GREMLIN Database
Q9HSN0 - Mercury(II) reductase
UniProt: Q9HSN0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (437)
Sequences: 14136 (9476)
Seq/√Len: 453.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_V262_G4.2101.00
294_A298_A4.1001.00
37_D118_T3.7531.00
175_S199_D3.0671.00
285_T292_D2.9891.00
414_Y428_M2.9061.00
199_D232_D2.8441.00
201_T234_R2.7461.00
376_D407_D2.7041.00
6_P113_T2.7031.00
146_A276_P2.6231.00
123_D126_T2.6011.00
6_P33_T2.5741.00
5_Q137_D2.5531.00
126_T133_R2.5491.00
278_G281_E2.5151.00
222_L226_R2.4821.00
376_D406_A2.4781.00
427_T446_Y2.4611.00
172_F198_M2.4541.00
21_A140_V2.4301.00
5_Q135_E2.3551.00
136_A139_V2.3531.00
405_D408_D2.3491.00
146_A274_S2.3261.00
215_P368_E2.2481.00
148_N272_T2.2391.00
175_S263_E2.2081.00
409_G439_R2.2031.00
120_R128_V2.2031.00
9_V134_I2.1791.00
378_V406_A2.1491.00
33_T115_H2.1431.00
177_V203_I2.1401.00
365_L370_A2.1361.00
17_A307_V2.1111.00
128_V133_R2.1101.00
410_T435_G2.1051.00
251_R259_T2.0871.00
365_L373_A2.0821.00
8_V25_L2.0771.00
122_V128_V2.0491.00
241_A253_R2.0441.00
327_A331_A2.0421.00
431_V436_M2.0241.00
153_P241_A2.0221.00
243_E253_R1.9971.00
9_V35_I1.9881.00
186_V202_V1.9621.00
234_R258_T1.9381.00
207_D236_E1.9271.00
416_G421_A1.9111.00
117_D129_V1.9081.00
162_G165_D1.8761.00
9_V127_L1.8671.00
138_Y303_H1.8561.00
367_A371_R1.8341.00
146_A272_T1.8221.00
126_T135_E1.8191.00
125_R303_H1.7871.00
377_V403_V1.7681.00
122_V133_R1.7621.00
243_E251_R1.7561.00
193_S199_D1.7481.00
368_E372_A1.7231.00
121_F139_V1.6961.00
35_I134_I1.6941.00
9_V136_A1.6911.00
251_R261_E1.6911.00
80_D83_A1.6791.00
367_A401_R1.6441.00
176_G198_M1.6291.00
402_L414_Y1.6271.00
359_P422_D1.6191.00
240_E255_D1.6131.00
11_V119_A1.6081.00
298_A302_D1.6041.00
7_H137_D1.6001.00
186_V353_S1.5991.00
176_G192_L1.5981.00
160_W242_V1.5951.00
238_R255_D1.5881.00
140_V331_A1.5881.00
205_H238_R1.5681.00
253_R259_T1.5651.00
370_A377_V1.5641.00
177_V252_V1.5621.00
240_E253_R1.5581.00
208_R218_G1.5581.00
141_L310_A1.5541.00
7_H31_T1.5531.00
9_V33_T1.5341.00
8_V30_V1.5281.00
234_R237_V1.5271.00
161_M264_Q1.4991.00
174_D199_D1.4841.00
115_H134_I1.4771.00
375_H412_L1.4761.00
75_A80_D1.4671.00
216_V381_Q1.4671.00
305_F330_N1.4531.00
83_A86_D1.4511.00
193_S231_V1.4501.00
249_G261_E1.4431.00
437_D440_E1.4391.00
161_M169_A1.4341.00
369_A372_A1.4261.00
245_T251_R1.4241.00
75_A78_D1.4241.00
402_L458_F1.4191.00
370_A403_V1.4061.00
143_T310_A1.3941.00
201_T232_D1.3931.00
89_D93_L1.3811.00
297_Q311_M1.3791.00
138_Y331_A1.3701.00
174_D263_E1.3691.00
24_E329_R1.3681.00
220_E417_L1.3661.00
104_H116_H1.3501.00
296_M330_N1.3441.00
214_H401_R1.3421.00
194_E229_F1.3201.00
151_D155_I1.3191.00
237_V256_D1.3191.00
295_T339_D1.3191.00
376_D405_D1.3091.00
41_G114_F1.2971.00
8_V140_V1.2891.00
6_P115_H1.2891.00
140_V307_V1.2841.00
287_D292_D1.2791.00
379_T403_V1.2781.00
301_D304_V1.2701.00
298_A303_H1.2691.00
33_T134_I1.2671.00
166_V192_L1.2571.00
203_I260_A1.2491.00
62_H65_Q1.2481.00
181_F209_P1.2351.00
324_G328_G1.2251.00
121_F141_L1.2171.00
120_R278_G1.2041.00
285_T300_D1.2031.00
282_T301_D1.1981.00
159_D244_E1.1971.00
217_F417_L1.1901.00
222_L233_I1.1861.00
384_A418_H1.1851.00
86_D90_D1.1811.00
48_R164_R1.1801.00
223_A226_R1.1771.00
208_R215_P1.1771.00
217_F399_A1.1751.00
405_D410_T1.1681.00
213_F349_Q1.1681.00
31_T113_T1.1581.00
402_L428_M1.1571.00
85_V89_D1.1551.00
360_F417_L1.1541.00
291_V310_A1.1491.00
254_L260_A1.1361.00
221_I417_L1.1361.00
215_P219_E1.1351.00
73_T76_V1.1301.00
121_F127_L1.1291.00
202_V233_I1.1211.00
34_L107_A1.1211.00
11_V141_L1.1191.00
400_A453_V1.1161.00
307_V327_A1.1131.00
204_E235_T1.1121.00
35_I119_A1.1111.00
279_I284_L1.1081.00
216_V401_R1.1071.00
242_V265_L1.1051.00
68_H71_R1.1011.00
245_T261_E1.1001.00
179_M265_L1.1001.00
245_T249_G1.0991.00
38_G48_R1.0991.00
428_M454_L1.0991.00
213_F362_S1.0981.00
75_A83_A1.0931.00
370_A375_H1.0931.00
122_V126_T1.0911.00
434_A440_E1.0851.00
367_A379_T1.0791.00
81_L85_V1.0761.00
103_V107_A1.0721.00
149_V162_G1.0691.00
175_S249_G1.0681.00
208_R222_L1.0661.00
104_H108_E1.0631.00
157_D244_E1.0621.00
161_M165_D1.0531.00
17_A320_A1.0511.00
381_Q399_A1.0481.00
128_V131_G1.0471.00
103_V106_M1.0471.00
222_L235_T1.0381.00
221_I360_F1.0371.00
369_A373_A1.0371.00
361_A425_A1.0301.00
186_V225_Y1.0281.00
284_L301_D1.0271.00
367_A377_V1.0171.00
375_H405_D1.0171.00
102_A106_M1.0131.00
243_E259_T1.0111.00
159_D264_Q1.0101.00
23_E110_E1.0101.00
366_T369_A1.0081.00
113_T132_E1.0041.00
58_S62_H1.0021.00
226_R232_D1.0011.00
275_Y286_P1.0001.00
371_R377_V0.9981.00
293_P311_M0.9971.00
129_V134_I0.9961.00
115_H132_E0.9951.00
378_V409_G0.9941.00
176_G264_Q0.9941.00
24_E28_E0.9941.00
297_Q327_A0.9901.00
345_P432_L0.9891.00
203_I254_L0.9891.00
293_P306_V0.9891.00
217_F415_H0.9861.00
220_E224_Q0.9861.00
90_D94_G0.9851.00
361_A421_A0.9841.00
349_Q362_S0.9781.00
284_L291_V0.9781.00
154_G157_D0.9771.00
28_E329_R0.9721.00
176_G266_F0.9671.00
225_Y231_V0.9661.00
175_S261_E0.9631.00
409_G438_V0.9611.00
121_F136_A0.9591.00
30_V137_D0.9571.00
436_M440_E0.9541.00
126_T129_V0.9511.00
121_F282_T0.9501.00
152_L155_I0.9491.00
25_L328_G0.9461.00
121_F278_G0.9421.00
327_A330_N0.9371.00
326_A330_N0.9371.00
175_S198_M0.9361.00
426_K451_P0.9351.00
35_I129_V0.9291.00
121_F281_E0.9281.00
234_R260_A0.9281.00
28_E332_L0.9271.00
13_A34_L0.9251.00
117_D130_D0.9251.00
219_E223_A0.9251.00
420_H423_V0.9221.00
177_V260_A0.9211.00
13_A41_G0.9191.00
208_R368_E0.9181.00
209_P235_T0.9171.00
237_V254_L0.9131.00
282_T304_V0.9111.00
411_V428_M0.9101.00
30_V332_L0.9081.00
244_E250_V0.9081.00
363_L432_L0.9071.00
30_V138_Y0.9061.00
286_P292_D0.9061.00
298_A330_N0.9041.00
175_S201_T0.9021.00
120_R281_E0.9011.00
85_V88_K0.9001.00
82_D170_T0.9001.00
125_R129_V0.8991.00
375_H403_V0.8981.00
88_K92_V0.8971.00
101_A105_D0.8961.00
279_I282_T0.8951.00
292_D300_D0.8921.00
112_V117_D0.8911.00
209_P233_I0.8891.00
66_A69_D0.8891.00
107_A112_V0.8891.00
185_G204_E0.8881.00
350_V422_D0.8871.00
161_M166_V0.8841.00
209_P222_L0.8811.00
7_H30_V0.8811.00
82_D86_D0.8811.00
181_F204_E0.8791.00
175_S262_G0.8781.00
224_Q417_L0.8781.00
381_Q401_R0.8771.00
365_L369_A0.8771.00
165_D168_D0.8761.00
179_M269_T0.8761.00
147_L150_P0.8721.00
284_L300_D0.8701.00
101_A104_H0.8671.00
45_C50_C0.8661.00
107_A114_F0.8661.00
367_A403_V0.8661.00
283_R301_D0.8651.00
242_V250_V0.8631.00
64_Y67_R0.8631.00
138_Y305_F0.8621.00
139_V304_V0.8591.00
153_P157_D0.8581.00
44_L47_L0.8571.00
183_Y351_M0.8571.00
400_A416_G0.8561.00
153_P156_A0.8551.00
6_P31_T0.8541.00
278_G282_T0.8531.00
20_A321_K0.8531.00
64_Y229_F0.8521.00
431_V441_I0.8521.00
59_A84_V0.8511.00
342_T433_A0.8501.00
179_M267_L0.8491.00
171_E264_Q0.8451.00
203_I234_R0.8421.00
232_D258_T0.8361.00
189_V231_V0.8361.00
100_R103_V0.8321.00
73_T77_P0.8301.00
366_T415_H0.8251.00
224_Q397_R0.8251.00
250_V253_R0.8241.00
237_V258_T0.8211.00
328_G332_L0.8191.00
11_V277_A0.8191.00
159_D250_V0.8181.00
220_E223_A0.8181.00
298_A305_F0.8181.00
148_N269_T0.8161.00
25_L30_V0.8151.00
224_Q229_F0.8131.00
60_G194_E0.8111.00
193_S229_F0.8111.00
179_M239_E0.8091.00
299_R306_V0.8091.00
291_V306_V0.8091.00
217_F360_F0.8051.00
72_L77_P0.8041.00
158_T244_E0.8001.00
59_A87_T0.7991.00
21_A324_G0.7991.00
427_T430_V0.7981.00
436_M441_I0.7971.00
203_I237_V0.7961.00
201_T262_G0.7951.00
306_V310_A0.7911.00
219_E222_L0.7871.00
100_R104_H0.7861.00
287_D312_G0.7831.00
86_D170_T0.7831.00
66_A76_V0.7831.00
21_A327_A0.7821.00
21_A328_G0.7811.00
99_R102_A0.7801.00
152_L156_A0.7771.00
99_R103_V0.7751.00
9_V139_V0.7731.00
124_D303_H0.7731.00
57_L191_Y0.7731.00
380_S457_L0.7721.00
24_E27_D0.7721.00
282_T300_D0.7701.00
249_G254_L0.7691.00
204_E211_D0.7671.00
64_Y68_H0.7641.00
30_V331_A0.7641.00
428_M432_L0.7641.00
89_D92_V0.7591.00
178_V266_F0.7581.00
207_D215_P0.7531.00
24_E328_G0.7531.00
378_V404_V0.7521.00
433_A443_D0.7511.00
160_W267_L0.7511.00
383_D386_S0.7501.00
149_V155_I0.7491.00
206_D211_D0.7481.00
35_I117_D0.7481.00
370_A412_L0.7461.00
58_S61_A0.7451.00
363_L429_Q0.7451.00
72_L76_V0.7451.00
214_H415_H0.7441.00
297_Q330_N0.7401.00
79_V84_V0.7401.00
8_V328_G0.7391.00
282_T286_P0.7381.00
326_A340_L0.7381.00
402_L457_L0.7361.00
298_A301_D0.7331.00
63_R67_R0.7331.00
125_R135_E0.7321.00
244_E249_G0.7321.00
276_P280_E0.7311.00
405_D412_L0.7311.00
140_V327_A0.7271.00
148_N151_D0.7271.00
208_R219_E0.7261.00
194_E354_G0.7261.00
56_V85_V0.7251.00
150_P267_L0.7251.00
10_I18_G0.7231.00
189_V202_V0.7231.00
64_Y194_E0.7181.00
88_K91_H0.7181.00
71_R77_P0.7171.00
10_I22_A0.7161.00
61_A65_Q0.7141.00
139_V303_H0.7141.00
249_G252_V0.7131.00
329_R334_V0.7121.00
414_Y432_L0.7121.00
105_D109_R0.7111.00
225_Y233_I0.7101.00
43_G46_I0.7091.00
221_I353_S0.7071.00
83_A87_T0.7051.00
297_Q326_A0.7041.00
74_G77_P0.7031.00
42_G46_I0.7021.00
125_R301_D0.7021.00
71_R76_V0.7001.00
205_H211_D0.6991.00
94_G391_K0.6951.00
124_D283_R0.6941.00
90_D93_L0.6941.00
371_R374_G0.6941.00
149_V154_G0.6881.00
210_L221_I0.6851.00
279_I286_P0.6841.00
314_R346_F0.6831.00
249_G263_E0.6821.00
411_V432_L0.6811.00
124_D129_V0.6811.00
322_E325_Y0.6801.00
275_Y310_A0.6781.00
430_V436_M0.6781.00
359_P420_H0.6771.00
254_L258_T0.6761.00
296_M335_E0.6761.00
6_P9_V0.6761.00
191_Y196_A0.6751.00
178_V185_G0.6751.00
319_N346_F0.6741.00
143_T277_A0.6701.00
149_V267_L0.6701.00
410_T437_D0.6691.00
277_A282_T0.6691.00
251_R254_L0.6691.00
157_D165_D0.6691.00
440_E443_D0.6691.00
403_V406_A0.6681.00
416_G424_M0.6681.00
152_L239_E0.6661.00
47_L100_R0.6661.00
185_G205_H0.6641.00
186_V209_P0.6641.00
237_V255_D0.6641.00
169_A264_Q0.6631.00
11_V127_L0.6631.00
105_D108_E0.6631.00
53_S57_L0.6611.00
430_V434_A0.6601.00
380_S404_V0.6601.00
384_A453_V0.6581.00
53_S188_L0.6551.00
323_E343_Y0.6551.00
447_H452_E0.6541.00
155_I160_W0.6511.00
438_V442_P0.6501.00
408_D435_G0.6491.00
295_T342_T0.6491.00
423_V451_P0.6471.00
81_L88_K0.6461.00
87_T91_H0.6461.00
36_D40_P0.6451.00
234_R254_L0.6451.00
86_D89_D0.6451.00
190_P194_E0.6410.99
329_R333_A0.6390.99
87_T90_D0.6380.99
102_A105_D0.6380.99
7_H33_T0.6380.99
82_D85_V0.6360.99
70_D75_A0.6350.99
84_V196_A0.6340.99
186_V233_I0.6340.99
418_H421_A0.6340.99
430_V441_I0.6330.99
404_V438_V0.6330.99
50_C54_K0.6330.99
217_F220_E0.6300.99
389_V392_T0.6300.99
359_P450_T0.6290.99
17_A142_G0.6290.99
28_E334_V0.6290.99
26_V32_L0.6260.99
145_S271_R0.6230.99
284_L304_V0.6230.99
307_V324_G0.6230.99
42_G45_C0.6220.99
190_P225_Y0.6220.99
67_R70_D0.6210.99
163_S271_R0.6190.99
164_R271_R0.6190.99
26_V112_V0.6190.99
147_L155_I0.6150.99
104_H114_F0.6150.99
411_V414_Y0.6140.99
430_V444_R0.6140.99
117_D122_V0.6130.99
213_F351_M0.6120.99
293_P297_Q0.6090.99
150_P155_I0.6080.99
142_G307_V0.6060.99
220_E399_A0.6040.99
250_V265_L0.6040.99
155_I267_L0.6030.99
441_I458_F0.5990.99
69_D76_V0.5980.99
190_P229_F0.5970.99
198_M263_E0.5970.99
175_S193_S0.5970.99
414_Y454_L0.5970.99
104_H107_A0.5960.99
322_E326_A0.5950.99
37_D274_S0.5940.99
245_T248_G0.5940.99
151_D156_A0.5920.99
396_A419_Y0.5920.99
395_A419_Y0.5900.99
27_D110_E0.5890.99
23_E27_D0.5860.99
65_Q68_H0.5860.99
71_R74_G0.5850.99
69_D72_L0.5840.99
113_T116_H0.5840.99
40_P48_R0.5840.99
348_H353_S0.5830.99
365_L375_H0.5800.99
115_H129_V0.5780.99
66_A74_G0.5780.99
70_D83_A0.5770.99
319_N323_E0.5770.99
254_L257_G0.5770.99
124_D282_T0.5760.99
344_D373_A0.5760.99
150_P154_G0.5760.99
404_V409_G0.5760.99
173_P198_M0.5750.99
291_V299_R0.5740.99
25_L331_A0.5740.99
151_D154_G0.5730.99
68_H394_D0.5720.99
286_P291_V0.5710.99
343_Y346_F0.5710.99
429_Q433_A0.5710.99
185_G268_F0.5700.99
140_V328_G0.5670.99
99_R106_M0.5650.99
414_Y425_A0.5640.99
5_Q31_T0.5640.99
25_L332_L0.5620.99
25_L32_L0.5620.99
296_M339_D0.5600.99
115_H118_T0.5580.99
388_G392_T0.5580.99
28_E328_G0.5570.99
44_L49_G0.5570.99
398_G416_G0.5570.99
85_V170_T0.5540.99
377_V412_L0.5540.99
51_M54_K0.5530.99
390_F450_T0.5530.99
349_Q354_G0.5530.99
288_P292_D0.5520.98
204_E239_E0.5520.98
322_E455_D0.5490.98
188_L191_Y0.5490.98
242_V267_L0.5490.98
38_G164_R0.5470.98
192_L198_M0.5460.98
439_R443_D0.5460.98
368_E371_R0.5460.98
93_L101_A0.5440.98
377_V406_A0.5440.98
43_G47_L0.5430.98
88_K168_D0.5400.98
325_Y329_R0.5390.98
340_L343_Y0.5370.98
311_M323_E0.5360.98
66_A70_D0.5350.98
185_G211_D0.5330.98
188_L266_F0.5330.98
36_D114_F0.5320.98
362_S415_H0.5310.98
424_M450_T0.5310.98
218_G222_L0.5310.98
380_S402_L0.5300.98
321_K455_D0.5300.98
190_P354_G0.5300.98
177_V265_L0.5290.98
58_S393_K0.5290.98
19_V34_L0.5290.98
119_A122_V0.5280.98
159_D248_G0.5280.98
242_V252_V0.5270.98
205_H269_T0.5230.98
91_H94_G0.5230.98
45_C54_K0.5220.98
21_A307_V0.5220.98
81_L84_V0.5220.98
183_Y349_Q0.5210.98
121_F277_A0.5210.98
155_I162_G0.5200.98
51_M388_G0.5190.98
121_F303_H0.5190.98
160_W265_L0.5180.98
47_L51_M0.5170.98
164_R167_L0.5170.98
427_T451_P0.5160.98
432_L436_M0.5160.98
365_L413_G0.5160.98
101_A106_M0.5150.98
145_S315_M0.5150.98
169_A192_L0.5150.98
366_T403_V0.5150.98
141_L291_V0.5140.98
383_D397_R0.5110.98
433_A444_R0.5110.98
415_H428_M0.5100.97
203_I262_G0.5100.97
201_T260_A0.5100.97
163_S184_V0.5100.97
57_L61_A0.5090.97
221_I225_Y0.5090.97
61_A354_G0.5080.97
147_L151_D0.5080.97
65_Q69_D0.5080.97
10_I32_L0.5070.97
232_D235_T0.5070.97
345_P429_Q0.5040.97
89_D168_D0.5030.97
305_F331_A0.5020.97
391_K396_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9656 100 0.223 Contact Map
3ic9A 2 0.9699 100 0.225 Contact Map
3ladA 2 0.9634 100 0.236 Contact Map
1zmdA 4 0.9699 100 0.239 Contact Map
3o0hA 2 0.957 100 0.241 Contact Map
1xdiA 3 0.9484 100 0.242 Contact Map
2r9zA 2 0.957 100 0.243 Contact Map
2eq6A 2 0.957 100 0.244 Contact Map
2wpfA 2 0.9634 100 0.245 Contact Map
3dk9A 2 0.9484 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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