GREMLIN Database
MUTS1 - DNA mismatch repair protein MutS 1
UniProt: Q9HSM2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 871 (794)
Sequences: 4534 (3036)
Seq/√Len: 107.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
584_A643_D5.7941.00
564_A638_S5.6221.00
582_I585_G5.5381.00
312_D315_Q5.4081.00
316_A571_R5.0301.00
455_R490_A4.4991.00
85_S95_E4.2581.00
285_I633_L3.9181.00
319_G571_R3.8921.00
428_D525_L3.8721.00
573_E646_R3.8721.00
575_V646_R3.8581.00
581_D646_R3.7661.00
40_V75_R3.6311.00
318_V560_L3.5811.00
583_D644_A3.5221.00
308_R312_D3.4171.00
631_V650_V3.2221.00
14_T96_I3.2071.00
480_T503_Y3.1301.00
282_L286_D3.0991.00
651_D685_T3.0911.00
319_G323_D3.0721.00
433_E514_E3.0521.00
560_L638_S3.0371.00
65_L69_L3.0021.00
574_L647_I2.9381.00
269_L301_V2.9281.00
410_A413_P2.9121.00
583_D643_D2.8771.00
426_G432_D2.7411.00
403_A407_D2.7091.00
632_L653_I2.7081.00
308_R574_L2.7031.00
601_A627_V2.6331.00
583_D600_D2.6241.00
40_V77_Y2.6031.00
264_Q269_L2.5761.00
139_F227_A2.5421.00
331_L371_V2.5311.00
269_L636_V2.5151.00
451_R507_E2.4201.00
315_Q574_L2.4171.00
287_H566_A2.4131.00
142_T251_F2.4051.00
315_Q319_G2.3501.00
36_T77_Y2.3391.00
308_R576_A2.3361.00
608_R741_A2.3331.00
630_I640_V2.3261.00
131_F157_F2.3011.00
581_D602_R2.2831.00
18_L29_F2.2581.00
366_A406_A2.2391.00
312_D571_R2.2241.00
408_A427_Y2.1931.00
411_D424_Q2.1791.00
431_L522_R2.1741.00
83_E97_E2.1561.00
32_A35_R2.1541.00
609_F712_T2.1491.00
47_E54_S2.1481.00
259_L263_T2.1401.00
404_E536_R2.1281.00
585_G630_I2.1241.00
429_E433_E2.1221.00
506_A510_S2.1151.00
86_E93_E2.1131.00
611_V742_V2.0931.00
681_L785_V2.0891.00
477_N480_T2.0661.00
475_V483_V2.0621.00
300_W557_L2.0581.00
128_G226_A2.0561.00
308_R649_L2.0531.00
443_A447_G2.0531.00
332_G558_V2.0531.00
322_A565_A2.0361.00
436_A440_E2.0351.00
288_T294_G2.0301.00
270_T302_T2.0301.00
310_E313_R2.0241.00
409_L533_L2.0011.00
536_R539_E1.9981.00
584_A600_D1.9961.00
739_L742_V1.9871.00
447_G451_R1.9831.00
319_G639_F1.9711.00
716_H739_L1.9691.00
324_A327_A1.9681.00
258_E652_G1.9571.00
610_Q745_V1.9361.00
117_A154_L1.9321.00
315_Q571_R1.9241.00
586_R591_E1.9151.00
573_E644_A1.9111.00
321_L331_L1.9001.00
686_S720_R1.8981.00
612_V724_L1.8911.00
328_R565_A1.8901.00
394_D543_V1.8891.00
339_Y364_T1.8811.00
679_R683_A1.8681.00
9_A13_E1.8641.00
194_F229_A1.8581.00
562_E566_A1.8521.00
690_V721_A1.8491.00
569_W633_L1.8391.00
715_L719_V1.8361.00
6_E21_M1.8231.00
5_D9_A1.8201.00
320_A380_E1.8031.00
569_W588_P1.8021.00
257_V306_R1.8011.00
117_A157_F1.7971.00
300_W556_A1.7961.00
532_A536_R1.7941.00
14_T99_V1.7921.00
581_D644_A1.7921.00
289_A332_G1.7881.00
132_V234_I1.7871.00
289_A336_G1.7751.00
788_R791_G1.7731.00
452_E491_Y1.7681.00
540_R543_V1.7551.00
567_N592_Q1.7551.00
528_E532_A1.7551.00
296_R556_A1.7531.00
69_L100_V1.7471.00
452_E455_R1.7361.00
362_R406_A1.7201.00
111_A294_G1.7181.00
560_L636_V1.7161.00
408_A533_L1.7151.00
296_R552_A1.7151.00
400_D543_V1.7131.00
116_L230_A1.7081.00
311_L574_L1.7071.00
713_E788_R1.7061.00
20_A65_L1.7051.00
305_T310_E1.7051.00
792_V796_L1.7021.00
748_A763_R1.7001.00
690_V715_L1.6971.00
430_A433_E1.6931.00
450_D454_D1.6911.00
313_R388_D1.6891.00
272_T280_S1.6841.00
117_A131_F1.6821.00
585_G626_Q1.6761.00
677_L711_A1.6751.00
351_G535_E1.6751.00
783_E787_D1.6701.00
464_D472_Y1.6641.00
255_D307_D1.6611.00
473_I491_Y1.6591.00
692_L695_V1.6561.00
385_P553_E1.6561.00
200_T204_R1.6511.00
788_R792_V1.6341.00
401_V537_V1.6341.00
460_H478_S1.6281.00
440_E443_A1.6271.00
202_R235_A1.6161.00
301_V636_V1.6111.00
337_E367_A1.6111.00
359_L362_R1.6061.00
425_A435_L1.6011.00
153_E156_R1.5951.00
307_D310_E1.5911.00
316_A319_G1.5751.00
677_L692_L1.5751.00
143_R223_V1.5691.00
451_R455_R1.5511.00
442_R519_E1.5461.00
628_A691_V1.5411.00
583_D602_R1.5411.00
332_G562_E1.5341.00
285_I563_H1.5311.00
584_A761_T1.5281.00
425_A436_A1.5191.00
631_V689_L1.5121.00
476_G479_E1.5061.00
315_Q318_V1.5011.00
716_H742_V1.5001.00
755_A777_A1.4961.00
201_H205_E1.4941.00
623_Y762_V1.4931.00
37_V43_L1.4821.00
285_I636_V1.4791.00
36_T40_V1.4751.00
716_H741_A1.4591.00
404_E533_L1.4521.00
474_Q500_A1.4511.00
353_A357_D1.4511.00
118_A163_L1.4501.00
366_A402_R1.4481.00
479_E482_A1.4471.00
132_V245_V1.4461.00
455_R491_Y1.4391.00
395_R399_A1.4261.00
580_L631_V1.4251.00
223_V250_P1.4241.00
348_A353_A1.4211.00
29_F58_A1.4201.00
715_L723_T1.4181.00
585_G601_A1.4141.00
582_I630_I1.4101.00
317_A385_P1.4091.00
745_V764_D1.4061.00
60_V65_L1.4041.00
601_A623_Y1.4021.00
8_Q31_A1.3961.00
774_H790_R1.3891.00
312_D316_A1.3871.00
449_A453_K1.3871.00
707_I711_A1.3661.00
29_F37_V1.3651.00
355_A422_L1.3621.00
116_L132_V1.3571.00
129_L153_E1.3551.00
563_H567_N1.3541.00
582_I601_A1.3521.00
143_R220_D1.3411.00
777_A783_E1.3391.00
338_I364_T1.3360.99
743_V764_D1.3330.99
306_R649_L1.3320.99
746_H763_R1.3320.99
358_L537_V1.3290.99
423_L529_L1.3280.99
493_R501_T1.3260.99
607_R764_D1.3250.99
747_V762_V1.3230.99
677_L695_V1.3230.99
73_V100_V1.3200.99
458_I475_V1.3180.99
485_D490_A1.3110.99
327_A378_T1.3110.99
535_E539_E1.3090.99
359_L413_P1.3030.99
126_D143_R1.3010.99
389_V550_A1.3010.99
635_Q650_V1.2900.99
189_H193_A1.2890.99
50_N54_S1.2850.99
428_D532_A1.2850.99
20_A29_F1.2830.99
111_A286_D1.2790.99
287_H563_H1.2790.99
308_R315_Q1.2780.99
777_A790_R1.2690.99
317_A557_L1.2690.99
292_A552_A1.2680.99
460_H479_E1.2660.99
18_L37_V1.2650.99
14_T17_D1.2570.99
362_R405_L1.2530.99
311_L315_Q1.2520.99
256_H303_R1.2510.99
609_F716_H1.2510.99
392_R546_D1.2460.99
525_L528_E1.2430.99
315_Q636_V1.2410.99
334_V371_V1.2400.99
130_A226_A1.2380.99
607_R743_V1.2150.99
117_A162_V1.2150.99
305_T311_L1.2130.99
272_T276_G1.2070.99
6_E10_L1.2070.99
575_V648_G1.2040.99
280_S283_A1.1940.99
568_Q643_D1.1920.99
355_A527_R1.1900.99
321_L558_V1.1890.99
121_R127_W1.1880.99
504_T509_D1.1880.99
578_D687_D1.1870.99
714_Y718_E1.1860.99
348_A538_G1.1850.99
18_L36_T1.1820.99
578_D648_G1.1760.99
371_V551_L1.1700.99
36_T39_S1.1680.99
132_V230_A1.1670.99
38_A45_V1.1670.99
117_A159_P1.1640.99
203_V227_A1.1630.99
574_L577_G1.1610.99
318_V322_A1.1560.99
574_L648_G1.1530.99
749_A756_V1.1490.98
648_G722_T1.1470.98
167_A191_A1.1460.98
331_L558_V1.1460.98
138_Q249_Q1.1440.98
272_T279_G1.1430.98
392_R553_E1.1410.98
570_V639_F1.1390.98
312_D573_E1.1380.98
328_R562_E1.1380.98
128_G143_R1.1370.98
3_I57_M1.1350.98
119_V162_V1.1340.98
334_V367_A1.1330.98
66_T109_T1.1330.98
87_T92_I1.1330.98
13_E95_E1.1330.98
448_L451_R1.1320.98
11_K33_D1.1300.98
121_R165_G1.1300.98
12_A15_D1.1270.98
754_G790_R1.1260.98
220_D223_V1.1240.98
410_A414_P1.1230.98
209_D215_L1.1190.98
17_D99_V1.1170.98
264_Q302_T1.1140.98
141_V227_A1.1140.98
745_V762_V1.1120.98
600_D761_T1.1090.98
85_S93_E1.1080.98
557_L560_L1.1040.98
73_V105_L1.1040.98
425_A439_D1.1010.98
119_V150_A1.1000.98
601_A626_Q1.0990.98
51_H54_S1.0980.98
10_L96_I1.0950.98
536_R540_R1.0850.98
635_Q649_L1.0780.98
736_A742_V1.0770.98
31_A55_Y1.0760.98
118_A194_F1.0740.98
373_D376_T1.0730.98
87_T90_G1.0720.98
23_V48_K1.0710.98
579_G646_R1.0700.98
437_A514_E1.0690.98
22_Q83_E1.0690.98
264_Q270_T1.0670.98
112_D160_A1.0660.98
662_E667_R1.0660.98
266_N273_M1.0650.97
328_R558_V1.0650.97
31_A50_N1.0640.97
300_W305_T1.0640.97
140_R249_Q1.0640.97
3_I23_V1.0640.97
315_Q639_F1.0580.97
224_V228_G1.0580.97
279_G283_A1.0580.97
364_T551_L1.0570.97
777_A786_V1.0570.97
217_V220_D1.0560.97
143_R222_P1.0540.97
20_A60_V1.0460.97
47_E51_H1.0440.97
257_V653_I1.0410.97
112_D298_A1.0380.97
270_T282_L1.0380.97
47_E50_N1.0360.97
685_T688_S1.0360.97
378_T386_A1.0360.97
706_S709_W1.0340.97
312_D574_L1.0330.97
50_N53_S1.0330.97
80_A99_V1.0300.97
527_R531_A1.0300.97
263_T655_T1.0270.97
510_S514_E1.0250.97
430_A521_E1.0240.97
88_D92_I1.0200.97
315_Q560_L1.0190.97
734_A737_D1.0170.97
22_Q62_V1.0170.97
404_E409_L1.0110.97
329_D562_E1.0090.97
736_A764_D1.0090.97
28_E59_G1.0070.96
476_G480_T1.0060.96
296_R300_W1.0060.96
571_R639_F1.0050.96
444_W511_H1.0020.96
295_R340_D1.0010.96
194_F228_G0.9950.96
345_A544_L0.9940.96
370_D373_D0.9930.96
117_A129_L0.9920.96
49_S54_S0.9870.96
678_S682_H0.9860.96
733_T766_A0.9840.96
204_R209_D0.9840.96
530_F534_R0.9830.96
271_E276_G0.9780.96
368_L551_L0.9780.96
288_T559_S0.9760.96
433_E437_A0.9750.96
559_S563_H0.9700.96
163_L229_A0.9690.96
604_D607_R0.9680.96
153_E251_F0.9680.96
584_A598_P0.9680.96
631_V647_I0.9650.96
9_A93_E0.9640.95
431_L529_L0.9640.95
19_L82_A0.9620.95
630_I645_A0.9610.95
318_V561_A0.9590.95
684_A719_V0.9580.95
466_N472_Y0.9580.95
276_G280_S0.9560.95
212_I215_L0.9560.95
578_D722_T0.9530.95
635_Q647_I0.9490.95
285_I559_S0.9480.95
166_P190_D0.9480.95
404_E408_A0.9460.95
257_V631_V0.9450.95
460_H476_G0.9440.95
10_L19_L0.9430.95
300_W553_E0.9410.95
322_A639_F0.9380.95
746_H749_A0.9370.95
386_A389_V0.9360.95
3_I21_M0.9360.95
47_E53_S0.9340.95
214_S682_H0.9290.94
579_G602_R0.9270.94
220_D250_P0.9270.94
345_A541_A0.9250.94
579_G604_D0.9250.94
446_D449_A0.9230.94
257_V636_V0.9210.94
320_A379_P0.9210.94
422_L527_R0.9210.94
26_F59_G0.9180.94
257_V635_Q0.9140.94
375_L386_A0.9130.94
511_H514_E0.9110.94
315_Q322_A0.9110.94
19_L80_A0.9080.94
706_S710_A0.9070.94
610_Q623_Y0.9070.94
624_M726_A0.9050.94
448_L452_E0.9050.94
630_I641_P0.9020.94
311_L649_L0.9020.94
306_R687_D0.9010.94
406_A424_Q0.8990.93
667_R675_E0.8980.93
627_V689_L0.8940.93
315_Q633_L0.8920.93
89_A93_E0.8920.93
260_D652_G0.8890.93
746_H766_A0.8870.93
213_E218_A0.8860.93
405_L409_L0.8840.93
580_L648_G0.8840.93
782_P785_V0.8830.93
199_A202_R0.8830.93
154_L178_L0.8830.93
142_T153_E0.8820.93
603_F610_Q0.8820.93
119_V129_L0.8810.93
256_H305_T0.8810.93
128_G223_V0.8800.93
574_L649_L0.8790.93
4_V31_A0.8780.93
713_E717_N0.8760.93
118_A230_A0.8750.93
781_V785_V0.8740.92
402_R406_A0.8710.92
203_V215_L0.8710.92
612_V762_V0.8710.92
257_V632_L0.8710.92
398_A547_V0.8710.92
272_T275_G0.8700.92
662_E665_G0.8690.92
748_A761_T0.8690.92
138_Q299_A0.8670.92
359_L363_D0.8620.92
624_M627_V0.8580.92
48_K57_M0.8580.92
792_V795_R0.8570.92
113_P138_Q0.8520.92
444_W448_L0.8510.91
556_A560_L0.8510.91
286_D294_G0.8500.91
467_K498_K0.8500.91
617_M622_T0.8490.91
9_A12_A0.8480.91
139_F230_A0.8470.91
356_T414_P0.8470.91
32_A36_T0.8450.91
580_L627_V0.8430.91
245_V248_I0.8420.91
640_V645_A0.8410.91
318_V328_R0.8400.91
29_F60_V0.8390.91
394_D400_D0.8390.91
113_P133_D0.8390.91
259_L655_T0.8380.91
576_A687_D0.8380.91
580_L647_I0.8380.91
569_W591_E0.8380.91
702_Y729_Y0.8380.91
341_L544_L0.8380.91
7_F23_V0.8370.91
35_R39_S0.8370.91
8_Q12_A0.8360.91
400_D540_R0.8360.91
315_Q638_S0.8350.91
423_L533_L0.8350.91
287_H559_S0.8350.91
255_D310_E0.8340.91
577_G646_R0.8330.91
69_L81_V0.8290.90
95_E239_E0.8290.90
199_A228_G0.8280.90
318_V639_F0.8270.90
251_F256_H0.8250.90
214_S679_R0.8250.90
311_L636_V0.8250.90
35_R38_A0.8230.90
275_G278_D0.8210.90
174_F179_R0.8200.90
458_I483_V0.8200.90
338_I551_L0.8200.90
532_A535_E0.8190.90
86_E89_A0.8160.90
591_E630_I0.8150.90
6_E43_L0.8140.90
386_A390_L0.8140.90
650_V722_T0.8130.89
599_N626_Q0.8130.89
320_A387_R0.8120.89
277_S282_L0.8120.89
344_L361_V0.8120.89
574_L634_A0.8120.89
648_G687_D0.8100.89
469_D494_I0.8100.89
334_V370_D0.8090.89
549_R553_E0.8050.89
203_V206_Q0.8050.89
697_R700_A0.8040.89
433_E436_A0.8030.89
368_L393_V0.8000.89
320_A324_A0.7990.89
385_P389_V0.7980.89
322_A564_A0.7970.89
349_A541_A0.7970.89
410_A421_G0.7970.89
98_R107_A0.7970.89
308_R575_V0.7930.88
313_R384_S0.7920.88
585_G627_V0.7920.88
57_M60_V0.7910.88
301_V633_L0.7900.88
162_V184_A0.7900.88
131_F140_R0.7890.88
435_L522_R0.7890.88
200_T218_A0.7880.88
3_I31_A0.7850.88
437_A448_L0.7840.88
756_V774_H0.7830.88
507_E510_S0.7820.88
35_R56_P0.7810.88
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328_R332_G0.5100.58
574_L794_D0.5100.58
696_G704_G0.5090.58
257_V644_A0.5080.58
438_H522_R0.5080.58
266_N283_A0.5080.58
279_G593_T0.5080.58
98_R352_R0.5080.58
576_A646_R0.5070.57
801_A808_A0.5060.57
731_E773_V0.5060.57
25_D30_F0.5060.57
69_L189_H0.5050.57
356_T415_K0.5050.57
618_S749_A0.5050.57
452_E461_L0.5050.57
3_I8_Q0.5050.57
39_S44_Q0.5050.57
434_L521_E0.5050.57
199_A203_V0.5050.57
121_R147_R0.5050.57
115_Y157_F0.5050.57
14_T82_A0.5040.57
368_L469_D0.5040.57
288_T297_L0.5040.57
23_V55_Y0.5030.57
25_D46_S0.5030.57
373_D377_T0.5030.57
580_L646_R0.5030.57
308_R635_Q0.5030.57
558_V562_E0.5030.57
257_V575_V0.5030.57
802_V806_G0.5030.57
30_F61_P0.5030.57
257_V350_S0.5020.57
568_Q591_E0.5020.57
627_V630_I0.5020.57
123_A222_P0.5010.57
405_L537_V0.5010.57
469_D504_T0.5010.57
12_A77_Y0.5010.57
569_W629_V0.5010.57
476_G498_K0.5000.56
483_V503_Y0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wb9A 2 0.8852 100 0.253 Contact Map
3thxA 1 0.9265 100 0.259 Contact Map
2o8bB 1 0.8852 100 0.27 Contact Map
3thxB 1 0.915 100 0.284 Contact Map
1ewqA 2 0.8496 100 0.299 Contact Map
4hseA 1 0.3272 99.2 0.946 Contact Map
2px0A 4 0.2847 98.9 0.952 Contact Map
2r8rA 1 0.2388 98.8 0.954 Contact Map
2i3bA 1 0.1515 98.7 0.955 Contact Map
4uxhA 3 0.1871 98.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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