GREMLIN Database
NIKR - Putative nickel-responsive regulator
UniProt: Q9HSN7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (128)
Sequences: 695 (485)
Seq/√Len: 42.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_G95_H3.3631.00
57_V102_L3.1471.00
63_Y77_H2.8681.00
117_R125_I2.7781.00
77_H90_H2.7771.00
77_H96_C2.7481.00
95_H123_L2.7241.00
88_H96_C2.6241.00
8_M36_S2.5331.00
105_S108_S2.5311.00
30_E37_R2.5171.00
55_G102_L2.3871.00
25_Y34_E2.2841.00
30_E33_R2.2441.00
63_Y90_H2.2041.00
58_T128_S2.1451.00
90_H96_C2.0800.99
50_G107_E2.0570.99
15_R44_E1.9230.99
53_L109_I1.9170.99
78_E93_G1.8780.99
57_V116_I1.8770.99
57_V127_Y1.8750.99
16_L31_V1.8730.99
25_Y30_E1.7390.98
63_Y96_C1.7370.98
13_L17_D1.5130.95
54_M91_V1.4450.93
32_V99_L1.4070.92
84_A103_E1.3450.91
30_E34_E1.3150.90
32_V67_T1.2610.88
63_Y88_H1.2600.88
33_R37_R1.2570.87
61_F90_H1.2530.87
59_V116_I1.2470.87
87_F101_V1.2250.86
51_R105_S1.2220.86
16_L36_S1.1970.85
35_A39_L1.1740.84
72_M116_I1.1470.82
78_E115_K1.1470.82
124_T130_L1.1440.82
73_M77_H1.1430.82
20_A31_V1.1390.82
32_V78_E1.1380.82
56_V101_V1.1370.82
77_H88_H1.1310.81
38_N126_D1.1260.81
44_E85_S1.1220.81
4_V7_S1.0980.79
64_E93_G1.0980.79
73_M90_H1.0930.79
34_E122_T1.0720.78
89_S97_M1.0700.77
16_L20_A1.0560.76
111_T115_K1.0510.76
80_E112_F1.0390.75
79_H111_T1.0390.75
69_E73_M1.0210.74
68_V93_G1.0110.73
8_M21_D1.0070.73
117_R124_T0.9910.72
7_S16_L0.9650.70
5_S80_E0.9550.69
113_V127_Y0.9550.69
6_V13_L0.9440.68
4_V32_V0.9420.68
108_S111_T0.9380.68
59_V125_I0.9280.67
50_G55_G0.9260.67
87_F131_P0.9140.65
11_E108_S0.9140.65
81_G108_S0.9030.65
113_V125_I0.9000.64
15_R24_G0.8930.64
7_S12_L0.8830.63
76_R100_F0.8810.63
56_V130_L0.8810.63
9_P55_G0.8780.62
10_E14_E0.8760.62
83_V112_F0.8710.62
86_N102_L0.8630.61
50_G106_L0.8600.61
14_E23_H0.8570.60
65_T120_K0.8540.60
3_V17_D0.8520.60
117_R126_D0.8470.60
4_V64_E0.8350.58
19_F40_L0.8340.58
13_L16_L0.8320.58
3_V98_E0.8280.58
68_V119_T0.8190.57
39_L43_F0.8140.56
5_S120_K0.8140.56
17_D28_R0.8080.56
12_L37_R0.7820.53
105_S109_I0.7800.53
88_H98_E0.7690.52
18_D22_D0.7590.51
41_G131_P0.7550.51
32_V44_E0.7460.50
92_G109_I0.7460.50
26_T129_V0.7420.50
87_F99_L0.7360.49
89_S92_G0.7350.49
78_E108_S0.7340.49
31_V39_L0.7210.48
42_E46_K0.7190.48
51_R106_L0.7150.47
16_L100_F0.7090.47
98_E104_G0.7040.46
73_M96_C0.7020.46
95_H109_I0.7000.46
3_V34_E0.6930.45
64_E88_H0.6900.45
41_G45_D0.6870.44
17_D114_G0.6820.44
5_S69_E0.6790.44
79_H105_S0.6790.44
59_V73_M0.6750.43
22_D50_G0.6740.43
59_V100_F0.6710.43
66_T115_K0.6700.43
45_D109_I0.6610.42
22_D43_F0.6570.42
61_F88_H0.6560.42
3_V33_R0.6510.41
41_G130_L0.6510.41
27_G35_A0.6490.41
6_V37_R0.6450.41
51_R82_L0.6450.41
53_L130_L0.6420.40
7_S25_Y0.6350.40
20_A25_Y0.6330.39
16_L35_A0.6310.39
40_L126_D0.6280.39
10_E131_P0.6260.39
109_I113_V0.6230.39
63_Y98_E0.6210.38
33_R96_C0.6140.38
35_A125_I0.6080.37
3_V27_G0.6060.37
49_E52_E0.6050.37
3_V31_V0.5980.36
24_G100_F0.5970.36
55_G58_T0.5940.36
27_G124_T0.5910.36
15_R18_D0.5910.36
26_T119_T0.5900.36
16_L64_E0.5870.35
23_H117_R0.5860.35
27_G119_T0.5850.35
60_V114_G0.5810.35
110_S114_G0.5790.35
64_E87_F0.5780.35
119_T131_P0.5740.34
76_R90_H0.5710.34
79_H113_V0.5690.34
20_A92_G0.5670.34
34_E37_R0.5620.33
3_V35_A0.5540.33
26_T114_G0.5530.33
18_D107_E0.5510.32
7_S58_T0.5510.32
64_E90_H0.5480.32
74_H106_L0.5460.32
7_S130_L0.5450.32
34_E92_G0.5430.32
17_D33_R0.5400.31
12_L28_R0.5400.31
11_E65_T0.5390.31
52_E58_T0.5370.31
18_D21_D0.5340.31
50_G75_L0.5300.31
90_H93_G0.5260.30
24_G32_V0.5250.30
5_S31_V0.5240.30
28_R98_E0.5190.30
74_H129_V0.5190.30
86_N112_F0.5170.30
27_G122_T0.5160.30
67_T75_L0.5160.30
70_E74_H0.5140.29
24_G82_L0.5090.29
9_P43_F0.5070.29
12_L40_L0.5070.29
83_V123_L0.5060.29
21_D74_H0.5050.29
82_L108_S0.5040.29
54_M124_T0.5040.29
75_L115_K0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wvfA 2 0.9577 100 0.196 Contact Map
2hzaA 3 0.9225 100 0.216 Contact Map
2bj7A 3 0.9577 100 0.261 Contact Map
1q5yA 4 0.5915 99.9 0.523 Contact Map
2nzcA 3 0.5634 99.8 0.586 Contact Map
3kxeC 2 0.5211 98.9 0.769 Contact Map
4me7E 2 0.5563 98.8 0.775 Contact Map
2k5jA 2 0.507 98.7 0.788 Contact Map
2cpgA 2 0.3099 98.4 0.805 Contact Map
2mdvA 2 0.2676 98 0.825 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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