GREMLIN Database
Q9HSM1 - Hydrogenase expression/formation
UniProt: Q9HSM1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (293)
Sequences: 14721 (9391)
Seq/√Len: 548.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_R299_D3.2471.00
242_S302_V3.0861.00
242_S304_E2.9901.00
278_V286_V2.7091.00
282_S285_A2.6591.00
157_P305_A2.6301.00
159_D216_T2.4621.00
160_R302_V2.4221.00
62_E110_R2.3931.00
214_E282_S2.3831.00
244_A247_A2.3811.00
47_A81_L2.3201.00
160_R283_V2.2791.00
234_A241_L2.2541.00
216_T279_D2.2391.00
62_E103_A2.2271.00
103_A106_E2.2261.00
162_V299_D2.1841.00
161_V277_A2.1631.00
239_V303_V2.1321.00
40_A146_A2.1271.00
162_V287_L2.1161.00
283_V299_D2.0731.00
230_L241_L2.0661.00
109_D113_R2.0411.00
279_D282_S1.9981.00
240_G304_E1.9931.00
287_L297_A1.9541.00
162_V297_A1.9171.00
62_E106_E1.8971.00
283_V287_L1.8801.00
171_T174_M1.8131.00
157_P239_V1.8051.00
230_L243_V1.8041.00
240_G306_G1.8001.00
242_S310_T1.7851.00
61_I134_T1.7801.00
160_R280_P1.7791.00
84_A143_V1.7511.00
162_V278_V1.7501.00
280_P302_V1.7341.00
49_A140_A1.7301.00
72_C140_A1.7231.00
284_D288_G1.7211.00
76_V81_L1.7181.00
233_L277_A1.6971.00
66_W111_E1.6901.00
161_V241_L1.6851.00
162_V283_V1.6491.00
45_V146_A1.6461.00
44_S147_E1.6381.00
212_A289_A1.6101.00
285_A288_G1.5981.00
110_R113_R1.5691.00
216_T277_A1.5661.00
48_M87_A1.5601.00
155_A217_A1.5581.00
205_D290_L1.5511.00
156_Q279_D1.5501.00
38_V47_A1.5461.00
21_A113_R1.5361.00
299_D302_V1.5261.00
241_L303_V1.4821.00
106_E110_R1.4701.00
27_R45_V1.4691.00
269_S272_G1.4661.00
110_R114_A1.4581.00
23_R26_V1.4421.00
159_D279_D1.4211.00
156_Q216_T1.4011.00
44_S146_A1.3951.00
88_V108_F1.3901.00
218_M276_A1.3891.00
290_L297_A1.3821.00
217_A233_L1.3821.00
63_R198_A1.3801.00
288_G292_D1.3801.00
155_A277_A1.3791.00
169_V177_V1.3711.00
230_L275_I1.3651.00
268_A271_E1.3641.00
82_S207_A1.3511.00
287_L299_D1.3401.00
63_R66_W1.3391.00
36_F79_S1.3301.00
268_A272_G1.3241.00
90_L101_F1.3221.00
76_V140_A1.3201.00
155_A303_V1.3191.00
87_A121_T1.3181.00
150_V218_M1.3171.00
209_M286_V1.3131.00
91_N127_Y1.3071.00
63_R107_V1.2941.00
162_V286_V1.2911.00
14_H102_D1.2871.00
266_W271_E1.2861.00
284_D287_L1.2861.00
111_E114_A1.2811.00
287_L291_G1.2741.00
169_V251_L1.2631.00
144_G149_V1.2541.00
277_A303_V1.2521.00
48_M141_L1.2471.00
166_G169_V1.2431.00
37_G120_T1.2341.00
289_A293_E1.2321.00
285_A289_A1.2311.00
173_G178_L1.2271.00
145_A148_D1.2231.00
244_A302_V1.2181.00
69_F108_F1.2141.00
159_D303_V1.2101.00
85_H120_T1.2051.00
221_A275_I1.2031.00
190_A198_A1.2021.00
44_S145_A1.1961.00
23_R27_R1.1961.00
50_T89_D1.1951.00
78_L218_M1.1921.00
45_V149_V1.1901.00
218_M274_V1.1781.00
69_F86_L1.1701.00
202_P273_T1.1601.00
82_S204_R1.1521.00
221_A229_G1.1511.00
240_G307_S1.1361.00
50_T139_T1.1231.00
42_A143_V1.1231.00
36_F47_A1.1191.00
68_A136_G1.1161.00
38_V149_V1.1111.00
112_A119_L1.1111.00
173_G177_V1.1081.00
66_W114_A1.1061.00
26_V30_P1.1011.00
45_V144_G1.1011.00
61_I100_T1.1011.00
289_A292_D1.0831.00
148_D211_A1.0771.00
26_V29_G1.0701.00
73_V140_A1.0511.00
203_V207_A1.0421.00
174_M178_L1.0401.00
60_G63_R1.0391.00
266_W272_G1.0381.00
86_L140_A1.0371.00
161_V275_I1.0341.00
278_V283_V1.0291.00
160_R278_V1.0221.00
217_A277_A1.0201.00
47_A76_V1.0201.00
70_H111_E1.0151.00
171_T176_G1.0121.00
18_R106_E1.0111.00
92_L101_F1.0101.00
27_R30_P1.0041.00
288_G291_G0.9991.00
212_A285_A0.9971.00
190_A194_R0.9941.00
267_A272_G0.9941.00
219_H232_E0.9931.00
87_A139_T0.9921.00
185_I188_A0.9901.00
49_A76_V0.9881.00
286_V289_A0.9831.00
97_A100_T0.9691.00
48_M139_T0.9681.00
208_T293_E0.9661.00
226_L275_I0.9651.00
73_V117_V0.9641.00
154_G216_T0.9631.00
155_A233_L0.9561.00
23_R82_S0.9531.00
69_F112_A0.9431.00
193_A196_R0.9411.00
41_I143_V0.9411.00
181_D184_P0.9381.00
34_A79_S0.9351.00
206_A276_A0.9351.00
186_S189_A0.9311.00
208_T212_A0.9301.00
267_A270_S0.9301.00
66_W110_R0.9261.00
173_G176_G0.9221.00
206_A210_A0.9181.00
192_A196_R0.9151.00
151_T155_A0.9131.00
265_A269_S0.9111.00
250_V255_R0.9061.00
205_D208_T0.8931.00
151_T154_G0.8911.00
82_S211_A0.8891.00
69_F73_V0.8891.00
148_D213_G0.8881.00
23_R30_P0.8821.00
276_A286_V0.8791.00
171_T175_L0.8781.00
266_W270_S0.8781.00
249_P298_A0.8771.00
65_A107_V0.8751.00
171_T177_V0.8661.00
230_L234_A0.8651.00
13_D17_G0.8631.00
92_L104_I0.8621.00
85_H141_L0.8591.00
255_R259_E0.8581.00
47_A144_G0.8561.00
159_D277_A0.8561.00
180_G183_L0.8511.00
66_W70_H0.8501.00
40_A45_V0.8491.00
208_T289_A0.8441.00
219_H275_I0.8441.00
175_L178_L0.8341.00
164_T205_D0.8331.00
192_A195_D0.8321.00
108_F138_A0.8291.00
15_I19_T0.8271.00
85_H118_S0.8261.00
69_F111_E0.8251.00
13_D16_A0.8211.00
286_V290_L0.8161.00
112_A117_V0.8141.00
158_G302_V0.8131.00
115_L201_T0.8111.00
52_P89_D0.8101.00
174_M177_V0.8081.00
242_S245_R0.8081.00
161_V303_V0.8061.00
35_D219_H0.8061.00
291_G296_P0.8051.00
27_R40_A0.8041.00
52_P137_G0.8031.00
67_F271_E0.7991.00
24_D27_R0.7961.00
86_L138_A0.7951.00
40_A44_S0.7941.00
38_V79_S0.7921.00
156_Q159_D0.7921.00
157_P304_E0.7881.00
234_A303_V0.7871.00
73_V111_E0.7841.00
164_T274_V0.7831.00
256_A259_E0.7821.00
213_G289_A0.7801.00
234_A309_V0.7761.00
68_A138_A0.7741.00
190_A195_D0.7721.00
94_P126_T0.7681.00
150_V210_A0.7681.00
39_V85_H0.7681.00
226_L230_L0.7681.00
28_L151_T0.7651.00
157_P160_R0.7641.00
191_A194_R0.7641.00
101_F126_T0.7631.00
208_T292_D0.7571.00
155_A237_S0.7531.00
229_G275_I0.7531.00
104_I108_F0.7511.00
78_L274_V0.7501.00
167_P170_E0.7461.00
100_T104_I0.7451.00
60_G194_R0.7371.00
258_C265_A0.7361.00
86_L108_F0.7351.00
270_S273_T0.7311.00
204_R208_T0.7301.00
189_A192_A0.7291.00
45_V145_A0.7261.00
102_D106_E0.7251.00
25_D40_A0.7241.00
280_P283_V0.7241.00
221_A273_T0.7221.00
82_S116_G0.7191.00
65_A104_I0.7191.00
265_A271_E0.7191.00
213_G286_V0.7191.00
81_L144_G0.7161.00
98_T102_D0.7161.00
265_A268_A0.7151.00
38_V45_V0.7141.00
180_G184_P0.7101.00
150_V215_V0.7091.00
34_A152_P0.7081.00
214_E285_A0.7081.00
91_N125_G0.7061.00
265_A270_S0.7021.00
170_E270_S0.7001.00
25_D30_P0.7001.00
65_A108_F0.6991.00
86_L112_A0.6991.00
267_A271_E0.6931.00
265_A272_G0.6911.00
172_T175_L0.6911.00
164_T276_A0.6911.00
176_G179_F0.6901.00
132_F135_V0.6891.00
240_G308_G0.6871.00
99_E103_A0.6871.00
146_A149_V0.6871.00
14_H18_R0.6871.00
221_A226_L0.6851.00
25_D39_V0.6831.00
16_A19_T0.6811.00
195_D199_D0.6781.00
57_R130_C0.6771.00
228_N232_E0.6721.00
45_V147_E0.6701.00
247_A298_A0.6701.00
89_D137_G0.6681.00
234_A237_S0.6621.00
96_T101_F0.6621.00
175_L179_F0.6611.00
169_V195_D0.6601.00
206_A274_V0.6591.00
228_N267_A0.6581.00
195_D198_A0.6571.00
188_A191_A0.6571.00
56_L67_F0.6561.00
194_R197_F0.6561.00
82_S143_V0.6551.00
196_R199_D0.6541.00
53_V71_I0.6501.00
23_R28_L0.6501.00
53_V68_A0.6501.00
191_A195_D0.6501.00
205_D295_I0.6491.00
205_D293_E0.6471.00
77_A207_A0.6441.00
193_A197_F0.6441.00
15_I18_R0.6401.00
26_V118_S0.6401.00
162_V276_A0.6391.00
25_D28_L0.6391.00
171_T178_L0.6391.00
100_T103_A0.6351.00
238_G306_G0.6331.00
284_D299_D0.6311.00
266_W269_S0.6261.00
164_T290_L0.6261.00
24_D30_P0.6241.00
49_A72_C0.6231.00
23_R118_S0.6221.00
50_T137_G0.6211.00
128_E133_P0.6201.00
62_E107_V0.6191.00
18_R21_A0.6181.00
187_A190_A0.6171.00
26_V120_T0.6171.00
52_P91_N0.6171.00
86_L119_L0.6171.00
127_Y131_S0.6161.00
163_V249_P0.6131.00
206_A209_M0.6111.00
36_F49_A0.6101.00
104_I136_G0.6081.00
170_E196_R0.6071.00
154_G161_V0.6061.00
90_L136_G0.6031.00
96_T100_T0.5991.00
39_V48_M0.5991.00
165_K298_A0.5971.00
152_P236_A0.5961.00
61_I103_A0.5961.00
58_A133_P0.5961.00
88_V105_W0.5951.00
66_W193_A0.5941.00
60_G103_A0.5941.00
169_V174_M0.5931.00
24_D28_L0.5931.00
72_C138_A0.5921.00
30_P33_G0.5911.00
201_T204_R0.5901.00
213_G282_S0.5901.00
173_G179_F0.5901.00
161_V243_V0.5891.00
159_D280_P0.5871.00
208_T211_A0.5851.00
286_V297_A0.5841.00
252_P255_R0.5800.99
187_A191_A0.5760.99
170_E173_G0.5720.99
172_T178_L0.5720.99
40_A43_D0.5710.99
73_V115_L0.5700.99
304_E307_S0.5700.99
185_I189_A0.5690.99
48_M85_H0.5690.99
165_K296_P0.5680.99
228_N231_H0.5650.99
220_D232_E0.5650.99
57_R104_I0.5640.99
50_T87_A0.5620.99
189_A193_A0.5610.99
219_H233_L0.5590.99
155_A216_T0.5590.99
185_I192_A0.5590.99
155_A239_V0.5560.99
64_A104_I0.5550.99
91_N135_V0.5540.99
210_A218_M0.5530.99
14_H17_G0.5520.99
77_A203_V0.5520.99
114_A200_A0.5510.99
114_A204_R0.5510.99
304_E310_T0.5500.99
188_A256_A0.5490.99
306_G310_T0.5480.99
278_V282_S0.5470.99
190_A193_A0.5460.99
239_V305_A0.5460.99
87_A120_T0.5440.99
75_D220_D0.5400.99
245_R266_W0.5390.99
214_E279_D0.5370.99
51_D75_D0.5360.99
209_M290_L0.5350.99
249_P255_R0.5330.99
161_V165_K0.5280.99
231_H235_A0.5270.99
70_H201_T0.5270.99
163_V167_P0.5250.99
160_R281_G0.5250.99
172_T177_V0.5250.99
23_R39_V0.5220.99
283_V297_A0.5190.99
18_R102_D0.5160.99
251_L296_P0.5130.99
284_D291_G0.5130.99
46_V141_L0.5120.99
214_E289_A0.5120.99
92_L100_T0.5110.99
204_R207_A0.5100.99
14_H19_T0.5070.99
255_R258_C0.5050.99
166_G296_P0.5050.99
150_V154_G0.5000.98
35_D220_D0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3viuA 1 0.941 100 0.289 Contact Map
2yxzA 2 0.8732 100 0.293 Contact Map
3c9uA 2 0.8791 100 0.297 Contact Map
3wjpA 2 0.9263 100 0.3 Contact Map
3fd5A 2 0.9115 100 0.302 Contact Map
2btuA 2 0.885 100 0.305 Contact Map
3mcqA 2 0.8584 100 0.305 Contact Map
2z01A 2 0.8555 100 0.306 Contact Map
2rb9A 2 0.9145 100 0.311 Contact Map
2zodA 2 0.8525 100 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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