Q9HSQ3 - HALSA - GREMLIN Contacts

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Q9HSQ3 - Uncharacterized protein

UniProt:	Q9HSQ3	Sequences: MTTRMDEPVLLTGASGRVGQAILGGIGDDYTWRLFDREPPTDDPDHEFVVADITDETAVREAASDVGAIVHLAGDPRPEAPWESVLRNNIDGTRTVLDAALAAGVDRVVFASSNHAVGHYETDRKPDLYRSDDDFRLDGTERPRPGNLYGVSKAAGETLGRYYHDEHGLTFAAVRIGNLTAGHPPIDYERGQAMWLSPRDCAHLIDRCLSADYDYEVVYGISDNDRKYYSLARAKDALGYEPRDNSAEWDGDEKLSGGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	259 (235)
Sequences:	53034 (36441)
Seq/√Len:	2377.2

ECOLI - GM4D RMLB1 RMLB2 GALE YBJS HLDD FCL RMLD YFCH YEEZ QOR2 YRAR ARNA
BACSU - YTBQ RMLB YFNG YTCB GALE YFHF SPSK YHEG YWNB YHFK YESF
HALSA - Q9HSQ3 Q9HSU9 Q9HRD1 Q9HSV1 Q9HSE7 Q9HML4 Q9HS50 Q9HNV3 Q9HR86 Q9HPF1
SULSO - Q97VN5 Q980W1 Q7LXG5 Q97UM3 Q97XJ9 Q7LXE8 Q97XG1 Q7LX44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_A	34_L	3.092	1.00
8_P	31_T	2.625	1.00
87_R	91_D	2.613	1.00
25_G	203_H	2.597	1.00
111_A	205_I	2.255	1.00
68_A	209_L	2.254	1.00
25_G	206_D	2.186	1.00
60_R	102_A	2.159	1.00
245_N	248_E	2.158	1.00
107_R	170_T	2.090	1.00
81_P	84_S	2.071	1.00
35_F	51_A	2.061	1.00
25_G	28_D	2.036	1.00
176_I	205_I	2.017	1.00
8_P	33_R	2.007	1.00
160_G	171_F	1.996	1.00
51_A	58_A	1.980	1.00
71_H	110_F	1.963	1.00
70_V	209_L	1.945	1.00
33_R	66_V	1.920	1.00
55_D	58_A	1.860	1.00
174_V	208_C	1.849	1.00
203_H	243_R	1.846	1.00
33_R	47_E	1.831	1.00
10_L	66_V	1.805	1.00
33_R	49_V	1.801	1.00
138_D	141_E	1.800	1.00
12_T	71_H	1.780	1.00
60_R	99_A	1.771	1.00
232_A	236_D	1.764	1.00
94_R	159_L	1.756	1.00
235_K	241_E	1.736	1.00
199_R	252_D	1.719	1.00
28_D	206_D	1.711	1.00
203_H	207_R	1.710	1.00
93_T	156_G	1.700	1.00
56_E	98_D	1.647	1.00
91_D	94_R	1.634	1.00
31_T	47_E	1.619	1.00
154_A	158_T	1.601	1.00
206_D	210_S	1.594	1.00
180_T	249_W	1.594	1.00
94_R	98_D	1.593	1.00
54_T	87_R	1.590	1.00
22_I	72_L	1.573	1.00
101_L	167_H	1.572	1.00
112_S	116_A	1.571	1.00
11_L	23_L	1.571	1.00
9_V	30_Y	1.550	1.00
197_S	252_D	1.543	1.00
72_L	111_A	1.540	1.00
231_L	235_K	1.538	1.00
22_I	70_V	1.502	1.00
56_E	95_T	1.494	1.00
22_I	202_A	1.480	1.00
86_L	155_A	1.479	1.00
28_D	210_S	1.464	1.00
18_V	179_L	1.461	1.00
143_P	154_A	1.455	1.00
58_A	61_E	1.442	1.00
234_A	238_L	1.438	1.00
25_G	202_A	1.433	1.00
107_R	172_A	1.426	1.00
56_E	60_R	1.413	1.00
207_R	211_A	1.401	1.00
38_E	48_F	1.398	1.00
69_I	100_A	1.379	1.00
67_G	106_D	1.376	1.00
60_R	103_A	1.365	1.00
79_E	82_W	1.363	1.00
244_D	252_D	1.348	1.00
14_A	23_L	1.337	1.00
8_P	67_G	1.328	1.00
23_L	34_L	1.305	1.00
83_E	87_R	1.299	1.00
176_I	201_C	1.292	1.00
196_L	201_C	1.285	1.00
158_T	161_R	1.282	1.00
110_F	156_G	1.280	1.00
111_A	176_I	1.278	1.00
64_S	103_A	1.274	1.00
164_H	171_F	1.272	1.00
177_G	229_Y	1.261	1.00
139_G	233_R	1.254	1.00
34_L	46_H	1.249	1.00
24_G	183_H	1.247	1.00
53_I	92_G	1.241	1.00
89_N	152_S	1.230	1.00
149_Y	153_K	1.213	1.00
70_V	205_I	1.210	1.00
100_A	108_V	1.207	1.00
30_Y	210_S	1.202	1.00
110_F	160_G	1.199	1.00
9_V	68_A	1.193	1.00
248_E	252_D	1.189	1.00
197_S	249_W	1.188	1.00
110_F	173_A	1.187	1.00
97_L	163_Y	1.183	1.00
25_G	199_R	1.181	1.00
151_V	155_A	1.179	1.00
10_L	35_F	1.176	1.00
15_S	36_D	1.165	1.00
71_H	93_T	1.164	1.00
248_E	251_G	1.149	1.00
63_A	66_V	1.149	1.00
97_L	108_V	1.138	1.00
218_V	221_I	1.126	1.00
98_D	101_L	1.120	1.00
75_D	88_N	1.119	1.00
231_L	242_P	1.117	1.00
161_R	173_A	1.113	1.00
233_R	237_A	1.100	1.00
24_G	27_G	1.096	1.00
96_V	108_V	1.081	1.00
59_V	99_A	1.076	1.00
107_R	212_D	1.069	1.00
21_A	199_R	1.067	1.00
109_V	174_V	1.066	1.00
63_A	99_A	1.064	1.00
137_L	141_E	1.055	1.00
53_I	73_A	1.054	1.00
198_P	202_A	1.051	1.00
159_L	162_Y	1.044	1.00
90_I	155_A	1.034	1.00
26_I	206_D	1.034	1.00
21_A	198_P	1.032	1.00
95_T	98_D	1.031	1.00
99_A	102_A	1.026	1.00
179_L	201_C	1.022	1.00
60_R	64_S	1.020	1.00
91_D	95_T	1.017	1.00
174_V	205_I	1.009	1.00
108_V	160_G	1.009	1.00
72_L	205_I	1.008	1.00
100_A	105_V	1.006	1.00
99_A	103_A	0.999	1.00
162_Y	166_E	0.996	1.00
101_L	169_L	0.995	1.00
9_V	26_I	0.993	1.00
42_D	46_H	0.985	1.00
157_E	175_R	0.984	1.00
35_F	58_A	0.983	1.00
35_F	62_A	0.981	1.00
68_A	107_R	0.978	1.00
86_L	91_D	0.975	1.00
98_D	102_A	0.974	1.00
63_A	69_I	0.973	1.00
172_A	208_C	0.970	1.00
97_L	160_G	0.967	1.00
192_Q	226_R	0.966	1.00
161_R	171_F	0.964	1.00
215_Y	218_V	0.956	1.00
61_E	64_S	0.950	1.00
8_P	30_Y	0.948	1.00
88_N	92_G	0.939	1.00
8_P	66_V	0.933	1.00
197_S	244_D	0.932	1.00
207_R	210_S	0.923	1.00
244_D	248_E	0.921	1.00
12_T	96_V	0.921	1.00
86_L	90_I	0.920	1.00
93_T	160_G	0.912	1.00
20_Q	183_H	0.912	1.00
161_R	165_D	0.911	1.00
199_R	244_D	0.910	1.00
17_R	198_P	0.897	1.00
218_V	222_S	0.889	1.00
114_N	177_G	0.877	1.00
23_L	32_W	0.874	1.00
9_V	70_V	0.874	1.00
38_E	50_V	0.873	1.00
69_I	96_V	0.873	1.00
54_T	88_N	0.869	1.00
63_A	103_A	0.868	1.00
39_P	50_V	0.863	1.00
56_E	102_A	0.856	1.00
35_F	59_V	0.854	1.00
21_A	24_G	0.852	1.00
37_R	52_D	0.849	1.00
75_D	85_V	0.847	1.00
58_A	62_A	0.846	1.00
204_L	234_A	0.844	1.00
36_D	48_F	0.841	1.00
172_A	212_D	0.841	1.00
57_T	61_E	0.841	1.00
138_D	230_S	0.839	1.00
49_V	62_A	0.839	1.00
57_T	60_R	0.834	1.00
197_S	200_D	0.830	1.00
203_H	206_D	0.829	1.00
203_H	244_D	0.829	1.00
122_T	141_E	0.828	1.00
21_A	25_G	0.827	1.00
112_S	157_E	0.825	1.00
122_T	138_D	0.824	1.00
155_A	158_T	0.815	1.00
232_A	235_K	0.813	1.00
75_D	84_S	0.811	1.00
85_V	152_S	0.803	1.00
216_E	219_Y	0.801	1.00
247_A	251_G	0.789	1.00
22_I	26_I	0.785	1.00
217_V	220_G	0.784	1.00
33_R	65_D	0.784	1.00
218_V	223_D	0.780	1.00
12_T	73_A	0.778	1.00
106_D	170_T	0.774	1.00
158_T	162_Y	0.773	1.00
84_S	87_R	0.770	1.00
95_T	99_A	0.770	1.00
244_D	249_W	0.768	1.00
163_Y	167_H	0.762	1.00
151_V	158_T	0.757	1.00
123_D	136_R	0.745	1.00
204_L	240_Y	0.744	1.00
98_D	163_Y	0.736	1.00
233_R	236_D	0.734	1.00
140_T	233_R	0.732	1.00
116_A	157_E	0.729	1.00
116_A	143_P	0.727	1.00
115_H	150_G	0.727	1.00
204_L	220_G	0.726	1.00
179_L	196_L	0.724	1.00
71_H	96_V	0.722	1.00
176_I	179_L	0.715	1.00
218_V	237_A	0.710	1.00
9_V	209_L	0.710	1.00
202_A	206_D	0.708	1.00
63_A	100_A	0.707	1.00
180_T	197_S	0.705	1.00
219_Y	223_D	0.703	1.00
17_R	181_A	0.701	1.00
93_T	97_L	0.701	1.00
82_W	151_V	0.698	1.00
21_A	202_A	0.691	1.00
215_Y	219_Y	0.690	1.00
86_L	152_S	0.689	1.00
221_I	224_N	0.687	1.00
151_V	162_Y	0.687	1.00
101_L	168_G	0.683	1.00
219_Y	222_S	0.679	1.00
97_L	159_L	0.675	1.00
41_T	44_P	0.673	1.00
155_A	159_L	0.673	1.00
43_D	46_H	0.673	1.00
101_L	163_Y	0.672	1.00
121_E	141_E	0.671	1.00
218_V	224_N	0.671	1.00
22_I	205_I	0.670	1.00
114_N	229_Y	0.668	1.00
56_E	99_A	0.668	1.00
235_K	242_P	0.667	1.00
182_G	252_D	0.666	1.00
84_S	88_N	0.665	1.00
59_V	95_T	0.665	1.00
92_G	95_T	0.663	1.00
59_V	63_A	0.657	1.00
30_Y	67_G	0.654	1.00
10_L	63_A	0.648	1.00
219_Y	225_D	0.647	1.00
15_S	38_E	0.646	1.00
148_L	151_V	0.646	1.00
69_I	108_V	0.645	1.00
203_H	240_Y	0.642	1.00
26_I	209_L	0.641	1.00
182_G	197_S	0.640	1.00
208_C	238_L	0.638	1.00
55_D	59_V	0.636	1.00
156_G	160_G	0.635	1.00
68_A	106_D	0.634	1.00
36_D	40_P	0.633	1.00
143_P	158_T	0.632	1.00
219_Y	224_N	0.629	1.00
147_N	150_G	0.629	1.00
200_D	203_H	0.629	1.00
42_D	45_D	0.628	1.00
207_R	238_L	0.627	1.00
170_T	213_Y	0.627	1.00
136_R	139_G	0.625	1.00
79_E	148_L	0.623	1.00
216_E	220_G	0.623	1.00
109_V	209_L	0.621	1.00
34_L	48_F	0.619	1.00
222_S	225_D	0.615	1.00
20_Q	24_G	0.611	1.00
174_V	204_L	0.611	1.00
31_T	45_D	0.610	1.00
162_Y	165_D	0.607	1.00
160_G	173_A	0.605	1.00
18_V	201_C	0.605	1.00
208_C	234_A	0.604	1.00
21_A	183_H	0.603	1.00
116_A	175_R	0.601	1.00
8_P	65_D	0.600	1.00
177_G	194_M	0.597	1.00
207_R	240_Y	0.593	1.00
178_N	193_A	0.589	1.00
207_R	239_G	0.589	1.00
41_T	46_H	0.584	1.00
234_A	242_P	0.581	1.00
123_D	226_R	0.576	1.00
10_L	51_A	0.576	1.00
145_P	150_G	0.575	1.00
109_V	205_I	0.574	1.00
86_L	151_V	0.573	1.00
234_A	237_A	0.573	1.00
145_P	154_A	0.570	1.00
200_D	243_R	0.568	1.00
161_R	164_H	0.564	1.00
11_L	26_I	0.559	1.00
30_Y	68_A	0.557	1.00
10_L	62_A	0.556	1.00
220_G	224_N	0.556	1.00
52_D	55_D	0.555	1.00
21_A	182_G	0.549	1.00
243_R	248_E	0.548	1.00
164_H	169_L	0.546	1.00
119_H	146_G	0.545	1.00
217_V	222_S	0.544	1.00
139_G	234_A	0.539	1.00
28_D	203_H	0.537	1.00
184_P	187_D	0.536	1.00
163_Y	169_L	0.536	1.00
10_L	69_I	0.535	1.00
216_E	233_R	0.533	1.00
72_L	176_I	0.529	1.00
139_G	142_R	0.529	1.00
17_R	21_A	0.529	1.00
82_W	148_L	0.528	1.00
192_Q	228_Y	0.528	1.00
29_D	32_W	0.528	1.00
37_R	40_P	0.525	1.00
178_N	195_W	0.525	1.00
75_D	89_N	0.523	1.00
211_A	214_D	0.522	1.00
51_A	62_A	0.520	1.00
182_G	199_R	0.519	1.00
220_G	223_D	0.513	1.00
217_V	223_D	0.513	1.00
216_E	222_S	0.513	1.00
113_S	116_A	0.512	1.00
71_H	108_V	0.511	1.00
164_H	170_T	0.511	1.00
36_D	39_P	0.509	1.00
68_A	109_V	0.509	1.00
152_S	156_G	0.507	1.00
231_L	240_Y	0.506	1.00
170_T	212_D	0.505	1.00
22_I	206_D	0.502	1.00
24_G	199_R	0.501	1.00
170_T	214_D	0.501	1.00
26_I	30_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sb8A	2	0.9498	100	0.248	Contact Map
3rufA	2	0.9498	100	0.25	Contact Map
3wmwA	2	0.8224	100	0.253	Contact Map
1rkxA	3	0.9575	100	0.254	Contact Map
2pk3A	2	0.9305	100	0.258	Contact Map
4wkgA	5	0.9382	100	0.258	Contact Map
3slgA	4	0.9305	100	0.261	Contact Map
1gy8A	2	0.9498	100	0.263	Contact Map
1oc2A	2	0.9846	100	0.264	Contact Map
1z45A	2	0.9498	100	0.266	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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