Q9HSM9 - HALSA - GREMLIN Contacts

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Q9HSM9 - Uncharacterized protein

UniProt:	Q9HSM9	Sequences: MRDVTLRVRNHGAPASDVSADYPAVTVRAVSSLPGSDGDRSRILAVRGPGDHVQGFLDTVAAADPVRSVDAWSGRDADHVFVAVTHDTTDWRSVTAHLADHGIHHRGGSVVRAGWEHWTLYLPDGDPDPTEAVAAIEAAGSDAELVAAASVEAGAGGEHFAVSRMLDALTDRQREVLALATRMGYYDEAATVRVADIADEIGLADTTTWEHLSRAEETVMAEVGAHLAARGH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	232 (205)
Sequences:	1861 (1499)
Seq/√Len:	104.7

HALSA - Q9HSM9 O54637 Q9HR58 Q9HSR5 Q9HQD9 Q9HPS7 DMSR Q9HQU9
SULSO - Q97YL7 Q97UD7 Q97YT8 Q97Y14 Q97WR0 Q97X87 Q7LXI8 Q97UC0 Q97ZB6 Q97ZX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
186_Y	216_E	4.553	1.00
192_V	197_I	4.250	1.00
179_L	183_M	4.115	1.00
183_M	197_I	3.375	1.00
207_T	211_H	3.366	1.00
204_A	207_T	3.154	1.00
98_L	103_I	3.153	1.00
176_V	201_I	3.062	1.00
103_I	122_L	3.026	1.00
172_R	211_H	3.012	1.00
183_M	200_E	2.931	1.00
192_V	196_D	2.851	1.00
179_L	197_I	2.817	1.00
187_D	191_T	2.807	1.00
193_R	196_D	2.786	1.00
181_T	221_A	2.771	1.00
44_L	84_V	2.516	1.00
172_R	176_V	2.477	1.00
188_E	209_W	2.361	1.00
172_R	175_E	2.339	1.00
194_V	208_T	2.266	1.00
19_S	114_G	2.227	1.00
57_L	82_V	2.214	1.00
174_R	178_A	2.132	1.00
7_R	115_W	2.094	1.00
203_L	208_T	1.991	1.00
106_R	121_Y	1.940	1.00
46_V	56_F	1.889	1.00
18_V	63_A	1.824	1.00
176_V	211_H	1.804	1.00
177_L	220_M	1.770	1.00
205_D	209_W	1.760	1.00
194_V	209_W	1.751	1.00
52_H	55_G	1.687	1.00
211_H	214_R	1.644	1.00
6_L	120_L	1.605	1.00
197_I	208_T	1.598	1.00
177_L	186_Y	1.595	1.00
7_R	144_E	1.594	1.00
192_V	200_E	1.514	1.00
176_V	197_I	1.468	1.00
199_D	202_G	1.456	1.00
190_A	213_S	1.452	1.00
188_E	210_E	1.398	1.00
66_V	69_V	1.396	1.00
183_M	192_V	1.381	1.00
220_M	223_V	1.379	1.00
176_V	208_T	1.377	1.00
131_E	134_A	1.356	0.99
219_V	223_V	1.341	0.99
184_G	191_T	1.324	0.99
196_D	199_D	1.324	0.99
70_D	192_V	1.320	0.99
186_Y	212_L	1.305	0.99
207_T	210_E	1.304	0.99
194_V	211_H	1.295	0.99
124_D	128_D	1.270	0.99
210_E	214_R	1.269	0.99
186_Y	215_A	1.257	0.99
220_M	224_G	1.249	0.99
211_H	218_T	1.240	0.99
7_R	146_V	1.240	0.99
181_T	224_G	1.239	0.99
136_I	141_S	1.228	0.99
125_G	204_A	1.226	0.99
72_W	111_V	1.220	0.99
42_R	86_H	1.212	0.99
206_T	210_E	1.144	0.98
35_G	202_G	1.120	0.98
207_T	212_L	1.108	0.98
169_L	215_A	1.101	0.98
105_H	120_L	1.101	0.98
198_A	208_T	1.094	0.98
53_V	80_V	1.093	0.98
185_Y	190_A	1.089	0.98
176_V	203_L	1.089	0.98
53_V	56_F	1.085	0.98
121_Y	186_Y	1.080	0.97
117_H	146_V	1.077	0.97
166_L	223_V	1.075	0.97
195_A	205_D	1.075	0.97
8_V	67_R	1.074	0.97
188_E	211_H	1.059	0.97
71_A	82_V	1.058	0.97
112_R	115_W	1.056	0.97
176_V	215_A	1.050	0.97
217_E	221_A	1.049	0.97
25_V	31_S	1.046	0.97
71_A	80_V	1.045	0.97
47_R	79_H	1.041	0.97
23_P	140_G	1.034	0.97
201_I	208_T	1.033	0.97
4_V	125_G	1.032	0.97
27_V	44_L	1.023	0.96
168_A	222_E	0.999	0.96
188_E	213_S	0.996	0.96
133_V	143_A	0.996	0.96
18_V	25_V	0.995	0.96
188_E	206_T	0.986	0.96
57_L	69_V	0.974	0.95
212_L	216_E	0.955	0.95
122_L	144_E	0.941	0.94
181_T	186_Y	0.933	0.94
194_V	205_D	0.929	0.94
178_A	182_R	0.926	0.94
148_A	185_Y	0.924	0.94
54_Q	76_D	0.922	0.94
194_V	207_T	0.921	0.94
145_L	148_A	0.917	0.94
204_A	213_S	0.915	0.94
172_R	210_E	0.914	0.94
21_D	224_G	0.905	0.93
207_T	215_A	0.891	0.93
96_A	100_D	0.890	0.93
82_V	128_D	0.887	0.92
205_D	214_R	0.884	0.92
188_E	217_E	0.882	0.92
17_D	65_P	0.882	0.92
6_L	119_T	0.881	0.92
6_L	133_V	0.869	0.92
130_T	133_V	0.864	0.91
4_V	129_P	0.862	0.91
80_V	83_A	0.856	0.91
186_Y	194_V	0.852	0.91
175_E	178_A	0.848	0.91
78_D	90_D	0.845	0.91
27_V	31_S	0.842	0.90
45_A	133_V	0.837	0.90
144_E	152_E	0.835	0.90
72_W	81_F	0.831	0.90
36_S	135_A	0.819	0.89
4_V	120_L	0.809	0.89
47_R	50_G	0.808	0.89
194_V	215_A	0.806	0.88
134_A	138_A	0.804	0.88
219_V	222_E	0.803	0.88
185_Y	194_V	0.803	0.88
215_A	220_M	0.800	0.88
25_V	29_A	0.794	0.88
13_A	116_E	0.792	0.87
19_S	27_V	0.792	0.87
63_A	215_A	0.783	0.87
35_G	42_R	0.783	0.87
52_H	113_A	0.779	0.87
19_S	115_W	0.779	0.87
4_V	154_G	0.777	0.86
102_G	135_A	0.776	0.86
188_E	195_A	0.775	0.86
16_S	66_V	0.770	0.86
13_A	19_S	0.765	0.86
60_V	127_P	0.755	0.85
203_L	206_T	0.755	0.85
207_T	214_R	0.752	0.85
6_L	118_W	0.747	0.84
123_P	200_E	0.746	0.84
132_A	210_E	0.743	0.84
27_V	30_V	0.741	0.84
108_G	186_Y	0.740	0.84
197_I	201_I	0.737	0.83
109_S	118_W	0.734	0.83
185_Y	212_L	0.734	0.83
46_V	50_G	0.733	0.83
54_Q	69_V	0.733	0.83
101_H	135_A	0.732	0.83
133_V	207_T	0.731	0.83
31_S	34_P	0.728	0.83
122_L	186_Y	0.728	0.83
55_G	59_T	0.723	0.82
105_H	131_E	0.722	0.82
5_T	175_E	0.722	0.82
57_L	60_V	0.719	0.82
63_A	66_V	0.719	0.82
128_D	131_E	0.718	0.82
95_T	208_T	0.717	0.82
184_G	209_W	0.716	0.82
58_D	62_A	0.713	0.81
85_T	205_D	0.710	0.81
214_R	217_E	0.707	0.81
110_V	117_H	0.706	0.81
46_V	59_T	0.706	0.81
20_A	114_G	0.701	0.80
183_M	208_T	0.698	0.80
11_H	183_M	0.695	0.80
13_A	16_S	0.692	0.79
175_E	179_L	0.690	0.79
56_F	82_V	0.687	0.79
155_A	163_S	0.685	0.79
177_L	224_G	0.677	0.78
99_A	197_I	0.673	0.78
36_S	39_D	0.670	0.77
103_I	108_G	0.665	0.77
54_Q	67_R	0.664	0.77
132_A	205_D	0.661	0.76
5_T	117_H	0.659	0.76
123_P	137_E	0.659	0.76
10_N	13_A	0.659	0.76
86_H	166_L	0.658	0.76
68_S	71_A	0.654	0.76
79_H	171_D	0.650	0.75
179_L	201_I	0.650	0.75
96_A	102_G	0.649	0.75
10_N	118_W	0.649	0.75
73_S	201_I	0.644	0.74
97_H	100_D	0.643	0.74
148_A	206_T	0.643	0.74
24_A	112_R	0.642	0.74
67_R	138_A	0.641	0.74
4_V	122_L	0.640	0.74
76_D	149_A	0.639	0.74
167_D	223_V	0.631	0.73
4_V	145_L	0.628	0.73
98_L	120_L	0.627	0.72
53_V	57_L	0.627	0.72
56_F	151_V	0.625	0.72
4_V	10_N	0.622	0.72
95_T	215_A	0.621	0.72
60_V	140_G	0.617	0.71
14_P	17_D	0.616	0.71
16_S	81_F	0.615	0.71
137_E	203_L	0.615	0.71
97_H	193_R	0.615	0.71
8_V	141_S	0.612	0.71
61_A	131_E	0.610	0.70
165_M	214_R	0.608	0.70
55_G	58_D	0.608	0.70
93_S	96_A	0.607	0.70
214_R	219_V	0.605	0.70
27_V	46_V	0.603	0.70
120_L	124_D	0.600	0.69
13_A	86_H	0.599	0.69
127_P	185_Y	0.599	0.69
177_L	216_E	0.598	0.69
187_D	217_E	0.596	0.69
65_P	170_T	0.595	0.68
173_Q	176_V	0.594	0.68
14_P	18_V	0.591	0.68
192_V	208_T	0.588	0.68
130_T	207_T	0.588	0.68
13_A	118_W	0.588	0.68
10_N	16_S	0.587	0.67
197_I	202_G	0.586	0.67
181_T	220_M	0.585	0.67
106_R	119_T	0.584	0.67
104_H	121_Y	0.582	0.67
51_D	124_D	0.582	0.67
174_R	223_V	0.581	0.67
79_H	147_A	0.577	0.66
131_E	191_T	0.572	0.65
22_Y	51_D	0.568	0.65
103_I	106_R	0.567	0.65
186_Y	220_M	0.565	0.65
179_L	200_E	0.564	0.64
24_A	73_S	0.563	0.64
42_R	46_V	0.559	0.64
83_A	188_E	0.559	0.64
140_G	200_E	0.558	0.64
108_G	216_E	0.558	0.64
54_Q	57_L	0.558	0.64
145_L	203_L	0.557	0.63
20_A	77_A	0.557	0.63
22_Y	58_D	0.554	0.63
39_D	67_R	0.553	0.63
62_A	183_M	0.550	0.62
78_D	84_V	0.548	0.62
70_D	83_A	0.548	0.62
41_S	44_L	0.547	0.62
31_S	45_A	0.546	0.62
60_V	214_R	0.543	0.61
95_T	105_H	0.542	0.61
12_G	44_L	0.542	0.61
38_G	42_R	0.542	0.61
163_S	214_R	0.541	0.61
122_L	213_S	0.539	0.61
90_D	198_A	0.539	0.61
120_L	142_D	0.538	0.61
4_V	210_E	0.535	0.60
43_I	105_H	0.535	0.60
41_S	146_V	0.533	0.60
18_V	37_D	0.532	0.60
43_I	109_S	0.531	0.60
129_P	175_E	0.528	0.59
191_T	197_I	0.527	0.59
177_L	215_A	0.527	0.59
29_A	129_P	0.524	0.59
168_A	221_A	0.524	0.59
68_S	128_D	0.523	0.59
130_T	165_M	0.521	0.58
78_D	138_A	0.518	0.58
115_W	163_S	0.517	0.58
146_V	221_A	0.516	0.58
10_N	116_E	0.516	0.58
201_I	209_W	0.516	0.58
179_L	192_V	0.514	0.57
142_D	182_R	0.514	0.57
91_W	98_L	0.511	0.57
190_A	219_V	0.510	0.57
77_A	202_G	0.509	0.57
76_D	217_E	0.507	0.56
10_N	14_P	0.507	0.56
103_I	109_S	0.506	0.56
181_T	223_V	0.506	0.56
174_R	222_E	0.505	0.56
129_P	147_A	0.505	0.56
178_A	224_G	0.503	0.56
100_D	155_A	0.502	0.56
58_D	224_G	0.501	0.55
25_V	56_F	0.500	0.55
6_L	114_G	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ku3A	1	0.2629	97.7	0.839	Contact Map
4wszA	2	0.2629	97.5	0.846	Contact Map
1je8A	2	0.2672	97.5	0.846	Contact Map
1s7oA	3	0.3233	97.4	0.847	Contact Map
1xsvA	2	0.319	97.2	0.852	Contact Map
3hugA	3	0.3448	97.2	0.853	Contact Map
2o8xA	7	0.2629	97.2	0.854	Contact Map
2rnjA	1	0.2629	97.2	0.854	Contact Map
1fseA	2	0.2716	97.1	0.854	Contact Map
1x3uA	1	0.3103	97.1	0.855	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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