Q9HSP7 - HALSA - GREMLIN Contacts

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Q9HSP7 - Acetoin utilization protein

UniProt:	Q9HSP7	Sequences: MRFGFSEACLEHDPGVRHPESPDRLRAIKRGLQKRHGVTYEDAPDADLSDITAVHDPDYATEVRSFCERGGGSWDPDTAATESTWPAIRASAGLAMDAIDAALDGADGRDTPFSLGRPPGHHAITDDAMGFCFVNNAAVAAQHALDAHGLDRVAIFDWDVHHGNGTQDIFYDRGDVFYTSIHEDGLYPGTGSVAQTGDCDGAGTTLNLPFPTGAGDADYAAAVDDFIAPAIRAFDPDLFVVSAGFDAHHHDPISRLHLSTEGYAMLTDRVRRISARTDAPLAFVLEGGYSLDTLADGVSTVHETFDGRDPTEPEDDVSDSVRDLFERVRDTHQAFGST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	338 (294)
Sequences:	5252 (3451)
Seq/√Len:	201.3

BACSU - ACUC
HALSA - Q9HSP7
SULSO - Q981B8 Q981D8 Q97Z24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
145_L	175_D	3.775	1.00
102_A	282_A	3.175	1.00
48_L	64_R	3.106	1.00
170_F	176_V	2.997	1.00
47_D	50_D	2.816	1.00
224_D	269_R	2.801	1.00
151_D	237_D	2.790	1.00
95_A	284_V	2.709	1.00
144_A	238_L	2.595	1.00
142_Q	145_L	2.558	1.00
154_A	231_I	2.514	1.00
167_Q	195_Q	2.502	1.00
142_Q	173_R	2.441	1.00
97_D	101_A	2.351	1.00
95_A	140_A	2.330	1.00
215_G	218_D	2.326	1.00
54_V	169_I	2.294	1.00
99_I	144_A	2.281	1.00
53_A	146_D	2.259	1.00
216_D	262_G	2.258	1.00
44_P	50_D	2.244	1.00
265_M	268_D	2.217	1.00
137_A	240_V	2.202	1.00
98_A	282_A	2.151	1.00
98_A	112_P	2.092	1.00
125_T	168_D	2.072	1.00
60_A	134_V	2.056	1.00
129_M	164_N	2.046	1.00
52_T	60_A	2.031	1.00
100_D	143_H	2.014	1.00
84_T	133_F	1.992	1.00
179_T	227_I	1.939	1.00
63_V	134_V	1.930	1.00
156_F	270_V	1.860	1.00
150_L	237_D	1.856	1.00
48_L	52_T	1.854	1.00
177_F	206_L	1.853	1.00
160_V	254_S	1.845	1.00
57_P	61_T	1.812	1.00
206_L	230_A	1.790	1.00
124_I	168_D	1.781	1.00
56_D	125_T	1.780	1.00
247_A	258_L	1.766	1.00
99_I	140_A	1.749	1.00
101_A	106_A	1.735	1.00
52_T	57_P	1.715	1.00
283_F	301_V	1.707	1.00
48_L	61_T	1.695	1.00
54_V	142_Q	1.679	1.00
8_A	90_A	1.669	1.00
258_L	262_G	1.659	1.00
63_V	133_F	1.658	1.00
201_G	204_T	1.645	1.00
174_G	200_D	1.632	1.00
44_P	97_D	1.608	1.00
138_A	169_I	1.606	1.00
216_D	259_S	1.577	1.00
46_A	93_G	1.560	1.00
29_K	33_Q	1.539	1.00
141_A	240_V	1.535	1.00
92_A	139_V	1.525	1.00
162_H	167_Q	1.508	1.00
137_A	284_V	1.484	1.00
239_F	274_S	1.481	1.00
88_I	134_V	1.467	1.00
245_F	301_V	1.462	1.00
220_A	265_M	1.462	1.00
142_Q	146_D	1.453	1.00
125_T	169_I	1.445	1.00
64_R	85_W	1.438	1.00
100_D	147_A	1.427	1.00
45_D	90_A	1.420	1.00
129_M	187_Y	1.409	1.00
56_D	126_D	1.388	1.00
214_A	218_D	1.386	1.00
196_T	202_A	1.385	1.00
178_Y	242_S	1.385	1.00
48_L	89_R	1.384	1.00
28_I	298_V	1.382	1.00
23_D	26_R	1.382	1.00
155_I	166_T	1.349	1.00
100_D	148_H	1.343	1.00
249_H	257_H	1.343	1.00
241_V	270_V	1.338	1.00
124_I	127_D	1.337	1.00
210_F	222_A	1.336	1.00
134_V	139_V	1.325	1.00
181_I	223_V	1.318	1.00
41_E	101_A	1.317	1.00
264_A	304_T	1.315	1.00
113_F	285_L	1.315	1.00
137_A	242_S	1.309	1.00
51_I	139_V	1.295	1.00
249_H	259_S	1.291	1.00
59_Y	128_A	1.290	1.00
268_D	304_T	1.287	1.00
51_I	89_R	1.277	1.00
145_L	173_R	1.269	1.00
138_A	170_F	1.268	1.00
231_I	239_F	1.268	1.00
248_H	260_T	1.263	1.00
231_I	273_I	1.259	1.00
143_H	147_A	1.250	1.00
124_I	164_N	1.249	1.00
219_Y	266_L	1.232	1.00
154_A	177_F	1.221	1.00
247_A	263_Y	1.216	1.00
103_L	150_L	1.211	1.00
193_V	209_P	1.204	1.00
160_V	256_L	1.204	1.00
50_D	143_H	1.195	1.00
269_R	272_R	1.194	1.00
61_T	65_S	1.192	1.00
141_A	155_I	1.188	1.00
85_W	134_V	1.182	1.00
271_R	281_L	1.179	1.00
8_A	11_E	1.172	1.00
103_L	148_H	1.172	1.00
267_T	301_V	1.169	1.00
224_D	265_M	1.167	1.00
210_F	256_L	1.165	1.00
283_F	305_F	1.165	1.00
221_A	225_D	1.160	1.00
95_A	116_G	1.157	1.00
51_I	60_A	1.154	1.00
158_W	266_L	1.152	1.00
142_Q	175_D	1.142	1.00
166_T	242_S	1.136	1.00
30_R	33_Q	1.129	1.00
44_P	90_A	1.127	1.00
183_E	255_R	1.126	1.00
260_T	296_D	1.122	1.00
259_S	262_G	1.122	1.00
50_D	53_A	1.116	1.00
8_A	86_P	1.089	1.00
141_A	153_V	1.088	1.00
6_S	42_D	1.080	1.00
48_L	57_P	1.058	1.00
177_F	234_F	1.054	1.00
96_M	143_H	1.044	1.00
179_T	208_L	1.036	1.00
10_L	26_R	1.030	1.00
61_T	64_R	1.026	1.00
92_A	136_N	1.017	1.00
158_W	243_A	1.015	1.00
46_A	96_M	1.013	1.00
31_G	299_S	1.011	1.00
155_I	176_V	1.005	1.00
171_Y	205_T	1.001	1.00
11_E	83_S	1.000	1.00
124_I	129_M	1.000	1.00
20_E	119_P	0.999	1.00
53_A	143_H	0.996	1.00
274_S	279_A	0.987	1.00
154_A	239_F	0.987	1.00
241_V	283_F	0.986	1.00
268_D	272_R	0.986	1.00
70_G	74_W	0.981	1.00
212_T	255_R	0.975	1.00
89_R	93_G	0.973	1.00
45_D	89_R	0.967	0.99
228_A	269_R	0.967	0.99
97_D	100_D	0.964	0.99
152_R	234_F	0.964	0.99
156_F	179_T	0.957	0.99
50_D	96_M	0.952	0.99
49_S	52_T	0.951	0.99
183_E	212_T	0.948	0.99
66_F	80_A	0.941	0.99
219_Y	258_L	0.939	0.99
9_C	94_L	0.933	0.99
150_L	153_V	0.931	0.99
248_H	297_G	0.930	0.99
178_Y	205_T	0.923	0.99
240_V	282_A	0.922	0.99
154_A	179_T	0.917	0.99
48_L	60_A	0.915	0.99
271_R	304_T	0.913	0.99
45_D	86_P	0.913	0.99
174_G	204_T	0.911	0.99
229_P	233_A	0.903	0.99
228_A	232_R	0.898	0.99
75_D	78_T	0.895	0.99
184_D	209_P	0.894	0.99
242_S	286_E	0.894	0.99
191_G	207_N	0.892	0.99
99_I	240_V	0.884	0.99
64_R	89_R	0.879	0.99
239_F	281_L	0.878	0.99
44_P	100_D	0.874	0.99
167_Q	207_N	0.871	0.99
100_D	104_D	0.870	0.99
98_A	114_S	0.869	0.99
54_V	139_V	0.864	0.99
223_V	227_I	0.862	0.99
156_F	223_V	0.857	0.99
53_A	142_Q	0.856	0.99
260_T	297_G	0.848	0.99
163_G	178_Y	0.846	0.99
274_S	280_P	0.841	0.99
63_V	85_W	0.841	0.99
158_W	270_V	0.840	0.99
140_A	240_V	0.840	0.99
113_F	271_R	0.839	0.99
138_A	166_T	0.832	0.98
158_W	267_T	0.831	0.98
172_D	200_D	0.828	0.98
99_I	282_A	0.825	0.98
31_G	35_R	0.824	0.98
154_A	230_A	0.823	0.98
231_I	279_A	0.821	0.98
46_A	51_I	0.820	0.98
228_A	273_I	0.818	0.98
264_A	300_T	0.817	0.98
230_A	233_A	0.814	0.98
171_Y	197_G	0.813	0.98
31_G	34_K	0.807	0.98
171_Y	195_Q	0.806	0.98
299_S	303_E	0.805	0.98
31_G	296_D	0.805	0.98
46_A	50_D	0.803	0.98
56_D	59_Y	0.802	0.98
218_D	221_A	0.802	0.98
181_I	210_F	0.801	0.98
51_I	134_V	0.800	0.98
167_Q	171_Y	0.799	0.98
267_T	304_T	0.798	0.98
240_V	284_V	0.797	0.98
206_L	226_F	0.796	0.98
214_A	219_Y	0.796	0.98
119_P	136_N	0.796	0.98
264_A	268_D	0.790	0.98
248_H	293_T	0.786	0.98
247_A	256_L	0.783	0.98
95_A	282_A	0.781	0.98
99_I	143_H	0.781	0.98
91_S	118_P	0.778	0.98
171_Y	201_G	0.775	0.98
239_F	270_V	0.775	0.98
227_I	270_V	0.772	0.97
52_T	61_T	0.772	0.97
54_V	138_A	0.770	0.97
181_I	219_Y	0.770	0.97
155_I	170_F	0.770	0.97
29_K	40_Y	0.769	0.97
28_I	32_L	0.769	0.97
142_Q	170_F	0.767	0.97
94_L	116_G	0.766	0.97
265_M	269_R	0.764	0.97
245_F	286_E	0.760	0.97
274_S	281_L	0.758	0.97
128_A	133_F	0.757	0.97
54_V	125_T	0.757	0.97
26_R	30_R	0.755	0.97
250_H	290_S	0.752	0.97
177_F	230_A	0.752	0.97
220_A	224_D	0.752	0.97
101_A	107_D	0.750	0.97
239_F	279_A	0.747	0.97
30_R	34_K	0.745	0.97
102_A	112_P	0.745	0.97
51_I	92_A	0.744	0.97
168_D	171_Y	0.743	0.97
33_Q	40_Y	0.740	0.97
293_T	297_G	0.739	0.97
197_G	200_D	0.737	0.97
211_P	214_A	0.736	0.97
35_R	299_S	0.735	0.97
48_L	85_W	0.735	0.97
213_G	257_H	0.728	0.96
93_G	97_D	0.725	0.96
47_D	93_G	0.722	0.96
173_R	234_F	0.721	0.96
181_I	226_F	0.716	0.96
186_L	255_R	0.716	0.96
141_A	176_V	0.713	0.96
146_D	175_D	0.713	0.96
94_L	114_S	0.709	0.96
14_P	81_T	0.708	0.96
84_T	88_I	0.708	0.96
32_L	302_H	0.705	0.96
85_W	89_R	0.703	0.96
264_A	303_E	0.703	0.96
6_S	9_C	0.702	0.96
135_N	169_I	0.702	0.96
20_E	117_R	0.701	0.96
9_C	25_L	0.701	0.96
230_A	234_F	0.698	0.95
43_A	94_L	0.688	0.95
290_S	293_T	0.686	0.95
83_S	87_A	0.685	0.95
181_I	222_A	0.685	0.95
241_V	281_L	0.683	0.95
143_H	146_D	0.681	0.95
208_L	222_A	0.680	0.95
243_A	301_V	0.677	0.95
183_E	254_S	0.676	0.95
68_E	71_G	0.675	0.95
152_R	237_D	0.670	0.94
126_D	168_D	0.670	0.94
162_H	190_T	0.668	0.94
62_E	66_F	0.667	0.94
136_N	286_E	0.665	0.94
183_E	186_L	0.665	0.94
178_Y	182_H	0.664	0.94
181_I	227_I	0.660	0.94
186_L	212_T	0.660	0.94
269_R	273_I	0.656	0.94
88_I	91_S	0.655	0.94
155_I	242_S	0.655	0.94
141_A	166_T	0.654	0.94
191_G	195_Q	0.652	0.93
53_A	92_A	0.652	0.93
50_D	93_G	0.651	0.93
298_V	301_V	0.649	0.93
197_G	204_T	0.647	0.93
156_F	227_I	0.646	0.93
158_W	181_I	0.645	0.93
83_S	86_P	0.644	0.93
208_L	226_F	0.641	0.93
267_T	283_F	0.640	0.93
160_V	247_A	0.635	0.93
184_D	211_P	0.635	0.93
54_V	170_F	0.633	0.92
250_H	293_T	0.633	0.92
156_F	231_I	0.632	0.92
104_D	148_H	0.630	0.92
148_H	237_D	0.623	0.92
166_T	178_Y	0.622	0.92
94_L	118_P	0.621	0.92
117_R	286_E	0.619	0.92
13_D	22_P	0.619	0.92
91_S	116_G	0.619	0.92
58_D	61_T	0.619	0.92
53_A	139_V	0.617	0.91
19_P	131_F	0.617	0.91
190_T	195_Q	0.617	0.91
167_Q	191_G	0.615	0.91
177_F	204_T	0.611	0.91
32_L	35_R	0.611	0.91
162_H	191_G	0.610	0.91
48_L	51_I	0.609	0.91
197_G	202_A	0.608	0.91
245_F	294_L	0.606	0.91
88_I	136_N	0.605	0.91
10_L	25_L	0.604	0.91
39_T	107_D	0.603	0.91
7_E	10_L	0.602	0.90
215_G	257_H	0.601	0.90
293_T	296_D	0.601	0.90
94_L	97_D	0.599	0.90
14_P	79_A	0.599	0.90
20_E	118_P	0.596	0.90
101_A	105_G	0.595	0.90
44_P	47_D	0.591	0.90
62_E	72_G	0.587	0.89
241_V	267_T	0.587	0.89
153_V	238_L	0.587	0.89
261_E	264_A	0.582	0.89
70_G	73_S	0.580	0.89
27_A	30_R	0.579	0.89
214_A	222_A	0.579	0.89
225_D	229_P	0.578	0.89
169_I	176_V	0.578	0.89
118_P	286_E	0.578	0.89
41_E	97_D	0.576	0.88
86_P	90_A	0.576	0.88
182_H	191_G	0.576	0.88
116_G	136_N	0.576	0.88
158_W	241_V	0.576	0.88
76_P	128_A	0.575	0.88
143_H	148_H	0.574	0.88
158_W	223_V	0.574	0.88
216_D	220_A	0.574	0.88
119_P	286_E	0.572	0.88
113_F	298_V	0.571	0.88
281_L	305_F	0.570	0.88
294_L	297_G	0.567	0.88
223_V	266_L	0.567	0.88
59_Y	63_V	0.567	0.88
45_D	93_G	0.563	0.87
99_I	238_L	0.561	0.87
104_D	272_R	0.559	0.87
144_A	149_G	0.558	0.87
49_S	53_A	0.556	0.87
145_L	151_D	0.556	0.87
124_I	169_I	0.556	0.87
13_D	23_D	0.555	0.87
295_A	298_V	0.555	0.87
5_F	29_K	0.554	0.87
267_T	271_R	0.552	0.86
140_A	282_A	0.552	0.86
201_G	205_T	0.551	0.86
181_I	208_L	0.550	0.86
88_I	133_F	0.550	0.86
116_G	119_P	0.550	0.86
63_V	80_A	0.549	0.86
60_A	85_W	0.548	0.86
211_P	218_D	0.548	0.86
23_D	27_A	0.547	0.86
245_F	285_L	0.546	0.86
285_L	294_L	0.546	0.86
27_A	31_G	0.545	0.86
92_A	134_V	0.545	0.86
238_L	282_A	0.544	0.86
208_L	227_I	0.544	0.86
217_A	265_M	0.542	0.85
95_A	240_V	0.541	0.85
145_L	150_L	0.541	0.85
77_D	131_F	0.539	0.85
220_A	262_G	0.537	0.85
59_Y	124_I	0.536	0.85
162_H	207_N	0.535	0.85
19_P	24_R	0.534	0.84
270_V	281_L	0.532	0.84
148_H	153_V	0.532	0.84
160_V	183_E	0.531	0.84
210_F	215_G	0.530	0.84
58_D	62_E	0.530	0.84
197_G	201_G	0.529	0.84
232_R	235_D	0.529	0.84
20_E	24_R	0.523	0.83
261_E	300_T	0.522	0.83
243_A	283_F	0.522	0.83
157_D	161_H	0.518	0.83
218_D	222_A	0.514	0.82
179_T	226_F	0.512	0.82
262_G	265_M	0.512	0.82
226_F	229_P	0.511	0.82
217_A	221_A	0.510	0.82
96_M	99_I	0.510	0.82
24_R	27_A	0.509	0.82
160_V	186_L	0.508	0.81
77_D	186_L	0.508	0.81
26_R	33_Q	0.508	0.81
90_A	94_L	0.507	0.81
144_A	150_L	0.507	0.81
131_F	253_I	0.507	0.81
185_G	190_T	0.505	0.81
160_V	253_I	0.504	0.81
292_D	296_D	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zz1A	4	0.9911	100	0.125	Contact Map
2vqmA	1	0.9675	100	0.129	Contact Map
4bkxB	1	0.9704	100	0.151	Contact Map
4ly1A	2	0.9704	100	0.155	Contact Map
4a69A	1	0.9704	100	0.158	Contact Map
4zurA	2	0.8817	100	0.158	Contact Map
1c3pA	1	0.9645	100	0.159	Contact Map
3menA	3	0.8846	100	0.163	Contact Map
4qa5A	1	0.9645	100	0.168	Contact Map
4bz7A	3	0.9527	100	0.178	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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