GREMLIN Database
Q9HSM9 - Uncharacterized protein
UniProt: Q9HSM9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (205)
Sequences: 1861 (1499)
Seq/√Len: 104.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_Y216_E4.5531.00
192_V197_I4.2501.00
179_L183_M4.1151.00
183_M197_I3.3751.00
207_T211_H3.3661.00
204_A207_T3.1541.00
98_L103_I3.1531.00
176_V201_I3.0621.00
103_I122_L3.0261.00
172_R211_H3.0121.00
183_M200_E2.9311.00
192_V196_D2.8511.00
179_L197_I2.8171.00
187_D191_T2.8071.00
193_R196_D2.7861.00
181_T221_A2.7711.00
44_L84_V2.5161.00
172_R176_V2.4771.00
188_E209_W2.3611.00
172_R175_E2.3391.00
194_V208_T2.2661.00
19_S114_G2.2271.00
57_L82_V2.2141.00
174_R178_A2.1321.00
7_R115_W2.0941.00
203_L208_T1.9911.00
106_R121_Y1.9401.00
46_V56_F1.8891.00
18_V63_A1.8241.00
176_V211_H1.8041.00
177_L220_M1.7701.00
205_D209_W1.7601.00
194_V209_W1.7511.00
52_H55_G1.6871.00
211_H214_R1.6441.00
6_L120_L1.6051.00
197_I208_T1.5981.00
177_L186_Y1.5951.00
7_R144_E1.5941.00
192_V200_E1.5141.00
176_V197_I1.4681.00
199_D202_G1.4561.00
190_A213_S1.4521.00
188_E210_E1.3981.00
66_V69_V1.3961.00
183_M192_V1.3811.00
220_M223_V1.3791.00
176_V208_T1.3771.00
131_E134_A1.3560.99
219_V223_V1.3410.99
184_G191_T1.3240.99
196_D199_D1.3240.99
70_D192_V1.3200.99
186_Y212_L1.3050.99
207_T210_E1.3040.99
194_V211_H1.2950.99
124_D128_D1.2700.99
210_E214_R1.2690.99
186_Y215_A1.2570.99
220_M224_G1.2490.99
211_H218_T1.2400.99
7_R146_V1.2400.99
181_T224_G1.2390.99
136_I141_S1.2280.99
125_G204_A1.2260.99
72_W111_V1.2200.99
42_R86_H1.2120.99
206_T210_E1.1440.98
35_G202_G1.1200.98
207_T212_L1.1080.98
169_L215_A1.1010.98
105_H120_L1.1010.98
198_A208_T1.0940.98
53_V80_V1.0930.98
185_Y190_A1.0890.98
176_V203_L1.0890.98
53_V56_F1.0850.98
121_Y186_Y1.0800.97
117_H146_V1.0770.97
166_L223_V1.0750.97
195_A205_D1.0750.97
8_V67_R1.0740.97
188_E211_H1.0590.97
71_A82_V1.0580.97
112_R115_W1.0560.97
176_V215_A1.0500.97
217_E221_A1.0490.97
25_V31_S1.0460.97
71_A80_V1.0450.97
47_R79_H1.0410.97
23_P140_G1.0340.97
201_I208_T1.0330.97
4_V125_G1.0320.97
27_V44_L1.0230.96
168_A222_E0.9990.96
188_E213_S0.9960.96
133_V143_A0.9960.96
18_V25_V0.9950.96
188_E206_T0.9860.96
57_L69_V0.9740.95
212_L216_E0.9550.95
122_L144_E0.9410.94
181_T186_Y0.9330.94
194_V205_D0.9290.94
178_A182_R0.9260.94
148_A185_Y0.9240.94
54_Q76_D0.9220.94
194_V207_T0.9210.94
145_L148_A0.9170.94
204_A213_S0.9150.94
172_R210_E0.9140.94
21_D224_G0.9050.93
207_T215_A0.8910.93
96_A100_D0.8900.93
82_V128_D0.8870.92
205_D214_R0.8840.92
188_E217_E0.8820.92
17_D65_P0.8820.92
6_L119_T0.8810.92
6_L133_V0.8690.92
130_T133_V0.8640.91
4_V129_P0.8620.91
80_V83_A0.8560.91
186_Y194_V0.8520.91
175_E178_A0.8480.91
78_D90_D0.8450.91
27_V31_S0.8420.90
45_A133_V0.8370.90
144_E152_E0.8350.90
72_W81_F0.8310.90
36_S135_A0.8190.89
4_V120_L0.8090.89
47_R50_G0.8080.89
194_V215_A0.8060.88
134_A138_A0.8040.88
219_V222_E0.8030.88
185_Y194_V0.8030.88
215_A220_M0.8000.88
25_V29_A0.7940.88
13_A116_E0.7920.87
19_S27_V0.7920.87
63_A215_A0.7830.87
35_G42_R0.7830.87
52_H113_A0.7790.87
19_S115_W0.7790.87
4_V154_G0.7770.86
102_G135_A0.7760.86
188_E195_A0.7750.86
16_S66_V0.7700.86
13_A19_S0.7650.86
60_V127_P0.7550.85
203_L206_T0.7550.85
207_T214_R0.7520.85
6_L118_W0.7470.84
123_P200_E0.7460.84
132_A210_E0.7430.84
27_V30_V0.7410.84
108_G186_Y0.7400.84
197_I201_I0.7370.83
109_S118_W0.7340.83
185_Y212_L0.7340.83
46_V50_G0.7330.83
54_Q69_V0.7330.83
101_H135_A0.7320.83
133_V207_T0.7310.83
31_S34_P0.7280.83
122_L186_Y0.7280.83
55_G59_T0.7230.82
105_H131_E0.7220.82
5_T175_E0.7220.82
57_L60_V0.7190.82
63_A66_V0.7190.82
128_D131_E0.7180.82
95_T208_T0.7170.82
184_G209_W0.7160.82
58_D62_A0.7130.81
85_T205_D0.7100.81
214_R217_E0.7070.81
110_V117_H0.7060.81
46_V59_T0.7060.81
20_A114_G0.7010.80
183_M208_T0.6980.80
11_H183_M0.6950.80
13_A16_S0.6920.79
175_E179_L0.6900.79
56_F82_V0.6870.79
155_A163_S0.6850.79
177_L224_G0.6770.78
99_A197_I0.6730.78
36_S39_D0.6700.77
103_I108_G0.6650.77
54_Q67_R0.6640.77
132_A205_D0.6610.76
5_T117_H0.6590.76
123_P137_E0.6590.76
10_N13_A0.6590.76
86_H166_L0.6580.76
68_S71_A0.6540.76
79_H171_D0.6500.75
179_L201_I0.6500.75
96_A102_G0.6490.75
10_N118_W0.6490.75
73_S201_I0.6440.74
97_H100_D0.6430.74
148_A206_T0.6430.74
24_A112_R0.6420.74
67_R138_A0.6410.74
4_V122_L0.6400.74
76_D149_A0.6390.74
167_D223_V0.6310.73
4_V145_L0.6280.73
98_L120_L0.6270.72
53_V57_L0.6270.72
56_F151_V0.6250.72
4_V10_N0.6220.72
95_T215_A0.6210.72
60_V140_G0.6170.71
14_P17_D0.6160.71
16_S81_F0.6150.71
137_E203_L0.6150.71
97_H193_R0.6150.71
8_V141_S0.6120.71
61_A131_E0.6100.70
165_M214_R0.6080.70
55_G58_D0.6080.70
93_S96_A0.6070.70
214_R219_V0.6050.70
27_V46_V0.6030.70
120_L124_D0.6000.69
13_A86_H0.5990.69
127_P185_Y0.5990.69
177_L216_E0.5980.69
187_D217_E0.5960.69
65_P170_T0.5950.68
173_Q176_V0.5940.68
14_P18_V0.5910.68
192_V208_T0.5880.68
130_T207_T0.5880.68
13_A118_W0.5880.68
10_N16_S0.5870.67
197_I202_G0.5860.67
181_T220_M0.5850.67
106_R119_T0.5840.67
104_H121_Y0.5820.67
51_D124_D0.5820.67
174_R223_V0.5810.67
79_H147_A0.5770.66
131_E191_T0.5720.65
22_Y51_D0.5680.65
103_I106_R0.5670.65
186_Y220_M0.5650.65
179_L200_E0.5640.64
24_A73_S0.5630.64
42_R46_V0.5590.64
83_A188_E0.5590.64
140_G200_E0.5580.64
108_G216_E0.5580.64
54_Q57_L0.5580.64
145_L203_L0.5570.63
20_A77_A0.5570.63
22_Y58_D0.5540.63
39_D67_R0.5530.63
62_A183_M0.5500.62
78_D84_V0.5480.62
70_D83_A0.5480.62
41_S44_L0.5470.62
31_S45_A0.5460.62
60_V214_R0.5430.61
95_T105_H0.5420.61
12_G44_L0.5420.61
38_G42_R0.5420.61
163_S214_R0.5410.61
122_L213_S0.5390.61
90_D198_A0.5390.61
120_L142_D0.5380.61
4_V210_E0.5350.60
43_I105_H0.5350.60
41_S146_V0.5330.60
18_V37_D0.5320.60
43_I109_S0.5310.60
129_P175_E0.5280.59
191_T197_I0.5270.59
177_L215_A0.5270.59
29_A129_P0.5240.59
168_A221_A0.5240.59
68_S128_D0.5230.59
130_T165_M0.5210.58
78_D138_A0.5180.58
115_W163_S0.5170.58
146_V221_A0.5160.58
10_N116_E0.5160.58
201_I209_W0.5160.58
179_L192_V0.5140.57
142_D182_R0.5140.57
91_W98_L0.5110.57
190_A219_V0.5100.57
77_A202_G0.5090.57
76_D217_E0.5070.56
10_N14_P0.5070.56
103_I109_S0.5060.56
181_T223_V0.5060.56
174_R222_E0.5050.56
129_P147_A0.5050.56
178_A224_G0.5030.56
100_D155_A0.5020.56
58_D224_G0.5010.55
25_V56_F0.5000.55
6_L114_G0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ku3A 1 0.2629 97.7 0.839 Contact Map
4wszA 2 0.2629 97.5 0.846 Contact Map
1je8A 2 0.2672 97.5 0.846 Contact Map
1s7oA 3 0.3233 97.4 0.847 Contact Map
1xsvA 2 0.319 97.2 0.852 Contact Map
3hugA 3 0.3448 97.2 0.853 Contact Map
2o8xA 7 0.2629 97.2 0.854 Contact Map
2rnjA 1 0.2629 97.2 0.854 Contact Map
1fseA 2 0.2716 97.1 0.854 Contact Map
1x3uA 1 0.3103 97.1 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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