GREMLIN Database
Q9HSR6 - Uncharacterized protein
UniProt: Q9HSR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (213)
Sequences: 2385 (1986)
Seq/√Len: 136.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_R190_D4.7101.00
219_E223_L3.3721.00
217_I223_L3.2401.00
181_L192_V3.2061.00
43_L51_P2.9501.00
202_E208_R2.9341.00
134_R137_E2.9241.00
214_E221_R2.5451.00
143_T177_F2.5261.00
65_T68_T2.3821.00
188_V226_W2.3381.00
194_V213_V2.3151.00
139_L177_F2.0531.00
155_D174_V2.0411.00
194_V217_I2.0301.00
198_A212_L2.0171.00
226_W230_N1.9621.00
33_D42_V1.9571.00
160_R176_S1.9571.00
210_W213_V1.9391.00
41_V55_L1.8921.00
32_I39_V1.8431.00
90_L189_I1.8341.00
26_D31_R1.8101.00
165_R168_S1.7941.00
48_E52_E1.7761.00
135_A182_V1.7511.00
86_A93_D1.7451.00
150_M216_E1.7291.00
135_A139_L1.7151.00
201_R212_L1.6941.00
97_V110_E1.6921.00
171_T203_S1.6911.00
156_R174_V1.6891.00
173_G200_L1.6271.00
184_A188_V1.6141.00
90_L138_H1.5981.00
30_P54_L1.5831.00
143_T157_I1.5831.00
177_F193_V1.5791.00
147_A154_Y1.5561.00
89_Y134_R1.5481.00
158_E174_V1.5411.00
58_N61_W1.5071.00
169_C200_L1.4621.00
146_L194_V1.4601.00
32_I54_L1.4551.00
162_Q178_N1.4451.00
187_D223_L1.4381.00
212_L215_M1.4171.00
202_E212_L1.4141.00
128_E132_R1.3991.00
214_E220_Y1.3951.00
56_S59_L1.3911.00
152_H201_R1.3791.00
194_V197_L1.3781.00
170_S176_S1.3761.00
23_R46_E1.3671.00
131_Y183_M1.3651.00
180_R183_M1.3601.00
142_R145_A1.3561.00
86_A95_E1.3521.00
138_H189_I1.3521.00
145_A149_S1.3461.00
187_D226_W1.3371.00
191_Y210_W1.3241.00
173_G203_S1.3161.00
19_Y52_E1.3141.00
150_M194_V1.3081.00
47_S50_S1.3061.00
143_T193_V1.2911.00
219_E222_E1.2891.00
52_E56_S1.2731.00
19_Y55_L1.2701.00
61_W65_T1.2651.00
168_S176_S1.2601.00
185_P226_W1.2591.00
225_D229_T1.2561.00
161_N180_R1.2451.00
22_R40_T1.2431.00
27_A42_V1.2391.00
41_V51_P1.2331.00
81_F84_G1.2301.00
31_R42_V1.2181.00
128_E161_N1.2161.00
184_A226_W1.2031.00
81_F85_A1.2001.00
162_Q176_S1.1891.00
154_Y197_L1.1740.99
34_I39_V1.1680.99
19_Y41_V1.1590.99
30_P43_L1.1570.99
145_A190_D1.1570.99
194_V216_E1.1470.99
142_R186_P1.1450.99
90_L186_P1.1300.99
146_L149_S1.1270.99
143_T197_L1.1260.99
207_D211_R1.0960.99
150_M198_A1.0820.99
155_D172_N1.0810.99
152_H200_L1.0770.99
119_D122_S1.0650.99
17_V39_V1.0510.99
142_R193_V1.0450.99
28_T31_R1.0440.99
27_A31_R1.0430.99
136_R140_T1.0270.99
224_S228_D1.0270.99
140_T144_D1.0220.98
22_R42_V1.0210.98
170_S174_V1.0160.98
36_I69_Y1.0150.98
138_H186_P1.0060.98
158_E176_S1.0060.98
89_Y130_F1.0010.98
159_L179_W0.9950.98
188_V223_L0.9880.98
83_P98_V0.9840.98
24_S42_V0.9770.98
184_A231_S0.9760.98
89_Y94_H0.9750.98
113_L123_L0.9720.98
82_E85_A0.9690.98
138_H141_D0.9670.98
146_L193_V0.9660.98
143_T175_L0.9570.98
161_N179_W0.9550.98
79_R85_A0.9530.98
55_L59_L0.9510.98
89_Y182_V0.9490.98
147_A153_T0.9470.98
130_F134_R0.9460.98
83_P97_V0.9410.97
147_A197_L0.9350.97
34_I65_T0.9260.97
177_F197_L0.9230.97
24_S27_A0.9190.97
143_T154_Y0.9160.97
223_L226_W0.9120.97
99_E112_R0.9010.97
88_P93_D0.8970.97
226_W231_S0.8950.97
139_L193_V0.8940.96
61_W168_S0.8890.96
124_K128_E0.8880.96
146_L190_D0.8770.96
59_L63_L0.8730.96
188_V230_N0.8690.96
202_E206_N0.8590.96
206_N212_L0.8520.95
144_D154_Y0.8490.95
32_I58_N0.8490.95
193_V197_L0.8470.95
220_Y224_S0.8340.95
146_L150_M0.8340.95
87_F131_Y0.8240.94
154_Y157_I0.8230.94
81_F96_I0.8220.94
39_V62_V0.8200.94
15_H67_R0.8180.94
23_R43_L0.8170.94
50_S53_A0.8160.94
140_T157_I0.8110.94
213_V220_Y0.8090.94
24_S31_R0.8050.94
101_R114_R0.8020.94
108_D111_I0.8020.94
33_D40_T0.7970.93
79_R86_A0.7960.93
52_E55_L0.7940.93
147_A152_H0.7880.93
23_R47_S0.7860.93
139_L143_T0.7830.93
125_R129_N0.7790.93
35_D40_T0.7760.93
136_R159_L0.7750.92
32_I41_V0.7720.92
198_A213_V0.7720.92
177_F181_L0.7680.92
198_A216_E0.7670.92
188_V227_L0.7670.92
150_M200_L0.7560.92
24_S28_T0.7510.91
51_P55_L0.7510.91
123_L126_V0.7490.91
127_L131_Y0.7480.91
90_L182_V0.7450.91
133_S137_E0.7400.91
191_Y224_S0.7390.91
172_N176_S0.7320.90
81_F87_F0.7290.90
135_A177_F0.7240.90
154_Y200_L0.7160.89
134_R138_H0.7120.89
146_L217_I0.7080.89
94_H109_G0.7060.89
191_Y213_V0.7060.89
139_L182_V0.7050.88
135_A179_W0.7040.88
162_Q165_R0.7030.88
210_W220_Y0.6960.88
187_D219_E0.6870.87
23_R48_E0.6810.87
99_E114_R0.6770.86
141_D145_A0.6770.86
149_S216_E0.6760.86
164_T176_S0.6760.86
44_P61_W0.6700.86
25_E45_A0.6640.85
105_G112_R0.6630.85
96_I113_L0.6610.85
90_L135_A0.6600.85
21_V51_P0.6550.85
64_E68_T0.6520.84
84_G96_I0.6500.84
94_H111_I0.6470.84
30_P51_P0.6450.84
113_L127_L0.6440.84
150_M197_L0.6390.83
88_P183_M0.6320.82
146_L216_E0.6310.82
98_V123_L0.6310.82
208_R212_L0.6300.82
24_S33_D0.6290.82
184_A230_N0.6280.82
211_R214_E0.6280.82
220_Y228_D0.6270.82
97_V112_R0.6240.82
111_I115_Q0.6240.82
58_N65_T0.6230.81
15_H63_L0.6210.81
83_P95_E0.6190.81
194_V198_A0.6150.81
94_H106_V0.6150.81
107_G110_E0.6090.80
159_L162_Q0.6080.80
120_Q123_L0.6010.79
49_E53_A0.5980.79
169_C175_L0.5970.79
131_Y182_V0.5960.79
192_V224_S0.5950.78
169_C180_R0.5930.78
30_P55_L0.5920.78
167_G181_L0.5900.78
185_P188_V0.5880.78
85_A96_I0.5840.77
81_F127_L0.5830.77
210_W224_S0.5820.77
89_Y92_D0.5810.77
54_L58_N0.5810.77
80_R85_A0.5790.77
160_R178_N0.5780.76
106_V111_I0.5770.76
58_N62_V0.5770.76
195_H199_H0.5760.76
206_N210_W0.5740.76
21_V48_E0.5740.76
21_V43_L0.5700.75
41_V54_L0.5690.75
98_V115_Q0.5680.75
142_R189_I0.5640.75
32_I61_W0.5640.75
201_R215_M0.5600.74
203_S206_N0.5540.73
190_D217_I0.5530.73
38_G66_K0.5530.73
143_T146_L0.5530.73
144_D147_A0.5520.73
103_A133_S0.5520.73
190_D193_V0.5510.73
195_H205_H0.5500.73
96_I124_K0.5500.73
66_K70_E0.5480.73
19_Y39_V0.5480.73
175_L197_L0.5460.72
122_S125_R0.5460.72
26_D42_V0.5440.72
181_L184_A0.5440.72
139_L189_I0.5430.72
167_G177_F0.5410.72
137_E141_D0.5390.71
95_E110_E0.5390.71
50_S57_E0.5370.71
130_F183_M0.5370.71
51_P54_L0.5360.71
194_V223_L0.5360.71
155_D175_L0.5350.71
196_E199_H0.5340.71
222_E225_D0.5330.71
46_E57_E0.5330.71
155_D173_G0.5320.70
135_A159_L0.5290.70
53_A57_E0.5280.70
199_H205_H0.5280.70
55_L62_V0.5270.70
79_R131_Y0.5260.70
106_V109_G0.5250.69
86_A123_L0.5220.69
150_M201_R0.5210.69
85_A88_P0.5180.68
143_T147_A0.5170.68
160_R179_W0.5150.68
27_A43_L0.5140.68
142_R146_L0.5140.68
162_Q188_V0.5120.68
49_E52_E0.5110.67
157_I177_F0.5090.67
27_A183_M0.5090.67
111_I130_F0.5080.67
158_E164_T0.5070.67
158_E162_Q0.5060.67
122_S129_N0.5050.66
136_R176_S0.5040.66
160_R164_T0.5030.66
147_A150_M0.5020.66
198_A204_G0.5020.66
58_N218_P0.5010.66
84_G95_E0.5010.66
164_T174_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jiuA 1 0.4191 100 0.527 Contact Map
4qhjA 2 0.4191 100 0.546 Contact Map
4jixA 2 0.444 100 0.548 Contact Map
3cqbA 4 0.4191 98.1 0.862 Contact Map
3c37A 1 0.5477 90.7 0.921 Contact Map
3dteA 2 0.4896 90.3 0.921 Contact Map
1cgeA 1 0.5104 85.9 0.927 Contact Map
1k7iA 1 0.7759 85 0.928 Contact Map
1hv5A 2 0.5145 83.3 0.93 Contact Map
4xctA 1 0.527 81.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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