GREMLIN Database
Q9HSR5 - Uncharacterized protein
UniProt: Q9HSR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (206)
Sequences: 1847 (1450)
Seq/√Len: 101.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_Y206_E4.2801.00
182_C187_L4.1041.00
169_T173_R3.8501.00
166_A191_L3.3481.00
173_R187_L3.3131.00
194_S197_A3.1981.00
173_R190_E3.0331.00
162_K201_L2.9861.00
45_I82_I2.9151.00
182_C186_E2.9011.00
101_G119_F2.8781.00
197_A201_L2.8311.00
177_D181_Q2.8001.00
96_P101_G2.7881.00
171_F211_G2.7591.00
183_S186_E2.7131.00
169_T187_L2.5381.00
184_T198_A2.3151.00
20_A111_D2.1931.00
19_V62_H2.1501.00
162_K166_A2.1341.00
178_S199_S2.1211.00
193_V198_A2.1131.00
56_E80_Y2.0381.00
164_Y168_R1.9651.00
162_K165_R1.9521.00
47_V55_F1.8271.00
195_A199_S1.7651.00
8_L112_G1.7441.00
167_I210_I1.7231.00
104_L118_V1.6531.00
184_T199_S1.6501.00
187_L198_A1.6461.00
201_L204_R1.6371.00
121_D124_A1.5951.00
166_A201_L1.5811.00
166_A193_V1.5771.00
69_S182_C1.5551.00
201_L208_Q1.5521.00
31_S46_R1.5521.00
8_L140_E1.4931.00
85_A141_L1.4771.00
210_I213_T1.4761.00
173_R182_C1.4061.00
156_Q213_T1.4031.00
167_I176_Y1.3901.00
180_R203_R1.3851.00
48_A77_G1.3841.00
186_E189_A1.3810.99
8_L142_V1.3690.99
189_A192_G1.3660.99
182_C190_E1.3440.99
171_F214_V1.2840.99
159_L205_A1.2800.99
70_E80_Y1.2650.99
174_G181_Q1.2530.99
43_F84_V1.2520.99
188_A198_A1.2480.99
65_V68_V1.2390.99
178_S200_D1.2210.99
207_R211_G1.2190.99
52_Q55_F1.2040.99
175_Y180_R1.2040.99
132_C137_I1.2020.99
5_A125_L1.2010.99
89_G175_Y1.1880.98
209_L213_T1.1800.98
7_I117_K1.1580.98
200_D204_R1.1480.98
127_T130_D1.1480.98
196_A200_D1.1360.98
191_L198_A1.1360.98
18_S64_Q1.1190.98
184_T201_L1.1150.98
67_S70_E1.1110.98
197_A202_L1.1020.98
101_G105_E1.0950.97
30_I33_S1.0920.97
61_A76_D1.0800.97
114_H142_V1.0790.97
71_I79_F1.0770.97
168_R172_A1.0690.97
202_L206_E1.0560.97
176_Y202_L1.0550.97
166_A187_L1.0500.97
197_A205_A1.0340.96
185_R195_A1.0320.96
22_A214_V1.0190.96
141_L144_I1.0130.96
129_R139_F1.0100.96
197_A200_D1.0060.96
26_G49_A1.0040.96
100_E121_D1.0040.96
103_A117_K1.0000.96
158_G212_E0.9990.96
166_A198_A0.9890.95
124_A127_T0.9850.95
14_L17_V0.9770.95
210_I214_V0.9770.95
35_P38_D0.9750.95
184_T195_A0.9750.95
178_S196_A0.9690.95
70_E78_W0.9690.95
178_S203_R0.9610.95
209_L212_E0.9600.94
176_Y184_T0.9570.94
42_L112_G0.9530.94
171_F176_Y0.9500.94
52_Q56_E0.9450.94
7_I129_R0.9440.94
95_D128_L0.9400.94
187_L191_L0.9360.94
56_E68_V0.9360.94
118_V176_Y0.9340.94
28_L47_V0.9320.94
144_I175_Y0.9300.93
119_F140_E0.9290.93
166_A205_A0.9210.93
185_R203_R0.9180.93
7_I111_D0.9150.93
130_D134_V0.9130.93
71_I108_V0.9130.93
46_R77_G0.9120.93
178_S207_R0.9100.93
154_R164_Y0.9070.93
175_Y184_T0.9050.93
100_E131_R0.9030.92
13_D193_V0.8960.92
168_R214_V0.8760.91
178_S185_R0.8660.91
54_A58_E0.8620.91
14_L20_A0.8390.89
59_A68_V0.8390.89
5_A8_L0.8390.89
59_A123_D0.8350.89
162_K200_D0.8320.89
103_A127_T0.8310.89
64_Q160_T0.8290.89
38_D41_L0.8290.89
195_A204_R0.8220.88
96_P117_K0.8130.88
23_I49_A0.8120.88
120_S133_A0.8110.88
128_L200_D0.8110.88
30_I45_I0.8100.88
59_A136_D0.8090.88
6_E114_H0.7850.86
169_T190_E0.7810.86
18_S142_V0.7780.86
184_T205_A0.7770.85
126_A129_R0.7740.85
52_Q78_W0.7740.85
176_Y205_A0.7700.85
184_T197_A0.7690.85
204_R207_R0.7640.85
125_L165_R0.7600.84
103_A156_Q0.7590.84
177_D207_R0.7550.84
106_A176_Y0.7550.84
165_R168_R0.7540.84
194_S203_R0.7530.84
42_L142_V0.7530.84
46_R79_F0.7520.84
193_V196_A0.7520.84
173_R198_A0.7520.84
56_E82_I0.7520.84
109_T112_G0.7470.83
62_H65_V0.7460.83
108_V113_I0.7440.83
35_P115_E0.7430.83
13_D45_I0.7390.82
54_A57_D0.7370.82
15_P19_V0.7320.82
39_G61_A0.7300.82
55_F181_Q0.7280.82
65_V70_E0.7220.81
178_S201_L0.7210.81
122_Y144_I0.7210.81
133_A193_V0.7200.81
108_V119_F0.7180.81
20_A112_G0.7150.80
51_S54_A0.7130.80
47_V52_Q0.7030.79
79_F151_P0.7030.79
44_T118_V0.7010.79
102_V118_V0.7000.79
129_R197_A0.6990.79
193_V201_L0.6990.79
48_A54_A0.6990.79
144_I196_A0.6970.79
175_Y202_L0.6940.78
20_A108_V0.6930.78
66_A69_S0.6920.78
81_R139_F0.6900.78
83_I195_A0.6890.78
143_A187_L0.6860.78
30_I35_P0.6780.77
101_G104_L0.6770.77
182_C198_A0.6730.76
169_T191_L0.6700.76
22_A25_S0.6700.76
167_I214_V0.6650.75
9_L14_L0.6640.75
126_A197_A0.6630.75
75_A128_L0.6630.75
174_G199_S0.6600.75
64_Q104_L0.6590.75
31_S79_F0.6580.75
55_F63_P0.6560.74
150_H187_L0.6490.74
165_R169_T0.6490.74
43_F82_I0.6480.73
158_G211_G0.6480.73
10_A17_V0.6460.73
44_T81_R0.6450.73
99_F131_R0.6440.73
84_V96_P0.6420.73
164_Y213_T0.6410.73
165_R198_A0.6370.72
114_H190_E0.6340.72
127_T181_Q0.6330.72
148_P154_R0.6310.72
156_Q164_Y0.6290.71
30_I118_V0.6270.71
10_A208_Q0.6240.71
28_L204_R0.6230.71
174_G177_D0.6200.70
197_A204_R0.6170.70
16_L113_I0.6160.70
29_S211_G0.6150.70
111_D134_V0.6140.69
138_P157_F0.6120.69
19_V28_L0.6090.69
69_S81_R0.6080.69
205_A210_I0.6060.68
105_E191_L0.6050.68
42_L160_T0.6000.68
23_I58_E0.6000.68
6_E185_R0.5970.67
137_I145_A0.5970.67
91_V127_T0.5960.67
163_Q208_Q0.5950.67
157_F213_T0.5940.67
106_A120_S0.5930.67
43_F90_L0.5910.67
77_G80_Y0.5900.66
162_K206_E0.5890.66
84_V88_T0.5870.66
117_K128_L0.5860.66
51_S110_A0.5860.66
30_I122_Y0.5850.66
66_A134_V0.5840.66
30_I34_V0.5820.65
60_R68_V0.5760.65
128_L195_A0.5750.64
18_S34_V0.5720.64
11_D113_I0.5700.64
5_A11_D0.5690.64
181_Q187_L0.5690.64
121_D164_Y0.5680.63
71_I120_S0.5680.63
28_L122_Y0.5670.63
141_L193_V0.5670.63
30_I215_G0.5620.63
77_G209_L0.5600.62
165_R193_V0.5590.62
119_F176_Y0.5590.62
36_L55_F0.5570.62
96_P103_A0.5560.62
179_P203_R0.5560.62
169_T182_C0.5530.61
95_D173_R0.5520.61
32_N172_A0.5520.61
180_R209_L0.5510.61
27_E48_A0.5480.61
50_D153_E0.5420.60
14_L113_I0.5410.60
65_V83_I0.5370.59
6_E203_R0.5360.59
10_A111_D0.5360.59
140_E207_R0.5360.59
77_G161_D0.5340.59
47_V58_E0.5320.59
98_E134_V0.5310.58
20_A110_A0.5300.58
22_A103_A0.5300.58
96_P115_E0.5290.58
89_G100_E0.5280.58
137_I144_I0.5260.58
95_D98_E0.5260.58
166_A169_T0.5240.57
39_G177_D0.5240.57
58_E85_A0.5220.57
138_P172_A0.5210.57
16_L59_A0.5210.57
14_L115_E0.5170.56
53_A127_T0.5170.56
47_V159_L0.5150.56
95_D183_S0.5140.56
125_L144_I0.5130.56
25_S31_S0.5120.56
68_V71_I0.5060.55
6_E145_A0.5050.55
167_I206_E0.5040.55
110_A117_K0.5040.55
61_A173_R0.5040.55
124_A149_E0.5020.54
56_E59_A0.5000.54
21_D111_D0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ku3A 1 0.2711 97.4 0.848 Contact Map
1s7oA 3 0.3467 97.3 0.851 Contact Map
4wszA 2 0.2533 97.3 0.851 Contact Map
2o8xA 7 0.2711 97.3 0.853 Contact Map
3hugA 3 0.3556 97.2 0.854 Contact Map
3c57A 2 0.2089 97.2 0.854 Contact Map
1xsvA 2 0.3422 97.2 0.854 Contact Map
1je8A 2 0.2578 97.1 0.856 Contact Map
1fseA 2 0.2622 96.9 0.86 Contact Map
2rnjA 1 0.2533 96.8 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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