GREMLIN Database
Q9HSN2 - Regulatory protein
UniProt: Q9HSN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (173)
Sequences: 1929 (1391)
Seq/√Len: 105.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_G132_A3.8191.00
62_A67_A3.5901.00
151_R158_A2.7781.00
69_V74_T2.7371.00
76_T115_A2.6771.00
62_A65_G2.5901.00
77_P194_A2.5431.00
104_H213_I2.5001.00
57_D71_T2.4511.00
62_A148_T2.4501.00
153_A157_R2.2951.00
193_N199_E2.2651.00
121_F183_F2.2211.00
152_P158_A2.1991.00
122_D125_R2.1741.00
208_D211_Q2.0991.00
63_A132_A2.0711.00
98_L189_T2.0641.00
127_T130_R2.0321.00
132_A136_E2.0311.00
101_I213_I2.0211.00
61_P67_A1.9181.00
86_H125_R1.9101.00
125_R181_Y1.8371.00
135_G149_F1.8291.00
63_A135_G1.8061.00
106_A109_G1.7901.00
87_C91_C1.7811.00
154_G159_K1.7541.00
193_N197_Y1.7461.00
62_A69_V1.7151.00
157_R160_A1.6441.00
70_S73_E1.6381.00
34_L38_D1.6351.00
59_T68_T1.5781.00
74_T78_A1.5691.00
56_P165_D1.5681.00
163_T170_F1.5331.00
108_N217_E1.5211.00
113_D194_A1.4941.00
106_A141_D1.4801.00
215_D219_V1.4481.00
154_G170_F1.4401.00
83_F118_P1.4361.00
74_T148_T1.4311.00
80_Y119_V1.4141.00
83_F95_V1.3991.00
91_C185_H1.3741.00
68_T157_R1.3651.00
130_R133_S1.3581.00
82_F166_F1.3200.99
44_S47_P1.3170.99
84_Y182_M1.3150.99
87_C185_H1.3100.99
104_H210_Q1.3060.99
75_E196_G1.2710.99
133_S137_R1.2600.99
115_A148_T1.2340.99
86_H122_D1.1920.99
118_P147_W1.1860.99
55_V166_F1.1820.99
128_A151_R1.1810.99
202_Y215_D1.1720.99
99_R139_H1.1700.99
94_L97_T1.1690.99
81_T95_V1.1680.99
60_V119_V1.1660.99
83_F149_F1.1650.99
135_G147_W1.1450.98
175_P178_M1.1230.98
77_P199_E1.1150.98
57_D72_R1.1100.98
80_Y192_V1.1050.98
160_A165_D1.1040.98
123_P151_R1.0820.98
79_L216_L1.0770.98
210_Q214_A1.0660.97
61_P68_T1.0650.97
120_T151_R1.0640.97
77_P193_N1.0590.97
134_Y138_M1.0590.97
90_V187_A1.0480.97
129_D133_S1.0450.97
49_P52_G1.0420.97
119_V161_V1.0380.97
124_E172_R1.0370.97
61_P151_R1.0350.97
120_T123_P1.0300.97
34_L37_P1.0300.97
95_V118_P1.0200.97
60_V152_P1.0150.96
95_V134_Y1.0070.96
80_Y117_R1.0070.96
156_D160_A1.0040.96
35_P38_D1.0030.96
77_P216_L1.0000.96
81_T94_L0.9920.96
108_N113_D0.9890.96
84_Y167_G0.9830.96
58_A166_F0.9810.96
166_F190_V0.9760.96
140_V149_F0.9630.95
71_T196_G0.9590.95
69_V73_E0.9560.95
58_A84_Y0.9440.95
191_L202_Y0.9080.93
199_E219_V0.8990.93
124_E154_G0.8970.93
69_V150_L0.8960.93
74_T117_R0.8860.93
153_A156_D0.8850.93
102_Q116_L0.8850.93
189_T212_L0.8820.92
215_D218_T0.8820.92
59_T67_A0.8780.92
78_A115_A0.8770.92
71_T78_A0.8730.92
69_V148_T0.8720.92
209_E213_I0.8710.92
164_D169_T0.8680.92
94_L189_T0.8630.92
159_K164_D0.8580.91
213_I217_E0.8520.91
55_V161_V0.8300.90
116_L147_W0.8220.90
63_A128_A0.8200.89
57_D70_S0.8120.89
118_P149_F0.7840.87
170_F188_L0.7660.86
98_L116_L0.7630.86
101_I104_H0.7610.86
100_N209_E0.7580.85
36_E40_E0.7450.84
188_L201_T0.7410.84
58_A70_S0.7380.84
77_P219_V0.7360.84
83_F147_W0.7350.84
63_A148_T0.7340.84
173_T182_M0.7330.83
101_I116_L0.7330.83
100_N104_H0.7300.83
88_Q95_V0.7290.83
122_D138_M0.7280.83
193_N219_V0.7280.83
154_G172_R0.7260.83
120_T156_D0.7240.83
42_D45_A0.7240.83
94_L116_L0.7150.82
181_Y184_S0.7070.81
82_F92_P0.7030.81
40_E45_A0.7000.81
138_M141_D0.7000.81
109_G217_E0.7000.81
90_V199_E0.6980.80
81_T189_T0.6960.80
48_Y51_W0.6960.80
117_R150_L0.6950.80
102_Q141_D0.6920.80
118_P148_T0.6890.80
105_A217_E0.6880.79
59_T157_R0.6870.79
95_V149_F0.6820.79
101_I212_L0.6820.79
79_L97_T0.6770.78
41_Y44_S0.6770.78
121_F186_A0.6760.78
121_F170_F0.6750.78
43_A47_P0.6750.78
36_E41_Y0.6690.78
171_K174_H0.6680.77
95_V138_M0.6670.77
154_G163_T0.6670.77
174_H178_M0.6670.77
125_R130_R0.6640.77
77_P114_I0.6580.76
78_A192_V0.6560.76
99_R138_M0.6550.76
79_L189_T0.6510.76
96_S99_R0.6500.75
161_V166_F0.6470.75
104_H209_E0.6460.75
61_P66_D0.6450.75
81_T118_P0.6410.74
190_V200_R0.6390.74
40_E43_A0.6320.73
98_L102_Q0.6270.73
102_Q147_W0.6270.73
93_V187_A0.6250.73
120_T158_A0.6180.72
82_F168_V0.6170.72
89_T182_M0.6140.71
76_T112_D0.6130.71
59_T70_S0.6120.71
99_R103_T0.6090.71
121_F187_A0.6090.71
67_A85_S0.6050.70
119_V166_F0.6030.70
214_A218_T0.5970.69
158_A161_V0.5970.69
202_Y212_L0.5960.69
149_F168_V0.5940.69
69_V78_A0.5930.69
44_S49_P0.5930.69
78_A117_R0.5930.69
103_T106_A0.5910.68
93_V97_T0.5890.68
105_A216_L0.5890.68
97_T206_S0.5880.68
210_Q213_I0.5870.68
87_C196_G0.5860.68
102_Q139_H0.5850.68
168_V190_V0.5850.68
129_D156_D0.5830.67
105_A108_N0.5830.67
131_L147_W0.5770.67
63_A117_R0.5750.66
214_A217_E0.5740.66
119_V167_G0.5680.65
44_S48_Y0.5670.65
200_R215_D0.5660.65
122_D149_F0.5660.65
116_L139_H0.5650.65
126_D131_L0.5620.65
189_T204_S0.5620.65
46_L211_Q0.5580.64
85_S126_D0.5550.64
53_E158_A0.5520.63
85_S183_F0.5500.63
80_Y166_F0.5500.63
85_S131_L0.5430.62
96_S138_M0.5430.62
140_V147_W0.5420.62
106_A112_D0.5420.62
82_F190_V0.5410.62
47_P50_A0.5410.62
173_T181_Y0.5350.61
74_T115_A0.5310.60
161_V174_H0.5300.60
209_E215_D0.5300.60
208_D217_E0.5290.60
91_C196_G0.5290.60
150_L158_A0.5280.60
79_L103_T0.5270.60
141_D147_W0.5250.59
62_A132_A0.5250.59
190_V198_V0.5240.59
49_P218_T0.5210.59
165_D169_T0.5190.58
163_T166_F0.5150.58
99_R136_E0.5130.58
104_H217_E0.5120.57
86_H130_R0.5110.57
212_L215_D0.5110.57
93_V96_S0.5090.57
169_T184_S0.5080.57
172_R183_F0.5070.57
126_D191_L0.5070.57
128_A135_G0.5050.56
124_E156_D0.5020.56
94_L183_F0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggtA 1 0.7252 100 0.453 Contact Map
1xzoA 3 0.7568 100 0.491 Contact Map
2k6vA 1 0.7613 100 0.502 Contact Map
4bpyA 1 0.7027 100 0.522 Contact Map
2rliA 1 0.7342 100 0.527 Contact Map
2b7kA 1 0.7342 99.9 0.53 Contact Map
4hdeA 1 0.7432 99.9 0.533 Contact Map
4txoD 1 0.7117 99.9 0.535 Contact Map
3me7A 1 0.7162 99.9 0.549 Contact Map
2f8aA 3 0.7072 99.9 0.564 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.