GREMLIN Database
Q9HSQ6 - Uncharacterized protein
UniProt: Q9HSQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (227)
Sequences: 2133 (1588)
Seq/√Len: 105.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_A105_D3.4241.00
65_A239_E3.2851.00
231_A235_D3.2841.00
49_G53_I3.2421.00
183_E186_V3.2341.00
167_P229_R3.0581.00
98_T105_D2.7631.00
108_G141_Q2.7411.00
97_D101_A2.6161.00
175_H231_A2.5591.00
55_A123_G2.4541.00
56_H76_P2.4191.00
107_V138_I2.3471.00
57_A176_T2.3411.00
94_V102_T2.3321.00
34_L120_V2.2761.00
104_R137_T2.1641.00
57_A61_A2.1171.00
23_D182_R2.1041.00
32_A74_A2.0971.00
175_H234_L2.0911.00
61_A64_D1.9961.00
32_A115_W1.9781.00
42_H169_E1.9321.00
32_A110_L1.9121.00
174_R183_E1.8951.00
41_Q85_H1.8641.00
41_Q217_G1.8311.00
20_T182_R1.8091.00
107_V118_V1.7961.00
104_R141_Q1.7611.00
77_I102_T1.7211.00
176_T234_L1.6801.00
238_T242_C1.6771.00
171_A226_D1.6741.00
175_H227_A1.6651.00
62_G241_L1.6571.00
15_R60_A1.6561.00
87_Q211_A1.6371.00
82_S85_H1.6371.00
92_L106_V1.6231.00
53_I177_D1.6131.00
188_A221_D1.5851.00
61_A234_L1.5831.00
45_H170_T1.5681.00
98_T101_A1.5631.00
171_A229_R1.5571.00
61_A175_H1.5351.00
172_F234_L1.5161.00
52_H76_P1.5151.00
74_A110_L1.4711.00
167_P224_A1.4641.00
182_R185_R1.4621.00
65_A238_T1.4581.00
38_S82_S1.4321.00
63_A73_V1.4321.00
235_D239_E1.4271.00
171_A174_R1.4181.00
187_Q216_N1.4051.00
79_V92_L1.4031.00
34_L74_A1.3801.00
227_A231_A1.3651.00
100_R133_E1.3460.99
101_A105_D1.3310.99
62_G242_C1.3150.99
66_Y70_E1.3000.99
18_D180_L1.2980.99
19_A72_I1.2960.99
95_A98_T1.2850.99
62_G238_T1.2850.99
100_R134_V1.2770.99
57_A60_A1.2760.99
85_H125_G1.2760.99
107_V120_V1.2730.99
16_L24_A1.2720.99
243_A246_A1.2560.99
59_A73_V1.2470.99
111_A144_A1.2450.99
147_V244_L1.2400.99
56_H60_A1.2040.99
33_V245_L1.1960.99
226_D229_R1.1890.99
61_A235_D1.1820.99
77_I106_V1.1780.99
59_A121_V1.1770.99
174_R225_G1.1720.99
34_L118_V1.1670.99
210_A214_T1.1570.98
103_V131_L1.1490.98
188_A222_P1.1450.98
228_D231_A1.1370.98
177_D180_L1.1360.98
15_R18_D1.1230.98
65_A235_D1.1210.98
182_R186_V1.1130.98
61_A231_A1.1090.98
117_R145_Y1.0930.98
234_L238_T1.0920.98
239_E243_A1.0910.98
217_G220_G1.0870.98
85_H126_G1.0850.98
50_T173_L1.0820.98
33_V73_V1.0760.97
21_W88_F1.0720.97
53_I173_L1.0710.97
119_V245_L1.0650.97
49_G180_L1.0640.97
24_A115_W1.0630.97
17_A56_H1.0610.97
37_G55_A1.0590.97
174_R227_A1.0480.97
55_A121_V1.0420.97
108_G142_D1.0420.97
21_W89_T1.0410.97
79_V106_V1.0290.97
65_A242_C1.0160.96
50_T53_I1.0090.96
20_T23_D0.9950.96
41_Q82_S0.9910.96
86_R93_W0.9840.96
129_A132_G0.9740.95
19_A27_V0.9720.95
22_T25_D0.9570.95
96_P130_A0.9530.95
35_P55_A0.9490.95
57_A234_L0.9490.95
22_T26_G0.9480.95
214_T220_G0.9440.95
36_V131_L0.9400.95
16_L110_L0.9370.94
118_V144_A0.9260.94
33_V63_A0.9260.94
53_I180_L0.9210.94
81_V130_A0.9180.94
105_D109_S0.9150.94
33_V59_A0.9140.94
16_L74_A0.9130.94
41_Q91_T0.9130.94
242_C246_A0.9130.94
130_A133_E0.9090.93
86_R113_H0.9070.93
59_A63_A0.9050.93
60_A64_D0.9020.93
85_H217_G0.8890.93
171_A225_G0.8830.92
159_S162_M0.8750.92
36_V99_F0.8740.92
98_T102_T0.8710.92
225_G230_G0.8640.92
50_T169_E0.8600.91
58_V237_A0.8590.91
244_L248_V0.8590.91
30_D116_D0.8580.91
160_S163_G0.8550.91
84_E126_G0.8490.91
61_A65_A0.8480.91
58_V234_L0.8460.91
178_P227_A0.8440.91
58_V152_F0.8440.91
43_G218_V0.8410.91
159_S163_G0.8380.90
51_D169_E0.8330.90
37_G79_V0.8320.90
186_V223_R0.8320.90
40_E124_H0.8300.90
54_T172_F0.8230.90
54_T123_G0.8200.89
104_R134_V0.8190.89
228_D232_A0.8160.89
55_A59_A0.8140.89
111_A116_D0.8130.89
74_A79_V0.8130.89
98_T109_S0.8120.89
22_T185_R0.8120.89
152_F241_L0.8090.89
37_G59_A0.8050.88
58_V238_T0.8000.88
210_A220_G0.8000.88
42_H51_D0.7980.88
243_A247_A0.7970.88
109_S112_S0.7950.88
37_G123_G0.7940.88
52_H78_T0.7930.88
44_P218_V0.7900.88
120_V146_A0.7860.87
60_A73_V0.7790.87
101_A104_R0.7750.87
52_H82_S0.7730.86
55_A76_P0.7690.86
97_D137_T0.7620.86
24_A48_L0.7580.85
122_N127_N0.7530.85
82_S127_N0.7530.85
46_A181_I0.7520.85
172_F233_L0.7490.85
62_G121_V0.7470.84
174_R181_I0.7470.84
94_V99_F0.7450.84
151_W154_A0.7420.84
151_W237_A0.7380.84
16_L113_H0.7350.84
50_T127_N0.7300.83
66_Y246_A0.7290.83
167_P171_A0.7290.83
58_V241_L0.7280.83
163_G166_G0.7280.83
23_D185_R0.7180.82
240_S243_A0.7170.82
17_A49_G0.7150.82
81_V96_P0.7120.82
188_A223_R0.7110.81
111_A142_D0.7080.81
226_D230_G0.7080.81
66_Y71_V0.7070.81
139_T208_A0.7050.81
84_E125_G0.7030.81
39_T78_T0.6990.80
86_R112_S0.6950.80
100_R137_T0.6920.80
48_L90_G0.6880.79
126_G163_G0.6870.79
167_P220_G0.6840.79
93_W109_S0.6800.79
123_G151_W0.6780.78
33_V71_V0.6760.78
19_A23_D0.6740.78
107_V111_A0.6690.77
36_V103_V0.6690.77
131_L148_P0.6680.77
158_H161_D0.6660.77
58_V123_G0.6620.77
183_E226_D0.6620.77
84_E166_G0.6580.76
41_Q84_E0.6560.76
154_A157_D0.6550.76
82_S126_G0.6540.76
31_L117_R0.6520.76
66_Y242_C0.6520.76
236_A240_S0.6490.75
23_D26_G0.6480.75
152_F155_V0.6470.75
37_G76_P0.6440.75
24_A89_T0.6430.75
16_L21_W0.6400.74
54_T151_W0.6390.74
170_T222_P0.6380.74
34_L103_V0.6340.74
57_A238_T0.6320.73
143_D146_A0.6320.73
42_H50_T0.6310.73
71_V245_L0.6300.73
208_A212_A0.6280.73
47_P50_T0.6250.72
82_S217_G0.6230.72
209_D212_A0.6190.72
52_H55_A0.6170.72
137_T141_Q0.6150.71
189_A216_N0.6130.71
122_N125_G0.6110.71
36_V77_I0.6110.71
47_P180_L0.6100.71
170_T218_V0.6090.71
129_A136_A0.6090.71
135_C146_A0.6060.70
165_A204_A0.6050.70
122_N131_L0.6040.70
63_A70_E0.6030.70
21_W41_Q0.6030.70
18_D177_D0.6030.70
85_H88_F0.6020.70
18_D179_E0.5980.69
16_L48_L0.5970.69
56_H78_T0.5930.69
51_D80_G0.5920.68
132_G136_A0.5900.68
58_V62_G0.5890.68
110_L113_H0.5890.68
122_N169_E0.5870.68
172_F237_A0.5840.67
130_A134_V0.5840.67
31_L245_L0.5830.67
119_V244_L0.5820.67
46_A173_L0.5800.67
97_D100_R0.5790.67
173_L181_I0.5790.67
85_H93_W0.5770.66
112_S235_D0.5730.66
77_I94_V0.5720.66
232_A236_A0.5700.65
119_V248_V0.5680.65
171_A230_G0.5680.65
99_F130_A0.5610.64
110_L141_Q0.5570.64
88_F211_A0.5530.63
28_D64_D0.5530.63
21_W25_D0.5490.63
165_A212_A0.5480.62
43_G90_G0.5480.62
28_D243_A0.5470.62
27_V72_I0.5460.62
38_S41_Q0.5440.62
50_T126_G0.5420.62
108_G197_W0.5410.61
25_D89_T0.5390.61
114_G117_R0.5380.61
59_A123_G0.5380.61
122_N151_W0.5330.60
210_A217_G0.5320.60
46_A170_T0.5320.60
74_A106_V0.5320.60
38_S127_N0.5270.59
120_V135_C0.5260.59
136_A140_R0.5250.59
237_A240_S0.5220.59
139_T212_A0.5220.59
62_G73_V0.5210.59
172_F238_T0.5200.58
50_T55_A0.5180.58
87_Q165_A0.5170.58
39_T79_V0.5170.58
83_A219_V0.5150.58
149_F244_L0.5150.58
123_G152_F0.5150.58
62_G66_Y0.5140.58
35_P73_V0.5140.58
77_I99_F0.5120.57
51_D123_G0.5120.57
99_F102_T0.5110.57
108_G112_S0.5100.57
41_Q127_N0.5090.57
62_G65_A0.5070.57
21_W44_P0.5060.56
228_D233_L0.5040.56
119_V149_F0.5040.56
118_V245_L0.5040.56
57_A177_D0.5040.56
20_T183_E0.5040.56
151_W172_F0.5020.56
41_Q93_W0.5010.56
116_D239_E0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lubA 4 0.9385 100 0.167 Contact Map
3no4A 5 0.9154 100 0.18 Contact Map
1v7zA 5 0.8885 100 0.191 Contact Map
2vbfA 2 0.6077 32.8 0.957 Contact Map
2zqeA 1 0.2962 29.8 0.957 Contact Map
4od6A 1 0.3038 29.2 0.958 Contact Map
2x7jA 4 0.5923 23.9 0.96 Contact Map
3skvA 2 0.6231 23.7 0.96 Contact Map
2panA 3 0.5808 22.5 0.96 Contact Map
3f7xA 2 0.45 21.2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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