GREMLIN Database
Q9HSP1 - Uncharacterized protein
UniProt: Q9HSP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (113)
Sequences: 170 (113)
Seq/√Len: 10.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_K92_D3.0350.94
12_D53_D3.0220.94
63_V76_Q2.8440.92
33_F71_L2.6750.89
48_I52_V2.6000.88
16_D73_Q2.2540.79
26_K59_A2.2540.79
19_L45_V2.2010.77
29_D85_Y2.1400.75
22_F39_T1.9940.69
14_T18_L1.9830.69
39_T95_E1.9830.69
12_D68_S1.9780.69
63_V78_N1.7930.61
48_I97_A1.7180.57
24_G93_P1.7070.57
16_D102_R1.6960.56
50_E98_D1.6680.55
12_D42_A1.5980.52
62_A84_Y1.5800.51
108_Y114_L1.5500.49
22_F77_I1.5480.49
19_L46_D1.5450.49
102_R121_K1.5250.48
22_F69_A1.4770.46
100_M103_L1.3710.41
40_N70_G1.3610.41
45_V119_E1.3470.40
116_Q120_T1.3180.39
36_L45_V1.3170.39
15_C86_H1.2890.37
19_L70_G1.2860.37
29_D62_A1.2670.36
55_E85_Y1.2630.36
56_R61_R1.2550.36
8_Q88_Y1.2320.35
53_D59_A1.2320.35
72_I121_K1.2300.35
61_R78_N1.2240.35
15_C60_Y1.2210.34
72_I75_E1.2190.34
104_L117_E1.1950.33
72_I96_I1.1880.33
36_L72_I1.1850.33
39_T44_T1.1800.33
49_A59_A1.1800.33
28_L93_P1.1800.33
36_L104_L1.1780.33
13_M68_S1.1770.33
87_V105_N1.1290.31
48_I77_I1.1150.30
17_G73_Q1.0630.28
50_E67_L1.0550.28
98_D119_E1.0400.27
57_S76_Q1.0270.27
29_D41_D1.0270.27
18_L34_Q1.0270.27
36_L63_V1.0260.27
27_Q100_M1.0060.26
84_Y97_A1.0040.26
53_D102_R1.0040.26
64_Q67_L0.9880.25
8_Q119_E0.9860.25
24_G111_M0.9840.25
50_E81_Q0.9800.25
64_Q68_S0.9780.25
20_E23_H0.9710.25
43_L115_I0.9650.24
74_K96_I0.9570.24
102_R109_A0.9550.24
16_D121_K0.9430.24
100_M115_I0.9430.24
67_L70_G0.9420.24
47_D67_L0.9390.24
73_Q92_D0.9370.23
90_P104_L0.9300.23
70_G91_T0.9230.23
59_A121_K0.9230.23
85_Y106_D0.9120.23
29_D49_A0.8920.22
43_L87_V0.8810.22
91_T115_I0.8790.22
13_M77_I0.8760.21
29_D65_R0.8760.21
55_E107_W0.8640.21
59_A103_L0.8620.21
41_D47_D0.8470.21
92_D103_L0.8390.20
51_R75_E0.8280.20
16_D30_K0.8250.20
35_A51_R0.8250.20
63_V80_D0.8190.20
98_D106_D0.8130.20
24_G91_T0.8050.19
88_Y116_Q0.7970.19
65_R74_K0.7840.19
100_M114_L0.7640.18
80_D101_Q0.7630.18
9_L106_D0.7580.18
53_D90_P0.7550.18
104_L118_F0.7540.18
11_H72_I0.7540.18
33_F92_D0.7510.18
48_I61_R0.7440.18
20_E30_K0.7430.18
55_E79_Y0.7410.17
11_H16_D0.7410.17
101_Q112_G0.7370.17
41_D50_E0.7340.17
20_E46_D0.7300.17
44_T85_Y0.7290.17
54_R120_T0.7260.17
27_Q53_D0.6990.16
53_D92_D0.6910.16
21_C111_M0.6890.16
101_Q115_I0.6870.16
58_T96_I0.6860.16
37_V109_A0.6840.16
32_V52_V0.6760.16
24_G52_V0.6660.16
53_D120_T0.6650.16
24_G54_R0.6600.15
52_V74_K0.6530.15
15_C85_Y0.6520.15
11_H89_E0.6500.15
32_V74_K0.6480.15
71_L89_E0.6430.15
89_E116_Q0.6380.15
31_G35_A0.6370.15
41_D77_I0.6210.14
35_A48_I0.6130.14
9_L12_D0.5950.14
94_A119_E0.5910.14
41_D71_L0.5830.14
23_H61_R0.5820.14
31_G43_L0.5760.13
51_R92_D0.5740.13
94_A115_I0.5690.13
27_Q121_K0.5680.13
57_S82_G0.5640.13
24_G33_F0.5630.13
58_T84_Y0.5630.13
9_L114_L0.5610.13
51_R68_S0.5600.13
27_Q90_P0.5570.13
40_N71_L0.5560.13
15_C42_A0.5560.13
27_Q63_V0.5550.13
45_V69_A0.5520.13
75_E89_E0.5510.13
65_R101_Q0.5460.13
14_T34_Q0.5410.13
32_V100_M0.5380.13
88_Y119_E0.5340.13
42_A59_A0.5330.13
57_S61_R0.5320.12
10_R97_A0.5310.12
31_G92_D0.5310.12
84_Y103_L0.5310.12
100_M106_D0.5290.12
87_V94_A0.5250.12
26_K58_T0.5230.12
64_Q85_Y0.5190.12
68_S121_K0.5190.12
57_S78_N0.5180.12
13_M23_H0.5160.12
61_R82_G0.5090.12
85_Y111_M0.5090.12
93_P97_A0.5040.12
69_A80_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r0aA 2 0.903 99.6 0.666 Contact Map
3qphA 2 0.8134 99.4 0.708 Contact Map
1sfxA 3 0.8134 99 0.757 Contact Map
1q1hA 1 0.6269 99 0.757 Contact Map
2d1hA 2 0.7537 98.9 0.764 Contact Map
1okrA 2 0.8284 98.8 0.772 Contact Map
2g9wA 2 0.6791 98.6 0.784 Contact Map
4nb5A 4 0.9328 98.6 0.785 Contact Map
2oqgA 4 0.8134 98.6 0.786 Contact Map
3cuoA 2 0.7313 98.6 0.788 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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