GREMLIN Database
MUTL - DNA mismatch repair protein MutL
UniProt: Q9HSM6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 659 (610)
Sequences: 3407 (2719)
Seq/√Len: 110.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_A61_D9.8801.00
115_R143_A5.6771.00
40_G63_R5.5161.00
37_L187_V5.3961.00
46_V177_V5.3831.00
109_E151_D5.0971.00
237_R294_D4.9091.00
29_V56_I3.8061.00
493_H595_A3.5971.00
66_T69_D3.3051.00
33_V177_V3.2811.00
123_G141_H3.1781.00
117_R143_A3.1321.00
70_L114_T3.1011.00
43_S61_D3.0631.00
473_V480_L3.0141.00
560_A564_R2.9781.00
116_P119_A2.9671.00
227_D237_R2.8791.00
70_L124_A2.8691.00
125_R137_A2.8411.00
74_V110_L2.8181.00
298_V309_V2.7691.00
6_R83_D2.7651.00
593_S597_K2.7101.00
111_T125_R2.6811.00
48_V173_V2.6761.00
28_V152_L2.5821.00
229_D237_R2.5751.00
4_R69_D2.5211.00
483_V611_L2.5071.00
130_H154_G2.4951.00
47_S57_V2.4931.00
462_R475_E2.4851.00
259_V309_V2.4841.00
472_V607_V2.4761.00
466_Q485_Q2.4471.00
50_A54_D2.4461.00
539_E548_T2.4361.00
473_V482_L2.4351.00
129_D134_G2.4061.00
45_D190_S2.4001.00
239_H294_D2.3911.00
273_V289_A2.3891.00
55_R148_E2.3631.00
211_A241_Y2.3441.00
109_E129_D2.3401.00
65_M70_L2.3071.00
623_C627_R2.2981.00
49_D55_R2.1901.00
609_A613_A2.1861.00
71_R136_V2.1801.00
257_T273_V2.1391.00
113_T125_R2.0791.00
9_D12_T2.0721.00
53_T166_A2.0701.00
592_C625_H2.0561.00
55_R150_T2.0521.00
30_K34_E2.0121.00
463_V472_V2.0101.00
72_M78_T2.0051.00
505_S549_A1.9981.00
57_V146_T1.9941.00
313_D316_G1.9861.00
44_V187_V1.9661.00
520_E571_L1.9611.00
111_T150_T1.9601.00
537_D549_A1.9551.00
227_D239_H1.9461.00
226_V242_V1.9451.00
28_V56_I1.9201.00
72_M75_R1.9151.00
513_E544_T1.9131.00
608_V612_D1.8991.00
113_T139_A1.8951.00
592_C623_C1.8941.00
226_V291_L1.8731.00
273_V325_V1.8691.00
596_I602_L1.8671.00
114_T124_A1.8461.00
464_L480_L1.8371.00
170_F193_H1.8251.00
170_F198_V1.8051.00
47_S59_A1.8001.00
7_A75_R1.7971.00
73_A101_L1.7871.00
532_R537_D1.7851.00
201_T210_A1.7841.00
206_D209_D1.7711.00
215_Y256_A1.7681.00
584_D588_A1.7651.00
592_C627_R1.7571.00
484_D487_A1.7571.00
529_G532_R1.7391.00
113_T148_E1.7371.00
203_G210_A1.7231.00
65_M73_A1.7191.00
228_A324_G1.7141.00
257_T269_L1.7051.00
463_V607_V1.7031.00
486_H592_C1.6881.00
491_R617_C1.6571.00
128_V133_A1.6551.00
486_H627_R1.6411.00
74_V112_V1.6231.00
175_R179_R1.6091.00
470_T598_G1.6041.00
634_D637_E1.6031.00
82_L87_G1.5901.00
525_E540_L1.5891.00
238_V320_A1.5841.00
527_A530_G1.5691.00
259_V311_F1.5391.00
276_G322_E1.5301.00
353_P356_S1.5281.00
43_S188_A1.5251.00
112_V126_I1.5231.00
48_V170_F1.5221.00
188_A203_G1.5181.00
492_V610_L1.5171.00
474_A483_V1.5141.00
197_E200_A1.5111.00
47_S192_T1.5071.00
603_A606_S1.5071.00
528_L532_R1.4901.00
37_L184_N1.4881.00
561_E565_D1.4861.00
524_F545_A1.4841.00
224_R328_A1.4751.00
113_T141_H1.4751.00
130_H155_E1.4741.00
170_F191_L1.4691.00
458_L461_L1.4671.00
70_L126_I1.4641.00
495_E617_C1.4631.00
355_H360_R1.4561.00
239_H292_F1.4541.00
29_V173_V1.4541.00
113_T123_G1.4481.00
596_I610_L1.4381.00
614_L620_P1.4361.00
425_T428_F1.4171.00
464_L473_V1.4161.00
467_L480_L1.4161.00
614_L617_C1.4161.00
10_D14_A1.4151.00
65_M69_D1.4121.00
255_L289_A1.4101.00
604_E608_V1.4101.00
33_V189_V1.4051.00
111_T148_E1.4001.00
236_E293_V1.3991.00
489_D493_H1.3891.00
466_Q602_L1.3791.00
613_A616_A1.3771.00
486_H625_H1.3771.00
487_A490_E1.3751.00
517_T520_E1.3561.00
67_G119_A1.3531.00
486_H490_E1.3511.00
65_M71_R1.3441.00
425_T429_D1.3441.00
368_G371_A1.3441.00
228_A320_A1.3431.00
70_L112_V1.3431.00
491_R495_E1.3411.00
583_A587_L1.3401.00
490_E623_C1.3261.00
414_R417_P1.3200.99
483_V488_A1.3180.99
37_L94_L1.3120.99
486_H623_C1.3080.99
94_L261_G1.3070.99
410_T413_T1.3050.99
490_E625_H1.3030.99
73_A112_V1.2960.99
486_H489_D1.2950.99
588_A591_A1.2880.99
168_T172_H1.2860.99
363_G366_G1.2800.99
485_Q602_L1.2740.99
45_D192_T1.2670.99
102_Y106_S1.2650.99
248_T285_R1.2610.99
123_G140_G1.2580.99
479_G632_E1.2570.99
568_S572_A1.2510.99
490_E592_C1.2480.99
190_S200_A1.2430.99
28_V149_V1.2350.99
467_L473_V1.2310.99
275_D322_E1.2300.99
4_R66_T1.2270.99
58_V147_V1.2210.99
411_D415_E1.2160.99
421_T424_R1.2120.99
547_V563_A1.2040.99
74_V128_V1.2020.99
496_R613_A1.1990.99
472_V485_Q1.1990.99
382_A385_G1.1980.99
422_E425_T1.1930.99
17_A20_E1.1910.99
126_I133_A1.1890.99
204_T209_D1.1800.99
50_A166_A1.1790.99
369_D372_G1.1720.99
496_R500_R1.1720.99
604_E607_V1.1700.99
522_A526_A1.1690.99
180_Y189_V1.1640.99
520_E564_R1.1550.99
420_G423_S1.1540.99
177_V189_V1.1460.99
466_Q486_H1.1460.99
468_H479_G1.1450.99
467_L638_L1.1400.99
380_R383_A1.1390.98
625_H628_P1.1350.98
367_G371_A1.1340.98
521_A545_A1.1330.98
127_T135_S1.1190.98
421_T425_T1.1180.98
141_H146_T1.1110.98
520_E568_S1.1090.98
211_A290_V1.1060.98
170_F174_N1.1030.98
82_L91_V1.0990.98
563_A567_L1.0920.98
12_T85_A1.0920.98
271_E318_K1.0900.98
498_Q587_L1.0860.98
362_A365_A1.0860.98
10_D132_D1.0800.98
28_V32_L1.0790.98
622_A629_T1.0780.98
359_D367_G1.0760.98
270_R289_A1.0740.98
243_S247_V1.0740.98
29_V33_V1.0730.98
493_H496_R1.0730.98
464_L467_L1.0700.98
353_P358_T1.0700.98
410_T414_R1.0680.98
417_P423_S1.0680.98
90_G296_E1.0680.98
461_L474_A1.0670.98
208_Q220_A1.0650.98
174_N191_L1.0620.98
208_Q241_Y1.0610.98
541_A544_T1.0590.98
600_T606_S1.0580.98
358_T367_G1.0540.98
414_R419_S1.0520.97
297_G312_E1.0520.97
469_D601_S1.0450.97
365_A368_G1.0440.97
364_A367_G1.0430.97
412_G416_R1.0390.97
493_H594_P1.0390.97
361_D370_A1.0350.97
111_T127_T1.0320.97
67_G124_A1.0300.97
410_T416_R1.0270.97
501_V587_L1.0250.97
302_V310_R1.0170.97
592_C597_K1.0170.97
515_E544_T1.0140.97
118_N143_A1.0090.97
513_E546_R1.0090.97
466_Q607_V1.0060.97
368_G372_G1.0030.97
261_G294_D0.9970.97
67_G136_V0.9970.97
365_A374_S0.9950.96
256_A263_A0.9930.96
96_F306_K0.9930.96
516_L524_F0.9910.96
105_G126_I0.9910.96
226_V240_G0.9900.96
11_A15_R0.9890.96
499_A503_G0.9890.96
53_T163_L0.9880.96
530_G533_E0.9880.96
20_E25_P0.9880.96
188_A200_A0.9870.96
366_G372_G0.9860.96
240_G291_L0.9820.96
293_V320_A0.9800.96
415_E418_G0.9760.96
349_A352_S0.9760.96
436_R439_T0.9760.96
230_P320_A0.9710.96
359_D365_A0.9640.96
323_A327_D0.9610.96
445_E449_Q0.9600.96
369_D373_Q0.9590.96
379_Q382_A0.9580.96
592_C628_P0.9550.96
366_G369_D0.9460.95
15_R85_A0.9460.95
444_P447_D0.9440.95
377_N380_R0.9440.95
381_T385_G0.9430.95
374_S379_Q0.9430.95
580_A583_A0.9430.95
469_D599_N0.9410.95
416_R420_G0.9410.95
266_D314_E0.9410.95
378_G382_A0.9390.95
279_D622_A0.9390.95
365_A370_A0.9390.95
354_E358_T0.9370.95
116_P143_A0.9350.95
54_D151_D0.9330.95
175_R178_T0.9310.95
365_A369_D0.9290.95
370_A373_Q0.9280.95
366_G371_A0.9280.95
295_C298_V0.9230.95
558_L561_E0.9150.94
434_N439_T0.9150.94
322_E326_R0.9150.94
114_T119_A0.9120.94
415_E419_S0.9110.94
4_R63_R0.9110.94
236_E317_V0.9100.94
375_D378_G0.9100.94
110_L128_V0.9080.94
242_V289_A0.9080.94
355_H358_T0.9080.94
619_N622_A0.9050.94
413_T425_T0.9040.94
112_V147_V0.9040.94
359_D362_A0.9020.94
412_G415_E0.8990.94
352_S355_H0.8940.94
417_P421_T0.8940.94
104_I149_V0.8940.94
411_D414_R0.8940.94
258_F292_F0.8930.94
523_V527_A0.8900.93
414_R418_G0.8890.93
67_G138_P0.8880.93
412_G418_G0.8860.93
107_V152_L0.8860.93
623_C628_P0.8840.93
354_E361_D0.8840.93
487_A495_E0.8810.93
174_N178_T0.8800.93
299_D306_K0.8800.93
521_A540_L0.8780.93
614_L621_Y0.8780.93
516_L567_L0.8780.93
243_S288_F0.8740.93
490_E627_R0.8720.93
65_M68_D0.8720.93
529_G533_E0.8720.93
499_A618_E0.8720.93
468_H635_G0.8710.93
36_S40_G0.8700.93
356_S359_D0.8680.93
460_D463_V0.8680.93
115_R121_D0.8650.93
351_I354_E0.8650.93
621_Y630_I0.8630.92
282_A622_A0.8630.92
348_D351_I0.8620.92
413_T416_R0.8610.92
547_V559_D0.8610.92
434_N437_L0.8600.92
368_G373_Q0.8600.92
326_R330_L0.8590.92
96_F99_E0.8590.92
437_L441_A0.8570.92
414_R421_T0.8570.92
297_G313_D0.8560.92
224_R242_V0.8560.92
361_D372_G0.8550.92
349_A353_P0.8550.92
327_D331_D0.8520.92
419_S423_S0.8510.92
472_V486_H0.8510.92
352_S358_T0.8500.92
66_T116_P0.8500.92
444_P448_D0.8480.92
485_Q490_E0.8470.92
236_E320_A0.8460.92
350_E353_P0.8410.91
494_Y498_Q0.8380.91
592_C596_I0.8370.91
413_T418_G0.8370.91
367_G373_Q0.8360.91
435_A439_T0.8350.91
366_G370_A0.8350.91
71_R133_A0.8350.91
11_A293_V0.8350.91
282_A285_R0.8340.91
229_D235_V0.8330.91
471_Y486_H0.8310.91
358_T361_D0.8310.91
489_D597_K0.8290.91
243_S248_T0.8280.91
484_D489_D0.8270.91
507_A549_A0.8240.91
165_R168_T0.8240.91
16_I20_E0.8240.91
470_T484_D0.8210.90
486_H495_E0.8200.90
487_A627_R0.8190.90
76_Q114_T0.8190.90
361_D383_A0.8190.90
362_A367_G0.8190.90
252_R274_L0.8170.90
65_M116_P0.8170.90
597_K625_H0.8160.90
360_R364_A0.8160.90
476_A479_G0.8160.90
151_D154_G0.8160.90
21_V52_G0.8150.90
45_D59_A0.8140.90
18_A25_P0.8130.90
376_G381_T0.8130.90
418_G421_T0.8130.90
370_A378_G0.8110.90
265_T307_L0.8090.90
418_G425_T0.8090.90
257_T270_R0.8090.90
96_F299_D0.8070.90
346_P349_A0.8060.90
470_T639_A0.8050.90
367_G372_G0.8040.89
201_T204_T0.8010.89
228_A327_D0.8010.89
51_G170_F0.7990.89
524_F567_L0.7990.89
96_F100_A0.7980.89
589_D593_S0.7950.89
33_V44_V0.7940.89
219_V288_F0.7940.89
617_C620_P0.7930.89
364_A371_A0.7890.89
205_G210_A0.7880.89
372_G375_D0.7860.88
70_L73_A0.7840.88
71_R75_R0.7840.88
29_V48_V0.7830.88
493_H497_L0.7820.88
29_V32_L0.7810.88
25_P303_H0.7790.88
263_A307_L0.7780.88
497_L594_P0.7780.88
222_S244_D0.7770.88
623_C626_G0.7770.88
97_R100_A0.7760.88
53_T160_R0.7760.88
33_V180_Y0.7750.88
361_D364_A0.7750.88
361_D371_A0.7740.88
374_S378_G0.7720.88
15_R106_S0.7710.87
637_E640_A0.7700.87
217_R221_Q0.7700.87
420_G425_T0.7700.87
65_M72_M0.7700.87
363_G367_G0.7690.87
33_V46_V0.7690.87
468_H491_R0.7660.87
474_A611_L0.7650.87
20_E303_H0.7630.87
127_T134_G0.7630.87
179_R263_A0.7620.87
521_A525_E0.7620.87
487_A592_C0.7620.87
527_A570_F0.7610.87
365_A375_D0.7610.87
426_G429_D0.7610.87
21_V77_H0.7600.87
348_D360_R0.7590.87
363_G369_D0.7580.87
541_A546_R0.7580.87
225_T240_G0.7560.86
60_D64_G0.7540.86
17_A303_H0.7540.86
411_D424_R0.7530.86
208_Q225_T0.7530.86
497_L587_L0.7510.86
236_E295_C0.7500.86
602_L607_V0.7480.86
5_I114_T0.7470.86
352_S356_S0.7470.86
612_D615_D0.7460.86
515_E543_R0.7450.86
352_S359_D0.7450.86
61_D143_A0.7420.85
222_S246_E0.7410.85
445_E448_D0.7390.85
580_A584_D0.7370.85
466_Q472_V0.7370.85
513_E542_G0.7360.85
413_T420_G0.7340.85
411_D418_G0.7340.85
243_S277_Y0.7340.85
320_A324_G0.7340.85
238_V293_V0.7330.85
358_T364_A0.7330.85
368_G381_T0.7300.84
350_E357_P0.7300.84
252_R286_Y0.7300.84
225_T239_H0.7280.84
428_F431_P0.7270.84
531_L563_A0.7240.84
425_T430_A0.7240.84
249_R254_Y0.7230.84
597_K627_R0.7220.84
370_A376_G0.7220.84
372_G377_N0.7210.84
17_A77_H0.7200.84
351_I358_T0.7190.84
23_E310_R0.7190.84
357_P364_A0.7190.84
230_P235_V0.7180.83
364_A368_G0.7170.83
34_E301_N0.7150.83
68_D71_R0.7150.83
481_V491_R0.7140.83
414_R420_G0.7140.83
424_R427_R0.7130.83
77_H106_S0.7110.83
417_P424_R0.7100.83
423_S428_F0.7090.83
597_K623_C0.7070.83
301_N304_P0.7070.83
472_V484_D0.7070.83
413_T419_S0.7060.82
482_L599_N0.7020.82
424_R429_D0.7010.82
192_T197_E0.7010.82
419_S424_R0.7000.82
421_T426_G0.6990.82
367_G370_A0.6980.82
484_D592_C0.6980.82
466_Q484_D0.6970.82
353_P359_D0.6960.82
412_G419_S0.6960.82
124_A136_V0.6950.81
366_G453_S0.6950.81
371_A375_D0.6950.81
470_T485_Q0.6950.81
14_A102_Y0.6950.81
39_A58_V0.6950.81
182_L290_V0.6940.81
25_P51_G0.6940.81
97_R299_D0.6920.81
373_Q376_G0.6910.81
355_H362_A0.6910.81
377_N381_T0.6910.81
482_L638_L0.6890.81
415_E422_E0.6880.81
416_R421_T0.6870.81
238_V520_E0.6860.81
410_T417_P0.6860.81
378_G384_S0.6840.80
416_R425_T0.6840.80
299_D304_P0.6830.80
375_D382_A0.6810.80
413_T423_S0.6800.80
598_G625_H0.6790.80
347_G350_E0.6780.80
370_A375_D0.6760.80
354_E357_P0.6760.80
419_S422_E0.6750.80
30_K301_N0.6750.80
17_A25_P0.6750.80
418_G422_E0.6750.80
28_V108_A0.6740.79
28_V104_I0.6740.79
482_L633_V0.6730.79
440_G446_A0.6720.79
133_A136_V0.6720.79
249_R253_E0.6720.79
321_V328_A0.6720.79
487_A623_C0.6700.79
364_A373_Q0.6680.79
620_P630_I0.6680.79
353_P360_R0.6660.79
597_K631_V0.6650.79
20_E24_R0.6640.78
365_A372_G0.6620.78
362_A369_D0.6620.78
360_R370_A0.6620.78
365_A371_A0.6610.78
94_L183_A0.6610.78
368_G374_S0.6610.78
590_L594_P0.6610.78
490_E495_E0.6610.78
356_S361_D0.6600.78
528_L538_A0.6600.78
26_A176_A0.6600.78
240_G243_S0.6580.78
318_K322_E0.6580.78
435_A440_G0.6580.78
410_T422_E0.6580.78
301_N306_K0.6570.78
99_E260_N0.6570.78
412_G417_P0.6570.78
242_V325_V0.6570.78
586_V589_D0.6560.78
444_P452_T0.6560.78
410_T415_E0.6550.77
522_A525_E0.6550.77
420_G426_G0.6540.77
458_L615_D0.6520.77
415_E421_T0.6520.77
225_T241_Y0.6510.77
319_A323_A0.6500.77
102_Y196_R0.6500.77
421_T427_R0.6500.77
367_G374_S0.6480.77
461_L615_D0.6450.76
281_L329_L0.6450.76
524_F563_A0.6450.76
372_G380_R0.6440.76
97_R304_P0.6430.76
528_L545_A0.6410.76
379_Q384_S0.6400.76
592_C598_G0.6390.76
486_H596_I0.6390.76
490_E497_L0.6380.76
624_P627_R0.6380.76
513_E541_A0.6380.76
417_P420_G0.6380.76
521_A543_R0.6380.76
431_P435_A0.6370.76
115_R118_N0.6370.76
374_S384_S0.6370.76
357_P360_R0.6340.75
372_G449_Q0.6330.75
7_A13_V0.6320.75
185_P241_Y0.6310.75
371_A374_S0.6310.75
255_L274_L0.6300.75
181_A214_V0.6300.75
420_G427_R0.6290.75
384_S451_T0.6290.75
358_T363_G0.6280.74
484_D627_R0.6280.74
416_R419_S0.6270.74
484_D495_E0.6240.74
415_E426_G0.6230.74
48_V191_L0.6220.74
377_N384_S0.6210.74
352_S357_P0.6200.74
201_T214_V0.6200.74
257_T289_A0.6190.73
598_G623_C0.6190.73
364_A372_G0.6180.73
498_Q618_E0.6180.73
224_R244_D0.6180.73
607_V622_A0.6180.73
596_I625_H0.6180.73
94_L184_N0.6180.73
417_P425_T0.6170.73
19_G304_P0.6170.73
446_A451_T0.6160.73
411_D427_R0.6150.73
271_E275_D0.6150.73
585_A589_D0.6140.73
167_A171_G0.6130.73
598_G627_R0.6130.73
277_Y329_L0.6130.73
615_D618_E0.6120.73
276_G325_V0.6110.72
594_P597_K0.6100.72
57_V148_E0.6100.72
492_V617_C0.6090.72
558_L562_L0.6080.72
418_G429_D0.6080.72
539_E542_G0.6080.72
358_T378_G0.6070.72
357_P363_G0.6070.72
35_N38_D0.6070.72
427_R430_A0.6060.72
70_L128_V0.6060.72
362_A373_Q0.6050.72
447_D450_D0.6050.72
12_T91_V0.6030.71
363_G380_R0.6030.71
282_A639_A0.6020.71
259_V264_V0.6020.71
71_R126_I0.6010.71
448_D452_T0.6010.71
485_Q489_D0.6010.71
16_I19_G0.5980.71
41_A44_V0.5980.71
172_H271_E0.5980.71
486_H597_K0.5970.71
416_R423_S0.5960.71
96_F304_P0.5960.71
415_E425_T0.5960.71
346_P387_T0.5960.71
379_Q386_A0.5960.71
593_S598_G0.5960.71
9_D282_A0.5950.70
485_Q620_P0.5940.70
617_C629_T0.5940.70
348_D352_S0.5940.70
420_G424_R0.5930.70
426_G430_A0.5910.70
18_A303_H0.5910.70
203_G215_Y0.5900.70
441_A444_P0.5900.70
465_G470_T0.5890.70
497_L501_V0.5890.70
96_F301_N0.5890.70
210_A266_D0.5880.70
34_E52_G0.5860.69
4_R68_D0.5860.69
591_A594_P0.5860.69
210_A215_Y0.5850.69
476_A632_E0.5850.69
317_V321_V0.5840.69
211_A223_L0.5840.69
419_S426_G0.5840.69
177_V199_F0.5830.69
358_T362_A0.5830.69
411_D417_P0.5830.69
376_G387_T0.5830.69
65_M93_T0.5830.69
491_R494_Y0.5820.69
620_P624_P0.5810.69
512_A560_A0.5810.69
356_S360_R0.5800.69
368_G375_D0.5800.69
356_S365_A0.5800.69
162_Y311_F0.5800.69
364_A376_G0.5790.68
19_G25_P0.5790.68
355_H359_D0.5790.68
417_P427_R0.5780.68
448_D451_T0.5770.68
377_N383_A0.5760.68
69_D73_A0.5760.68
537_D548_T0.5750.68
411_D419_S0.5750.68
22_V158_A0.5750.68
436_R452_T0.5740.68
598_G622_A0.5730.68
474_A481_V0.5720.67
487_A493_H0.5720.67
380_R385_G0.5700.67
353_P386_A0.5700.67
539_E546_R0.5690.67
463_V611_L0.5690.67
596_I627_R0.5680.67
481_V632_E0.5680.67
100_A299_D0.5680.67
481_V487_A0.5660.67
364_A379_Q0.5650.67
36_S58_V0.5650.67
369_D387_T0.5630.66
354_E386_A0.5630.66
361_D369_D0.5620.66
185_P210_A0.5620.66
272_A276_G0.5610.66
411_D430_A0.5610.66
616_A633_V0.5610.66
377_N437_L0.5610.66
115_R119_A0.5610.66
547_V636_D0.5610.66
33_V176_A0.5600.66
366_G374_S0.5600.66
488_A614_L0.5590.66
436_R440_G0.5590.66
82_L96_F0.5580.66
367_G375_D0.5580.66
359_D364_A0.5580.66
14_A179_R0.5570.65
324_G328_A0.5570.65
359_D363_G0.5560.65
360_R363_G0.5550.65
372_G378_G0.5550.65
424_R434_N0.5530.65
314_E318_K0.5530.65
366_G451_T0.5530.65
415_E423_S0.5530.65
351_I357_P0.5530.65
360_R366_G0.5520.65
377_N382_A0.5520.65
14_A180_Y0.5520.65
348_D353_P0.5520.65
463_V608_V0.5510.65
255_L472_V0.5510.65
355_H364_A0.5490.64
101_L110_L0.5490.64
614_L630_I0.5480.64
119_A124_A0.5480.64
516_L545_A0.5470.64
383_A417_P0.5470.64
412_G420_G0.5460.64
351_I356_S0.5460.64
359_D369_D0.5450.64
16_I106_S0.5450.64
22_V107_V0.5450.64
100_A306_K0.5450.64
376_G380_R0.5430.64
607_V621_Y0.5430.64
487_A629_T0.5430.64
223_L243_S0.5430.64
350_E363_G0.5430.64
420_G429_D0.5420.63
472_V491_R0.5420.63
471_Y484_D0.5420.63
303_H308_E0.5420.63
466_Q490_E0.5410.63
422_E428_F0.5410.63
550_V559_D0.5410.63
438_P452_T0.5400.63
498_Q584_D0.5390.63
19_G303_H0.5390.63
18_A78_T0.5390.63
212_L220_A0.5380.63
359_D370_A0.5370.63
361_D365_A0.5360.63
348_D365_A0.5360.63
363_G371_A0.5360.63
364_A384_S0.5350.62
65_M282_A0.5350.62
57_V174_N0.5350.62
351_I360_R0.5350.62
349_A364_A0.5330.62
65_M74_V0.5330.62
418_G428_F0.5320.62
440_G444_P0.5320.62
311_F318_K0.5320.62
497_L591_A0.5300.62
494_Y624_P0.5300.62
373_Q378_G0.5300.62
423_S429_D0.5290.62
361_D366_G0.5290.62
108_A296_E0.5290.62
521_A544_T0.5280.61
348_D366_G0.5280.61
20_E23_E0.5270.61
349_A355_H0.5270.61
364_A369_D0.5270.61
413_T417_P0.5270.61
346_P350_E0.5270.61
369_D374_S0.5260.61
262_R306_K0.5250.61
468_H475_E0.5250.61
495_E498_Q0.5250.61
443_G447_D0.5250.61
350_E361_D0.5250.61
13_V90_G0.5250.61
415_E424_R0.5250.61
620_P629_T0.5240.61
105_G128_V0.5240.61
445_E451_T0.5240.61
346_P370_A0.5240.61
354_E369_D0.5230.61
173_V191_L0.5230.61
418_G423_S0.5220.61
347_G351_I0.5210.60
82_L122_T0.5210.60
370_A380_R0.5200.60
421_T428_F0.5190.60
582_A587_L0.5180.60
347_G352_S0.5170.60
359_D371_A0.5170.60
494_Y588_A0.5160.60
376_G446_A0.5150.59
349_A354_E0.5150.59
487_A625_H0.5150.59
91_V483_V0.5150.59
30_K300_A0.5150.59
439_T452_T0.5150.59
442_G448_D0.5150.59
550_V555_A0.5140.59
356_S369_D0.5140.59
443_G446_A0.5140.59
235_V316_G0.5130.59
447_D452_T0.5130.59
487_A491_R0.5120.59
611_L615_D0.5120.59
358_T365_A0.5120.59
58_V585_A0.5110.59
350_E426_G0.5110.59
378_G381_T0.5110.59
441_A447_D0.5110.59
22_V612_D0.5110.59
615_D620_P0.5110.59
423_S426_G0.5100.59
350_E354_E0.5100.59
97_R306_K0.5100.59
376_G384_S0.5100.59
211_A214_V0.5090.59
383_A386_A0.5090.59
215_Y254_Y0.5090.59
370_A444_P0.5080.58
381_T420_G0.5070.58
416_R428_F0.5070.58
442_G450_D0.5050.58
59_A141_H0.5050.58
217_R514_L0.5030.58
29_V46_V0.5030.58
425_T431_P0.5030.58
76_Q99_E0.5020.58
428_F444_P0.5020.58
355_H361_D0.5020.58
598_G639_A0.5020.58
119_A122_T0.5010.57
52_G301_N0.5010.57
355_H380_R0.5010.57
36_S148_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h4lA 2 0.4977 100 0.561 Contact Map
1b63A 2 0.4917 100 0.566 Contact Map
1h7sA 1 0.4476 100 0.567 Contact Map
4p7aA 2 0.4476 100 0.573 Contact Map
3ncvA 2 0.2792 100 0.711 Contact Map
3kdgA 2 0.2853 100 0.715 Contact Map
4e4wB 1 0.3111 100 0.728 Contact Map
3cwvA 1 0.4643 100 0.737 Contact Map
1kijA 2 0.5068 100 0.763 Contact Map
4ipeA 2 0.7906 100 0.763 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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