GREMLIN Database
Q9HSN4 - Uncharacterized protein
UniProt: Q9HSN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (205)
Sequences: 5055 (3307)
Seq/√Len: 230.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_T121_G5.1301.00
191_E195_R3.6631.00
95_G202_V3.2581.00
53_A117_V3.2211.00
10_A160_V3.1171.00
14_A167_A3.0101.00
55_A166_A2.8781.00
99_A202_V2.8311.00
192_S195_R2.8051.00
192_S196_A2.7181.00
104_P107_T2.6221.00
63_G159_G2.5021.00
116_S119_G2.2991.00
95_G99_A2.2821.00
92_V205_G2.2481.00
15_G19_T2.2451.00
11_A15_G2.1901.00
48_V174_L2.1741.00
96_V101_G2.1631.00
20_T161_Y2.1491.00
82_A85_P2.1451.00
70_L151_L2.1291.00
184_R187_G2.1281.00
88_G205_G2.1271.00
82_A86_L1.9881.00
92_V202_V1.9761.00
59_I162_A1.9701.00
55_A170_V1.9111.00
51_A173_T1.9071.00
63_G162_A1.8481.00
52_A56_V1.8371.00
61_T125_G1.8151.00
94_V201_M1.7791.00
199_V203_A1.7061.00
100_A103_G1.6891.00
79_A82_A1.6761.00
198_G202_V1.6581.00
67_G155_V1.6491.00
195_R199_V1.5761.00
104_P108_V1.5701.00
107_T111_P1.5321.00
49_A117_V1.5051.00
81_P85_P1.5001.00
50_A120_F1.4941.00
88_G209_I1.4891.00
52_A170_V1.4211.00
189_Y192_S1.4191.00
57_G121_G1.4091.00
49_A52_A1.4071.00
66_A154_A1.4071.00
105_R109_V1.3821.00
10_A156_T1.3291.00
149_H153_G1.3161.00
13_A142_V1.3051.00
14_A163_A1.2981.00
109_V113_R1.2971.00
68_V71_A1.2931.00
104_P109_V1.2921.00
207_G210_V1.2891.00
46_A50_A1.2791.00
70_L73_G1.2711.00
92_V209_I1.2541.00
207_G212_G1.2351.00
59_I63_G1.2341.00
53_A57_G1.2341.00
95_G198_G1.2331.00
59_I159_G1.2261.00
151_L154_A1.2191.00
16_A138_V1.2021.00
104_P112_E1.1981.00
186_L189_Y1.1951.00
20_T23_A1.1881.00
23_A26_A1.1761.00
99_A198_G1.1761.00
13_A157_V1.1541.00
53_A121_G1.1491.00
97_L102_R1.1471.00
193_I197_A1.1411.00
89_L93_V1.1411.00
143_I147_V1.1401.00
85_P89_L1.1321.00
53_A120_F1.1321.00
106_I109_V1.1291.00
105_R108_V1.1151.00
156_T160_V1.1141.00
56_V121_G1.1021.00
69_V147_V1.0981.00
14_A160_V1.0971.00
191_E194_E1.0871.00
109_V112_E1.0751.00
187_G190_T1.0571.00
46_A49_A1.0561.00
206_V210_V1.0521.00
103_G194_E1.0511.00
184_R189_Y1.0411.00
94_V140_I1.0271.00
24_P27_F1.0251.00
125_G129_L1.0231.00
185_E189_Y1.0181.00
54_A127_Y1.0161.00
91_L208_Q1.0041.00
66_A143_I0.9981.00
67_G71_A0.9911.00
41_R44_D0.9721.00
60_T125_G0.9701.00
144_G147_V0.9651.00
51_A55_A0.9561.00
58_A61_T0.9531.00
92_V206_V0.9501.00
66_A70_L0.9441.00
54_A120_F0.9271.00
190_T193_I0.9221.00
29_L32_G0.9201.00
143_I158_L0.9201.00
182_A185_E0.9141.00
48_V170_V0.9091.00
51_A170_V0.9091.00
121_G125_G0.9091.00
85_P209_I0.9010.99
142_V157_V0.8980.99
66_A158_L0.8980.99
92_V96_V0.8970.99
99_A102_R0.8960.99
93_V102_R0.8920.99
43_S46_A0.8920.99
196_A199_V0.8850.99
205_G209_I0.8820.99
25_C134_C0.8810.99
83_V87_I0.8780.99
21_F33_Y0.8660.99
189_Y193_I0.8620.99
16_A137_P0.8570.99
155_V158_L0.8560.99
66_A73_G0.8520.99
203_A207_G0.8380.99
167_A171_G0.8340.99
188_A192_S0.8310.99
185_E188_A0.8300.99
57_G124_G0.8300.99
63_G155_V0.8300.99
177_G181_D0.8290.99
77_K80_L0.8260.99
162_A166_A0.8250.99
99_A199_V0.8150.99
175_L179_G0.8150.99
56_V159_G0.8130.99
172_V175_L0.8110.99
152_P155_V0.8100.99
89_L209_I0.8100.99
40_E50_A0.8050.99
199_V202_V0.8040.99
152_P156_T0.7970.99
136_V139_F0.7900.99
186_L190_T0.7740.98
68_V72_A0.7630.98
141_G144_G0.7600.98
31_P35_G0.7600.98
33_Y37_Y0.7560.98
23_A28_P0.7530.98
179_G182_A0.7520.98
138_V142_V0.7510.98
67_G70_L0.7500.98
64_A67_G0.7500.98
56_V60_T0.7480.98
26_A135_V0.7480.98
74_Q77_K0.7470.98
48_V51_A0.7460.98
9_A157_V0.7440.98
159_G163_A0.7390.98
175_L183_W0.7380.98
48_V52_A0.7370.98
146_A158_L0.7360.98
65_V143_I0.7360.98
125_G128_A0.7340.98
132_A136_V0.7320.98
186_L193_I0.7310.98
153_G157_V0.7270.98
108_V112_E0.7220.98
190_T194_E0.7210.98
131_A135_V0.7190.97
84_E211_V0.7160.97
108_V111_P0.7150.97
23_A29_L0.7140.97
33_Y135_V0.7070.97
97_L101_G0.7040.97
165_V169_L0.7020.97
140_I158_L0.6980.97
12_F16_A0.6960.97
38_V172_V0.6950.97
65_V80_L0.6940.97
96_V172_V0.6920.97
91_L201_M0.6900.97
114_P119_G0.6880.97
81_P84_E0.6880.97
106_I110_L0.6880.97
101_G198_G0.6850.97
104_P111_P0.6830.97
128_A165_V0.6670.96
155_V159_G0.6660.96
171_G183_W0.6650.96
141_G146_A0.6620.96
140_I144_G0.6590.96
18_V167_A0.6570.96
40_E114_P0.6570.96
114_P118_V0.6560.96
50_A141_G0.6490.95
20_T138_V0.6430.95
16_A19_T0.6430.95
12_F19_T0.6410.95
135_V165_V0.6400.95
110_L113_R0.6350.95
35_G197_A0.6300.95
147_V158_L0.6300.95
21_F132_A0.6290.95
139_F154_A0.6280.95
188_A191_E0.6280.95
107_T112_E0.6270.94
53_A56_V0.6250.94
18_V168_P0.6220.94
172_V185_E0.6210.94
21_F165_V0.6160.94
146_A154_A0.6150.94
122_V125_G0.6090.94
74_Q78_A0.6080.94
61_T128_A0.6080.94
40_E45_I0.6070.93
62_L139_F0.6070.93
132_A140_I0.6060.93
30_L172_V0.6030.93
51_A54_A0.6020.93
127_Y133_G0.6010.93
28_P131_A0.5980.93
201_M205_G0.5970.93
76_V129_L0.5950.93
38_V201_M0.5930.93
134_C137_P0.5930.93
157_V175_L0.5920.93
47_V173_T0.5920.93
57_G164_G0.5920.93
118_V122_V0.5890.92
144_G149_H0.5880.92
60_T64_A0.5880.92
97_L103_G0.5870.92
38_V41_R0.5840.92
27_F208_Q0.5800.92
103_G126_V0.5790.92
96_V202_V0.5770.92
87_I126_V0.5760.92
151_L155_V0.5720.91
106_I112_E0.5710.91
179_G186_L0.5700.91
73_G76_V0.5700.91
99_A195_R0.5700.91
145_Q149_H0.5690.91
178_A181_D0.5690.91
133_G140_I0.5670.91
27_F30_L0.5660.91
173_T177_G0.5620.91
9_A29_L0.5620.91
72_A168_P0.5620.91
65_V69_V0.5620.91
178_A182_A0.5620.91
33_Y169_L0.5610.91
67_G151_L0.5610.91
70_L147_V0.5590.90
175_L197_A0.5590.90
172_V178_A0.5560.90
59_I155_V0.5550.90
32_G35_G0.5520.90
131_A136_V0.5510.90
136_V140_I0.5510.90
70_L155_V0.5490.90
32_G88_G0.5460.89
71_A75_P0.5450.89
141_G145_Q0.5440.89
58_A165_V0.5440.89
96_V100_A0.5430.89
21_F131_A0.5400.89
72_A75_P0.5400.89
98_T197_A0.5390.89
28_P136_V0.5370.89
56_V82_A0.5370.89
59_I98_T0.5370.89
21_F136_V0.5350.88
14_A164_G0.5340.88
75_P78_A0.5340.88
16_A136_V0.5320.88
66_A160_V0.5290.88
62_L128_A0.5280.88
204_A208_Q0.5200.87
13_A146_A0.5200.87
124_G164_G0.5190.87
37_Y50_A0.5190.87
11_A167_A0.5180.87
21_F28_P0.5180.87
21_F201_M0.5140.86
105_R111_P0.5130.86
166_A170_V0.5120.86
29_L211_V0.5100.86
130_A133_G0.5090.86
145_Q157_V0.5090.86
207_G211_V0.5060.85
50_A117_V0.5050.85
181_D184_R0.5030.85
27_F131_A0.5030.85
28_P169_L0.5010.85
67_G159_G0.5010.85
66_A162_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.8386 23.2 0.935 Contact Map
2gfpA 2 0.9058 18.9 0.937 Contact Map
3o7qA 1 0.9417 16.3 0.939 Contact Map
2cfqA 1 0.4798 14.1 0.941 Contact Map
3j1zP 8 0.8161 11.6 0.943 Contact Map
1pw4A 1 0.4933 9 0.946 Contact Map
4ikvA 1 0.9327 8.7 0.946 Contact Map
3qe7A 2 0.6592 5.8 0.95 Contact Map
4tphA 2 0.8789 5.8 0.95 Contact Map
4pypA 1 0.9148 5.5 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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