GREMLIN Database
CCA - CCA-adding enzyme
UniProt: Q9HSP6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (410)
Sequences: 235 (188)
Seq/√Len: 9.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_I254_F6.1421.00
16_D154_A5.8991.00
182_L225_V4.4470.99
48_D72_R3.7320.97
144_L188_V3.5130.96
182_L235_V3.4730.96
57_R141_T3.3880.95
176_Q240_S3.3110.95
165_G265_P3.1950.94
162_F193_F3.0190.91
19_P23_R2.9920.91
165_G264_T2.9840.91
341_L398_A2.9720.91
352_H370_Y2.9650.91
379_P389_V2.9190.90
243_N246_T2.7360.87
194_E254_F2.5450.82
143_Y212_A2.5200.82
8_I158_L2.4100.79
90_G107_V2.3780.78
242_A383_D2.3060.75
163_L168_V2.2850.75
397_T400_G2.2470.73
200_I247_V2.2000.72
22_R58_G2.1820.71
187_V196_M2.1760.71
190_Y244_V2.1610.70
21_E86_G2.1490.70
8_I194_E2.1410.69
33_T69_L2.1310.69
57_R144_L2.1190.69
166_I250_H2.1100.68
239_V247_V2.0810.67
197_L251_A2.0650.67
395_V404_T2.0400.66
171_S304_P2.0280.65
52_V304_P1.9880.63
104_H136_R1.9570.62
324_V341_L1.9230.61
60_W205_P1.9010.60
18_T62_A1.8940.60
127_A139_F1.8920.59
52_V303_Y1.8780.59
90_G109_G1.8710.59
239_V244_V1.8550.58
74_P98_H1.8510.58
31_R111_F1.8320.57
64_D164_K1.8050.56
196_M296_D1.8040.56
156_V159_C1.8020.56
79_R103_E1.7920.55
324_V398_A1.7920.55
21_E63_G1.7890.55
101_Y181_Y1.7870.55
298_V305_Q1.7780.54
32_L109_G1.7710.54
12_R16_D1.7600.54
224_V308_R1.7540.53
171_S390_E1.7500.53
74_P302_L1.7470.53
134_V137_T1.7440.53
321_G342_A1.7210.52
90_G121_C1.7160.52
159_C196_M1.7120.52
350_E391_R1.6730.50
176_Q307_Y1.6590.49
182_L295_P1.6590.49
57_R173_L1.6560.49
57_R380_F1.6360.48
105_P136_R1.6330.48
11_V14_R1.6300.48
134_V340_E1.5780.46
32_L229_T1.5690.45
244_V338_F1.5690.45
32_L67_I1.5650.45
174_R185_L1.5510.45
195_A198_A1.5330.44
157_R171_S1.5300.44
172_D192_G1.5130.43
118_L124_V1.5130.43
276_L337_V1.4960.42
205_P358_S1.4880.42
116_V124_V1.4820.42
30_S406_L1.4780.41
152_L192_G1.4380.40
288_L402_A1.4360.40
57_R175_T1.4340.39
94_L109_G1.4310.39
149_D152_L1.4210.39
223_L244_V1.4200.39
124_V139_F1.4080.38
194_E198_A1.3930.38
124_V130_I1.3900.38
313_V402_A1.3860.37
200_I203_W1.3810.37
134_V304_P1.3770.37
137_T203_W1.3720.37
142_T146_E1.3720.37
283_R340_E1.3660.37
259_S381_V1.3640.37
86_G155_D1.3630.37
254_F262_A1.3630.37
352_H389_V1.3600.36
303_Y331_A1.3510.36
207_V244_V1.3500.36
31_R112_E1.3470.36
55_T173_L1.3440.36
141_T380_F1.3350.35
226_V311_D1.3280.35
123_D282_R1.3260.35
182_L236_A1.3240.35
380_F389_V1.3230.35
132_S305_Q1.3190.35
18_T419_V1.3160.35
242_A262_A1.3150.35
299_A303_Y1.3100.34
49_V69_L1.3010.34
109_G303_Y1.2990.34
148_L219_F1.2970.34
91_A107_V1.2870.33
197_L255_R1.2860.33
157_R179_S1.2820.33
317_L398_A1.2760.33
82_L86_G1.2750.33
299_A304_P1.2710.33
110_T142_T1.2690.33
99_E352_H1.2680.33
55_T141_T1.2630.33
192_G196_M1.2620.32
381_V397_T1.2600.32
298_V307_Y1.2540.32
210_D235_V1.2470.32
285_T412_G1.2350.31
127_A219_F1.2200.31
193_F263_F1.2180.31
212_A308_R1.2110.31
203_W393_R1.2080.30
89_V197_L1.1970.30
326_R339_V1.1950.30
175_T402_A1.1900.30
12_R154_A1.1870.30
121_C304_P1.1860.30
290_V324_V1.1830.29
16_D62_A1.1650.29
295_P412_G1.1650.29
90_G305_Q1.1560.29
126_A256_A1.1550.28
356_P389_V1.1510.28
61_V108_T1.1490.28
239_V369_T1.1480.28
84_T88_T1.1410.28
198_A209_I1.1370.28
101_Y134_V1.1340.28
116_V331_A1.1320.28
304_P412_G1.1280.28
20_A80_E1.1270.27
102_A121_C1.1230.27
171_S283_R1.1140.27
57_R130_I1.1140.27
155_D281_D1.1120.27
310_R327_A1.1070.27
142_T334_R1.1040.27
91_A99_E1.1000.27
61_V183_C1.0980.26
69_L187_V1.0960.26
117_D185_L1.0950.26
102_A136_R1.0940.26
239_V308_R1.0940.26
109_G121_C1.0930.26
47_A71_V1.0910.26
75_S139_F1.0840.26
173_L303_Y1.0670.25
88_T187_V1.0660.25
223_L308_R1.0650.25
13_Q257_T1.0560.25
58_G153_A1.0540.25
292_L325_V1.0510.25
285_T340_E1.0410.25
314_V339_V1.0400.25
69_L398_A1.0370.24
11_V62_A1.0300.24
210_D226_V1.0290.24
175_T401_F1.0280.24
172_D238_V1.0280.24
223_L235_V1.0260.24
61_V155_D1.0250.24
87_T305_Q1.0210.24
107_V224_V1.0210.24
156_V369_T1.0200.24
21_E340_E1.0170.24
379_P386_R1.0150.24
48_D123_D1.0140.24
144_L250_H1.0110.24
27_A268_P1.0090.24
201_E363_A1.0060.23
220_D288_L1.0000.23
356_P379_P0.9970.23
103_E165_G0.9970.23
109_G304_P0.9960.23
172_D250_H0.9950.23
27_A290_V0.9940.23
187_V364_E0.9910.23
249_H387_Y0.9890.23
47_A394_D0.9890.23
395_V401_F0.9890.23
173_L304_P0.9880.23
36_A209_I0.9880.23
143_Y311_D0.9880.23
56_A210_D0.9870.23
186_L317_L0.9860.23
102_A105_P0.9840.23
7_V394_D0.9830.23
58_G199_A0.9780.23
171_S243_N0.9710.22
104_H134_V0.9700.22
166_I384_D0.9680.22
254_F318_R0.9680.22
304_P349_V0.9670.22
210_D215_Q0.9650.22
196_M247_V0.9650.22
52_V134_V0.9620.22
61_V157_R0.9610.22
38_A107_V0.9570.22
295_P352_H0.9560.22
8_I62_A0.9530.22
114_Y185_L0.9520.22
56_A121_C0.9480.22
298_V331_A0.9450.22
241_A384_D0.9440.22
136_R230_D0.9410.21
164_K262_A0.9360.21
381_V410_A0.9350.21
148_L156_V0.9290.21
51_Q55_T0.9270.21
159_C164_K0.9270.21
190_Y211_P0.9270.21
40_I44_P0.9260.21
239_V304_P0.9190.21
166_I222_P0.9160.21
67_I94_L0.9150.21
354_G366_F0.9130.21
355_P366_F0.9130.21
187_V361_T0.9100.21
322_F393_R0.9090.20
290_V339_V0.9090.20
229_T262_A0.9060.20
259_S262_A0.9010.20
78_P81_Q0.9000.20
104_H230_D0.8970.20
101_Y213_A0.8960.20
103_E305_Q0.8960.20
57_R138_P0.8930.20
13_Q112_E0.8910.20
87_T99_E0.8900.20
71_V413_A0.8890.20
304_P340_E0.8850.20
196_M255_R0.8840.20
8_I15_V0.8820.20
335_A401_F0.8810.20
13_Q425_D0.8810.20
130_I340_E0.8770.20
378_G386_R0.8760.20
76_D278_S0.8740.20
161_Q264_T0.8720.19
152_L415_I0.8720.19
357_V380_F0.8670.19
393_R398_A0.8660.19
62_A165_G0.8660.19
49_V311_D0.8660.19
76_D217_A0.8660.19
168_V246_T0.8650.19
357_V379_P0.8640.19
67_I109_G0.8600.19
206_P244_V0.8600.19
316_G401_F0.8590.19
114_Y368_E0.8530.19
278_S368_E0.8470.19
66_D135_D0.8450.19
280_I372_D0.8440.19
11_V204_Q0.8440.19
111_F114_Y0.8400.19
63_G237_A0.8390.19
286_T308_R0.8390.19
122_Y337_V0.8340.18
174_R303_Y0.8320.18
57_R370_Y0.8290.18
158_L254_F0.8260.18
30_S315_R0.8250.18
90_G122_Y0.8250.18
86_G113_G0.8240.18
237_A319_E0.8240.18
108_T117_D0.8240.18
219_F224_V0.8230.18
91_A262_A0.8220.18
174_R249_H0.8220.18
19_P198_A0.8200.18
182_L223_L0.8200.18
8_I163_L0.8140.18
38_A168_V0.8130.18
99_E107_V0.8130.18
61_V372_D0.8120.18
82_L117_D0.8120.18
241_A244_V0.8110.18
356_P386_R0.8100.18
62_A324_V0.8100.18
155_D291_V0.8090.18
102_A134_V0.8070.18
351_R382_D0.8070.18
143_Y201_E0.8000.18
147_H168_V0.8000.18
42_E125_A0.8000.18
168_V222_P0.7970.17
219_F305_Q0.7970.17
20_A161_Q0.7970.17
404_T407_G0.7960.17
109_G143_Y0.7950.17
64_D172_D0.7940.17
124_V128_T0.7940.17
122_Y340_E0.7930.17
109_G124_V0.7930.17
90_G148_L0.7920.17
105_P230_D0.7910.17
187_V348_A0.7890.17
52_V57_R0.7880.17
239_V325_V0.7870.17
126_A139_F0.7860.17
23_R146_E0.7850.17
166_I288_L0.7830.17
11_V15_V0.7820.17
311_D315_R0.7810.17
256_A368_E0.7800.17
101_Y104_H0.7780.17
67_I406_L0.7780.17
161_Q255_R0.7780.17
386_R394_D0.7770.17
80_E426_V0.7770.17
57_R172_D0.7760.17
229_T250_H0.7750.17
55_T171_S0.7730.17
60_W252_R0.7730.17
52_V340_E0.7710.17
288_L398_A0.7700.17
148_L181_Y0.7700.17
229_T237_A0.7690.17
146_E415_I0.7670.17
90_G94_L0.7660.17
226_V289_A0.7640.17
62_A123_D0.7630.17
100_E172_D0.7610.17
155_D237_A0.7600.17
105_P134_V0.7580.16
64_D309_S0.7580.16
244_V247_V0.7540.16
254_F276_L0.7540.16
66_D171_S0.7520.16
173_L362_H0.7520.16
252_R388_V0.7470.16
60_W237_A0.7460.16
86_G134_V0.7440.16
62_A365_R0.7430.16
84_T142_T0.7420.16
44_P275_A0.7390.16
160_K169_Y0.7380.16
73_F304_P0.7350.16
99_E137_T0.7350.16
87_T304_P0.7340.16
14_R118_L0.7340.16
124_V173_L0.7310.16
304_P390_E0.7270.16
63_G306_L0.7260.16
6_A364_E0.7220.16
399_G403_R0.7220.16
52_V103_E0.7200.16
81_Q313_V0.7200.16
52_V412_G0.7190.16
54_S68_D0.7190.16
53_G68_D0.7190.16
126_A198_A0.7140.15
207_V311_D0.7130.15
43_L47_A0.7120.15
100_E173_L0.7100.15
105_P141_T0.7100.15
147_H378_G0.7100.15
139_F207_V0.7100.15
29_A33_T0.7080.15
101_Y136_R0.7070.15
78_P229_T0.7060.15
31_R264_T0.7050.15
225_V235_V0.7040.15
171_S303_Y0.7030.15
52_V349_V0.7030.15
94_L384_D0.7010.15
210_D225_V0.7000.15
347_P370_Y0.7000.15
33_T49_V0.6980.15
82_L340_E0.6940.15
98_H172_D0.6920.15
11_V154_A0.6920.15
104_H132_S0.6920.15
87_T117_D0.6920.15
201_E291_V0.6910.15
73_F134_V0.6900.15
296_D325_V0.6890.15
256_A323_D0.6880.15
90_G243_N0.6880.15
209_I406_L0.6880.15
18_T369_T0.6880.15
380_F387_Y0.6860.15
159_C192_G0.6860.15
78_P410_A0.6850.15
90_G303_Y0.6840.15
45_V76_D0.6800.15
370_Y380_F0.6800.15
115_A203_W0.6780.15
117_D130_I0.6760.15
15_V118_L0.6740.15
415_I419_V0.6720.15
144_L357_V0.6710.14
312_G367_Y0.6680.14
280_I306_L0.6680.14
144_L147_H0.6680.14
23_R27_A0.6670.14
58_G61_V0.6650.14
69_L161_Q0.6650.14
260_E315_R0.6630.14
268_P277_R0.6620.14
10_R13_Q0.6620.14
132_S173_L0.6610.14
52_V121_C0.6590.14
96_D139_F0.6590.14
292_L306_L0.6580.14
109_G245_A0.6580.14
200_I251_A0.6580.14
93_V208_V0.6570.14
89_V187_V0.6560.14
99_E389_V0.6550.14
370_Y389_V0.6540.14
198_A313_V0.6540.14
217_A308_R0.6530.14
122_Y163_L0.6530.14
171_S239_V0.6530.14
151_G232_E0.6530.14
51_Q205_P0.6520.14
172_D175_T0.6510.14
137_T325_V0.6510.14
92_A95_P0.6500.14
86_G340_E0.6470.14
242_A299_A0.6460.14
226_V310_R0.6460.14
321_G386_R0.6430.14
30_S85_Y0.6420.14
242_A384_D0.6410.14
100_E380_F0.6400.14
104_H107_V0.6380.14
198_A338_F0.6380.14
326_R337_V0.6370.14
40_I47_A0.6370.14
79_R86_G0.6350.14
257_T403_R0.6330.14
124_V317_L0.6320.14
122_Y229_T0.6320.14
280_I415_I0.6310.14
319_E389_V0.6300.14
223_L312_G0.6300.14
204_Q241_A0.6280.14
198_A297_V0.6270.14
34_E195_A0.6250.14
237_A280_I0.6240.13
29_A139_F0.6230.13
143_Y338_F0.6230.13
22_R311_D0.6210.13
223_L238_V0.6200.13
132_S296_D0.6200.13
223_L247_V0.6180.13
21_E47_A0.6170.13
108_T141_T0.6170.13
225_V311_D0.6160.13
128_T380_F0.6150.13
158_L333_E0.6140.13
147_H188_V0.6140.13
55_T144_L0.6140.13
117_D235_V0.6130.13
302_L305_Q0.6120.13
194_E291_V0.6120.13
299_A305_Q0.6100.13
27_A213_A0.6070.13
14_R260_E0.6040.13
290_V426_V0.6030.13
235_V304_P0.6010.13
118_L123_D0.6010.13
341_L402_A0.6010.13
42_E77_L0.6000.13
300_D326_R0.6000.13
117_D133_A0.5980.13
187_V333_E0.5980.13
55_T94_L0.5960.13
102_A295_P0.5950.13
44_P337_V0.5940.13
175_T185_L0.5930.13
192_G323_D0.5930.13
23_R319_E0.5920.13
294_A335_A0.5920.13
108_T262_A0.5920.13
362_H388_V0.5910.13
78_P100_E0.5900.13
166_I415_I0.5890.13
90_G304_P0.5890.13
232_E384_D0.5890.13
69_L245_A0.5870.13
66_D370_Y0.5860.13
89_V353_V0.5830.13
352_H412_G0.5800.13
212_A307_Y0.5780.13
16_D141_T0.5750.13
237_A294_A0.5720.12
242_A358_S0.5710.12
89_V372_D0.5710.12
80_E256_A0.5700.12
275_A285_T0.5700.12
11_V134_V0.5700.12
125_A255_R0.5670.12
67_I309_S0.5670.12
245_A298_V0.5660.12
14_R264_T0.5660.12
156_V263_F0.5660.12
52_V380_F0.5660.12
42_E237_A0.5660.12
131_K406_L0.5650.12
21_E295_P0.5640.12
208_V394_D0.5640.12
12_R15_V0.5640.12
321_G350_E0.5640.12
8_I204_Q0.5620.12
158_L229_T0.5620.12
252_R318_R0.5610.12
242_A246_T0.5610.12
29_A364_E0.5600.12
39_A411_L0.5600.12
117_D295_P0.5600.12
356_P363_A0.5590.12
18_T256_A0.5590.12
28_A339_V0.5570.12
119_V169_Y0.5560.12
119_V160_K0.5560.12
104_H137_T0.5560.12
57_R174_R0.5560.12
19_P142_T0.5560.12
167_G206_P0.5560.12
56_A235_V0.5530.12
318_R349_V0.5520.12
103_E173_L0.5510.12
21_E102_A0.5510.12
11_V165_G0.5500.12
221_D304_P0.5500.12
90_G132_S0.5500.12
57_R387_Y0.5480.12
29_A329_A0.5480.12
73_F305_Q0.5480.12
83_E132_S0.5480.12
93_V108_T0.5460.12
104_H121_C0.5450.12
250_H338_F0.5420.12
82_L305_Q0.5420.12
75_S138_P0.5400.12
104_H305_Q0.5390.12
115_A159_C0.5390.12
63_G252_R0.5380.12
27_A112_E0.5370.12
80_E308_R0.5370.12
112_E197_L0.5370.12
80_E168_V0.5370.12
84_T89_V0.5350.12
352_H379_P0.5320.12
247_V393_R0.5320.12
202_D290_V0.5320.12
104_H117_D0.5320.12
113_G116_V0.5290.12
24_A213_A0.5290.12
294_A303_Y0.5290.12
147_H337_V0.5280.12
101_Y105_P0.5250.12
386_R389_V0.5250.12
103_E299_A0.5240.12
203_W236_A0.5230.12
84_T195_A0.5230.12
143_Y309_S0.5220.12
134_V235_V0.5220.12
225_V236_A0.5210.11
209_I395_V0.5200.11
28_A55_T0.5200.11
79_R291_V0.5190.11
62_A128_T0.5190.11
145_Q224_V0.5160.11
69_L312_G0.5140.11
52_V305_Q0.5130.11
132_S136_R0.5120.11
61_V426_V0.5110.11
60_W393_R0.5100.11
16_D155_D0.5100.11
102_A116_V0.5090.11
25_L324_V0.5090.11
167_G173_L0.5090.11
7_V13_Q0.5090.11
99_E143_Y0.5070.11
144_L157_R0.5060.11
109_G309_S0.5060.11
347_P363_A0.5060.11
8_I67_I0.5050.11
156_V185_L0.5030.11
210_D214_H0.5020.11
199_A317_L0.5010.11
279_H282_R0.5000.11
67_I124_V0.5000.11
148_L380_F0.5000.11
54_S59_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r89A 2 0.9602 100 0.355 Contact Map
1px5A 1 0.5841 100 0.725 Contact Map
4s3nA 1 0.6062 100 0.726 Contact Map
4xq7A 1 0.573 100 0.727 Contact Map
4at7B 1 0.5951 100 0.729 Contact Map
4at7A 1 0.6305 100 0.779 Contact Map
2hhpA 1 0.8429 100 0.802 Contact Map
1q79A 1 0.8142 100 0.806 Contact Map
4xj5A 1 0.5885 100 0.832 Contact Map
4ud4A 1 0.5509 100 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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