GREMLIN Database
Q9HSQ4 - Dihydroneopterin aldolase
UniProt: Q9HSQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 109 (105)
Sequences: 140 (105)
Seq/√Len: 10.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_Y70_E2.8160.91
51_E88_T2.5520.86
15_K50_C2.5460.86
16_F50_C2.4520.83
45_R52_G2.0930.72
92_E105_A2.0480.70
20_Y73_G1.9920.68
7_Q103_R1.9770.67
46_N66_H1.8810.63
24_A73_G1.8760.63
5_A105_A1.8730.63
37_E59_T1.8620.62
33_A59_T1.7750.59
55_V78_V1.7580.58
17_G43_S1.7430.57
12_A15_K1.7390.57
99_Y102_M1.7070.55
58_K77_D1.6230.52
7_Q105_A1.6200.51
35_S39_A1.6140.51
15_K20_Y1.5980.50
15_K49_F1.5000.46
9_C29_S1.4500.44
35_S73_G1.4270.42
35_S42_E1.4160.42
83_D86_G1.3970.41
3_T89_V1.3910.41
20_Y46_N1.3870.41
91_A104_L1.3340.38
4_D38_T1.3260.38
22_Q71_L1.3220.38
56_D77_D1.3160.38
44_I70_E1.2950.37
4_D85_E1.2720.36
3_T63_D1.2580.35
80_L91_A1.2480.35
37_E57_I1.2380.34
50_C75_Y1.2350.34
12_A49_F1.2100.33
13_G82_I1.2100.33
49_F94_A1.1830.32
41_E91_A1.1830.32
23_F45_R1.1670.31
90_A106_E1.1510.31
12_A20_Y1.1400.30
13_G16_F1.1390.30
34_P90_A1.1270.30
52_G80_L1.1170.29
38_T60_E1.1030.29
56_D81_R1.0990.29
66_H75_Y1.0930.28
88_T98_G1.0920.28
31_A83_D1.0770.28
97_D107_I1.0690.28
6_Q74_E1.0680.28
94_A103_R1.0670.27
44_I89_V1.0500.27
9_C74_E1.0480.27
81_R88_T1.0420.27
14_I28_V1.0410.27
63_D106_E1.0350.26
23_F26_T1.0280.26
73_G102_M1.0270.26
22_Q55_V1.0170.26
28_V83_D1.0100.25
28_V71_L1.0000.25
18_A53_V0.9870.25
92_E96_D0.9810.24
65_E98_G0.9740.24
41_E80_L0.9400.23
46_N50_C0.9390.23
23_F69_T0.9370.23
19_L23_F0.9350.23
16_F49_F0.9310.23
73_G100_P0.8990.22
32_S45_R0.8950.22
65_E96_D0.8920.21
38_T90_A0.8900.21
17_G84_Y0.8830.21
20_Y79_E0.8790.21
95_M103_R0.8730.21
24_A93_M0.8610.21
80_L90_A0.8500.20
82_I85_E0.8410.20
58_K66_H0.8330.20
18_A37_E0.8280.20
19_L66_H0.8210.19
5_A83_D0.8200.19
20_Y35_S0.8120.19
4_D63_D0.8090.19
57_I94_A0.8050.19
12_A91_A0.7940.19
32_S67_G0.7800.18
40_I85_E0.7710.18
41_E62_L0.7660.18
31_A81_R0.7600.18
5_A92_E0.7520.17
58_K76_M0.7300.17
96_D103_R0.7260.17
23_F44_I0.7230.17
16_F93_M0.7210.17
81_R90_A0.7170.17
34_P40_I0.7170.17
41_E61_R0.7120.16
71_L75_Y0.7110.16
85_E88_T0.7080.16
15_K102_M0.7000.16
79_E83_D0.6930.16
86_G107_I0.6710.15
32_S50_C0.6680.15
70_E103_R0.6580.15
6_Q104_L0.6490.15
74_E98_G0.6410.15
19_L40_I0.6300.14
34_P81_R0.6250.14
58_K83_D0.6170.14
34_P106_E0.6170.14
29_S73_G0.6160.14
79_E94_A0.6070.14
52_G107_I0.6060.14
18_A70_E0.6030.14
40_I104_L0.5970.14
24_A75_Y0.5960.14
6_Q57_I0.5940.14
32_S95_M0.5940.14
37_E76_M0.5910.14
69_T72_T0.5910.14
58_K106_E0.5900.14
56_D83_D0.5900.14
32_S100_P0.5880.13
34_P92_E0.5880.13
58_K61_R0.5880.13
34_P37_E0.5860.13
35_S78_V0.5860.13
94_A105_A0.5840.13
49_F91_A0.5760.13
30_P43_S0.5720.13
23_F71_L0.5690.13
31_A54_A0.5650.13
90_A98_G0.5630.13
44_I93_M0.5580.13
4_D82_I0.5570.13
43_S78_V0.5490.13
26_T70_E0.5490.13
94_A104_L0.5430.13
69_T93_M0.5400.12
33_A46_N0.5370.12
8_A49_F0.5370.12
3_T54_A0.5350.12
38_T94_A0.5290.12
16_F24_A0.5240.12
47_Q99_Y0.5210.12
49_F82_I0.5160.12
56_D69_T0.5160.12
37_E71_L0.5110.12
55_V71_L0.5050.12
40_I84_Y0.5040.12
36_L64_V0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iecA 4 1 100 0.056 Contact Map
2i52A 5 0.9908 100 0.077 Contact Map
2ogfA 4 0.9633 100 0.086 Contact Map
4hrzA 2 0.7615 49.1 0.929 Contact Map
2c7pA 1 0.4404 31.1 0.936 Contact Map
2ia7A 1 0.8257 29.5 0.937 Contact Map
1ky9A 5 0.5413 19.1 0.942 Contact Map
2qrvA 2 0.422 19.1 0.942 Contact Map
4a8cA 5 0.5596 18.5 0.943 Contact Map
3qv2A 1 0.4128 15.5 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.