GREMLIN Database
Q9HSQ3 - Uncharacterized protein
UniProt: Q9HSQ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (235)
Sequences: 53034 (36441)
Seq/√Len: 2377.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A34_L3.0921.00
8_P31_T2.6251.00
87_R91_D2.6131.00
25_G203_H2.5971.00
111_A205_I2.2551.00
68_A209_L2.2541.00
25_G206_D2.1861.00
60_R102_A2.1591.00
245_N248_E2.1581.00
107_R170_T2.0901.00
81_P84_S2.0711.00
35_F51_A2.0611.00
25_G28_D2.0361.00
176_I205_I2.0171.00
8_P33_R2.0071.00
160_G171_F1.9961.00
51_A58_A1.9801.00
71_H110_F1.9631.00
70_V209_L1.9451.00
33_R66_V1.9201.00
55_D58_A1.8601.00
174_V208_C1.8491.00
203_H243_R1.8461.00
33_R47_E1.8311.00
10_L66_V1.8051.00
33_R49_V1.8011.00
138_D141_E1.8001.00
12_T71_H1.7801.00
60_R99_A1.7711.00
232_A236_D1.7641.00
94_R159_L1.7561.00
235_K241_E1.7361.00
199_R252_D1.7191.00
28_D206_D1.7111.00
203_H207_R1.7101.00
93_T156_G1.7001.00
56_E98_D1.6471.00
91_D94_R1.6341.00
31_T47_E1.6191.00
154_A158_T1.6011.00
206_D210_S1.5941.00
180_T249_W1.5941.00
94_R98_D1.5931.00
54_T87_R1.5901.00
22_I72_L1.5731.00
101_L167_H1.5721.00
112_S116_A1.5711.00
11_L23_L1.5711.00
9_V30_Y1.5501.00
197_S252_D1.5431.00
72_L111_A1.5401.00
231_L235_K1.5381.00
22_I70_V1.5021.00
56_E95_T1.4941.00
22_I202_A1.4801.00
86_L155_A1.4791.00
28_D210_S1.4641.00
18_V179_L1.4611.00
143_P154_A1.4551.00
58_A61_E1.4421.00
234_A238_L1.4381.00
25_G202_A1.4331.00
107_R172_A1.4261.00
56_E60_R1.4131.00
207_R211_A1.4011.00
38_E48_F1.3981.00
69_I100_A1.3791.00
67_G106_D1.3761.00
60_R103_A1.3651.00
79_E82_W1.3631.00
244_D252_D1.3481.00
14_A23_L1.3371.00
8_P67_G1.3281.00
23_L34_L1.3051.00
83_E87_R1.2991.00
176_I201_C1.2921.00
196_L201_C1.2851.00
158_T161_R1.2821.00
110_F156_G1.2801.00
111_A176_I1.2781.00
64_S103_A1.2741.00
164_H171_F1.2721.00
177_G229_Y1.2611.00
139_G233_R1.2541.00
34_L46_H1.2491.00
24_G183_H1.2471.00
53_I92_G1.2411.00
89_N152_S1.2301.00
149_Y153_K1.2131.00
70_V205_I1.2101.00
100_A108_V1.2071.00
30_Y210_S1.2021.00
110_F160_G1.1991.00
9_V68_A1.1931.00
248_E252_D1.1891.00
197_S249_W1.1881.00
110_F173_A1.1871.00
97_L163_Y1.1831.00
25_G199_R1.1811.00
151_V155_A1.1791.00
10_L35_F1.1761.00
15_S36_D1.1651.00
71_H93_T1.1641.00
248_E251_G1.1491.00
63_A66_V1.1491.00
97_L108_V1.1381.00
218_V221_I1.1261.00
98_D101_L1.1201.00
75_D88_N1.1191.00
231_L242_P1.1171.00
161_R173_A1.1131.00
233_R237_A1.1001.00
24_G27_G1.0961.00
96_V108_V1.0811.00
59_V99_A1.0761.00
107_R212_D1.0691.00
21_A199_R1.0671.00
109_V174_V1.0661.00
63_A99_A1.0641.00
137_L141_E1.0551.00
53_I73_A1.0541.00
198_P202_A1.0511.00
159_L162_Y1.0441.00
90_I155_A1.0341.00
26_I206_D1.0341.00
21_A198_P1.0321.00
95_T98_D1.0311.00
99_A102_A1.0261.00
179_L201_C1.0221.00
60_R64_S1.0201.00
91_D95_T1.0171.00
174_V205_I1.0091.00
108_V160_G1.0091.00
72_L205_I1.0081.00
100_A105_V1.0061.00
99_A103_A0.9991.00
162_Y166_E0.9961.00
101_L169_L0.9951.00
9_V26_I0.9931.00
42_D46_H0.9851.00
157_E175_R0.9841.00
35_F58_A0.9831.00
35_F62_A0.9811.00
68_A107_R0.9781.00
86_L91_D0.9751.00
98_D102_A0.9741.00
63_A69_I0.9731.00
172_A208_C0.9701.00
97_L160_G0.9671.00
192_Q226_R0.9661.00
161_R171_F0.9641.00
215_Y218_V0.9561.00
61_E64_S0.9501.00
8_P30_Y0.9481.00
88_N92_G0.9391.00
8_P66_V0.9331.00
197_S244_D0.9321.00
207_R210_S0.9231.00
244_D248_E0.9211.00
12_T96_V0.9211.00
86_L90_I0.9201.00
93_T160_G0.9121.00
20_Q183_H0.9121.00
161_R165_D0.9111.00
199_R244_D0.9101.00
17_R198_P0.8971.00
218_V222_S0.8891.00
114_N177_G0.8771.00
23_L32_W0.8741.00
9_V70_V0.8741.00
38_E50_V0.8731.00
69_I96_V0.8731.00
54_T88_N0.8691.00
63_A103_A0.8681.00
39_P50_V0.8631.00
56_E102_A0.8561.00
35_F59_V0.8541.00
21_A24_G0.8521.00
37_R52_D0.8491.00
75_D85_V0.8471.00
58_A62_A0.8461.00
204_L234_A0.8441.00
36_D48_F0.8411.00
172_A212_D0.8411.00
57_T61_E0.8411.00
138_D230_S0.8391.00
49_V62_A0.8391.00
57_T60_R0.8341.00
197_S200_D0.8301.00
203_H206_D0.8291.00
203_H244_D0.8291.00
122_T141_E0.8281.00
21_A25_G0.8271.00
112_S157_E0.8251.00
122_T138_D0.8241.00
155_A158_T0.8151.00
232_A235_K0.8131.00
75_D84_S0.8111.00
85_V152_S0.8031.00
216_E219_Y0.8011.00
247_A251_G0.7891.00
22_I26_I0.7851.00
217_V220_G0.7841.00
33_R65_D0.7841.00
218_V223_D0.7801.00
12_T73_A0.7781.00
106_D170_T0.7741.00
158_T162_Y0.7731.00
84_S87_R0.7701.00
95_T99_A0.7701.00
244_D249_W0.7681.00
163_Y167_H0.7621.00
151_V158_T0.7571.00
123_D136_R0.7451.00
204_L240_Y0.7441.00
98_D163_Y0.7361.00
233_R236_D0.7341.00
140_T233_R0.7321.00
116_A157_E0.7291.00
116_A143_P0.7271.00
115_H150_G0.7271.00
204_L220_G0.7261.00
179_L196_L0.7241.00
71_H96_V0.7221.00
176_I179_L0.7151.00
218_V237_A0.7101.00
9_V209_L0.7101.00
202_A206_D0.7081.00
63_A100_A0.7071.00
180_T197_S0.7051.00
219_Y223_D0.7031.00
17_R181_A0.7011.00
93_T97_L0.7011.00
82_W151_V0.6981.00
21_A202_A0.6911.00
215_Y219_Y0.6901.00
86_L152_S0.6891.00
221_I224_N0.6871.00
151_V162_Y0.6871.00
101_L168_G0.6831.00
219_Y222_S0.6791.00
97_L159_L0.6751.00
41_T44_P0.6731.00
155_A159_L0.6731.00
43_D46_H0.6731.00
101_L163_Y0.6721.00
121_E141_E0.6711.00
218_V224_N0.6711.00
22_I205_I0.6701.00
114_N229_Y0.6681.00
56_E99_A0.6681.00
235_K242_P0.6671.00
182_G252_D0.6661.00
84_S88_N0.6651.00
59_V95_T0.6651.00
92_G95_T0.6631.00
59_V63_A0.6571.00
30_Y67_G0.6541.00
10_L63_A0.6481.00
219_Y225_D0.6471.00
15_S38_E0.6461.00
148_L151_V0.6461.00
69_I108_V0.6451.00
203_H240_Y0.6421.00
26_I209_L0.6411.00
182_G197_S0.6401.00
208_C238_L0.6381.00
55_D59_V0.6361.00
156_G160_G0.6351.00
68_A106_D0.6341.00
36_D40_P0.6331.00
143_P158_T0.6321.00
219_Y224_N0.6291.00
147_N150_G0.6291.00
200_D203_H0.6291.00
42_D45_D0.6281.00
207_R238_L0.6271.00
170_T213_Y0.6271.00
136_R139_G0.6251.00
79_E148_L0.6231.00
216_E220_G0.6231.00
109_V209_L0.6211.00
34_L48_F0.6191.00
222_S225_D0.6151.00
20_Q24_G0.6111.00
174_V204_L0.6111.00
31_T45_D0.6101.00
162_Y165_D0.6071.00
160_G173_A0.6051.00
18_V201_C0.6051.00
208_C234_A0.6041.00
21_A183_H0.6031.00
116_A175_R0.6011.00
8_P65_D0.6001.00
177_G194_M0.5971.00
207_R240_Y0.5931.00
178_N193_A0.5891.00
207_R239_G0.5891.00
41_T46_H0.5841.00
234_A242_P0.5811.00
123_D226_R0.5761.00
10_L51_A0.5761.00
145_P150_G0.5751.00
109_V205_I0.5741.00
86_L151_V0.5731.00
234_A237_A0.5731.00
145_P154_A0.5701.00
200_D243_R0.5681.00
161_R164_H0.5641.00
11_L26_I0.5591.00
30_Y68_A0.5571.00
10_L62_A0.5561.00
220_G224_N0.5561.00
52_D55_D0.5551.00
21_A182_G0.5491.00
243_R248_E0.5481.00
164_H169_L0.5461.00
119_H146_G0.5451.00
217_V222_S0.5441.00
139_G234_A0.5391.00
28_D203_H0.5371.00
184_P187_D0.5361.00
163_Y169_L0.5361.00
10_L69_I0.5351.00
216_E233_R0.5331.00
72_L176_I0.5291.00
139_G142_R0.5291.00
17_R21_A0.5291.00
82_W148_L0.5281.00
192_Q228_Y0.5281.00
29_D32_W0.5281.00
37_R40_P0.5251.00
178_N195_W0.5251.00
75_D89_N0.5231.00
211_A214_D0.5221.00
51_A62_A0.5201.00
182_G199_R0.5191.00
220_G223_D0.5131.00
217_V223_D0.5131.00
216_E222_S0.5131.00
113_S116_A0.5121.00
71_H108_V0.5111.00
164_H170_T0.5111.00
36_D39_P0.5091.00
68_A109_V0.5091.00
152_S156_G0.5071.00
231_L240_Y0.5061.00
170_T212_D0.5051.00
22_I206_D0.5021.00
24_G199_R0.5011.00
170_T214_D0.5011.00
26_I30_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9498 100 0.248 Contact Map
3rufA 2 0.9498 100 0.25 Contact Map
3wmwA 2 0.8224 100 0.253 Contact Map
1rkxA 3 0.9575 100 0.254 Contact Map
2pk3A 2 0.9305 100 0.258 Contact Map
4wkgA 5 0.9382 100 0.258 Contact Map
3slgA 4 0.9305 100 0.261 Contact Map
1gy8A 2 0.9498 100 0.263 Contact Map
1oc2A 2 0.9846 100 0.264 Contact Map
1z45A 2 0.9498 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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