GREMLIN Database
Q9HSN9 - Uncharacterized protein
UniProt: Q9HSN9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (122)
Sequences: 767 (560)
Seq/√Len: 50.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_S27_D3.6501.00
39_A140_E3.1931.00
52_L55_E3.0541.00
23_L28_A3.0481.00
46_E65_Y3.0191.00
33_R46_E2.9931.00
64_Y87_G2.5531.00
50_A63_P2.5021.00
29_I96_I2.4181.00
63_P98_A2.3241.00
39_A137_M2.3161.00
82_T124_D2.2061.00
86_L122_A2.1981.00
35_V38_D2.1521.00
113_R135_G2.1461.00
49_P79_L2.1331.00
48_S51_E2.1081.00
117_L134_T1.9821.00
16_E88_A1.9220.99
49_P66_V1.8310.99
33_R37_T1.7450.99
23_L31_H1.7280.99
133_T137_M1.6950.98
21_L28_A1.6940.98
111_I142_F1.6930.98
42_G56_K1.6660.98
30_E34_D1.6620.98
29_I65_Y1.5930.98
62_D84_N1.5840.98
54_N60_D1.5650.97
78_A86_L1.5470.97
34_D38_D1.5370.97
77_R133_T1.4700.96
76_D80_D1.3550.94
28_A109_V1.2960.93
99_E108_H1.2440.91
42_G72_P1.2400.91
51_E55_E1.2160.90
74_V134_T1.2130.90
115_A132_A1.1870.89
89_L118_L1.1870.89
135_G139_D1.1510.87
29_I33_R1.1050.85
45_V52_L1.1020.85
35_V141_A1.0680.83
98_A102_G1.0630.83
25_H96_I1.0620.83
81_A126_E1.0280.81
53_L57_I1.0250.80
36_F138_V1.0240.80
117_L120_M0.9920.78
84_N97_W0.9880.78
128_Q132_A0.9830.78
27_D30_E0.9740.77
18_Q110_S0.9590.76
112_M117_L0.9520.75
17_Q20_T0.9510.75
118_L134_T0.9450.75
59_A80_D0.9310.74
90_M114_I0.9310.74
115_A135_G0.9300.74
54_N58_D0.9190.73
89_L120_M0.9100.72
89_L112_M0.9090.72
62_D97_W0.9030.71
53_L61_R0.8980.71
57_I61_R0.8850.70
25_H65_Y0.8830.70
36_F67_L0.8820.70
61_R97_W0.8810.69
34_D37_T0.8770.69
126_E129_D0.8720.69
70_C75_A0.8520.67
39_A141_A0.8520.67
45_V68_G0.8480.66
62_D98_A0.8450.66
137_M140_E0.8410.66
73_D77_R0.8330.65
56_K75_A0.8230.64
74_V137_M0.8220.64
27_D31_H0.8210.64
68_G93_N0.8170.64
129_D133_T0.8140.63
119_G123_D0.8090.63
48_S65_Y0.8040.62
47_F52_L0.7990.62
59_A76_D0.7930.61
90_M138_V0.7900.61
64_Y71_H0.7740.59
53_L63_P0.7660.59
115_A139_D0.7650.58
22_E101_P0.7610.58
70_C92_C0.7520.57
55_E122_A0.7510.57
69_A95_V0.7420.56
139_D143_D0.7380.56
40_G58_D0.7330.55
129_D132_A0.7300.55
24_S54_N0.7280.55
114_I131_V0.7240.54
36_F141_A0.7240.54
41_F78_A0.7220.54
102_G135_G0.7220.54
47_F68_G0.7190.54
89_L93_N0.7170.54
125_S129_D0.7170.54
86_L124_D0.7160.54
60_D131_V0.7130.53
19_A23_L0.7100.53
55_E58_D0.7080.53
116_R120_M0.7010.52
16_E110_S0.6980.52
79_L95_V0.6890.51
45_V93_N0.6890.51
115_A128_Q0.6850.50
40_G86_L0.6830.50
85_R108_H0.6770.49
22_E27_D0.6730.49
69_A93_N0.6710.49
56_K70_C0.6700.49
100_S103_R0.6650.48
19_A31_H0.6640.48
60_D109_V0.6540.47
22_E28_A0.6490.47
52_L56_K0.6450.46
117_L127_M0.6430.46
24_S63_P0.6390.46
26_E65_Y0.6350.45
47_F94_V0.6330.45
41_F44_P0.6280.44
31_H73_D0.6220.44
47_F93_N0.6170.43
32_V35_V0.6150.43
73_D100_S0.6130.43
56_K92_C0.6100.43
23_L27_D0.6080.42
112_M116_R0.6070.42
39_A134_T0.6050.42
36_F90_M0.6040.42
43_V134_T0.6010.42
77_R81_A0.5990.42
42_G47_F0.5980.41
75_A90_M0.5910.41
88_A110_S0.5880.40
16_E85_R0.5860.40
27_D34_D0.5780.39
36_F94_V0.5730.39
66_V77_R0.5650.38
86_L118_L0.5640.38
78_A127_M0.5600.38
57_I82_T0.5590.38
85_R110_S0.5590.38
113_R116_R0.5570.37
25_H63_P0.5560.37
19_A110_S0.5550.37
58_D68_G0.5550.37
26_E63_P0.5540.37
20_T24_S0.5530.37
127_M130_I0.5530.37
69_A94_V0.5530.37
36_F87_G0.5510.37
87_G138_V0.5470.36
100_S119_G0.5450.36
36_F93_N0.5440.36
116_R125_S0.5440.36
108_H118_L0.5420.36
74_V77_R0.5420.36
47_F66_V0.5410.36
42_G68_G0.5360.35
80_D133_T0.5340.35
41_F134_T0.5280.35
25_H32_V0.5270.35
82_T113_R0.5260.34
66_V94_V0.5230.34
44_P71_H0.5220.34
31_H85_R0.5190.34
26_E140_E0.5150.33
66_V93_N0.5100.33
137_M141_A0.5060.33
26_E30_E0.5030.32
81_A128_Q0.5010.32
97_W108_H0.5010.32
53_L76_D0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j3mA 2 0.8552 100 0.376 Contact Map
1q9uA 2 0.869 100 0.388 Contact Map
4ozjA 3 0.7034 51.6 0.925 Contact Map
4r25A 3 0.7103 42.3 0.929 Contact Map
3bzqA 3 0.6759 41.1 0.93 Contact Map
2eg2A 5 0.6414 38.9 0.931 Contact Map
1hwuA 6 0.6621 36.1 0.932 Contact Map
4co3A 3 0.6621 33.7 0.933 Contact Map
2ns1B 3 0.7034 31.5 0.934 Contact Map
2o66A 5 0.6897 30.9 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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