Q9HSQ6 - HALSA - GREMLIN Contacts

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Q9HSQ6 - Uncharacterized protein

UniProt:	Q9HSQ6	Sequences: MAAYKRRGRVPSRMRLADATWTDADGVDTDLAVLPVGSTEQHGPHAPLGTDHITAHAVAAAGADAYSDGEVIVAPPITVGVSAEHRQFTGTLWVAPDTFRATVRDVVGSLASHGWDRVVVVNGHGGNTAALGEVCATITRQDDAYAVPFTWFDAVGDHSSDMGHAGPLETAFLRHTDPELIREDRVQAAAEDGADAWGKWVSHANLAADAAAFTDNGVVGDPRAGDADRGAALLDAATESLCALLAAVADRDTTAPLPHR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	260 (227)
Sequences:	2133 (1588)
Seq/√Len:	105.4

HALSA - Q9HSQ6 Q9HP77
SULSO - Q97V05

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
95_A	105_D	3.424	1.00
65_A	239_E	3.285	1.00
231_A	235_D	3.284	1.00
49_G	53_I	3.242	1.00
183_E	186_V	3.234	1.00
167_P	229_R	3.058	1.00
98_T	105_D	2.763	1.00
108_G	141_Q	2.741	1.00
97_D	101_A	2.616	1.00
175_H	231_A	2.559	1.00
55_A	123_G	2.454	1.00
56_H	76_P	2.419	1.00
107_V	138_I	2.347	1.00
57_A	176_T	2.341	1.00
94_V	102_T	2.332	1.00
34_L	120_V	2.276	1.00
104_R	137_T	2.164	1.00
57_A	61_A	2.117	1.00
23_D	182_R	2.104	1.00
32_A	74_A	2.097	1.00
175_H	234_L	2.091	1.00
61_A	64_D	1.996	1.00
32_A	115_W	1.978	1.00
42_H	169_E	1.932	1.00
32_A	110_L	1.912	1.00
174_R	183_E	1.895	1.00
41_Q	85_H	1.864	1.00
41_Q	217_G	1.831	1.00
20_T	182_R	1.809	1.00
107_V	118_V	1.796	1.00
104_R	141_Q	1.761	1.00
77_I	102_T	1.721	1.00
176_T	234_L	1.680	1.00
238_T	242_C	1.677	1.00
171_A	226_D	1.674	1.00
175_H	227_A	1.665	1.00
62_G	241_L	1.657	1.00
15_R	60_A	1.656	1.00
87_Q	211_A	1.637	1.00
82_S	85_H	1.637	1.00
92_L	106_V	1.623	1.00
53_I	177_D	1.613	1.00
188_A	221_D	1.585	1.00
61_A	234_L	1.583	1.00
45_H	170_T	1.568	1.00
98_T	101_A	1.563	1.00
171_A	229_R	1.557	1.00
61_A	175_H	1.535	1.00
172_F	234_L	1.516	1.00
52_H	76_P	1.515	1.00
74_A	110_L	1.471	1.00
167_P	224_A	1.464	1.00
182_R	185_R	1.462	1.00
65_A	238_T	1.458	1.00
38_S	82_S	1.432	1.00
63_A	73_V	1.432	1.00
235_D	239_E	1.427	1.00
171_A	174_R	1.418	1.00
187_Q	216_N	1.405	1.00
79_V	92_L	1.403	1.00
34_L	74_A	1.380	1.00
227_A	231_A	1.365	1.00
100_R	133_E	1.346	0.99
101_A	105_D	1.331	0.99
62_G	242_C	1.315	0.99
66_Y	70_E	1.300	0.99
18_D	180_L	1.298	0.99
19_A	72_I	1.296	0.99
95_A	98_T	1.285	0.99
62_G	238_T	1.285	0.99
100_R	134_V	1.277	0.99
57_A	60_A	1.276	0.99
85_H	125_G	1.276	0.99
107_V	120_V	1.273	0.99
16_L	24_A	1.272	0.99
243_A	246_A	1.256	0.99
59_A	73_V	1.247	0.99
111_A	144_A	1.245	0.99
147_V	244_L	1.240	0.99
56_H	60_A	1.204	0.99
33_V	245_L	1.196	0.99
226_D	229_R	1.189	0.99
61_A	235_D	1.182	0.99
77_I	106_V	1.178	0.99
59_A	121_V	1.177	0.99
174_R	225_G	1.172	0.99
34_L	118_V	1.167	0.99
210_A	214_T	1.157	0.98
103_V	131_L	1.149	0.98
188_A	222_P	1.145	0.98
228_D	231_A	1.137	0.98
177_D	180_L	1.136	0.98
15_R	18_D	1.123	0.98
65_A	235_D	1.121	0.98
182_R	186_V	1.113	0.98
61_A	231_A	1.109	0.98
117_R	145_Y	1.093	0.98
234_L	238_T	1.092	0.98
239_E	243_A	1.091	0.98
217_G	220_G	1.087	0.98
85_H	126_G	1.085	0.98
50_T	173_L	1.082	0.98
33_V	73_V	1.076	0.97
21_W	88_F	1.072	0.97
53_I	173_L	1.071	0.97
119_V	245_L	1.065	0.97
49_G	180_L	1.064	0.97
24_A	115_W	1.063	0.97
17_A	56_H	1.061	0.97
37_G	55_A	1.059	0.97
174_R	227_A	1.048	0.97
55_A	121_V	1.042	0.97
108_G	142_D	1.042	0.97
21_W	89_T	1.041	0.97
79_V	106_V	1.029	0.97
65_A	242_C	1.016	0.96
50_T	53_I	1.009	0.96
20_T	23_D	0.995	0.96
41_Q	82_S	0.991	0.96
86_R	93_W	0.984	0.96
129_A	132_G	0.974	0.95
19_A	27_V	0.972	0.95
22_T	25_D	0.957	0.95
96_P	130_A	0.953	0.95
35_P	55_A	0.949	0.95
57_A	234_L	0.949	0.95
22_T	26_G	0.948	0.95
214_T	220_G	0.944	0.95
36_V	131_L	0.940	0.95
16_L	110_L	0.937	0.94
118_V	144_A	0.926	0.94
33_V	63_A	0.926	0.94
53_I	180_L	0.921	0.94
81_V	130_A	0.918	0.94
105_D	109_S	0.915	0.94
33_V	59_A	0.914	0.94
16_L	74_A	0.913	0.94
41_Q	91_T	0.913	0.94
242_C	246_A	0.913	0.94
130_A	133_E	0.909	0.93
86_R	113_H	0.907	0.93
59_A	63_A	0.905	0.93
60_A	64_D	0.902	0.93
85_H	217_G	0.889	0.93
171_A	225_G	0.883	0.92
159_S	162_M	0.875	0.92
36_V	99_F	0.874	0.92
98_T	102_T	0.871	0.92
225_G	230_G	0.864	0.92
50_T	169_E	0.860	0.91
58_V	237_A	0.859	0.91
244_L	248_V	0.859	0.91
30_D	116_D	0.858	0.91
160_S	163_G	0.855	0.91
84_E	126_G	0.849	0.91
61_A	65_A	0.848	0.91
58_V	234_L	0.846	0.91
178_P	227_A	0.844	0.91
58_V	152_F	0.844	0.91
43_G	218_V	0.841	0.91
159_S	163_G	0.838	0.90
51_D	169_E	0.833	0.90
37_G	79_V	0.832	0.90
186_V	223_R	0.832	0.90
40_E	124_H	0.830	0.90
54_T	172_F	0.823	0.90
54_T	123_G	0.820	0.89
104_R	134_V	0.819	0.89
228_D	232_A	0.816	0.89
55_A	59_A	0.814	0.89
111_A	116_D	0.813	0.89
74_A	79_V	0.813	0.89
98_T	109_S	0.812	0.89
22_T	185_R	0.812	0.89
152_F	241_L	0.809	0.89
37_G	59_A	0.805	0.88
58_V	238_T	0.800	0.88
210_A	220_G	0.800	0.88
42_H	51_D	0.798	0.88
243_A	247_A	0.797	0.88
109_S	112_S	0.795	0.88
37_G	123_G	0.794	0.88
52_H	78_T	0.793	0.88
44_P	218_V	0.790	0.88
120_V	146_A	0.786	0.87
60_A	73_V	0.779	0.87
101_A	104_R	0.775	0.87
52_H	82_S	0.773	0.86
55_A	76_P	0.769	0.86
97_D	137_T	0.762	0.86
24_A	48_L	0.758	0.85
122_N	127_N	0.753	0.85
82_S	127_N	0.753	0.85
46_A	181_I	0.752	0.85
172_F	233_L	0.749	0.85
62_G	121_V	0.747	0.84
174_R	181_I	0.747	0.84
94_V	99_F	0.745	0.84
151_W	154_A	0.742	0.84
151_W	237_A	0.738	0.84
16_L	113_H	0.735	0.84
50_T	127_N	0.730	0.83
66_Y	246_A	0.729	0.83
167_P	171_A	0.729	0.83
58_V	241_L	0.728	0.83
163_G	166_G	0.728	0.83
23_D	185_R	0.718	0.82
240_S	243_A	0.717	0.82
17_A	49_G	0.715	0.82
81_V	96_P	0.712	0.82
188_A	223_R	0.711	0.81
111_A	142_D	0.708	0.81
226_D	230_G	0.708	0.81
66_Y	71_V	0.707	0.81
139_T	208_A	0.705	0.81
84_E	125_G	0.703	0.81
39_T	78_T	0.699	0.80
86_R	112_S	0.695	0.80
100_R	137_T	0.692	0.80
48_L	90_G	0.688	0.79
126_G	163_G	0.687	0.79
167_P	220_G	0.684	0.79
93_W	109_S	0.680	0.79
123_G	151_W	0.678	0.78
33_V	71_V	0.676	0.78
19_A	23_D	0.674	0.78
107_V	111_A	0.669	0.77
36_V	103_V	0.669	0.77
131_L	148_P	0.668	0.77
158_H	161_D	0.666	0.77
58_V	123_G	0.662	0.77
183_E	226_D	0.662	0.77
84_E	166_G	0.658	0.76
41_Q	84_E	0.656	0.76
154_A	157_D	0.655	0.76
82_S	126_G	0.654	0.76
31_L	117_R	0.652	0.76
66_Y	242_C	0.652	0.76
236_A	240_S	0.649	0.75
23_D	26_G	0.648	0.75
152_F	155_V	0.647	0.75
37_G	76_P	0.644	0.75
24_A	89_T	0.643	0.75
16_L	21_W	0.640	0.74
54_T	151_W	0.639	0.74
170_T	222_P	0.638	0.74
34_L	103_V	0.634	0.74
57_A	238_T	0.632	0.73
143_D	146_A	0.632	0.73
42_H	50_T	0.631	0.73
71_V	245_L	0.630	0.73
208_A	212_A	0.628	0.73
47_P	50_T	0.625	0.72
82_S	217_G	0.623	0.72
209_D	212_A	0.619	0.72
52_H	55_A	0.617	0.72
137_T	141_Q	0.615	0.71
189_A	216_N	0.613	0.71
122_N	125_G	0.611	0.71
36_V	77_I	0.611	0.71
47_P	180_L	0.610	0.71
170_T	218_V	0.609	0.71
129_A	136_A	0.609	0.71
135_C	146_A	0.606	0.70
165_A	204_A	0.605	0.70
122_N	131_L	0.604	0.70
63_A	70_E	0.603	0.70
21_W	41_Q	0.603	0.70
18_D	177_D	0.603	0.70
85_H	88_F	0.602	0.70
18_D	179_E	0.598	0.69
16_L	48_L	0.597	0.69
56_H	78_T	0.593	0.69
51_D	80_G	0.592	0.68
132_G	136_A	0.590	0.68
58_V	62_G	0.589	0.68
110_L	113_H	0.589	0.68
122_N	169_E	0.587	0.68
172_F	237_A	0.584	0.67
130_A	134_V	0.584	0.67
31_L	245_L	0.583	0.67
119_V	244_L	0.582	0.67
46_A	173_L	0.580	0.67
97_D	100_R	0.579	0.67
173_L	181_I	0.579	0.67
85_H	93_W	0.577	0.66
112_S	235_D	0.573	0.66
77_I	94_V	0.572	0.66
232_A	236_A	0.570	0.65
119_V	248_V	0.568	0.65
171_A	230_G	0.568	0.65
99_F	130_A	0.561	0.64
110_L	141_Q	0.557	0.64
88_F	211_A	0.553	0.63
28_D	64_D	0.553	0.63
21_W	25_D	0.549	0.63
165_A	212_A	0.548	0.62
43_G	90_G	0.548	0.62
28_D	243_A	0.547	0.62
27_V	72_I	0.546	0.62
38_S	41_Q	0.544	0.62
50_T	126_G	0.542	0.62
108_G	197_W	0.541	0.61
25_D	89_T	0.539	0.61
114_G	117_R	0.538	0.61
59_A	123_G	0.538	0.61
122_N	151_W	0.533	0.60
210_A	217_G	0.532	0.60
46_A	170_T	0.532	0.60
74_A	106_V	0.532	0.60
38_S	127_N	0.527	0.59
120_V	135_C	0.526	0.59
136_A	140_R	0.525	0.59
237_A	240_S	0.522	0.59
139_T	212_A	0.522	0.59
62_G	73_V	0.521	0.59
172_F	238_T	0.520	0.58
50_T	55_A	0.518	0.58
87_Q	165_A	0.517	0.58
39_T	79_V	0.517	0.58
83_A	219_V	0.515	0.58
149_F	244_L	0.515	0.58
123_G	152_F	0.515	0.58
62_G	66_Y	0.514	0.58
35_P	73_V	0.514	0.58
77_I	99_F	0.512	0.57
51_D	123_G	0.512	0.57
99_F	102_T	0.511	0.57
108_G	112_S	0.510	0.57
41_Q	127_N	0.509	0.57
62_G	65_A	0.507	0.57
21_W	44_P	0.506	0.56
228_D	233_L	0.504	0.56
119_V	149_F	0.504	0.56
118_V	245_L	0.504	0.56
57_A	177_D	0.504	0.56
20_T	183_E	0.504	0.56
151_W	172_F	0.502	0.56
41_Q	93_W	0.501	0.56
116_D	239_E	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lubA	4	0.9385	100	0.167	Contact Map
3no4A	5	0.9154	100	0.18	Contact Map
1v7zA	5	0.8885	100	0.191	Contact Map
2vbfA	2	0.6077	32.8	0.957	Contact Map
2zqeA	1	0.2962	29.8	0.957	Contact Map
4od6A	1	0.3038	29.2	0.958	Contact Map
2x7jA	4	0.5923	23.9	0.96	Contact Map
3skvA	2	0.6231	23.7	0.96	Contact Map
2panA	3	0.5808	22.5	0.96	Contact Map
3f7xA	2	0.45	21.2	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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