GREMLIN Database
Q9HSP9 - Replication A related protein
UniProt: Q9HSP9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 474 (372)
Sequences: 393 (289)
Seq/√Len: 15.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
410_T417_T7.9261.00
411_Q417_T5.1941.00
191_V225_A4.8401.00
255_V259_G4.1001.00
194_F204_V3.8871.00
232_D235_A3.5600.99
301_T309_E3.3900.99
192_R204_V3.3610.99
228_A261_V3.1860.99
345_A348_V3.0750.98
281_L324_I2.9910.98
413_P417_T2.8280.97
326_V345_A2.8270.97
62_E65_E2.7610.96
317_L343_V2.6730.96
244_V253_L2.6400.95
311_Q334_D2.5560.94
348_V360_A2.5530.94
294_R318_Q2.3500.91
292_V342_E2.3240.91
342_E384_D2.3040.90
201_E343_V2.2080.88
293_V418_P2.1900.88
245_R248_E2.1790.88
77_D242_G2.1210.86
407_A411_Q2.1130.86
298_P348_V2.0790.85
218_V259_G2.0350.84
209_V218_V1.9960.83
301_T311_Q1.9800.82
316_R323_D1.9680.82
289_I343_V1.9330.80
320_D400_E1.9030.79
172_L183_G1.8940.79
136_R197_D1.8750.78
285_D358_I1.8710.78
218_V255_V1.8570.78
269_V382_G1.8500.77
277_S320_D1.8360.77
255_V421_F1.8070.76
275_T344_A1.7930.75
231_L261_V1.7870.75
380_A383_S1.7420.73
184_E275_T1.7350.73
186_L266_D1.7240.72
171_D227_T1.7120.72
253_L257_D1.6890.70
410_T413_P1.6700.70
365_Q384_D1.6680.69
135_G192_R1.6540.69
332_K366_A1.6500.69
312_V324_I1.6420.68
217_R416_D1.6320.68
292_V339_P1.6070.67
233_A278_I1.6060.66
435_D438_E1.5990.66
304_R308_S1.5840.65
231_L347_D1.5830.65
289_I360_A1.5790.65
131_L317_L1.5690.65
292_V299_T1.5640.64
193_T206_N1.5440.63
192_R235_A1.5430.63
102_V185_V1.5340.63
378_D382_G1.5310.63
78_V261_V1.5260.62
234_G424_V1.5230.62
192_R255_V1.5030.61
151_V155_A1.4880.60
281_L345_A1.4750.60
195_D264_V1.4750.60
127_P352_D1.4640.59
185_V209_V1.4640.59
237_V240_V1.4560.59
260_A375_T1.4560.59
156_D159_I1.4550.59
176_V264_V1.4410.58
373_D378_D1.4290.57
139_D352_D1.4180.57
115_D118_A1.4170.56
62_E386_P1.4070.56
204_V306_D1.3920.55
371_L385_G1.3800.54
75_V315_V1.3800.54
143_G375_T1.3770.54
193_T201_E1.3770.54
239_I416_D1.3750.54
381_A385_G1.3730.54
85_D414_H1.3660.54
184_E291_G1.3630.53
155_A161_V1.3580.53
351_Q359_E1.3410.52
80_T96_R1.3250.51
220_L368_V1.3230.51
194_F303_D1.3220.51
123_D132_R1.3120.51
192_R403_A1.3070.50
71_K206_N1.3050.50
133_I428_A1.3040.50
315_V337_I1.3040.50
285_D420_E1.3030.50
362_A366_A1.2950.50
314_N325_R1.2900.49
73_T315_V1.2850.49
206_N293_V1.2820.49
82_D133_I1.2780.49
168_D171_D1.2740.48
396_D401_P1.2730.48
80_T308_S1.2730.48
112_S118_A1.2700.48
335_L425_V1.2700.48
153_L157_E1.2570.48
302_F305_D1.2500.47
407_A412_T1.2450.47
112_S116_E1.2440.47
207_L218_V1.2430.47
204_V304_R1.2400.47
169_A215_R1.2320.46
99_N114_W1.2230.46
315_V324_I1.2140.45
269_V307_G1.2120.45
112_S115_D1.2090.45
113_L317_L1.2010.44
110_R256_G1.2000.44
317_L373_D1.1920.44
341_D381_A1.1890.44
241_D264_V1.1880.44
101_T110_R1.1790.43
381_A422_T1.1780.43
152_E159_I1.1720.43
287_A386_P1.1690.43
209_V378_D1.1660.42
312_V327_A1.1610.42
185_V328_L1.1580.42
126_A129_D1.1570.42
81_F131_L1.1540.42
204_V225_A1.1500.42
411_Q415_S1.1500.42
81_F365_Q1.1500.42
279_D404_T1.1470.41
72_V379_A1.1440.41
209_V239_I1.1400.41
170_A336_D1.1220.40
204_V308_S1.1180.40
230_D261_V1.1040.39
96_R112_S1.1030.39
73_T79_R1.1030.39
293_V399_D1.1020.39
349_E397_S1.0990.39
203_R290_A1.0980.39
280_S408_A1.0960.39
244_V278_I1.0950.39
99_N110_R1.0950.39
177_S196_R1.0930.39
242_G253_L1.0930.39
72_V162_Q1.0860.38
293_V341_D1.0860.38
176_V241_D1.0850.38
128_G322_G1.0830.38
248_E253_L1.0810.38
113_L198_D1.0780.38
281_L312_V1.0730.37
310_G341_D1.0720.37
167_Y171_D1.0690.37
67_K239_I1.0680.37
198_D222_D1.0680.37
198_D397_S1.0650.37
170_A262_T1.0640.37
111_V367_S1.0630.37
139_D142_N1.0630.37
265_P425_V1.0620.37
293_V340_G1.0610.37
225_A228_A1.0590.37
291_G326_V1.0560.37
79_R141_Y1.0530.36
188_T237_V1.0530.36
192_R253_L1.0530.36
145_E381_A1.0520.36
237_V353_G1.0470.36
409_D412_T1.0450.36
295_S316_R1.0400.36
143_G278_I1.0350.35
113_L125_L1.0350.35
127_P244_V1.0340.35
326_V367_S1.0340.35
73_T276_T1.0320.35
397_S404_T1.0310.35
85_D132_R1.0280.35
184_E216_V1.0260.35
75_V421_F1.0230.35
286_T328_L1.0230.35
160_D343_V1.0200.35
170_A244_V1.0170.35
114_W384_D1.0130.34
285_D404_T1.0100.34
408_A433_I1.0070.34
245_R278_I1.0060.34
263_P316_R1.0010.34
191_V292_V0.9970.34
346_L438_E0.9960.34
226_D330_G0.9960.34
225_A261_V0.9950.33
176_V196_R0.9940.33
75_V270_S0.9820.33
314_N361_S0.9790.33
322_G425_V0.9760.33
293_V398_D0.9700.32
410_T415_S0.9690.32
282_E432_L0.9680.32
248_E436_D0.9650.32
113_L336_D0.9640.32
180_T284_D0.9550.31
222_D284_D0.9540.31
76_G429_Q0.9530.31
72_V223_D0.9510.31
213_T325_R0.9500.31
314_N356_D0.9480.31
98_V174_L0.9470.31
102_V131_L0.9400.31
304_R362_A0.9390.31
96_R130_V0.9370.31
215_R347_D0.9340.30
130_V261_V0.9310.30
171_D290_A0.9310.30
213_T347_D0.9280.30
205_S317_L0.9270.30
275_T346_L0.9270.30
352_D358_I0.9260.30
342_E426_V0.9260.30
290_A403_A0.9250.30
398_D401_P0.9240.30
226_D232_D0.9220.30
222_D440_T0.9190.30
333_A360_A0.9190.30
324_I342_E0.9190.30
255_V342_E0.9100.29
192_R314_N0.9060.29
156_D160_D0.9030.29
286_T315_V0.9010.29
255_V362_A0.9010.29
277_S389_G0.8990.29
70_A134_K0.8980.29
193_T298_P0.8920.29
184_E236_V0.8880.28
182_V264_V0.8850.28
397_S439_E0.8840.28
323_D348_V0.8810.28
256_G436_D0.8800.28
77_D204_V0.8790.28
131_L265_P0.8700.28
110_R436_D0.8700.28
174_L346_L0.8700.28
256_G434_L0.8680.27
289_I297_D0.8680.27
217_R293_V0.8670.27
127_P248_E0.8640.27
121_A186_L0.8620.27
172_L321_T0.8590.27
244_V345_A0.8570.27
257_D353_G0.8550.27
139_D312_V0.8500.27
68_F196_R0.8500.27
146_V210_G0.8490.27
110_R146_V0.8480.27
433_I436_D0.8440.26
357_D372_S0.8430.26
314_N318_Q0.8390.26
119_T122_A0.8340.26
332_K362_A0.8340.26
217_R252_E0.8330.26
178_D212_E0.8230.25
326_V420_E0.8150.25
107_D386_P0.8150.25
223_D395_A0.8140.25
334_D422_T0.8130.25
98_V170_A0.8130.25
73_T102_V0.8110.25
301_T391_A0.8100.25
168_D212_E0.8090.25
234_G369_I0.8080.25
231_L281_L0.8070.25
281_L358_I0.8050.25
314_N359_E0.8030.25
264_V341_D0.8030.25
287_A315_V0.8030.25
111_V429_Q0.7980.24
407_A410_T0.7970.24
126_A261_V0.7960.24
321_T404_T0.7950.24
322_G406_D0.7920.24
360_A419_V0.7890.24
362_A434_L0.7880.24
244_V287_A0.7860.24
296_V371_L0.7860.24
101_T128_G0.7860.24
79_R101_T0.7850.24
146_V427_Q0.7830.24
59_I402_A0.7810.24
310_G440_T0.7780.24
208_V397_S0.7760.24
174_L181_L0.7690.23
185_V349_E0.7680.23
397_S427_Q0.7670.23
102_V136_R0.7660.23
167_Y262_T0.7650.23
130_V273_P0.7640.23
106_T285_D0.7630.23
393_F436_D0.7580.23
86_A143_G0.7580.23
110_R244_V0.7560.23
230_D324_I0.7540.23
151_V192_R0.7510.23
133_I207_L0.7510.23
387_D393_F0.7480.22
218_V441_M0.7480.22
395_A411_Q0.7470.22
188_T247_R0.7470.22
86_A402_A0.7460.22
246_E396_D0.7440.22
82_D326_V0.7430.22
222_D283_Q0.7410.22
80_T334_D0.7410.22
59_I427_Q0.7410.22
213_T382_G0.7370.22
209_V380_A0.7360.22
71_K136_R0.7340.22
409_D423_G0.7340.22
172_L197_D0.7320.22
239_I255_V0.7310.22
343_V368_V0.7290.22
284_D423_G0.7270.22
299_T334_D0.7210.21
115_D327_A0.7190.21
205_S229_T0.7180.21
61_S353_G0.7180.21
83_R359_E0.7160.21
120_A278_I0.7140.21
86_A413_P0.7130.21
225_A315_V0.7120.21
203_R222_D0.7100.21
206_N374_S0.7060.21
208_V416_D0.7060.21
101_T309_E0.7060.21
212_E361_S0.7020.21
158_Q161_V0.6990.21
127_P436_D0.6970.20
109_V216_V0.6960.20
69_I196_R0.6950.20
179_V251_L0.6940.20
243_Y256_G0.6930.20
387_D403_A0.6930.20
207_L220_L0.6910.20
232_D271_F0.6900.20
76_G239_I0.6880.20
234_G302_F0.6880.20
152_E156_D0.6850.20
74_R383_S0.6800.20
402_A406_D0.6790.20
257_D349_E0.6790.20
430_D433_I0.6790.20
191_V440_T0.6780.20
190_A296_V0.6780.20
343_V367_S0.6760.20
110_R114_W0.6730.20
208_V245_R0.6720.20
75_V393_F0.6720.20
63_M172_L0.6710.20
154_D157_E0.6710.20
233_A253_L0.6700.20
58_D81_F0.6700.20
113_L349_E0.6680.19
174_L275_T0.6680.19
222_D331_E0.6680.19
365_Q373_D0.6650.19
285_D403_A0.6630.19
123_D375_T0.6630.19
251_L361_S0.6610.19
279_D343_V0.6610.19
224_Q306_D0.6610.19
166_E256_G0.6590.19
201_E234_G0.6590.19
185_V261_V0.6580.19
170_A324_I0.6570.19
343_V405_D0.6570.19
189_E225_A0.6560.19
307_G396_D0.6550.19
253_L369_I0.6550.19
304_R363_G0.6540.19
319_D329_W0.6520.19
276_T360_A0.6520.19
277_S330_G0.6510.19
324_I396_D0.6510.19
259_G393_F0.6490.19
290_A396_D0.6490.19
273_P366_A0.6470.19
71_K327_A0.6470.19
133_I159_I0.6470.19
98_V273_P0.6460.19
414_H417_T0.6460.19
235_A359_E0.6450.19
66_V266_D0.6420.19
321_T326_V0.6400.18
244_V325_R0.6390.18
338_G441_M0.6390.18
212_E271_F0.6380.18
73_T405_D0.6330.18
134_K432_L0.6320.18
241_D341_D0.6290.18
151_V156_D0.6280.18
106_T268_D0.6280.18
402_A405_D0.6260.18
293_V332_K0.6250.18
81_F138_T0.6240.18
157_E160_D0.6240.18
337_I414_H0.6210.18
171_D358_I0.6210.18
234_G373_D0.6190.18
386_P392_A0.6180.18
97_V115_D0.6180.18
239_I428_A0.6180.18
119_T136_R0.6180.18
76_G126_A0.6170.18
184_E376_Q0.6150.18
58_D108_D0.6150.18
288_D313_R0.6130.18
181_L216_V0.6130.18
352_D359_E0.6120.18
131_L323_D0.6120.18
206_N255_V0.6100.17
217_R268_D0.6090.17
252_E361_S0.6090.17
235_A241_D0.6070.17
158_Q292_V0.6070.17
208_V269_V0.6060.17
261_V320_D0.6050.17
128_G299_T0.6040.17
76_G98_V0.6030.17
307_G320_D0.6030.17
154_D159_I0.6010.17
113_L292_V0.6000.17
62_E67_K0.5990.17
120_A418_P0.5980.17
206_N256_G0.5970.17
83_R440_T0.5970.17
241_D276_T0.5960.17
70_A132_R0.5940.17
250_S310_G0.5910.17
346_L372_S0.5900.17
112_S350_I0.5900.17
75_V132_R0.5890.17
184_E342_E0.5890.17
274_D337_I0.5870.17
155_A421_F0.5860.17
221_W429_Q0.5850.17
223_D257_D0.5850.17
297_D316_R0.5840.17
398_D405_D0.5840.17
226_D414_H0.5810.17
83_R413_P0.5800.17
209_V368_V0.5790.17
385_G390_L0.5790.17
292_V346_L0.5780.16
170_A173_S0.5780.16
196_R199_G0.5770.16
242_G362_A0.5750.16
83_R287_A0.5730.16
293_V325_R0.5730.16
361_S365_Q0.5720.16
57_A61_S0.5720.16
240_V342_E0.5700.16
231_L260_A0.5700.16
86_A407_A0.5690.16
199_G291_G0.5680.16
181_L184_E0.5680.16
151_V281_L0.5680.16
77_D142_N0.5670.16
79_R209_V0.5670.16
154_D158_Q0.5660.16
263_P430_D0.5650.16
133_I406_D0.5650.16
106_T289_I0.5630.16
69_I394_G0.5620.16
75_V285_D0.5610.16
199_G307_G0.5600.16
181_L380_A0.5590.16
381_A427_Q0.5580.16
334_D345_A0.5560.16
252_E376_Q0.5550.16
238_E363_G0.5550.16
100_V113_L0.5540.16
108_D228_A0.5540.16
104_D329_W0.5530.16
175_G346_L0.5510.16
170_A269_V0.5500.16
97_V327_A0.5490.16
138_T381_A0.5470.16
190_A286_T0.5450.15
220_L362_A0.5450.15
121_A225_A0.5450.15
234_G273_P0.5450.15
173_S362_A0.5440.15
295_S392_A0.5410.15
64_D68_F0.5410.15
82_D139_D0.5400.15
188_T330_G0.5400.15
137_P147_S0.5400.15
177_S260_A0.5390.15
118_A230_D0.5380.15
297_D415_S0.5350.15
225_A390_L0.5340.15
141_Y428_A0.5340.15
416_D431_P0.5340.15
169_A183_G0.5330.15
102_V164_Q0.5330.15
184_E372_S0.5320.15
135_G197_D0.5320.15
238_E258_T0.5320.15
331_E414_H0.5310.15
396_D406_D0.5300.15
207_L352_D0.5290.15
336_D411_Q0.5290.15
306_D369_I0.5270.15
235_A263_P0.5240.15
174_L251_L0.5230.15
121_A377_D0.5220.15
361_S382_G0.5220.15
188_T305_D0.5220.15
214_G366_A0.5210.15
223_D400_E0.5200.15
126_A191_V0.5190.15
321_T337_I0.5190.15
98_V427_Q0.5180.15
302_F378_D0.5170.15
97_V103_A0.5160.15
413_P418_P0.5150.15
206_N254_H0.5140.15
158_Q162_Q0.5130.15
349_E409_D0.5130.15
171_D345_A0.5130.15
290_A376_Q0.5130.15
244_V256_G0.5110.15
166_E180_T0.5110.15
153_L156_D0.5110.15
280_S392_A0.5100.14
77_D259_G0.5100.14
310_G366_A0.5070.14
245_R434_L0.5060.14
253_L436_D0.5050.14
105_E198_D0.5050.14
398_D425_V0.5040.14
304_R364_W0.5040.14
225_A241_D0.5040.14
273_P406_D0.5040.14
191_V226_D0.5020.14
110_R227_T0.5020.14
155_A159_I0.5010.14
259_G409_D0.5000.14
245_R362_A0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gnxC 1 0.6392 100 0.619 Contact Map
1jmcA 1 0.4684 100 0.663 Contact Map
1ynxA 1 0.2236 100 0.838 Contact Map
1wjjA 1 0.2869 99.9 0.862 Contact Map
3dm3A 4 0.2046 99.8 0.873 Contact Map
2k75A 1 0.2236 99.8 0.874 Contact Map
2kbnA 1 0.23 99.8 0.879 Contact Map
1o7iA 1 0.2426 99.8 0.884 Contact Map
2k50A 1 0.23 99.6 0.896 Contact Map
3e0eA 1 0.192 99.6 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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