Q9HSR6 - HALSA - GREMLIN Contacts

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Q9HSR6 - Uncharacterized protein

UniProt:	Q9HSR6	Sequences: MSKTTQSRETTLAGHPVEYEVRRSEDATEPRIDIDIRGVTVVLPAESEESPEALLSENLNWVLETKRTYERHRERAPERRFEPGAAFPYLGDDHEIVVEPRPAHGVGDGEIRLRQSTVDQSSLKRVLENFYRSRAREHLTDRTDALADSMNHTYDRIELRNQRTRWGSCSTNGVLSFNWRLVMAPPDVIDYVVVHELAHLRESGHNDRFWRLVEMEIPEYRELSDWLDTNSVDLIFSKDDL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	241 (213)
Sequences:	2385 (1986)
Seq/√Len:	136.1

HALSA - Q9HSR6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_R	190_D	4.710	1.00
219_E	223_L	3.372	1.00
217_I	223_L	3.240	1.00
181_L	192_V	3.206	1.00
43_L	51_P	2.950	1.00
202_E	208_R	2.934	1.00
134_R	137_E	2.924	1.00
214_E	221_R	2.545	1.00
143_T	177_F	2.526	1.00
65_T	68_T	2.382	1.00
188_V	226_W	2.338	1.00
194_V	213_V	2.315	1.00
139_L	177_F	2.053	1.00
155_D	174_V	2.041	1.00
194_V	217_I	2.030	1.00
198_A	212_L	2.017	1.00
226_W	230_N	1.962	1.00
33_D	42_V	1.957	1.00
160_R	176_S	1.957	1.00
210_W	213_V	1.939	1.00
41_V	55_L	1.892	1.00
32_I	39_V	1.843	1.00
90_L	189_I	1.834	1.00
26_D	31_R	1.810	1.00
165_R	168_S	1.794	1.00
48_E	52_E	1.776	1.00
135_A	182_V	1.751	1.00
86_A	93_D	1.745	1.00
150_M	216_E	1.729	1.00
135_A	139_L	1.715	1.00
201_R	212_L	1.694	1.00
97_V	110_E	1.692	1.00
171_T	203_S	1.691	1.00
156_R	174_V	1.689	1.00
173_G	200_L	1.627	1.00
184_A	188_V	1.614	1.00
90_L	138_H	1.598	1.00
30_P	54_L	1.583	1.00
143_T	157_I	1.583	1.00
177_F	193_V	1.579	1.00
147_A	154_Y	1.556	1.00
89_Y	134_R	1.548	1.00
158_E	174_V	1.541	1.00
58_N	61_W	1.507	1.00
169_C	200_L	1.462	1.00
146_L	194_V	1.460	1.00
32_I	54_L	1.455	1.00
162_Q	178_N	1.445	1.00
187_D	223_L	1.438	1.00
212_L	215_M	1.417	1.00
202_E	212_L	1.414	1.00
128_E	132_R	1.399	1.00
214_E	220_Y	1.395	1.00
56_S	59_L	1.391	1.00
152_H	201_R	1.379	1.00
194_V	197_L	1.378	1.00
170_S	176_S	1.376	1.00
23_R	46_E	1.367	1.00
131_Y	183_M	1.365	1.00
180_R	183_M	1.360	1.00
142_R	145_A	1.356	1.00
86_A	95_E	1.352	1.00
138_H	189_I	1.352	1.00
145_A	149_S	1.346	1.00
187_D	226_W	1.337	1.00
191_Y	210_W	1.324	1.00
173_G	203_S	1.316	1.00
19_Y	52_E	1.314	1.00
150_M	194_V	1.308	1.00
47_S	50_S	1.306	1.00
143_T	193_V	1.291	1.00
219_E	222_E	1.289	1.00
52_E	56_S	1.273	1.00
19_Y	55_L	1.270	1.00
61_W	65_T	1.265	1.00
168_S	176_S	1.260	1.00
185_P	226_W	1.259	1.00
225_D	229_T	1.256	1.00
161_N	180_R	1.245	1.00
22_R	40_T	1.243	1.00
27_A	42_V	1.239	1.00
41_V	51_P	1.233	1.00
81_F	84_G	1.230	1.00
31_R	42_V	1.218	1.00
128_E	161_N	1.216	1.00
184_A	226_W	1.203	1.00
81_F	85_A	1.200	1.00
162_Q	176_S	1.189	1.00
154_Y	197_L	1.174	0.99
34_I	39_V	1.168	0.99
19_Y	41_V	1.159	0.99
30_P	43_L	1.157	0.99
145_A	190_D	1.157	0.99
194_V	216_E	1.147	0.99
142_R	186_P	1.145	0.99
90_L	186_P	1.130	0.99
146_L	149_S	1.127	0.99
143_T	197_L	1.126	0.99
207_D	211_R	1.096	0.99
150_M	198_A	1.082	0.99
155_D	172_N	1.081	0.99
152_H	200_L	1.077	0.99
119_D	122_S	1.065	0.99
17_V	39_V	1.051	0.99
142_R	193_V	1.045	0.99
28_T	31_R	1.044	0.99
27_A	31_R	1.043	0.99
136_R	140_T	1.027	0.99
224_S	228_D	1.027	0.99
140_T	144_D	1.022	0.98
22_R	42_V	1.021	0.98
170_S	174_V	1.016	0.98
36_I	69_Y	1.015	0.98
138_H	186_P	1.006	0.98
158_E	176_S	1.006	0.98
89_Y	130_F	1.001	0.98
159_L	179_W	0.995	0.98
188_V	223_L	0.988	0.98
83_P	98_V	0.984	0.98
24_S	42_V	0.977	0.98
184_A	231_S	0.976	0.98
89_Y	94_H	0.975	0.98
113_L	123_L	0.972	0.98
82_E	85_A	0.969	0.98
138_H	141_D	0.967	0.98
146_L	193_V	0.966	0.98
143_T	175_L	0.957	0.98
161_N	179_W	0.955	0.98
79_R	85_A	0.953	0.98
55_L	59_L	0.951	0.98
89_Y	182_V	0.949	0.98
147_A	153_T	0.947	0.98
130_F	134_R	0.946	0.98
83_P	97_V	0.941	0.97
147_A	197_L	0.935	0.97
34_I	65_T	0.926	0.97
177_F	197_L	0.923	0.97
24_S	27_A	0.919	0.97
143_T	154_Y	0.916	0.97
223_L	226_W	0.912	0.97
99_E	112_R	0.901	0.97
88_P	93_D	0.897	0.97
226_W	231_S	0.895	0.97
139_L	193_V	0.894	0.96
61_W	168_S	0.889	0.96
124_K	128_E	0.888	0.96
146_L	190_D	0.877	0.96
59_L	63_L	0.873	0.96
188_V	230_N	0.869	0.96
202_E	206_N	0.859	0.96
206_N	212_L	0.852	0.95
144_D	154_Y	0.849	0.95
32_I	58_N	0.849	0.95
193_V	197_L	0.847	0.95
220_Y	224_S	0.834	0.95
146_L	150_M	0.834	0.95
87_F	131_Y	0.824	0.94
154_Y	157_I	0.823	0.94
81_F	96_I	0.822	0.94
39_V	62_V	0.820	0.94
15_H	67_R	0.818	0.94
23_R	43_L	0.817	0.94
50_S	53_A	0.816	0.94
140_T	157_I	0.811	0.94
213_V	220_Y	0.809	0.94
24_S	31_R	0.805	0.94
101_R	114_R	0.802	0.94
108_D	111_I	0.802	0.94
33_D	40_T	0.797	0.93
79_R	86_A	0.796	0.93
52_E	55_L	0.794	0.93
147_A	152_H	0.788	0.93
23_R	47_S	0.786	0.93
139_L	143_T	0.783	0.93
125_R	129_N	0.779	0.93
35_D	40_T	0.776	0.93
136_R	159_L	0.775	0.92
32_I	41_V	0.772	0.92
198_A	213_V	0.772	0.92
177_F	181_L	0.768	0.92
198_A	216_E	0.767	0.92
188_V	227_L	0.767	0.92
150_M	200_L	0.756	0.92
24_S	28_T	0.751	0.91
51_P	55_L	0.751	0.91
123_L	126_V	0.749	0.91
127_L	131_Y	0.748	0.91
90_L	182_V	0.745	0.91
133_S	137_E	0.740	0.91
191_Y	224_S	0.739	0.91
172_N	176_S	0.732	0.90
81_F	87_F	0.729	0.90
135_A	177_F	0.724	0.90
154_Y	200_L	0.716	0.89
134_R	138_H	0.712	0.89
146_L	217_I	0.708	0.89
94_H	109_G	0.706	0.89
191_Y	213_V	0.706	0.89
139_L	182_V	0.705	0.88
135_A	179_W	0.704	0.88
162_Q	165_R	0.703	0.88
210_W	220_Y	0.696	0.88
187_D	219_E	0.687	0.87
23_R	48_E	0.681	0.87
99_E	114_R	0.677	0.86
141_D	145_A	0.677	0.86
149_S	216_E	0.676	0.86
164_T	176_S	0.676	0.86
44_P	61_W	0.670	0.86
25_E	45_A	0.664	0.85
105_G	112_R	0.663	0.85
96_I	113_L	0.661	0.85
90_L	135_A	0.660	0.85
21_V	51_P	0.655	0.85
64_E	68_T	0.652	0.84
84_G	96_I	0.650	0.84
94_H	111_I	0.647	0.84
30_P	51_P	0.645	0.84
113_L	127_L	0.644	0.84
150_M	197_L	0.639	0.83
88_P	183_M	0.632	0.82
146_L	216_E	0.631	0.82
98_V	123_L	0.631	0.82
208_R	212_L	0.630	0.82
24_S	33_D	0.629	0.82
184_A	230_N	0.628	0.82
211_R	214_E	0.628	0.82
220_Y	228_D	0.627	0.82
97_V	112_R	0.624	0.82
111_I	115_Q	0.624	0.82
58_N	65_T	0.623	0.81
15_H	63_L	0.621	0.81
83_P	95_E	0.619	0.81
194_V	198_A	0.615	0.81
94_H	106_V	0.615	0.81
107_G	110_E	0.609	0.80
159_L	162_Q	0.608	0.80
120_Q	123_L	0.601	0.79
49_E	53_A	0.598	0.79
169_C	175_L	0.597	0.79
131_Y	182_V	0.596	0.79
192_V	224_S	0.595	0.78
169_C	180_R	0.593	0.78
30_P	55_L	0.592	0.78
167_G	181_L	0.590	0.78
185_P	188_V	0.588	0.78
85_A	96_I	0.584	0.77
81_F	127_L	0.583	0.77
210_W	224_S	0.582	0.77
89_Y	92_D	0.581	0.77
54_L	58_N	0.581	0.77
80_R	85_A	0.579	0.77
160_R	178_N	0.578	0.76
106_V	111_I	0.577	0.76
58_N	62_V	0.577	0.76
195_H	199_H	0.576	0.76
206_N	210_W	0.574	0.76
21_V	48_E	0.574	0.76
21_V	43_L	0.570	0.75
41_V	54_L	0.569	0.75
98_V	115_Q	0.568	0.75
142_R	189_I	0.564	0.75
32_I	61_W	0.564	0.75
201_R	215_M	0.560	0.74
203_S	206_N	0.554	0.73
190_D	217_I	0.553	0.73
38_G	66_K	0.553	0.73
143_T	146_L	0.553	0.73
144_D	147_A	0.552	0.73
103_A	133_S	0.552	0.73
190_D	193_V	0.551	0.73
195_H	205_H	0.550	0.73
96_I	124_K	0.550	0.73
66_K	70_E	0.548	0.73
19_Y	39_V	0.548	0.73
175_L	197_L	0.546	0.72
122_S	125_R	0.546	0.72
26_D	42_V	0.544	0.72
181_L	184_A	0.544	0.72
139_L	189_I	0.543	0.72
167_G	177_F	0.541	0.72
137_E	141_D	0.539	0.71
95_E	110_E	0.539	0.71
50_S	57_E	0.537	0.71
130_F	183_M	0.537	0.71
51_P	54_L	0.536	0.71
194_V	223_L	0.536	0.71
155_D	175_L	0.535	0.71
196_E	199_H	0.534	0.71
222_E	225_D	0.533	0.71
46_E	57_E	0.533	0.71
155_D	173_G	0.532	0.70
135_A	159_L	0.529	0.70
53_A	57_E	0.528	0.70
199_H	205_H	0.528	0.70
55_L	62_V	0.527	0.70
79_R	131_Y	0.526	0.70
106_V	109_G	0.525	0.69
86_A	123_L	0.522	0.69
150_M	201_R	0.521	0.69
85_A	88_P	0.518	0.68
143_T	147_A	0.517	0.68
160_R	179_W	0.515	0.68
27_A	43_L	0.514	0.68
142_R	146_L	0.514	0.68
162_Q	188_V	0.512	0.68
49_E	52_E	0.511	0.67
157_I	177_F	0.509	0.67
27_A	183_M	0.509	0.67
111_I	130_F	0.508	0.67
158_E	164_T	0.507	0.67
158_E	162_Q	0.506	0.67
122_S	129_N	0.505	0.66
136_R	176_S	0.504	0.66
160_R	164_T	0.503	0.66
147_A	150_M	0.502	0.66
198_A	204_G	0.502	0.66
58_N	218_P	0.501	0.66
84_G	95_E	0.501	0.66
164_T	174_V	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4jiuA	1	0.4191	100	0.527	Contact Map
4qhjA	2	0.4191	100	0.546	Contact Map
4jixA	2	0.444	100	0.548	Contact Map
3cqbA	4	0.4191	98.1	0.862	Contact Map
3c37A	1	0.5477	90.7	0.921	Contact Map
3dteA	2	0.4896	90.3	0.921	Contact Map
1cgeA	1	0.5104	85.9	0.927	Contact Map
1k7iA	1	0.7759	85	0.928	Contact Map
1hv5A	2	0.5145	83.3	0.93	Contact Map
4xctA	1	0.527	81.6	0.931	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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