GREMLIN Database
Q9HSM7 - 2-keto-3-deoxygluconate kinase
UniProt: Q9HSM7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (282)
Sequences: 22437 (16658)
Seq/√Len: 992.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A268_A2.9781.00
132_H163_T2.9211.00
65_A80_T2.5451.00
236_A280_L2.4531.00
4_V128_A2.4371.00
275_D278_D2.4311.00
229_R235_L2.4311.00
50_A74_T2.3751.00
234_A262_F2.2621.00
42_A47_A2.2271.00
269_A274_G2.1951.00
62_R80_T2.1511.00
153_E188_D2.1321.00
217_A237_V2.0551.00
57_A82_R2.0541.00
54_K81_D2.0231.00
44_R71_Q2.0171.00
163_T267_L1.9691.00
196_E229_R1.9271.00
152_L162_A1.9201.00
155_A160_T1.9121.00
81_D84_D1.8831.00
269_A282_W1.8561.00
5_T39_A1.8491.00
54_K119_E1.8491.00
261_A286_T1.8401.00
272_D302_R1.8101.00
130_Y161_T1.8081.00
301_T304_D1.7931.00
190_D223_G1.7811.00
161_T190_D1.7541.00
40_V71_Q1.7521.00
193_F263_V1.7491.00
234_A284_A1.7281.00
274_G278_D1.7271.00
41_T264_G1.6981.00
210_D242_T1.6911.00
130_Y163_T1.6851.00
66_A70_A1.6771.00
122_P154_L1.6701.00
258_T291_R1.6651.00
149_A184_A1.6611.00
293_I304_D1.6501.00
69_R75_P1.6221.00
229_R244_T1.6131.00
65_A69_R1.6111.00
243_V277_E1.6051.00
266_Y279_A1.6021.00
287_A291_R1.6011.00
213_A237_V1.5981.00
236_A243_V1.5961.00
200_R206_T1.5761.00
235_L244_T1.5731.00
191_V224_T1.5691.00
226_V266_Y1.5651.00
67_T70_A1.5641.00
277_E281_A1.5531.00
265_G286_T1.5341.00
156_Q190_D1.5291.00
154_L158_T1.5271.00
254_D295_G1.5181.00
150_D153_E1.5171.00
165_D228_T1.5101.00
62_R66_A1.5001.00
9_T53_S1.4961.00
248_F285_A1.4911.00
42_A268_A1.4901.00
149_A153_E1.4801.00
208_D211_A1.4781.00
215_G218_D1.4741.00
236_A276_V1.4731.00
57_A62_R1.4701.00
245_Q280_L1.4691.00
31_V64_V1.4581.00
154_L157_E1.4461.00
3_V42_A1.4351.00
130_Y267_L1.4301.00
29_V63_K1.3951.00
150_D154_L1.3701.00
166_V194_V1.3601.00
85_L114_T1.3431.00
189_V192_L1.3421.00
265_G282_W1.3371.00
250_T292_T1.3371.00
13_L27_M1.3181.00
126_E158_T1.3171.00
229_R232_A1.3161.00
36_S68_L1.3131.00
61_G87_Q1.3101.00
161_T191_V1.3001.00
65_A78_T1.2921.00
214_R218_D1.2901.00
205_R215_G1.2891.00
161_T223_G1.2771.00
102_T105_Y1.2711.00
266_Y270_R1.2711.00
248_F281_A1.2501.00
210_D214_R1.2491.00
81_D85_L1.2431.00
57_A80_T1.2421.00
228_T262_F1.2361.00
48_E74_T1.2351.00
245_Q284_A1.2331.00
116_T119_E1.2271.00
224_T270_R1.2241.00
156_Q188_D1.2211.00
266_Y283_G1.2181.00
224_T266_Y1.2161.00
234_A280_L1.2151.00
252_T291_R1.1881.00
11_L63_K1.1821.00
278_D281_A1.1771.00
265_G283_G1.1741.00
214_R242_T1.1711.00
229_R233_G1.1681.00
66_A69_R1.1671.00
268_A272_D1.1641.00
117_A150_D1.1631.00
193_F228_T1.1581.00
248_F284_A1.1581.00
214_R237_V1.1571.00
31_V67_T1.1541.00
153_E157_E1.1521.00
43_G73_T1.1511.00
99_R102_T1.1501.00
238_R241_T1.1471.00
224_T276_V1.1451.00
269_A279_A1.1301.00
250_T291_R1.1281.00
45_L265_G1.1231.00
131_L155_A1.1131.00
133_T162_A1.1121.00
67_T71_Q1.1031.00
42_A49_T1.1001.00
125_V128_A1.0961.00
57_A84_D1.0931.00
248_F288_A1.0901.00
63_K66_A1.0901.00
205_R211_A1.0891.00
38_V132_H1.0841.00
199_A227_L1.0781.00
47_A271_V1.0771.00
237_V242_T1.0751.00
196_E232_A1.0731.00
62_R65_A1.0691.00
289_L293_I1.0641.00
191_V266_Y1.0591.00
247_V284_A1.0511.00
39_A49_T1.0491.00
289_L292_T1.0441.00
59_P62_R1.0391.00
213_A227_L1.0331.00
252_T255_P1.0321.00
284_A287_A1.0291.00
142_E146_A1.0291.00
81_D114_T1.0281.00
224_T236_A1.0281.00
40_V44_R1.0171.00
131_L160_T1.0161.00
41_T261_A1.0151.00
266_Y276_V1.0121.00
13_L29_V1.0101.00
100_G104_H1.0061.00
58_S87_Q1.0031.00
224_T238_R1.0021.00
56_P87_Q0.9891.00
55_L65_A0.9891.00
211_A214_R0.9801.00
179_R183_E0.9741.00
55_L61_G0.9701.00
261_A290_K0.9681.00
101_T104_H0.9671.00
122_P158_T0.9651.00
6_F131_L0.9641.00
100_G103_V0.9631.00
43_G72_G0.9611.00
191_V270_R0.9571.00
42_A264_G0.9561.00
269_A272_D0.9551.00
132_H267_L0.9551.00
199_A212_I0.9541.00
112_V115_A0.9541.00
50_A124_F0.9531.00
109_D112_V0.9521.00
9_T64_V0.9511.00
121_A150_D0.9481.00
193_F266_Y0.9461.00
123_A126_E0.9421.00
217_A239_N0.9411.00
279_A283_G0.9381.00
132_H263_V0.9361.00
47_A272_D0.9321.00
45_L286_T0.9301.00
146_A150_D0.9271.00
268_A282_W0.9261.00
164_L189_V0.9251.00
241_T277_E0.9241.00
133_T152_L0.9241.00
203_L212_I0.9221.00
50_A77_V0.9131.00
5_T35_E0.9101.00
9_T51_W0.9051.00
195_A198_D0.9041.00
233_G247_V0.9041.00
281_A285_A0.9011.00
55_L78_T0.9001.00
31_V63_K0.8941.00
43_G48_E0.8921.00
50_A128_A0.8901.00
122_P157_E0.8851.00
165_D193_F0.8811.00
196_E200_R0.8791.00
14_S30_R0.8791.00
268_A302_R0.8781.00
153_E184_A0.8771.00
75_P78_T0.8761.00
63_K67_T0.8721.00
252_T292_T0.8661.00
13_L89_L0.8601.00
261_A299_L0.8581.00
55_L80_T0.8581.00
232_A244_T0.8581.00
65_A75_P0.8541.00
133_T148_T0.8541.00
18_H99_R0.8531.00
4_V52_L0.8531.00
36_S297_V0.8521.00
13_L60_L0.8481.00
270_R279_A0.8381.00
3_V271_V0.8351.00
275_D279_A0.8331.00
128_A160_T0.8301.00
79_W119_E0.8301.00
250_T288_A0.8291.00
194_V199_A0.8281.00
213_A225_V0.8281.00
10_M88_G0.8231.00
214_R217_A0.8221.00
15_P91_F0.8211.00
213_A217_A0.8161.00
9_T36_S0.8161.00
217_A238_R0.8131.00
163_T193_F0.8061.00
6_F151_L0.8051.00
64_V87_Q0.7991.00
274_G282_W0.7961.00
265_G269_A0.7961.00
261_A265_G0.7951.00
165_D194_V0.7941.00
58_S61_G0.7911.00
38_V263_V0.7901.00
179_R182_L0.7891.00
262_F284_A0.7881.00
223_G238_R0.7851.00
251_E292_T0.7821.00
245_Q277_E0.7821.00
11_L60_L0.7791.00
282_W305_V0.7781.00
147_T151_L0.7721.00
184_A187_P0.7721.00
253_H294_P0.7671.00
284_A288_A0.7591.00
287_A290_K0.7581.00
4_V50_A0.7531.00
186_F189_V0.7501.00
125_V160_T0.7451.00
117_A146_A0.7451.00
152_L188_D0.7441.00
210_D244_T0.7441.00
4_V124_F0.7411.00
245_Q281_A0.7391.00
101_T105_Y0.7391.00
54_K79_W0.7371.00
43_G49_T0.7371.00
226_V236_A0.7361.00
243_V280_L0.7331.00
149_A188_D0.7271.00
261_A287_A0.7271.00
282_W302_R0.7251.00
11_L29_V0.7211.00
65_A79_W0.7161.00
130_Y271_V0.7101.00
39_A51_W0.7061.00
211_A215_G0.7051.00
199_A216_L0.7041.00
285_A289_L0.7001.00
131_L151_L0.7001.00
117_A147_T0.6981.00
143_T146_A0.6971.00
109_D113_T0.6951.00
231_E249_E0.6911.00
122_P126_E0.6851.00
213_A242_T0.6841.00
210_D237_V0.6781.00
92_L256_I0.6781.00
77_V124_F0.6761.00
262_F280_L0.6751.00
257_G299_L0.6751.00
217_A221_A0.6751.00
85_L111_A0.6711.00
29_V60_L0.6691.00
48_E129_G0.6691.00
45_L268_A0.6681.00
45_L282_W0.6641.00
235_L242_T0.6621.00
180_D183_E0.6621.00
274_G279_A0.6611.00
262_F283_G0.6571.00
233_G244_T0.6571.00
146_A149_A0.6531.00
12_R32_A0.6531.00
45_L305_V0.6521.00
40_V297_V0.6521.00
192_L225_V0.6511.00
289_L304_D0.6491.00
124_F128_A0.6491.00
163_T191_V0.6471.00
100_G105_Y0.6471.00
32_A37_N0.6431.00
178_A181_T0.6421.00
60_L89_L0.6391.00
118_D121_A0.6371.00
34_A167_N0.6291.00
210_D235_L0.6281.00
28_D294_P0.6241.00
67_T297_V0.6231.00
129_G160_T0.6191.00
71_Q301_T0.6181.00
280_L284_A0.6171.00
42_A267_L0.6141.00
163_T263_V0.6141.00
50_A76_E0.6141.00
155_A162_A0.6141.00
234_A245_Q0.6121.00
145_A181_T0.6111.00
141_S144_L0.6101.00
3_V130_Y0.6081.00
151_L154_L0.6071.00
130_Y191_V0.6041.00
222_F225_V0.6011.00
36_S51_W0.5991.00
262_F287_A0.5981.00
8_E167_N0.5941.00
149_A152_L0.5921.00
217_A222_F0.5921.00
15_P27_M0.5911.00
205_R212_I0.5911.00
226_V262_F0.5901.00
18_H95_G0.5891.00
3_V47_A0.5871.00
53_S78_T0.5871.00
145_A149_A0.5871.00
39_A73_T0.5851.00
289_L305_V0.5771.00
88_G112_V0.5701.00
35_E39_A0.5701.00
162_A189_V0.5691.00
62_R69_R0.5671.00
165_D260_D0.5661.00
230_G255_P0.5641.00
209_A229_R0.5611.00
38_V264_G0.5611.00
115_A120_L0.5611.00
264_G268_A0.5601.00
5_T49_T0.5581.00
17_G20_R0.5571.00
59_P63_K0.5551.00
231_E252_T0.5551.00
183_E187_P0.5541.00
245_Q248_F0.5521.00
45_L264_G0.5501.00
238_R242_T0.5491.00
38_V42_A0.5481.00
270_R273_G0.5481.00
15_P24_A0.5461.00
21_V34_A0.5451.00
238_R243_V0.5431.00
115_A119_E0.5421.00
68_L73_T0.5411.00
13_L91_F0.5411.00
205_R208_D0.5391.00
155_A158_T0.5391.00
59_P66_A0.5381.00
130_Y270_R0.5381.00
256_I296_D0.5371.00
210_D213_A0.5351.00
163_T270_R0.5341.00
38_V267_L0.5331.00
48_E271_V0.5331.00
273_G279_A0.5331.00
31_V297_V0.5311.00
37_N296_D0.5311.00
199_A209_A0.5301.00
217_A225_V0.5281.00
209_A212_I0.5281.00
278_D282_W0.5271.00
117_A121_A0.5271.00
199_A225_V0.5261.00
5_T42_A0.5251.00
228_T260_D0.5251.00
199_A237_V0.5251.00
276_V280_L0.5251.00
125_V154_L0.5221.00
27_M89_L0.5221.00
193_F226_V0.5211.00
194_V228_T0.5201.00
276_V279_A0.5191.00
226_V280_L0.5141.00
180_D184_A0.5141.00
196_E230_G0.5141.00
286_T305_V0.5141.00
203_L215_G0.5141.00
82_R85_L0.5111.00
35_E134_S0.5111.00
34_A136_I0.5101.00
221_A225_V0.5101.00
43_G71_Q0.5081.00
5_T51_W0.5031.00
40_V73_T0.5031.00
225_V237_V0.5031.00
34_A38_V0.5021.00
189_V222_F0.5011.00
258_T290_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iq0A 2 0.9623 100 0.178 Contact Map
2v78A 5 0.9591 100 0.181 Contact Map
2dcnA 5 0.9528 100 0.182 Contact Map
2rbcA 2 0.9308 100 0.19 Contact Map
3ktnA 5 0.9906 100 0.193 Contact Map
3ljsA 2 0.9623 100 0.199 Contact Map
4du5A 2 0.9214 100 0.199 Contact Map
4gm6A 5 0.9717 100 0.201 Contact Map
1tyyA 2 0.9182 100 0.207 Contact Map
1v1aA 5 0.934 100 0.208 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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