GREMLIN Database
HTPX - Protease HtpX homolog
UniProt: Q9HSQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (252)
Sequences: 4766 (3382)
Seq/√Len: 213.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_E288_R4.4121.00
75_S124_D4.3291.00
132_S203_D4.1541.00
122_E220_K3.9351.00
91_N112_R3.9301.00
63_E74_E3.6631.00
121_E210_T3.3811.00
128_A204_A3.1361.00
68_R120_H3.0731.00
205_R287_L2.8701.00
110_V127_L2.8161.00
198_Y282_K2.7751.00
202_A206_R2.4481.00
215_A284_I2.2961.00
72_R124_D2.2601.00
204_A208_I2.2531.00
58_A88_K2.2311.00
70_H84_K2.1731.00
62_D65_E2.1231.00
80_M207_A2.1101.00
121_E213_P2.0721.00
222_S281_E2.0201.00
219_E284_I1.9861.00
35_V39_V1.9861.00
282_K285_Q1.9671.00
208_I213_P1.9601.00
59_E91_N1.9561.00
119_E220_K1.9391.00
138_D199_V1.9341.00
122_E216_R1.9151.00
222_S280_T1.8741.00
39_V43_V1.8741.00
74_E78_R1.8401.00
73_V87_L1.8261.00
74_E84_K1.8241.00
119_E216_R1.7951.00
117_I224_G1.7861.00
12_Y16_I1.7861.00
210_T213_P1.7571.00
157_Q160_V1.7191.00
279_P282_K1.6791.00
7_I12_Y1.6781.00
60_D86_T1.6351.00
50_W54_R1.6221.00
114_L123_L1.6201.00
16_I20_W1.6091.00
98_F109_V1.5671.00
159_I162_F1.5511.00
72_R120_H1.5201.00
33_A154_I1.5111.00
67_P70_H1.4521.00
186_T190_L1.4351.00
138_D196_R1.4271.00
212_E288_R1.4251.00
165_D170_D1.4251.00
20_W24_G1.4211.00
60_D88_K1.4131.00
71_R75_S1.3981.00
118_L221_I1.3941.00
71_R74_E1.3941.00
68_R71_R1.3801.00
76_L131_L1.3621.00
137_R140_V1.3541.00
112_R116_D1.3451.00
272_K282_K1.3441.00
125_G214_L1.3351.00
20_W23_F1.3331.00
99_A108_V1.3091.00
41_V44_Q1.2981.00
106_G134_I1.2891.00
16_I23_F1.2721.00
70_H74_E1.2671.00
133_H197_E1.2611.00
161_L164_G1.2601.00
156_A159_I1.2591.00
158_Y162_F1.2581.00
76_L207_A1.2541.00
8_L20_W1.2201.00
142_M196_R1.2071.00
88_K107_T1.2051.00
195_Y199_V1.2021.00
130_E197_E1.1871.00
47_V51_M1.1781.00
66_F89_V1.1781.00
136_N203_D1.1711.00
124_D210_T1.1651.00
129_H197_E1.1621.00
285_Q288_R1.1561.00
9_F13_S1.1561.00
174_A178_G1.1441.00
198_Y286_R1.1351.00
17_A20_W1.1321.00
43_V47_V1.1301.00
136_N199_V1.1291.00
115_I123_L1.1291.00
93_G116_D1.1281.00
48_G53_L1.1251.00
157_Q161_L1.1191.00
202_A286_R1.1161.00
12_Y15_A1.1111.00
13_S17_A1.1061.00
282_K286_R1.1061.00
129_H133_H1.1001.00
42_G46_K1.0931.00
11_F15_A1.0791.00
59_E65_E1.0791.00
212_E215_A1.0771.00
8_L12_Y1.0761.00
67_P71_R1.0731.00
110_V114_L1.0671.00
82_I131_L1.0621.00
121_E216_R1.0571.00
38_V147_G1.0441.00
171_F174_A1.0431.00
14_V23_F1.0411.00
8_L16_I1.0371.00
275_S279_P1.0351.00
7_I11_F1.0341.00
196_R199_V1.0221.00
41_V45_Y1.0151.00
126_V217_A1.0151.00
199_V203_D1.0101.00
110_V115_I1.0051.00
215_A288_R1.0041.00
8_L11_F1.0011.00
197_E200_A0.9981.00
155_V159_I0.9971.00
208_I211_G0.9951.00
155_V160_V0.9941.00
158_Y161_L0.9931.00
16_I21_F0.9911.00
190_L276_T0.9581.00
280_T284_I0.9481.00
8_L15_A0.9461.00
102_R105_N0.9451.00
53_L98_F0.9430.99
15_A19_A0.9410.99
199_V202_A0.9410.99
130_E133_H0.9410.99
222_S226_E0.9380.99
12_Y19_A0.9350.99
30_L34_I0.9310.99
17_A21_F0.9260.99
13_S21_F0.9240.99
66_F70_H0.9170.99
278_P283_R0.9130.99
188_F192_I0.9120.99
15_A22_F0.9110.99
213_P216_R0.9080.99
69_I110_V0.9050.99
157_Q162_F0.9020.99
214_L218_L0.9000.99
82_I135_A0.9000.99
141_T199_V0.8980.99
177_V180_L0.8960.99
214_L287_L0.8920.99
125_G213_P0.8910.99
228_A231_Q0.8840.99
221_I225_N0.8720.99
16_I19_A0.8710.99
29_I33_A0.8690.99
34_I38_V0.8660.99
40_L44_Q0.8590.99
141_T196_R0.8570.99
205_R211_G0.8570.99
14_V18_A0.8530.99
64_Q67_P0.8500.99
76_L127_L0.8480.99
63_E71_R0.8450.99
71_R120_H0.8450.99
10_A13_S0.8390.99
161_L165_D0.8390.99
19_A22_F0.8390.99
281_E285_Q0.8390.99
7_I19_A0.8340.99
17_A24_G0.8310.99
19_A23_F0.8300.99
15_A18_A0.8280.99
129_H200_A0.8220.99
31_A35_V0.8210.99
12_Y23_F0.8150.99
9_F12_Y0.8110.98
230_Q233_R0.8090.98
66_F69_I0.8050.98
108_V127_L0.7990.98
95_P224_G0.7980.98
229_A233_R0.7960.98
114_L118_L0.7950.98
216_R220_K0.7910.98
139_V143_Q0.7910.98
19_A24_G0.7860.98
8_L21_F0.7860.98
77_S84_K0.7840.98
219_E222_S0.7840.98
12_Y20_W0.7810.98
75_S79_D0.7770.98
103_K106_G0.7760.98
61_M89_V0.7740.98
56_V90_A0.7720.98
47_V50_W0.7710.98
25_Q28_T0.7710.98
75_S78_R0.7690.98
119_E122_E0.7690.98
9_F20_W0.7660.98
14_V19_A0.7650.98
49_K53_L0.7610.98
69_I87_L0.7560.98
72_R76_L0.7560.98
63_E70_H0.7550.98
37_S41_V0.7540.98
78_R81_G0.7510.97
34_I41_V0.7510.97
9_F19_A0.7500.97
118_L220_K0.7470.97
193_S276_T0.7450.97
100_V139_V0.7430.97
259_A262_I0.7410.97
73_V127_L0.7390.97
197_E277_H0.7380.97
95_P117_I0.7350.97
56_V261_C0.7350.97
155_V158_Y0.7330.97
120_H124_D0.7280.97
7_I15_A0.7270.97
132_S207_A0.7230.97
11_F14_V0.7220.97
18_A23_F0.7210.97
46_K102_R0.7170.97
229_A232_Q0.7150.97
271_Q282_K0.7130.97
142_M193_S0.7130.97
212_E216_R0.7090.96
77_S131_L0.7090.96
260_L263_S0.7080.96
90_A111_S0.7060.96
118_L126_V0.7060.96
65_E70_H0.7050.96
221_I263_S0.7040.96
231_Q234_Q0.7010.96
149_A189_V0.7000.96
72_R75_S0.6970.96
175_I182_Q0.6960.96
79_D209_G0.6930.96
185_V188_F0.6900.96
49_K86_T0.6870.96
7_I10_A0.6810.96
10_A21_F0.6760.95
224_G227_Q0.6690.95
156_A160_V0.6680.95
133_H200_A0.6680.95
177_V181_V0.6660.95
211_G287_L0.6660.95
61_M90_A0.6560.95
171_F175_I0.6560.95
204_A214_L0.6510.94
230_Q234_Q0.6490.94
272_K275_S0.6490.94
211_G214_L0.6450.94
179_N182_Q0.6450.94
214_L217_A0.6430.94
146_Q150_S0.6430.94
135_A206_R0.6410.94
173_L177_V0.6400.94
149_A185_V0.6380.94
89_V115_I0.6380.94
85_P196_R0.6380.94
228_A232_Q0.6290.93
219_E223_Q0.6270.93
15_A24_G0.6270.93
90_A109_V0.6260.93
99_A106_G0.6260.93
277_H283_R0.6230.93
140_V144_L0.6220.93
77_S83_K0.6210.93
77_S81_G0.6190.93
131_L134_I0.6180.93
28_T32_I0.6160.93
7_I18_A0.6160.93
9_F16_I0.6150.92
136_N196_R0.6140.92
18_A22_F0.6140.92
21_F24_G0.6130.92
8_L13_S0.6120.92
187_L274_V0.6120.92
49_K52_A0.6120.92
7_I14_V0.6110.92
33_A36_G0.6060.92
145_G189_V0.6050.92
8_L23_F0.6040.92
73_V80_M0.6040.92
94_V221_I0.6040.92
145_G192_I0.6040.92
8_L19_A0.6040.92
28_T31_A0.5990.91
100_V107_T0.5970.91
96_N129_H0.5940.91
12_Y22_F0.5890.91
80_M131_L0.5890.91
183_F186_T0.5890.91
215_A219_E0.5850.91
191_A194_R0.5820.90
106_G139_V0.5800.90
152_V181_V0.5780.90
135_A203_D0.5780.90
144_L148_I0.5760.90
62_D66_F0.5750.90
182_Q185_V0.5750.90
177_V223_Q0.5740.90
13_S16_I0.5740.90
52_A107_T0.5710.89
92_M112_R0.5700.89
9_F14_V0.5680.89
180_L184_L0.5640.89
108_V131_L0.5630.89
125_G215_A0.5620.89
146_Q152_V0.5600.89
9_F18_A0.5600.89
33_A46_K0.5570.88
92_M95_P0.5570.88
209_G213_P0.5570.88
15_A20_W0.5560.88
10_A14_V0.5560.88
14_V17_A0.5560.88
93_G112_R0.5550.88
72_R127_L0.5540.88
223_Q227_Q0.5540.88
125_G218_L0.5520.88
142_M145_G0.5500.88
52_A56_V0.5490.88
7_I20_W0.5490.88
35_V43_V0.5470.87
53_L107_T0.5460.87
271_Q275_S0.5450.87
178_G182_Q0.5430.87
87_L110_V0.5420.87
191_A195_Y0.5410.87
71_R78_R0.5400.87
8_L24_G0.5390.87
93_G224_G0.5390.87
61_M66_F0.5380.87
14_V22_F0.5380.87
10_A16_I0.5370.86
192_I259_A0.5360.86
110_V134_I0.5360.86
205_R218_L0.5330.86
125_G204_A0.5330.86
86_T107_T0.5330.86
83_K105_N0.5310.86
45_Y48_G0.5300.86
7_I16_I0.5300.86
124_D128_A0.5280.85
69_I115_I0.5270.85
51_M117_I0.5270.85
56_V109_V0.5240.85
133_H277_H0.5230.85
6_T17_A0.5230.85
171_F178_G0.5210.85
142_M146_Q0.5200.85
90_A94_V0.5200.85
76_L124_D0.5190.85
59_E112_R0.5180.84
54_R57_G0.5180.84
118_L123_L0.5160.84
79_D206_R0.5150.84
36_G40_L0.5150.84
33_A37_S0.5150.84
36_G154_I0.5140.84
138_D203_D0.5140.84
18_A21_F0.5120.84
201_D283_R0.5100.83
76_L80_M0.5050.83
6_T16_I0.5050.83
73_V124_D0.5040.83
140_V143_Q0.5040.83
225_N228_A0.5030.83
211_G217_A0.5020.83
73_V110_V0.5010.82
13_S20_W0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.8685 100 0.292 Contact Map
4aw6A 2 0.8685 100 0.299 Contact Map
3c37A 1 0.6436 100 0.488 Contact Map
3cqbA 4 0.3529 99.9 0.635 Contact Map
4qhjA 2 0.3529 97.4 0.866 Contact Map
4jixA 2 0.3737 96.6 0.88 Contact Map
4jiuA 1 0.3529 95.5 0.891 Contact Map
3dteA 2 0.5017 93.6 0.901 Contact Map
1mhsA 2 0.2907 13.1 0.953 Contact Map
2r9rB 3 0.2042 8.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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