Q9HSN2 - HALSA - GREMLIN Contacts

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Q9HSN2 - Regulatory protein

UniProt:	Q9HSN2	Sequences: MRRRTYLSLVGSAAAAGTAGCLGVLGGDDTPTVLPEPDHEYDASALPYPAWGERVPDATVPAALGDATVSTRETETPALYTFFYSHCQTVCPVLVSTLRNIQTHAANNGYADDIALRPVTFDPERDTADRLASYGERMHVDTDADNWTFLRPAGVDRAKAVVTDDFGVTFKRTHPEDMAQYMFSHAALTVLVNADGYVERTYRSKSPDEQQLIADLETVRQA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	222 (173)
Sequences:	1929 (1391)
Seq/√Len:	105.8

BACSU - SCO1
HALSA - Q9HSN2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_G	132_A	3.819	1.00
62_A	67_A	3.590	1.00
151_R	158_A	2.778	1.00
69_V	74_T	2.737	1.00
76_T	115_A	2.677	1.00
62_A	65_G	2.590	1.00
77_P	194_A	2.543	1.00
104_H	213_I	2.500	1.00
57_D	71_T	2.451	1.00
62_A	148_T	2.450	1.00
153_A	157_R	2.295	1.00
193_N	199_E	2.265	1.00
121_F	183_F	2.221	1.00
152_P	158_A	2.199	1.00
122_D	125_R	2.174	1.00
208_D	211_Q	2.099	1.00
63_A	132_A	2.071	1.00
98_L	189_T	2.064	1.00
127_T	130_R	2.032	1.00
132_A	136_E	2.031	1.00
101_I	213_I	2.021	1.00
61_P	67_A	1.918	1.00
86_H	125_R	1.910	1.00
125_R	181_Y	1.837	1.00
135_G	149_F	1.829	1.00
63_A	135_G	1.806	1.00
106_A	109_G	1.790	1.00
87_C	91_C	1.781	1.00
154_G	159_K	1.754	1.00
193_N	197_Y	1.746	1.00
62_A	69_V	1.715	1.00
157_R	160_A	1.644	1.00
70_S	73_E	1.638	1.00
34_L	38_D	1.635	1.00
59_T	68_T	1.578	1.00
74_T	78_A	1.569	1.00
56_P	165_D	1.568	1.00
163_T	170_F	1.533	1.00
108_N	217_E	1.521	1.00
113_D	194_A	1.494	1.00
106_A	141_D	1.480	1.00
215_D	219_V	1.448	1.00
154_G	170_F	1.440	1.00
83_F	118_P	1.436	1.00
74_T	148_T	1.431	1.00
80_Y	119_V	1.414	1.00
83_F	95_V	1.399	1.00
91_C	185_H	1.374	1.00
68_T	157_R	1.365	1.00
130_R	133_S	1.358	1.00
82_F	166_F	1.320	0.99
44_S	47_P	1.317	0.99
84_Y	182_M	1.315	0.99
87_C	185_H	1.310	0.99
104_H	210_Q	1.306	0.99
75_E	196_G	1.271	0.99
133_S	137_R	1.260	0.99
115_A	148_T	1.234	0.99
86_H	122_D	1.192	0.99
118_P	147_W	1.186	0.99
55_V	166_F	1.182	0.99
128_A	151_R	1.181	0.99
202_Y	215_D	1.172	0.99
99_R	139_H	1.170	0.99
94_L	97_T	1.169	0.99
81_T	95_V	1.168	0.99
60_V	119_V	1.166	0.99
83_F	149_F	1.165	0.99
135_G	147_W	1.145	0.98
175_P	178_M	1.123	0.98
77_P	199_E	1.115	0.98
57_D	72_R	1.110	0.98
80_Y	192_V	1.105	0.98
160_A	165_D	1.104	0.98
123_P	151_R	1.082	0.98
79_L	216_L	1.077	0.98
210_Q	214_A	1.066	0.97
61_P	68_T	1.065	0.97
120_T	151_R	1.064	0.97
77_P	193_N	1.059	0.97
134_Y	138_M	1.059	0.97
90_V	187_A	1.048	0.97
129_D	133_S	1.045	0.97
49_P	52_G	1.042	0.97
119_V	161_V	1.038	0.97
124_E	172_R	1.037	0.97
61_P	151_R	1.035	0.97
120_T	123_P	1.030	0.97
34_L	37_P	1.030	0.97
95_V	118_P	1.020	0.97
60_V	152_P	1.015	0.96
95_V	134_Y	1.007	0.96
80_Y	117_R	1.007	0.96
156_D	160_A	1.004	0.96
35_P	38_D	1.003	0.96
77_P	216_L	1.000	0.96
81_T	94_L	0.992	0.96
108_N	113_D	0.989	0.96
84_Y	167_G	0.983	0.96
58_A	166_F	0.981	0.96
166_F	190_V	0.976	0.96
140_V	149_F	0.963	0.95
71_T	196_G	0.959	0.95
69_V	73_E	0.956	0.95
58_A	84_Y	0.944	0.95
191_L	202_Y	0.908	0.93
199_E	219_V	0.899	0.93
124_E	154_G	0.897	0.93
69_V	150_L	0.896	0.93
74_T	117_R	0.886	0.93
153_A	156_D	0.885	0.93
102_Q	116_L	0.885	0.93
189_T	212_L	0.882	0.92
215_D	218_T	0.882	0.92
59_T	67_A	0.878	0.92
78_A	115_A	0.877	0.92
71_T	78_A	0.873	0.92
69_V	148_T	0.872	0.92
209_E	213_I	0.871	0.92
164_D	169_T	0.868	0.92
94_L	189_T	0.863	0.92
159_K	164_D	0.858	0.91
213_I	217_E	0.852	0.91
55_V	161_V	0.830	0.90
116_L	147_W	0.822	0.90
63_A	128_A	0.820	0.89
57_D	70_S	0.812	0.89
118_P	149_F	0.784	0.87
170_F	188_L	0.766	0.86
98_L	116_L	0.763	0.86
101_I	104_H	0.761	0.86
100_N	209_E	0.758	0.85
36_E	40_E	0.745	0.84
188_L	201_T	0.741	0.84
58_A	70_S	0.738	0.84
77_P	219_V	0.736	0.84
83_F	147_W	0.735	0.84
63_A	148_T	0.734	0.84
173_T	182_M	0.733	0.83
101_I	116_L	0.733	0.83
100_N	104_H	0.730	0.83
88_Q	95_V	0.729	0.83
122_D	138_M	0.728	0.83
193_N	219_V	0.728	0.83
154_G	172_R	0.726	0.83
120_T	156_D	0.724	0.83
42_D	45_A	0.724	0.83
94_L	116_L	0.715	0.82
181_Y	184_S	0.707	0.81
82_F	92_P	0.703	0.81
40_E	45_A	0.700	0.81
138_M	141_D	0.700	0.81
109_G	217_E	0.700	0.81
90_V	199_E	0.698	0.80
81_T	189_T	0.696	0.80
48_Y	51_W	0.696	0.80
117_R	150_L	0.695	0.80
102_Q	141_D	0.692	0.80
118_P	148_T	0.689	0.80
105_A	217_E	0.688	0.79
59_T	157_R	0.687	0.79
95_V	149_F	0.682	0.79
101_I	212_L	0.682	0.79
79_L	97_T	0.677	0.78
41_Y	44_S	0.677	0.78
121_F	186_A	0.676	0.78
121_F	170_F	0.675	0.78
43_A	47_P	0.675	0.78
36_E	41_Y	0.669	0.78
171_K	174_H	0.668	0.77
95_V	138_M	0.667	0.77
154_G	163_T	0.667	0.77
174_H	178_M	0.667	0.77
125_R	130_R	0.664	0.77
77_P	114_I	0.658	0.76
78_A	192_V	0.656	0.76
99_R	138_M	0.655	0.76
79_L	189_T	0.651	0.76
96_S	99_R	0.650	0.75
161_V	166_F	0.647	0.75
104_H	209_E	0.646	0.75
61_P	66_D	0.645	0.75
81_T	118_P	0.641	0.74
190_V	200_R	0.639	0.74
40_E	43_A	0.632	0.73
98_L	102_Q	0.627	0.73
102_Q	147_W	0.627	0.73
93_V	187_A	0.625	0.73
120_T	158_A	0.618	0.72
82_F	168_V	0.617	0.72
89_T	182_M	0.614	0.71
76_T	112_D	0.613	0.71
59_T	70_S	0.612	0.71
99_R	103_T	0.609	0.71
121_F	187_A	0.609	0.71
67_A	85_S	0.605	0.70
119_V	166_F	0.603	0.70
214_A	218_T	0.597	0.69
158_A	161_V	0.597	0.69
202_Y	212_L	0.596	0.69
149_F	168_V	0.594	0.69
69_V	78_A	0.593	0.69
44_S	49_P	0.593	0.69
78_A	117_R	0.593	0.69
103_T	106_A	0.591	0.68
93_V	97_T	0.589	0.68
105_A	216_L	0.589	0.68
97_T	206_S	0.588	0.68
210_Q	213_I	0.587	0.68
87_C	196_G	0.586	0.68
102_Q	139_H	0.585	0.68
168_V	190_V	0.585	0.68
129_D	156_D	0.583	0.67
105_A	108_N	0.583	0.67
131_L	147_W	0.577	0.67
63_A	117_R	0.575	0.66
214_A	217_E	0.574	0.66
119_V	167_G	0.568	0.65
44_S	48_Y	0.567	0.65
200_R	215_D	0.566	0.65
122_D	149_F	0.566	0.65
116_L	139_H	0.565	0.65
126_D	131_L	0.562	0.65
189_T	204_S	0.562	0.65
46_L	211_Q	0.558	0.64
85_S	126_D	0.555	0.64
53_E	158_A	0.552	0.63
85_S	183_F	0.550	0.63
80_Y	166_F	0.550	0.63
85_S	131_L	0.543	0.62
96_S	138_M	0.543	0.62
140_V	147_W	0.542	0.62
106_A	112_D	0.542	0.62
82_F	190_V	0.541	0.62
47_P	50_A	0.541	0.62
173_T	181_Y	0.535	0.61
74_T	115_A	0.531	0.60
161_V	174_H	0.530	0.60
209_E	215_D	0.530	0.60
208_D	217_E	0.529	0.60
91_C	196_G	0.529	0.60
150_L	158_A	0.528	0.60
79_L	103_T	0.527	0.60
141_D	147_W	0.525	0.59
62_A	132_A	0.525	0.59
190_V	198_V	0.524	0.59
49_P	218_T	0.521	0.59
165_D	169_T	0.519	0.58
163_T	166_F	0.515	0.58
99_R	136_E	0.513	0.58
104_H	217_E	0.512	0.57
86_H	130_R	0.511	0.57
212_L	215_D	0.511	0.57
93_V	96_S	0.509	0.57
169_T	184_S	0.508	0.57
172_R	183_F	0.507	0.57
126_D	191_L	0.507	0.57
128_A	135_G	0.505	0.56
124_E	156_D	0.502	0.56
94_L	183_F	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ggtA	1	0.7252	100	0.453	Contact Map
1xzoA	3	0.7568	100	0.491	Contact Map
2k6vA	1	0.7613	100	0.502	Contact Map
4bpyA	1	0.7027	100	0.522	Contact Map
2rliA	1	0.7342	100	0.527	Contact Map
2b7kA	1	0.7342	99.9	0.53	Contact Map
4hdeA	1	0.7432	99.9	0.533	Contact Map
4txoD	1	0.7117	99.9	0.535	Contact Map
3me7A	1	0.7162	99.9	0.549	Contact Map
2f8aA	3	0.7072	99.9	0.564	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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