GREMLIN Database
Q9HSP7 - Acetoin utilization protein
UniProt: Q9HSP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (294)
Sequences: 5252 (3451)
Seq/√Len: 201.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_L175_D3.7751.00
102_A282_A3.1751.00
48_L64_R3.1061.00
170_F176_V2.9971.00
47_D50_D2.8161.00
224_D269_R2.8011.00
151_D237_D2.7901.00
95_A284_V2.7091.00
144_A238_L2.5951.00
142_Q145_L2.5581.00
154_A231_I2.5141.00
167_Q195_Q2.5021.00
142_Q173_R2.4411.00
97_D101_A2.3511.00
95_A140_A2.3301.00
215_G218_D2.3261.00
54_V169_I2.2941.00
99_I144_A2.2811.00
53_A146_D2.2591.00
216_D262_G2.2581.00
44_P50_D2.2441.00
265_M268_D2.2171.00
137_A240_V2.2021.00
98_A282_A2.1511.00
98_A112_P2.0921.00
125_T168_D2.0721.00
60_A134_V2.0561.00
129_M164_N2.0461.00
52_T60_A2.0311.00
100_D143_H2.0141.00
84_T133_F1.9921.00
179_T227_I1.9391.00
63_V134_V1.9301.00
156_F270_V1.8601.00
150_L237_D1.8561.00
48_L52_T1.8541.00
177_F206_L1.8531.00
160_V254_S1.8451.00
57_P61_T1.8121.00
206_L230_A1.7901.00
124_I168_D1.7811.00
56_D125_T1.7801.00
247_A258_L1.7661.00
99_I140_A1.7491.00
101_A106_A1.7351.00
52_T57_P1.7151.00
283_F301_V1.7071.00
48_L61_T1.6951.00
54_V142_Q1.6791.00
8_A90_A1.6691.00
258_L262_G1.6591.00
63_V133_F1.6581.00
201_G204_T1.6451.00
174_G200_D1.6321.00
44_P97_D1.6081.00
138_A169_I1.6061.00
216_D259_S1.5771.00
46_A93_G1.5601.00
29_K33_Q1.5391.00
141_A240_V1.5351.00
92_A139_V1.5251.00
162_H167_Q1.5081.00
137_A284_V1.4841.00
239_F274_S1.4811.00
88_I134_V1.4671.00
245_F301_V1.4621.00
220_A265_M1.4621.00
142_Q146_D1.4531.00
125_T169_I1.4451.00
64_R85_W1.4381.00
100_D147_A1.4271.00
45_D90_A1.4201.00
129_M187_Y1.4091.00
56_D126_D1.3881.00
214_A218_D1.3861.00
196_T202_A1.3851.00
178_Y242_S1.3851.00
48_L89_R1.3841.00
28_I298_V1.3821.00
23_D26_R1.3821.00
155_I166_T1.3491.00
100_D148_H1.3431.00
249_H257_H1.3431.00
241_V270_V1.3381.00
124_I127_D1.3371.00
210_F222_A1.3361.00
134_V139_V1.3251.00
181_I223_V1.3181.00
41_E101_A1.3171.00
264_A304_T1.3151.00
113_F285_L1.3151.00
137_A242_S1.3091.00
51_I139_V1.2951.00
249_H259_S1.2911.00
59_Y128_A1.2901.00
268_D304_T1.2871.00
51_I89_R1.2771.00
145_L173_R1.2691.00
138_A170_F1.2681.00
231_I239_F1.2681.00
248_H260_T1.2631.00
231_I273_I1.2591.00
143_H147_A1.2501.00
124_I164_N1.2491.00
219_Y266_L1.2321.00
154_A177_F1.2211.00
247_A263_Y1.2161.00
103_L150_L1.2111.00
193_V209_P1.2041.00
160_V256_L1.2041.00
50_D143_H1.1951.00
269_R272_R1.1941.00
61_T65_S1.1921.00
141_A155_I1.1881.00
85_W134_V1.1821.00
271_R281_L1.1791.00
8_A11_E1.1721.00
103_L148_H1.1721.00
267_T301_V1.1691.00
224_D265_M1.1671.00
210_F256_L1.1651.00
283_F305_F1.1651.00
221_A225_D1.1601.00
95_A116_G1.1571.00
51_I60_A1.1541.00
158_W266_L1.1521.00
142_Q175_D1.1421.00
166_T242_S1.1361.00
30_R33_Q1.1291.00
44_P90_A1.1271.00
183_E255_R1.1261.00
260_T296_D1.1221.00
259_S262_G1.1221.00
50_D53_A1.1161.00
8_A86_P1.0891.00
141_A153_V1.0881.00
6_S42_D1.0801.00
48_L57_P1.0581.00
177_F234_F1.0541.00
96_M143_H1.0441.00
179_T208_L1.0361.00
10_L26_R1.0301.00
61_T64_R1.0261.00
92_A136_N1.0171.00
158_W243_A1.0151.00
46_A96_M1.0131.00
31_G299_S1.0111.00
155_I176_V1.0051.00
171_Y205_T1.0011.00
11_E83_S1.0001.00
124_I129_M1.0001.00
20_E119_P0.9991.00
53_A143_H0.9961.00
274_S279_A0.9871.00
154_A239_F0.9871.00
241_V283_F0.9861.00
268_D272_R0.9861.00
70_G74_W0.9811.00
212_T255_R0.9751.00
89_R93_G0.9731.00
45_D89_R0.9670.99
228_A269_R0.9670.99
97_D100_D0.9640.99
152_R234_F0.9640.99
156_F179_T0.9570.99
50_D96_M0.9520.99
49_S52_T0.9510.99
183_E212_T0.9480.99
66_F80_A0.9410.99
219_Y258_L0.9390.99
9_C94_L0.9330.99
150_L153_V0.9310.99
248_H297_G0.9300.99
178_Y205_T0.9230.99
240_V282_A0.9220.99
154_A179_T0.9170.99
48_L60_A0.9150.99
271_R304_T0.9130.99
45_D86_P0.9130.99
174_G204_T0.9110.99
229_P233_A0.9030.99
228_A232_R0.8980.99
75_D78_T0.8950.99
184_D209_P0.8940.99
242_S286_E0.8940.99
191_G207_N0.8920.99
99_I240_V0.8840.99
64_R89_R0.8790.99
239_F281_L0.8780.99
44_P100_D0.8740.99
167_Q207_N0.8710.99
100_D104_D0.8700.99
98_A114_S0.8690.99
54_V139_V0.8640.99
223_V227_I0.8620.99
156_F223_V0.8570.99
53_A142_Q0.8560.99
260_T297_G0.8480.99
163_G178_Y0.8460.99
274_S280_P0.8410.99
63_V85_W0.8410.99
158_W270_V0.8400.99
140_A240_V0.8400.99
113_F271_R0.8390.99
138_A166_T0.8320.98
158_W267_T0.8310.98
172_D200_D0.8280.98
99_I282_A0.8250.98
31_G35_R0.8240.98
154_A230_A0.8230.98
231_I279_A0.8210.98
46_A51_I0.8200.98
228_A273_I0.8180.98
264_A300_T0.8170.98
230_A233_A0.8140.98
171_Y197_G0.8130.98
31_G34_K0.8070.98
171_Y195_Q0.8060.98
299_S303_E0.8050.98
31_G296_D0.8050.98
46_A50_D0.8030.98
56_D59_Y0.8020.98
218_D221_A0.8020.98
181_I210_F0.8010.98
51_I134_V0.8000.98
167_Q171_Y0.7990.98
267_T304_T0.7980.98
240_V284_V0.7970.98
206_L226_F0.7960.98
214_A219_Y0.7960.98
119_P136_N0.7960.98
264_A268_D0.7900.98
248_H293_T0.7860.98
247_A256_L0.7830.98
95_A282_A0.7810.98
99_I143_H0.7810.98
91_S118_P0.7780.98
171_Y201_G0.7750.98
239_F270_V0.7750.98
227_I270_V0.7720.97
52_T61_T0.7720.97
54_V138_A0.7700.97
181_I219_Y0.7700.97
155_I170_F0.7700.97
29_K40_Y0.7690.97
28_I32_L0.7690.97
142_Q170_F0.7670.97
94_L116_G0.7660.97
265_M269_R0.7640.97
245_F286_E0.7600.97
274_S281_L0.7580.97
128_A133_F0.7570.97
54_V125_T0.7570.97
26_R30_R0.7550.97
250_H290_S0.7520.97
177_F230_A0.7520.97
220_A224_D0.7520.97
101_A107_D0.7500.97
239_F279_A0.7470.97
30_R34_K0.7450.97
102_A112_P0.7450.97
51_I92_A0.7440.97
168_D171_Y0.7430.97
33_Q40_Y0.7400.97
293_T297_G0.7390.97
197_G200_D0.7370.97
211_P214_A0.7360.97
35_R299_S0.7350.97
48_L85_W0.7350.97
213_G257_H0.7280.96
93_G97_D0.7250.96
47_D93_G0.7220.96
173_R234_F0.7210.96
181_I226_F0.7160.96
186_L255_R0.7160.96
141_A176_V0.7130.96
146_D175_D0.7130.96
94_L114_S0.7090.96
14_P81_T0.7080.96
84_T88_I0.7080.96
32_L302_H0.7050.96
85_W89_R0.7030.96
264_A303_E0.7030.96
6_S9_C0.7020.96
135_N169_I0.7020.96
20_E117_R0.7010.96
9_C25_L0.7010.96
230_A234_F0.6980.95
43_A94_L0.6880.95
290_S293_T0.6860.95
83_S87_A0.6850.95
181_I222_A0.6850.95
241_V281_L0.6830.95
143_H146_D0.6810.95
208_L222_A0.6800.95
243_A301_V0.6770.95
183_E254_S0.6760.95
68_E71_G0.6750.95
152_R237_D0.6700.94
126_D168_D0.6700.94
162_H190_T0.6680.94
62_E66_F0.6670.94
136_N286_E0.6650.94
183_E186_L0.6650.94
178_Y182_H0.6640.94
181_I227_I0.6600.94
186_L212_T0.6600.94
269_R273_I0.6560.94
88_I91_S0.6550.94
155_I242_S0.6550.94
141_A166_T0.6540.94
191_G195_Q0.6520.93
53_A92_A0.6520.93
50_D93_G0.6510.93
298_V301_V0.6490.93
197_G204_T0.6470.93
156_F227_I0.6460.93
158_W181_I0.6450.93
83_S86_P0.6440.93
208_L226_F0.6410.93
267_T283_F0.6400.93
160_V247_A0.6350.93
184_D211_P0.6350.93
54_V170_F0.6330.92
250_H293_T0.6330.92
156_F231_I0.6320.92
104_D148_H0.6300.92
148_H237_D0.6230.92
166_T178_Y0.6220.92
94_L118_P0.6210.92
117_R286_E0.6190.92
13_D22_P0.6190.92
91_S116_G0.6190.92
58_D61_T0.6190.92
53_A139_V0.6170.91
19_P131_F0.6170.91
190_T195_Q0.6170.91
167_Q191_G0.6150.91
177_F204_T0.6110.91
32_L35_R0.6110.91
162_H191_G0.6100.91
48_L51_I0.6090.91
197_G202_A0.6080.91
245_F294_L0.6060.91
88_I136_N0.6050.91
10_L25_L0.6040.91
39_T107_D0.6030.91
7_E10_L0.6020.90
215_G257_H0.6010.90
293_T296_D0.6010.90
94_L97_D0.5990.90
14_P79_A0.5990.90
20_E118_P0.5960.90
101_A105_G0.5950.90
44_P47_D0.5910.90
62_E72_G0.5870.89
241_V267_T0.5870.89
153_V238_L0.5870.89
261_E264_A0.5820.89
70_G73_S0.5800.89
27_A30_R0.5790.89
214_A222_A0.5790.89
225_D229_P0.5780.89
169_I176_V0.5780.89
118_P286_E0.5780.89
41_E97_D0.5760.88
86_P90_A0.5760.88
182_H191_G0.5760.88
116_G136_N0.5760.88
158_W241_V0.5760.88
76_P128_A0.5750.88
143_H148_H0.5740.88
158_W223_V0.5740.88
216_D220_A0.5740.88
119_P286_E0.5720.88
113_F298_V0.5710.88
281_L305_F0.5700.88
294_L297_G0.5670.88
223_V266_L0.5670.88
59_Y63_V0.5670.88
45_D93_G0.5630.87
99_I238_L0.5610.87
104_D272_R0.5590.87
144_A149_G0.5580.87
49_S53_A0.5560.87
145_L151_D0.5560.87
124_I169_I0.5560.87
13_D23_D0.5550.87
295_A298_V0.5550.87
5_F29_K0.5540.87
267_T271_R0.5520.86
140_A282_A0.5520.86
201_G205_T0.5510.86
181_I208_L0.5500.86
88_I133_F0.5500.86
116_G119_P0.5500.86
63_V80_A0.5490.86
60_A85_W0.5480.86
211_P218_D0.5480.86
23_D27_A0.5470.86
245_F285_L0.5460.86
285_L294_L0.5460.86
27_A31_G0.5450.86
92_A134_V0.5450.86
238_L282_A0.5440.86
208_L227_I0.5440.86
217_A265_M0.5420.85
95_A240_V0.5410.85
145_L150_L0.5410.85
77_D131_F0.5390.85
220_A262_G0.5370.85
59_Y124_I0.5360.85
162_H207_N0.5350.85
19_P24_R0.5340.84
270_V281_L0.5320.84
148_H153_V0.5320.84
160_V183_E0.5310.84
210_F215_G0.5300.84
58_D62_E0.5300.84
197_G201_G0.5290.84
232_R235_D0.5290.84
20_E24_R0.5230.83
261_E300_T0.5220.83
243_A283_F0.5220.83
157_D161_H0.5180.83
218_D222_A0.5140.82
179_T226_F0.5120.82
262_G265_M0.5120.82
226_F229_P0.5110.82
217_A221_A0.5100.82
96_M99_I0.5100.82
24_R27_A0.5090.82
160_V186_L0.5080.81
77_D186_L0.5080.81
26_R33_Q0.5080.81
90_A94_L0.5070.81
144_A150_L0.5070.81
131_F253_I0.5070.81
185_G190_T0.5050.81
160_V253_I0.5040.81
292_D296_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zz1A 4 0.9911 100 0.125 Contact Map
2vqmA 1 0.9675 100 0.129 Contact Map
4bkxB 1 0.9704 100 0.151 Contact Map
4ly1A 2 0.9704 100 0.155 Contact Map
4a69A 1 0.9704 100 0.158 Contact Map
4zurA 2 0.8817 100 0.158 Contact Map
1c3pA 1 0.9645 100 0.159 Contact Map
3menA 3 0.8846 100 0.163 Contact Map
4qa5A 1 0.9645 100 0.168 Contact Map
4bz7A 3 0.9527 100 0.178 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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