5280.78
339_R342_I0.5270.78
58_I141_L0.5250.78
215_T219_I0.5240.78
138_H182_K0.5230.78
373_T377_W0.5210.77
75_N90_R0.5190.77
331_A349_P0.5190.77
106_P127_Y0.5180.77
138_H181_S0.5180.77
357_L362_A0.5180.77
303_M344_A0.5170.77
61_G104_Y0.5160.77
342_I358_T0.5140.76
297_Y333_E0.5130.76
284_I327_S0.5130.76
360_G402_L0.5120.76
52_G187_L0.5110.76
73_V139_V0.5100.76
73_V115_S0.5100.76
61_G136_D0.5090.76
230_L236_K0.5070.76
124_A158_E0.5070.76
215_T225_L0.5060.75
222_I226_K0.5060.75
300_T363_R0.5060.75
104_Y116_T0.5050.75
363_R397_F0.5050.75
164_A168_S0.5040.75
123_R135_I0.5020.75
300_T357_L0.5020.75
446_K451_Q0.5010.75
299_N338_I0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y7cA 1 0.8695 100 0.369 Contact Map
1yf2A 1 0.8589 100 0.401 Contact Map
3okgA 2 0.7937 100 0.417 Contact Map
1ydxA 1 0.7558 100 0.47 Contact Map
2ih2A 1 0.3811 94.5 0.943 Contact Map
3s1sA 1 0.4674 34.9 0.968 Contact Map
4i3mA 2 0.1937 14.4 0.973 Contact Map
3rfyA 2 0.3684 9.8 0.975 Contact Map
2kfdA 1 0.0884 9.5 0.975 Contact Map
4nl9C 1 0.12 8.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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