GREMLIN Database
Q9HSQ8 - Uncharacterized protein
UniProt: Q9HSQ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (129)
Sequences: 832 (670)
Seq/√Len: 59.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_R124_D3.1111.00
56_A71_R3.0541.00
74_L141_S2.9961.00
140_V144_W2.9001.00
123_G126_P2.7771.00
106_V138_L2.6251.00
144_W147_A2.6051.00
69_S96_S2.5321.00
111_N155_R2.4231.00
117_H146_A2.3061.00
106_V156_V2.2601.00
59_A63_E2.2561.00
72_E98_A2.2081.00
75_S78_E2.1751.00
76_A141_S2.1491.00
60_T63_E2.0961.00
113_T134_G2.0411.00
87_A108_A2.0191.00
90_R134_G1.9721.00
98_A122_D1.9451.00
104_I140_V1.8531.00
104_I145_T1.7980.99
112_I154_D1.7230.99
140_V145_T1.7190.99
92_Y103_I1.6980.99
53_V144_W1.6700.99
114_S131_E1.6040.99
127_L130_Y1.5590.98
113_T132_G1.5170.98
104_I137_V1.5170.98
55_V138_L1.5070.98
74_L99_F1.4990.98
62_G66_T1.4520.98
64_R84_H1.4230.97
84_H92_Y1.4120.97
46_T49_E1.4060.97
144_W148_H1.3310.96
130_Y134_G1.2790.95
107_G111_N1.2690.95
116_H119_T1.2600.94
68_L74_L1.2240.93
115_I145_T1.2160.93
137_V145_T1.2090.93
112_I115_I1.1800.92
119_T123_G1.1790.92
69_S97_M1.1660.92
107_G113_T1.1650.92
61_R64_R1.1600.91
53_V148_H1.1570.91
84_H137_V1.1450.91
119_T142_L1.1340.90
108_A135_K1.1250.90
73_S99_F1.1160.90
68_L141_S1.0820.88
104_I118_A1.0790.88
118_A137_V1.0740.88
89_S133_H1.0680.88
114_S152_V1.0650.87
36_A54_A1.0360.86
97_M101_I1.0320.86
64_R90_R1.0250.85
105_Y114_S1.0220.85
99_F141_S0.9970.84
76_A147_A0.9880.83
120_V123_G0.9870.83
84_H90_R0.9860.83
118_A142_L0.9810.83
72_E99_F0.9750.82
102_D117_H0.9660.82
54_A77_D0.9590.81
117_H145_T0.9570.81
102_D142_L0.9550.81
124_D127_L0.9550.81
123_G128_T0.9350.80
141_S147_A0.9340.80
106_V112_I0.9220.79
74_L78_E0.9190.78
102_D137_V0.9180.78
104_I150_V0.9170.78
104_I112_I0.9110.78
117_H142_L0.9080.78
35_D38_M0.8980.77
101_I143_N0.8890.76
74_L79_G0.8760.75
103_I137_V0.8690.74
99_F142_L0.8650.74
122_D130_Y0.8630.74
41_V44_A0.8600.74
118_A145_T0.8460.72
107_G136_W0.8440.72
83_V92_Y0.8350.71
114_S130_Y0.8330.71
35_D54_A0.8320.71
90_R137_V0.8280.71
136_W158_I0.8230.70
119_T128_T0.8190.70
36_A40_T0.8150.70
145_T148_H0.8060.69
68_L99_F0.8000.68
95_R121_P0.7810.66
53_V140_V0.7660.65
106_V150_V0.7590.64
102_D115_I0.7560.64
38_M42_V0.7470.63
87_A134_G0.7470.63
66_T93_V0.7420.62
70_T96_S0.7340.61
100_P150_V0.7330.61
45_D77_D0.7080.59
81_L106_V0.7060.58
87_A133_H0.7000.58
149_N157_R0.6980.58
111_N132_G0.6980.58
110_R158_I0.6960.57
80_M139_E0.6950.57
49_E149_N0.6950.57
67_G139_E0.6830.56
146_A149_N0.6820.56
62_G65_Y0.6810.56
30_T87_A0.6670.54
111_N152_V0.6640.54
93_V97_M0.6610.54
55_V79_G0.6590.53
65_Y124_D0.6580.53
121_P134_G0.6530.53
91_A129_R0.6520.53
37_P78_E0.6510.52
56_A156_V0.6460.52
36_A41_V0.6430.52
42_V46_T0.6430.52
70_T122_D0.6390.51
83_V136_W0.6320.50
103_I118_A0.6230.49
107_G134_G0.6230.49
113_T136_W0.6220.49
77_D141_S0.6160.49
53_V158_I0.6090.48
29_S32_E0.6020.47
104_I119_T0.5930.46
38_M41_V0.5910.46
45_D49_E0.5900.46
52_S77_D0.5890.46
110_R138_L0.5890.46
33_S37_P0.5850.45
85_E92_Y0.5830.45
81_L138_L0.5820.45
54_A78_E0.5790.44
118_A129_R0.5780.44
37_P55_V0.5750.44
42_V89_S0.5710.44
103_I138_L0.5710.44
118_A159_P0.5700.43
121_P128_T0.5700.43
75_S115_I0.5670.43
92_Y129_R0.5670.43
124_D128_T0.5670.43
45_D66_T0.5630.43
56_A106_V0.5620.43
33_S76_A0.5610.42
35_D59_A0.5610.42
85_E126_P0.5550.42
83_V135_K0.5550.42
83_V158_I0.5530.42
89_S116_H0.5520.42
66_T70_T0.5510.41
66_T98_A0.5430.41
74_L140_V0.5410.40
65_Y151_S0.5410.40
114_S132_G0.5380.40
128_T144_W0.5340.40
72_E97_M0.5340.40
50_H157_R0.5320.39
31_P47_G0.5280.39
103_I114_S0.5260.39
55_V128_T0.5260.39
29_S72_E0.5250.39
51_G144_W0.5250.39
60_T85_E0.5250.39
92_Y127_L0.5240.39
80_M93_V0.5200.38
151_S154_D0.5190.38
100_P119_T0.5180.38
87_A141_S0.5180.38
129_R132_G0.5160.38
72_E146_A0.5160.38
38_M54_A0.5150.38
73_S98_A0.5120.37
73_S100_P0.5120.37
102_D145_T0.5120.37
92_Y104_I0.5090.37
57_V158_I0.5080.37
50_H156_V0.5040.36
85_E151_S0.5030.36
123_G127_L0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjyA 1 0.7914 100 0.276 Contact Map
3m7aA 1 0.8589 100 0.278 Contact Map
3k6vA 1 0.6135 35.8 0.938 Contact Map
3zbiC 1 0.1656 25.5 0.943 Contact Map
4r2fA 1 0.7362 23.9 0.943 Contact Map
2oa4A 1 0.4233 23.6 0.943 Contact Map
1yfbA 2 0.2577 20.8 0.945 Contact Map
3vxbA 1 0.7791 20 0.945 Contact Map
2jrtA 1 0.4172 18.9 0.946 Contact Map
4r9fA 1 0.773 18.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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