Q9HSN4 - HALSA - GREMLIN Contacts

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Q9HSN4 - Uncharacterized protein

UniProt:	Q9HSN4	Sequences: MSALPLGGAAAFAAGAGVTTFFAPCAFPLLPGYVGYYVTERDSDIAVVAAAAAAAVGAITTLGAVAGVVLAAGQPVKAALPAVEPLIGLGLVVVGVLTAAGRGPRITVVLPERPASVVGFGVFGGVYALAAAGCVVPVFIGVIGQAVEHPLPGAVTVLGVYAAGVAAPLVGVTLLAGAGVDAWRELGAYTESIERAAGVVMVAAGVGQIVVGLGQVSAVGVSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	223 (205)
Sequences:	5055 (3307)
Seq/√Len:	230.9

ECOLI - DSBD
BACSU - CCDA
HALSA - Q9HSN4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_T	121_G	5.130	1.00
191_E	195_R	3.663	1.00
95_G	202_V	3.258	1.00
53_A	117_V	3.221	1.00
10_A	160_V	3.117	1.00
14_A	167_A	3.010	1.00
55_A	166_A	2.878	1.00
99_A	202_V	2.831	1.00
192_S	195_R	2.805	1.00
192_S	196_A	2.718	1.00
104_P	107_T	2.622	1.00
63_G	159_G	2.502	1.00
116_S	119_G	2.299	1.00
95_G	99_A	2.282	1.00
92_V	205_G	2.248	1.00
15_G	19_T	2.245	1.00
11_A	15_G	2.190	1.00
48_V	174_L	2.174	1.00
96_V	101_G	2.163	1.00
20_T	161_Y	2.149	1.00
82_A	85_P	2.145	1.00
70_L	151_L	2.129	1.00
184_R	187_G	2.128	1.00
88_G	205_G	2.127	1.00
82_A	86_L	1.988	1.00
92_V	202_V	1.976	1.00
59_I	162_A	1.970	1.00
55_A	170_V	1.911	1.00
51_A	173_T	1.907	1.00
63_G	162_A	1.848	1.00
52_A	56_V	1.837	1.00
61_T	125_G	1.815	1.00
94_V	201_M	1.779	1.00
199_V	203_A	1.706	1.00
100_A	103_G	1.689	1.00
79_A	82_A	1.676	1.00
198_G	202_V	1.658	1.00
67_G	155_V	1.649	1.00
195_R	199_V	1.576	1.00
104_P	108_V	1.570	1.00
107_T	111_P	1.532	1.00
49_A	117_V	1.505	1.00
81_P	85_P	1.500	1.00
50_A	120_F	1.494	1.00
88_G	209_I	1.489	1.00
52_A	170_V	1.421	1.00
189_Y	192_S	1.419	1.00
57_G	121_G	1.409	1.00
49_A	52_A	1.407	1.00
66_A	154_A	1.407	1.00
105_R	109_V	1.382	1.00
10_A	156_T	1.329	1.00
149_H	153_G	1.316	1.00
13_A	142_V	1.305	1.00
14_A	163_A	1.298	1.00
109_V	113_R	1.297	1.00
68_V	71_A	1.293	1.00
104_P	109_V	1.292	1.00
207_G	210_V	1.289	1.00
46_A	50_A	1.279	1.00
70_L	73_G	1.271	1.00
92_V	209_I	1.254	1.00
207_G	212_G	1.235	1.00
59_I	63_G	1.234	1.00
53_A	57_G	1.234	1.00
95_G	198_G	1.233	1.00
59_I	159_G	1.226	1.00
151_L	154_A	1.219	1.00
16_A	138_V	1.202	1.00
104_P	112_E	1.198	1.00
186_L	189_Y	1.195	1.00
20_T	23_A	1.188	1.00
23_A	26_A	1.176	1.00
99_A	198_G	1.176	1.00
13_A	157_V	1.154	1.00
53_A	121_G	1.149	1.00
97_L	102_R	1.147	1.00
193_I	197_A	1.141	1.00
89_L	93_V	1.141	1.00
143_I	147_V	1.140	1.00
85_P	89_L	1.132	1.00
53_A	120_F	1.132	1.00
106_I	109_V	1.129	1.00
105_R	108_V	1.115	1.00
156_T	160_V	1.114	1.00
56_V	121_G	1.102	1.00
69_V	147_V	1.098	1.00
14_A	160_V	1.097	1.00
191_E	194_E	1.087	1.00
109_V	112_E	1.075	1.00
187_G	190_T	1.057	1.00
46_A	49_A	1.056	1.00
206_V	210_V	1.052	1.00
103_G	194_E	1.051	1.00
184_R	189_Y	1.041	1.00
94_V	140_I	1.027	1.00
24_P	27_F	1.025	1.00
125_G	129_L	1.023	1.00
185_E	189_Y	1.018	1.00
54_A	127_Y	1.016	1.00
91_L	208_Q	1.004	1.00
66_A	143_I	0.998	1.00
67_G	71_A	0.991	1.00
41_R	44_D	0.972	1.00
60_T	125_G	0.970	1.00
144_G	147_V	0.965	1.00
51_A	55_A	0.956	1.00
58_A	61_T	0.953	1.00
92_V	206_V	0.950	1.00
66_A	70_L	0.944	1.00
54_A	120_F	0.927	1.00
190_T	193_I	0.922	1.00
29_L	32_G	0.920	1.00
143_I	158_L	0.920	1.00
182_A	185_E	0.914	1.00
48_V	170_V	0.909	1.00
51_A	170_V	0.909	1.00
121_G	125_G	0.909	1.00
85_P	209_I	0.901	0.99
142_V	157_V	0.898	0.99
66_A	158_L	0.898	0.99
92_V	96_V	0.897	0.99
99_A	102_R	0.896	0.99
93_V	102_R	0.892	0.99
43_S	46_A	0.892	0.99
196_A	199_V	0.885	0.99
205_G	209_I	0.882	0.99
25_C	134_C	0.881	0.99
83_V	87_I	0.878	0.99
21_F	33_Y	0.866	0.99
189_Y	193_I	0.862	0.99
16_A	137_P	0.857	0.99
155_V	158_L	0.856	0.99
66_A	73_G	0.852	0.99
203_A	207_G	0.838	0.99
167_A	171_G	0.834	0.99
188_A	192_S	0.831	0.99
185_E	188_A	0.830	0.99
57_G	124_G	0.830	0.99
63_G	155_V	0.830	0.99
177_G	181_D	0.829	0.99
77_K	80_L	0.826	0.99
162_A	166_A	0.825	0.99
99_A	199_V	0.815	0.99
175_L	179_G	0.815	0.99
56_V	159_G	0.813	0.99
172_V	175_L	0.811	0.99
152_P	155_V	0.810	0.99
89_L	209_I	0.810	0.99
40_E	50_A	0.805	0.99
199_V	202_V	0.804	0.99
152_P	156_T	0.797	0.99
136_V	139_F	0.790	0.99
186_L	190_T	0.774	0.98
68_V	72_A	0.763	0.98
141_G	144_G	0.760	0.98
31_P	35_G	0.760	0.98
33_Y	37_Y	0.756	0.98
23_A	28_P	0.753	0.98
179_G	182_A	0.752	0.98
138_V	142_V	0.751	0.98
67_G	70_L	0.750	0.98
64_A	67_G	0.750	0.98
56_V	60_T	0.748	0.98
26_A	135_V	0.748	0.98
74_Q	77_K	0.747	0.98
48_V	51_A	0.746	0.98
9_A	157_V	0.744	0.98
159_G	163_A	0.739	0.98
175_L	183_W	0.738	0.98
48_V	52_A	0.737	0.98
146_A	158_L	0.736	0.98
65_V	143_I	0.736	0.98
125_G	128_A	0.734	0.98
132_A	136_V	0.732	0.98
186_L	193_I	0.731	0.98
153_G	157_V	0.727	0.98
108_V	112_E	0.722	0.98
190_T	194_E	0.721	0.98
131_A	135_V	0.719	0.97
84_E	211_V	0.716	0.97
108_V	111_P	0.715	0.97
23_A	29_L	0.714	0.97
33_Y	135_V	0.707	0.97
97_L	101_G	0.704	0.97
165_V	169_L	0.702	0.97
140_I	158_L	0.698	0.97
12_F	16_A	0.696	0.97
38_V	172_V	0.695	0.97
65_V	80_L	0.694	0.97
96_V	172_V	0.692	0.97
91_L	201_M	0.690	0.97
114_P	119_G	0.688	0.97
81_P	84_E	0.688	0.97
106_I	110_L	0.688	0.97
101_G	198_G	0.685	0.97
104_P	111_P	0.683	0.97
128_A	165_V	0.667	0.96
155_V	159_G	0.666	0.96
171_G	183_W	0.665	0.96
141_G	146_A	0.662	0.96
140_I	144_G	0.659	0.96
18_V	167_A	0.657	0.96
40_E	114_P	0.657	0.96
114_P	118_V	0.656	0.96
50_A	141_G	0.649	0.95
20_T	138_V	0.643	0.95
16_A	19_T	0.643	0.95
12_F	19_T	0.641	0.95
135_V	165_V	0.640	0.95
110_L	113_R	0.635	0.95
35_G	197_A	0.630	0.95
147_V	158_L	0.630	0.95
21_F	132_A	0.629	0.95
139_F	154_A	0.628	0.95
188_A	191_E	0.628	0.95
107_T	112_E	0.627	0.94
53_A	56_V	0.625	0.94
18_V	168_P	0.622	0.94
172_V	185_E	0.621	0.94
21_F	165_V	0.616	0.94
146_A	154_A	0.615	0.94
122_V	125_G	0.609	0.94
74_Q	78_A	0.608	0.94
61_T	128_A	0.608	0.94
40_E	45_I	0.607	0.93
62_L	139_F	0.607	0.93
132_A	140_I	0.606	0.93
30_L	172_V	0.603	0.93
51_A	54_A	0.602	0.93
127_Y	133_G	0.601	0.93
28_P	131_A	0.598	0.93
201_M	205_G	0.597	0.93
76_V	129_L	0.595	0.93
38_V	201_M	0.593	0.93
134_C	137_P	0.593	0.93
157_V	175_L	0.592	0.93
47_V	173_T	0.592	0.93
57_G	164_G	0.592	0.93
118_V	122_V	0.589	0.92
144_G	149_H	0.588	0.92
60_T	64_A	0.588	0.92
97_L	103_G	0.587	0.92
38_V	41_R	0.584	0.92
27_F	208_Q	0.580	0.92
103_G	126_V	0.579	0.92
96_V	202_V	0.577	0.92
87_I	126_V	0.576	0.92
151_L	155_V	0.572	0.91
106_I	112_E	0.571	0.91
179_G	186_L	0.570	0.91
73_G	76_V	0.570	0.91
99_A	195_R	0.570	0.91
145_Q	149_H	0.569	0.91
178_A	181_D	0.569	0.91
133_G	140_I	0.567	0.91
27_F	30_L	0.566	0.91
173_T	177_G	0.562	0.91
9_A	29_L	0.562	0.91
72_A	168_P	0.562	0.91
65_V	69_V	0.562	0.91
178_A	182_A	0.562	0.91
33_Y	169_L	0.561	0.91
67_G	151_L	0.561	0.91
70_L	147_V	0.559	0.90
175_L	197_A	0.559	0.90
172_V	178_A	0.556	0.90
59_I	155_V	0.555	0.90
32_G	35_G	0.552	0.90
131_A	136_V	0.551	0.90
136_V	140_I	0.551	0.90
70_L	155_V	0.549	0.90
32_G	88_G	0.546	0.89
71_A	75_P	0.545	0.89
141_G	145_Q	0.544	0.89
58_A	165_V	0.544	0.89
96_V	100_A	0.543	0.89
21_F	131_A	0.540	0.89
72_A	75_P	0.540	0.89
98_T	197_A	0.539	0.89
28_P	136_V	0.537	0.89
56_V	82_A	0.537	0.89
59_I	98_T	0.537	0.89
21_F	136_V	0.535	0.88
14_A	164_G	0.534	0.88
75_P	78_A	0.534	0.88
16_A	136_V	0.532	0.88
66_A	160_V	0.529	0.88
62_L	128_A	0.528	0.88
204_A	208_Q	0.520	0.87
13_A	146_A	0.520	0.87
124_G	164_G	0.519	0.87
37_Y	50_A	0.519	0.87
11_A	167_A	0.518	0.87
21_F	28_P	0.518	0.87
21_F	201_M	0.514	0.86
105_R	111_P	0.513	0.86
166_A	170_V	0.512	0.86
29_L	211_V	0.510	0.86
130_A	133_G	0.509	0.86
145_Q	157_V	0.509	0.86
207_G	211_V	0.506	0.85
50_A	117_V	0.505	0.85
181_D	184_R	0.503	0.85
27_F	131_A	0.503	0.85
28_P	169_L	0.501	0.85
67_G	159_G	0.501	0.85
66_A	162_A	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wdoA	1	0.8386	23.2	0.935	Contact Map
2gfpA	2	0.9058	18.9	0.937	Contact Map
3o7qA	1	0.9417	16.3	0.939	Contact Map
2cfqA	1	0.4798	14.1	0.941	Contact Map
3j1zP	8	0.8161	11.6	0.943	Contact Map
1pw4A	1	0.4933	9	0.946	Contact Map
4ikvA	1	0.9327	8.7	0.946	Contact Map
3qe7A	2	0.6592	5.8	0.95	Contact Map
4tphA	2	0.8789	5.8	0.95	Contact Map
4pypA	1	0.9148	5.5	0.951	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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