GREMLIN Database
Q9HSL8 - Uncharacterized protein
UniProt: Q9HSL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 121 (111)
Sequences: 2535 (1941)
Seq/√Len: 184.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_R55_D2.7581.00
54_A68_R2.7421.00
32_F60_V2.5921.00
13_R50_A2.5611.00
35_G59_G2.4951.00
12_F81_R2.4211.00
38_A43_D2.4181.00
97_T104_G2.2111.00
24_T66_E2.1501.00
50_A72_D2.1381.00
58_D64_G2.1271.00
57_A67_I2.0771.00
28_Q31_A1.9771.00
18_S33_D1.8321.00
33_D37_F1.8101.00
64_G68_R1.6841.00
12_F77_R1.6541.00
98_F114_L1.6441.00
51_D68_R1.4991.00
17_A67_I1.4961.00
81_R84_F1.4931.00
13_R16_V1.4861.00
22_K29_W1.4771.00
78_D82_D1.4541.00
18_S32_F1.4531.00
68_R72_D1.4051.00
97_T106_R1.3981.00
55_D64_G1.3981.00
45_R52_V1.3841.00
85_A89_E1.3341.00
35_G56_I1.3231.00
18_S29_W1.3161.00
16_V74_E1.2881.00
100_Y117_L1.2861.00
66_E75_A1.2701.00
94_G97_T1.2691.00
70_V76_W1.2621.00
39_A56_I1.2351.00
20_Y70_V1.2351.00
113_Q116_R1.2321.00
35_G43_D1.2111.00
32_F36_V1.1781.00
9_V46_D1.1751.00
19_L83_E1.1681.00
69_T75_A1.1681.00
109_V113_Q1.1501.00
86_D102_G1.1471.00
19_L22_K1.1411.00
115_E119_E1.1361.00
63_D66_E1.1351.00
54_A64_G1.1081.00
27_E31_A1.0961.00
105_A117_L1.0841.00
111_P115_E1.0711.00
86_D90_A1.0701.00
17_A32_F1.0671.00
19_L76_W1.0451.00
14_A47_V1.0140.99
36_V53_L1.0070.99
23_E76_W1.0050.99
46_D49_D1.0020.99
24_T62_L1.0000.99
85_A88_R0.9980.99
17_A36_V0.9700.99
30_L34_E0.9680.99
39_A45_R0.9580.99
94_G106_R0.9570.99
77_R81_R0.9540.99
8_D40_L0.9410.99
35_G60_V0.9400.99
9_V48_G0.9360.99
17_A53_L0.9100.99
20_Y67_I0.9070.99
38_A42_A0.9040.99
82_D89_E0.8930.99
50_A54_A0.8640.98
110_P113_Q0.8630.98
54_A58_D0.8590.98
50_A68_R0.8580.98
106_R109_V0.8510.98
11_G15_Q0.8490.98
16_V70_V0.8470.98
55_D58_D0.8450.98
66_E69_T0.8400.98
88_R93_T0.8290.98
55_D59_G0.8190.98
39_A52_V0.8070.97
21_V27_E0.8040.97
28_Q60_V0.8010.97
83_E90_A0.7850.97
92_I104_G0.7850.97
20_Y76_W0.7800.97
16_V77_R0.7790.97
105_A114_L0.7740.97
90_A104_G0.7700.97
114_L117_L0.7690.97
18_S36_V0.7620.96
100_Y105_A0.7600.96
20_Y24_T0.7440.96
69_T73_D0.7400.96
16_V75_A0.7380.96
19_L79_R0.7330.96
82_D86_D0.7320.95
35_G39_A0.7320.95
54_A57_A0.7310.95
34_E38_A0.7290.95
24_T63_D0.7270.95
16_V76_W0.7170.95
14_A53_L0.7120.95
29_W33_D0.7100.95
86_D89_E0.7090.95
9_V40_L0.7080.95
11_G47_V0.6950.94
52_V56_I0.6900.94
20_Y66_E0.6810.93
87_A99_V0.6790.93
76_W79_R0.6760.93
23_E79_R0.6730.93
84_F88_R0.6580.92
20_Y62_L0.6510.92
8_D37_F0.6300.90
16_V73_D0.6300.90
41_W97_T0.6260.90
100_Y104_G0.6250.90
94_G108_A0.6220.90
19_L29_W0.6210.90
54_A67_I0.6190.90
66_E70_V0.6170.90
99_V104_G0.6160.89
83_E87_A0.6130.89
52_V55_D0.6070.89
12_F84_F0.6060.89
19_L23_E0.6030.88
56_I60_V0.5970.88
49_D52_V0.5920.88
22_K27_E0.5870.87
32_F57_A0.5810.87
98_F108_A0.5800.87
11_G33_D0.5780.86
32_F56_I0.5750.86
90_A99_V0.5730.86
50_A71_V0.5640.85
62_L67_I0.5630.85
38_A59_G0.5610.85
14_A44_D0.5600.85
79_R82_D0.5560.84
56_I59_G0.5530.84
8_D11_G0.5510.84
53_L71_V0.5500.84
46_D52_V0.5420.83
14_A48_G0.5390.82
17_A33_D0.5380.82
36_V47_V0.5370.82
108_A114_L0.5350.82
7_G46_D0.5340.82
19_L70_V0.5260.81
27_E32_F0.5230.80
80_L83_E0.5220.80
31_A35_G0.5180.80
84_F94_G0.5170.80
21_V62_L0.5150.79
65_E69_T0.5150.79
116_R119_E0.5140.79
88_R106_R0.5100.79
7_G44_D0.5050.78
112_S116_R0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gl5A 2 0.9835 99.9 0.347 Contact Map
3fz5A 2 1 99.9 0.355 Contact Map
3rppA 2 1 99.9 0.364 Contact Map
1r4wA 2 1 99.9 0.374 Contact Map
2imfA 2 0.9669 99.9 0.377 Contact Map
3kzqA 3 0.9835 99.9 0.395 Contact Map
2in3A 1 1 99.9 0.4 Contact Map
3ghaA 1 0.9917 99.8 0.453 Contact Map
3bciA 1 0.9835 99.8 0.459 Contact Map
3f4sA 1 0.9669 99.8 0.462 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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