GREMLIN Database
MUTS2 - DNA mismatch repair protein MutS 2
UniProt: Q9HSL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 863 (813)
Sequences: 4546 (3093)
Seq/√Len: 108.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
595_G655_A5.9371.00
576_A650_C5.6821.00
593_I596_G5.5961.00
333_A336_H5.5321.00
337_D583_K5.0941.00
471_R502_D4.5841.00
103_V116_A4.3311.00
585_V658_E4.0071.00
444_D537_L4.0071.00
340_G583_K3.9781.00
306_L645_L3.9521.00
592_H658_E3.8601.00
587_G658_E3.7971.00
58_I93_A3.6741.00
594_E656_A3.6411.00
339_V572_F3.6041.00
329_S333_A3.4681.00
340_G344_A3.3631.00
832_A835_V3.3201.00
643_V662_V3.3031.00
303_V307_D3.1641.00
32_Y117_V3.1481.00
663_D697_T3.1331.00
496_M515_Y3.1251.00
426_V429_P3.0531.00
449_D526_E3.0371.00
83_A87_I3.0251.00
572_F650_C3.0121.00
288_L322_L2.9641.00
586_M659_L2.9261.00
594_E655_A2.8991.00
419_G423_R2.7931.00
613_T639_V2.7391.00
329_S586_M2.7001.00
594_E612_D2.6991.00
283_L288_L2.6591.00
442_G448_D2.6581.00
644_V665_V2.6451.00
58_I95_Y2.5941.00
165_C241_C2.5481.00
352_L392_V2.5221.00
288_L648_A2.5201.00
467_S519_E2.5071.00
308_E578_A2.4701.00
336_H586_M2.4261.00
54_T95_Y2.3721.00
642_I652_V2.3471.00
592_H614_T2.3311.00
168_T270_Y2.3251.00
336_H340_G2.3011.00
50_A53_E2.2801.00
157_L183_F2.2761.00
36_L47_L2.2581.00
596_G642_I2.2301.00
445_E449_D2.2291.00
427_A440_R2.2191.00
424_A443_Y2.2181.00
341_E401_A2.1951.00
101_D118_T2.1931.00
329_S588_G2.1811.00
693_L797_V2.1701.00
65_A72_Q2.1691.00
333_A583_K2.1641.00
621_V724_T2.1601.00
491_V499_V2.1511.00
447_L534_A2.1221.00
620_R753_D2.1161.00
387_A422_D2.1161.00
623_V754_A2.1081.00
425_I545_I2.1021.00
353_H570_A2.0991.00
420_L548_R2.0971.00
105_D109_V2.0871.00
463_D467_S2.0791.00
751_L754_A2.0771.00
104_Q114_D2.0741.00
289_F323_R2.0711.00
518_P522_E2.0701.00
278_M282_A2.0681.00
595_G612_D2.0641.00
452_A456_A2.0571.00
340_G651_F2.0521.00
329_S661_V2.0371.00
331_A334_A2.0311.00
585_V656_A2.0241.00
548_R551_E2.0161.00
343_V577_A2.0121.00
698_D732_G2.0081.00
493_K496_M1.9991.00
321_W569_L1.9981.00
141_A180_L1.9751.00
622_A757_L1.9741.00
728_H751_L1.9711.00
277_Q664_R1.9691.00
154_G240_A1.9611.00
412_D555_R1.9471.00
334_A406_S1.9461.00
581_Y645_L1.9431.00
309_T315_R1.9341.00
18_L26_F1.9301.00
345_D348_S1.9301.00
624_I736_L1.9171.00
336_H583_K1.9091.00
691_S695_A1.9051.00
24_Q39_F1.8831.00
27_E31_R1.8811.00
459_Q463_D1.8801.00
213_F243_A1.8751.00
592_H656_A1.8651.00
349_R577_A1.8631.00
360_Y385_T1.8581.00
574_A578_A1.8471.00
342_L352_L1.8461.00
702_V733_A1.8461.00
727_I731_V1.8381.00
274_E328_D1.8331.00
800_R803_E1.8321.00
544_G548_R1.8291.00
572_F648_A1.8101.00
332_I586_M1.8011.00
310_A357_R1.7941.00
23_S27_E1.7941.00
141_A183_F1.7931.00
466_A470_E1.7921.00
276_L327_V1.7911.00
321_W568_A1.7851.00
468_E503_Y1.7831.00
540_E544_G1.7811.00
310_A353_H1.7791.00
158_L248_A1.7781.00
291_Q297_T1.7751.00
32_Y120_V1.7741.00
552_A555_R1.7701.00
468_E471_R1.7641.00
141_A157_L1.7581.00
152_G169_R1.7571.00
579_H603_R1.7551.00
317_K564_A1.7551.00
581_Y599_P1.7511.00
140_V244_L1.7471.00
326_L331_A1.7451.00
795_E799_D1.7371.00
725_E800_R1.7371.00
87_I121_V1.7351.00
446_R449_D1.7231.00
597_R602_E1.7201.00
596_G638_Q1.7201.00
760_A775_R1.7121.00
317_K568_A1.7091.00
417_I549_V1.7081.00
38_L83_A1.7021.00
424_A545_I1.7021.00
702_V727_I1.7001.00
416_E555_R1.6941.00
689_L723_V1.6921.00
480_G488_Y1.6921.00
135_A315_R1.6781.00
489_I503_Y1.6781.00
169_R237_E1.6771.00
328_D331_A1.6741.00
69_S72_Q1.6711.00
291_Q301_A1.6681.00
220_E224_D1.6651.00
322_L648_A1.6631.00
804_L808_P1.6631.00
836_A840_D1.6621.00
383_A422_D1.6551.00
372_G547_E1.6531.00
358_D388_V1.6441.00
704_L707_V1.6421.00
456_A459_Q1.6031.00
800_R804_L1.6021.00
441_D452_A1.5891.00
643_V701_L1.5831.00
595_G773_A1.5791.00
380_R383_A1.5761.00
441_D451_R1.5721.00
306_L575_V1.5571.00
219_R223_A1.5561.00
594_E614_T1.5541.00
179_E182_R1.5531.00
337_D340_G1.5521.00
458_K531_E1.5461.00
336_H339_V1.5361.00
689_L704_L1.5341.00
728_H754_A1.5261.00
640_A703_L1.5191.00
387_A418_R1.5181.00
158_L264_L1.5151.00
471_R503_Y1.5011.00
353_H574_A1.4981.00
635_Y774_V1.4971.00
476_S494_A1.4971.00
369_V374_A1.4961.00
492_T495_N1.4941.00
495_N498_A1.4851.00
407_L562_A1.4801.00
467_S471_R1.4771.00
767_G789_R1.4761.00
78_V83_A1.4661.00
376_A438_V1.4581.00
593_I642_I1.4531.00
591_I643_V1.4521.00
719_I723_V1.4501.00
728_H753_D1.4441.00
306_L648_A1.4411.00
420_L545_I1.4331.00
133_G136_D1.4291.00
374_A378_D1.4261.00
54_T58_I1.4251.00
47_L76_A1.4151.00
379_L549_V1.4051.00
146_G236_A1.4041.00
26_F49_C1.4041.00
596_G613_T1.4011.00
17_D23_S1.3971.00
727_I735_T1.3931.00
757_L776_A1.3931.00
91_L121_V1.3891.00
613_T635_Y1.3881.00
465_E469_R1.3861.00
221_R249_E1.3851.00
55_A61_V1.3841.00
47_L55_A1.3771.00
208_Y212_A1.3721.00
403_K565_A1.3691.00
140_V158_L1.3691.00
786_E802_R1.3681.00
758_H775_R1.3681.00
490_E512_A1.3661.00
135_A307_D1.3631.00
142_A189_V1.3511.00
759_F774_V1.3501.00
327_V661_V1.3461.00
755_L776_A1.3441.00
593_I613_T1.3411.00
505_R513_E1.3381.00
831_A835_V1.3371.00
439_I541_L1.3331.00
291_Q300_T1.3321.00
155_L179_E1.3310.99
333_A337_D1.3280.99
789_R795_E1.3250.99
237_E269_R1.3240.99
313_L564_A1.3240.99
383_A421_L1.3240.99
575_V579_H1.3200.99
619_R755_L1.3160.99
789_R802_R1.3150.99
308_E575_V1.3110.99
169_R234_T1.3080.99
444_D544_G1.3070.99
647_Q662_V1.3040.99
547_E551_E1.3040.99
333_A585_V1.2960.99
355_H392_V1.2950.99
834_I838_L1.2910.99
836_A839_R1.2900.99
329_S336_H1.2890.99
689_L707_V1.2830.99
621_V728_H1.2790.99
338_A403_K1.2700.99
32_Y35_A1.2690.99
145_G191_G1.2680.99
338_A569_L1.2650.99
590_G660_R1.2650.99
141_A188_L1.2620.99
537_L540_E1.2620.99
326_L332_I1.2610.99
19_T24_Q1.2600.99
193_G210_D1.2580.99
38_L47_L1.2520.99
36_L55_A1.2490.99
619_R776_A1.2460.99
516_V521_K1.2420.99
410_A558_A1.2400.99
332_I336_H1.2400.99
136_D319_T1.2390.99
359_V385_T1.2270.99
376_A539_Y1.2260.99
660_R734_T1.2230.99
156_A240_A1.2160.99
141_A185_P1.2140.99
474_V491_V1.2100.99
275_H324_R1.2090.99
348_S399_A1.2070.99
426_V430_P1.2040.99
56_A63_L1.2010.99
105_D108_E1.1990.99
352_L570_A1.1980.99
290_E296_G1.1970.99
835_V839_R1.1950.99
238_L242_G1.1940.99
31_R116_A1.1900.99
392_V563_L1.1860.99
234_T237_E1.1840.99
410_A565_A1.1830.99
143_L188_L1.1780.99
84_E130_E1.1740.99
336_H648_A1.1740.99
54_T57_R1.1690.99
587_G660_R1.1690.99
586_M660_R1.1680.99
580_D655_A1.1670.99
24_Q28_L1.1650.99
342_L570_A1.1640.99
590_G699_E1.1630.99
36_L54_T1.1630.99
441_D455_R1.1620.99
476_S495_N1.1620.99
222_V241_C1.1600.99
586_M589_D1.1490.99
746_A749_D1.1490.99
349_R574_A1.1480.98
355_H388_V1.1460.98
464_L467_S1.1460.98
142_A213_F1.1340.98
761_A768_V1.1340.98
21_M41_V1.1330.98
341_E400_D1.1320.98
394_G397_A1.1310.98
725_E729_D1.1260.98
321_W326_L1.1250.98
283_L323_R1.1220.98
21_M75_M1.1200.98
726_H730_A1.1200.98
339_V343_V1.1200.98
29_T51_A1.1200.98
569_L572_F1.1170.98
385_T563_L1.1160.98
104_Q109_V1.1150.98
369_V550_A1.1150.98
91_L126_V1.1130.98
103_V114_D1.1090.98
35_A120_V1.1080.98
65_A69_S1.1080.98
167_A241_C1.1080.98
154_G169_R1.1070.98
831_A836_A1.1060.98
158_L244_L1.1050.98
612_D773_A1.1040.98
301_A304_D1.1030.98
30_R33_D1.0950.98
166_Y268_T1.0950.98
380_R429_P1.0880.98
105_D111_G1.0870.98
145_G153_F1.0850.98
40_Q101_D1.0840.98
420_L424_A1.0790.98
49_C73_Y1.0770.98
169_R236_A1.0770.98
613_T638_Q1.0730.98
338_A401_A1.0700.98
674_D679_R1.0680.98
143_L176_V1.0670.98
213_F242_G1.0670.98
164_D268_T1.0650.98
766_D802_R1.0650.98
41_V66_R1.0650.98
582_T651_F1.0600.97
647_Q661_V1.0600.97
718_A721_R1.0590.97
453_T526_E1.0580.97
399_A404_L1.0560.97
300_T304_D1.0540.97
38_L78_V1.0530.97
98_A120_V1.0470.97
336_H572_F1.0460.97
789_R798_V1.0460.97
447_L541_L1.0460.97
67_E72_Q1.0450.97
583_K651_F1.0390.97
40_Q80_I1.0370.97
283_L289_F1.0360.97
522_E526_E1.0360.97
757_L774_V1.0340.97
105_D113_V1.0330.97
832_A836_A1.0330.97
285_S292_R1.0300.97
389_V563_L1.0300.97
282_A667_T1.0290.97
349_R570_A1.0260.97
492_T496_M1.0220.97
276_L665_V1.0190.97
420_L425_I1.0190.97
697_T700_S1.0180.97
595_G610_P1.0180.97
690_A694_R1.0160.97
18_L22_M1.0140.97
336_H651_F1.0140.97
317_K321_W1.0110.97
126_V132_L1.0060.97
264_L267_V1.0050.97
289_F303_V1.0040.96
152_G236_A1.0030.96
343_V651_F1.0020.96
449_D453_T1.0010.96
333_A586_M1.0000.96
28_L37_V0.9990.96
391_E394_G0.9960.96
446_R533_R0.9930.96
539_Y543_V0.9930.96
46_E77_G0.9870.96
316_R361_D0.9840.96
831_A839_R0.9820.96
141_A155_L0.9800.96
647_Q659_L0.9790.96
179_E270_Y0.9770.96
37_V100_A0.9750.96
616_N619_R0.9750.96
366_V556_M0.9740.96
590_G734_T0.9730.96
642_I657_A0.9730.96
28_L117_V0.9720.96
464_L468_E0.9720.96
542_F546_R0.9710.96
548_R552_A0.9690.96
18_L70_T0.9690.96
309_T571_S0.9680.96
460_W523_R0.9660.96
748_A754_A0.9630.96
279_D664_R0.9620.96
109_V112_V0.9600.95
136_D186_A0.9560.95
339_V573_A0.9510.95
380_R384_D0.9500.95
833_G836_A0.9490.95
21_M39_F0.9490.95
622_A635_Y0.9490.95
350_E574_A0.9490.95
624_I774_V0.9470.95
679_R687_T0.9460.95
748_A776_A0.9430.95
274_E331_A0.9430.95
615_L622_A0.9420.95
438_V539_Y0.9420.95
745_T778_A0.9420.95
831_A834_I0.9390.95
591_I639_V0.9390.95
233_P694_R0.9380.95
837_E840_D0.9370.95
306_L571_S0.9360.95
168_T179_E0.9340.95
571_S575_V0.9330.95
65_A70_T0.9320.95
643_V659_L0.9300.95
718_A722_A0.9290.95
234_T269_R0.9290.95
37_V98_A0.9260.94
696_A731_V0.9260.94
154_G237_E0.9200.94
834_I837_E0.9190.94
27_E114_D0.9190.94
639_V701_L0.9150.94
462_D465_E0.9130.94
476_S492_T0.9120.94
642_I653_P0.9120.94
418_R422_D0.9100.94
321_W565_A0.9090.94
327_V699_E0.9090.94
18_L49_C0.9080.94
339_V651_F0.9070.94
164_D320_D0.9060.94
291_Q296_G0.9050.94
298_D303_V0.9050.94
336_H343_V0.9030.94
523_R526_E0.9010.94
189_V243_A0.8990.94
482_N488_Y0.8980.94
366_V553_A0.8980.94
674_D677_G0.8970.94
44_F77_G0.8910.93
416_E552_A0.8910.93
276_L648_A0.8890.93
106_P113_V0.8880.93
421_L425_I0.8880.93
422_D440_R0.8870.93
794_P797_V0.8860.93
793_V797_V0.8850.93
588_G699_E0.8830.93
145_G151_A0.8810.93
414_L559_V0.8780.93
586_M661_V0.8780.93
758_H778_A0.8750.93
22_M49_C0.8730.93
119_R128_E0.8720.93
834_I839_R0.8690.92
27_E30_R0.8680.92
591_I660_R0.8660.92
760_A773_A0.8630.92
109_V114_D0.8610.92
586_M646_A0.8600.92
218_A242_G0.8590.92
47_L78_V0.8570.92
768_V786_E0.8560.92
26_F30_R0.8550.92
276_L643_V0.8550.92
87_I99_V0.8550.92
276_L647_Q0.8520.92
662_V734_T0.8510.92
142_A244_L0.8510.92
137_N164_D0.8500.92
397_A408_R0.8500.92
412_D416_E0.8480.91
343_V576_A0.8480.91
568_A572_F0.8480.91
270_Y275_H0.8470.91
714_T741_H0.8470.91
636_M639_V0.8430.91
276_L644_V0.8420.91
581_Y602_E0.8420.91
541_L544_G0.8410.91
460_W464_L0.8350.91
758_H761_A0.8340.91
50_A54_T0.8340.91
804_L807_A0.8320.91
449_D452_A0.8310.91
53_E57_R0.8260.90
351_E395_L0.8260.90
137_N159_D0.8260.90
308_E571_S0.8260.90
341_E405_Q0.8250.90
496_M499_V0.8250.90
439_I545_I0.8240.90
275_H326_L0.8220.90
65_A71_G0.8220.90
223_A228_G0.8210.90
326_L329_S0.8150.90
602_E642_I0.8140.90
336_H650_C0.8130.90
451_R534_A0.8130.90
589_D658_E0.8120.90
629_M634_T0.8120.90
25_Y41_V0.8110.90
519_E522_E0.8100.89
829_G832_A0.8100.89
336_H645_L0.8090.89
342_L404_L0.8080.89
87_I131_L0.8070.89
218_A221_R0.8050.89
339_V349_R0.8050.89
485_H510_K0.8030.89
426_V437_G0.7990.89
611_N638_Q0.7990.89
362_I556_M0.7980.89
806_D810_T0.7970.89
636_M738_A0.7950.89
393_R411_L0.7940.89
289_F322_L0.7940.89
239_R243_A0.7930.88
278_M667_T0.7930.88
596_G639_V0.7920.88
296_G299_G0.7920.88
474_V499_V0.7910.88
332_I661_V0.7890.88
544_G547_E0.7880.88
453_T464_L0.7870.88
233_P691_S0.7850.88
143_L155_L0.7850.88
47_L75_M0.7850.88
467_S502_D0.7810.88
66_R75_M0.7800.88
652_V657_A0.7790.88
591_I659_L0.7790.88
464_L517_T0.7790.88
485_H506_R0.7780.88
287_E292_R0.7780.88
307_D315_R0.7750.87
157_L166_Y0.7740.87
721_R725_E0.7730.87
53_E56_A0.7730.87
799_D803_E0.7730.87
384_D387_A0.7730.87
688_E737_F0.7710.87
709_R712_A0.7700.87
359_V563_L0.7690.87
377_R430_P0.7670.87
53_E74_P0.7670.87
332_I648_A0.7660.87
763_R781_A0.7660.87
84_E119_R0.7650.87
355_H391_E0.7630.86
483_S510_K0.7620.86
443_Y544_G0.7610.86
57_R95_Y0.7610.86
146_G150_D0.7600.86
426_V440_R0.7600.86
65_A73_Y0.7590.86
833_G837_E0.7590.86
532_Q536_D0.7590.86
627_P638_Q0.7590.86
348_S395_L0.7570.86
49_C69_S0.7570.86
34_D96_R0.7560.86
838_L841_V0.7550.86
561_R565_A0.7520.86
218_A239_R0.7520.86
660_R699_E0.7510.86
322_L645_L0.7500.86
167_A267_V0.7500.86
504_Q518_P0.7500.86
329_S587_G0.7490.85
228_G231_V0.7470.85
53_E71_G0.7450.85
132_L138_N0.7450.85
75_M78_V0.7440.85
144_A191_G0.7430.85
464_L519_E0.7420.85
189_V244_L0.7410.85
291_Q295_H0.7410.85
41_V48_F0.7410.85
190_V205_V0.7410.85
365_L382_L0.7410.85
714_T781_A0.7390.85
619_R757_L0.7380.85
265_N557_Q0.7380.85
582_T656_A0.7370.85
305_V603_R0.7370.85
64_T75_M0.7370.85
155_L170_L0.7360.84
696_A733_A0.7350.84
296_G300_T0.7340.84
803_E807_A0.7330.84
582_T652_V0.7320.84
627_P791_A0.7320.84
623_V744_L0.7310.84
758_H777_G0.7300.84
666_F695_A0.7290.84
46_E75_M0.7280.84
144_A239_R0.7280.84
629_M791_A0.7260.84
80_I101_D0.7260.84
568_A571_S0.7260.84
717_L721_R0.7250.84
154_G218_A0.7250.84
156_A165_C0.7240.84
343_V573_A0.7230.83
837_E841_V0.7230.83
59_C90_L0.7220.83
380_R426_V0.7220.83
24_Q61_V0.7210.83
298_D319_T0.7200.83
18_L23_S0.7180.83
153_F176_V0.7180.83
830_A835_V0.7170.83
350_E354_E0.7170.83
433_L438_V0.7170.83
19_T55_A0.7140.83
108_E111_G0.7130.83
320_D324_R0.7120.82
564_A568_A0.7120.82
89_A93_A0.7120.82
297_T301_A0.7120.82
639_V736_L0.7110.82
21_M49_C0.7090.82
326_L647_Q0.7090.82
228_G233_P0.7070.82
450_L530_A0.7070.82
212_A246_S0.7060.82
347_L351_E0.7050.82
103_V118_T0.7050.82
103_V107_D0.7050.82
116_A253_G0.7040.82
420_L443_Y0.7040.82
780_T783_Y0.7020.82
28_L39_F0.7020.82
529_R533_R0.7000.81
630_S758_H0.6990.81
192_P207_A0.6980.81
38_L101_D0.6980.81
301_A356_L0.6970.81
539_Y546_R0.6970.81
415_P419_G0.6970.81
453_T456_A0.6970.81
673_D681_T0.6950.81
376_A435_D0.6950.81
608_F634_T0.6940.81
417_I421_L0.6930.81
781_A809_A0.6930.81
621_V754_A0.6900.80
799_D802_R0.6900.80
819_T822_A0.6900.80
829_G833_G0.6890.80
453_T460_W0.6880.80
821_T828_R0.6880.80
443_Y541_L0.6880.80
504_Q521_K0.6880.80
575_V581_Y0.6870.80
714_T809_A0.6860.80
480_G516_V0.6850.80
70_T73_Y0.6840.80
622_A755_L0.6840.80
153_F180_L0.6840.80
429_P436_G0.6830.80
389_V559_V0.6830.80
502_D518_P0.6820.80
218_A226_F0.6820.80
165_C244_L0.6820.80
430_P437_G0.6810.80
798_V802_R0.6810.80
720_A737_F0.6810.80
630_S772_H0.6800.80
317_K320_D0.6790.79
670_G681_T0.6790.79
554_E557_Q0.6780.79
155_L183_F0.6780.79
572_F575_V0.6770.79
453_T457_G0.6770.79
288_L644_V0.6760.79
593_I639_V0.6760.79
590_G617_D0.6750.79
764_G767_G0.6750.79
41_V62_T0.6740.79
446_R540_E0.6740.79
509_L512_A0.6730.79
55_A76_A0.6720.79
139_F159_D0.6720.79
474_V495_N0.6720.79
642_I659_L0.6710.79
414_L555_R0.6700.79
327_V665_V0.6700.79
28_L100_A0.6690.78
154_G236_A0.6680.78
635_Y639_V0.6670.78
472_T475_D0.6670.78
805_L809_A0.6670.78
389_V411_L0.6660.78
420_L423_R0.6650.78
685_E709_R0.6640.78
327_V647_Q0.6630.78
85_P88_E0.6620.78
328_D333_A0.6610.78
192_P209_D0.6610.78
644_V647_Q0.6610.78
707_V723_V0.6610.78
348_S351_E0.6600.77
690_A738_A0.6590.77
727_I733_A0.6590.77
341_E399_A0.6580.77
549_V556_M0.6580.77
49_C74_P0.6580.77
476_S496_M0.6570.77
304_D603_R0.6570.77
489_I502_D0.6570.77
638_Q642_I0.6570.77
152_G171_G0.6560.77
834_I841_V0.6560.77
208_Y250_Y0.6550.77
299_G304_D0.6550.77
330_D333_A0.6550.77
416_E419_G0.6540.77
383_A418_R0.6540.77
409_E413_D0.6530.77
624_I757_L0.6530.77
726_H731_V0.6530.77
379_L546_R0.6520.77
282_A691_S0.6510.77
107_D114_D0.6510.77
167_A237_E0.6510.77
338_A404_L0.6500.76
536_D540_E0.6500.76
426_V441_D0.6490.76
458_K462_D0.6480.76
763_R786_E0.6480.76
25_Y39_F0.6470.76
620_R732_G0.6460.76
453_T530_A0.6460.76
372_G543_V0.6460.76
393_R408_R0.6450.76
785_V798_V0.6450.76
21_M25_Y0.6450.76
472_T502_D0.6440.76
403_K569_L0.6430.76
462_D466_A0.6430.76
69_S73_Y0.6430.76
415_P418_R0.6430.76
222_V225_Y0.6430.76
401_A404_L0.6420.76
278_M283_L0.6410.75
96_R630_S0.6400.75
203_A206_A0.6400.75
49_C70_T0.6400.75
321_W572_F0.6400.75
154_G234_T0.6390.75
788_A793_V0.6380.75
640_A683_M0.6380.75
138_N186_A0.6380.75
206_A209_D0.6380.75
322_L423_R0.6360.75
317_K561_R0.6350.75
320_D363_E0.6350.75
46_E64_T0.6350.75
21_M76_A0.6350.75
50_A146_G0.6350.75
215_P235_T0.6340.75
690_A793_V0.6340.75
290_E319_T0.6340.75
475_D498_A0.6340.75
703_L758_H0.6320.74
438_V451_R0.6320.74
39_F82_T0.6310.74
438_V535_Q0.6310.74
41_V74_P0.6310.74
336_H652_V0.6310.74
636_M667_T0.6300.74
311_C356_L0.6300.74
60_E89_A0.6300.74
40_Q63_L0.6290.74
321_W336_H0.6290.74
521_K524_E0.6290.74
45_Y101_D0.6280.74
59_C86_Y0.6280.74
85_P89_A0.6280.74
289_F292_R0.6280.74
681_T710_G0.6270.74
154_G185_P0.6270.74
341_E345_D0.6270.74
645_L648_A0.6260.74
309_T568_A0.6250.74
271_S274_E0.6240.73
345_D399_A0.6240.73
629_M787_V0.6220.73
153_F170_L0.6220.73
38_L65_A0.6220.73
435_D539_Y0.6210.73
411_L559_V0.6210.73
295_H299_G0.6200.73
746_A750_R0.6200.73
35_A98_A0.6200.73
491_V498_A0.6200.73
88_E92_D0.6190.73
581_Y650_C0.6180.73
410_A562_A0.6170.73
589_D699_E0.6160.73
587_G590_G0.6150.72
369_V549_V0.6140.72
108_E112_V0.6130.72
802_R806_D0.6120.72
664_R695_A0.6110.72
373_R636_M0.6110.72
28_L112_V0.6110.72
63_L76_A0.6100.72
154_G167_A0.6100.72
355_H395_L0.6090.72
105_D110_S0.6090.72
199_F206_A0.6090.72
621_V753_D0.6090.72
104_Q107_D0.6080.72
454_E718_A0.6080.72
228_G694_R0.6070.71
288_L600_V0.6070.71
571_S574_A0.6070.71
388_V391_E0.6070.71
298_D307_D0.6070.71
298_D301_A0.6070.71
634_T637_R0.6070.71
97_V121_V0.6060.71
66_R112_V0.6060.71
18_L69_S0.6060.71
330_D334_A0.6050.71
725_E804_L0.6050.71
28_L31_R0.6030.71
406_S410_A0.6030.71
82_T85_P0.6030.71
434_T437_G0.6020.71
431_Q434_T0.6010.71
413_D559_V0.6000.71
643_V660_R0.6000.71
303_V318_L0.5980.70
41_V83_A0.5980.70
467_S470_E0.5970.70
63_L75_M0.5970.70
283_L324_R0.5970.70
37_V59_C0.5960.70
209_D213_F0.5960.70
111_G117_V0.5950.70
525_E529_R0.5950.70
508_T513_E0.5950.70
41_V47_L0.5950.70
639_V644_V0.5940.70
216_A219_R0.5940.70
370_S553_A0.5940.70
484_V507_Q0.5940.70
41_V510_K0.5920.70
832_A841_V0.5920.70
726_H796_P0.5920.70
237_E240_A0.5910.69
338_A342_L0.5910.69
615_L734_T0.5900.69
577_A580_D0.5900.69
502_D519_E0.5900.69
394_G585_V0.5900.69
394_G398_D0.5890.69
761_A775_R0.5890.69
188_L203_A0.5880.69
608_F707_V0.5870.69
717_L738_A0.5870.69
237_E754_A0.5870.69
295_H630_S0.5870.69
122_T251_T0.5860.69
321_W335_R0.5860.69
475_D495_N0.5860.69
454_E531_E0.5860.69
630_S759_F0.5860.69
38_L118_T0.5860.69
709_R720_A0.5850.69
98_A117_V0.5830.68
326_L335_R0.5820.68
818_T822_A0.5820.68
199_F202_E0.5810.68
444_D541_L0.5800.68
308_E603_R0.5800.68
639_V643_V0.5800.68
222_V228_G0.5800.68
587_G659_L0.5790.68
553_A557_Q0.5790.68
55_A58_I0.5790.68
645_L650_C0.5780.68
165_C264_L0.5780.68
820_P823_D0.5770.68
470_E475_D0.5770.68
500_P704_L0.5760.67
453_T529_R0.5760.67
153_F172_D0.5760.67
125_T635_Y0.5750.67
317_K565_A0.5750.67
692_I737_F0.5750.67
21_M26_F0.5750.67
129_D368_R0.5750.67
704_L723_V0.5730.67
189_V268_T0.5730.67
41_V76_A0.5730.67
56_A60_E0.5720.67
275_H327_V0.5710.67
379_L421_L0.5700.67
142_A240_A0.5700.67
832_A839_R0.5700.67
418_R515_Y0.5690.66
546_R549_V0.5690.66
738_A761_A0.5690.66
223_A231_V0.5680.66
198_R201_D0.5670.66
276_L326_L0.5660.66
619_R622_A0.5660.66
365_L374_A0.5660.66
195_D207_A0.5660.66
477_L489_I0.5660.66
830_A840_D0.5650.66
732_G753_D0.5650.66
714_T759_F0.5650.66
715_D784_G0.5640.66
393_R413_D0.5640.66
126_V131_L0.5640.66
763_R766_D0.5630.66
48_F75_M0.5630.66
766_D786_E0.5630.66
300_T303_V0.5620.66
221_R224_D0.5620.66
354_E358_D0.5620.66
623_V756_N0.5620.66
601_V676_A0.5620.66
282_A285_S0.5620.66
464_L479_V0.5610.65
778_A842_S0.5610.65
215_P238_L0.5610.65
468_E489_I0.5610.65
457_G460_W0.5610.65
590_G698_D0.5610.65
837_E843_V0.5600.65
306_L581_Y0.5600.65
282_A289_F0.5600.65
807_A811_A0.5600.65
328_D334_A0.5590.65
421_L549_V0.5590.65
320_D565_A0.5590.65
461_V465_E0.5590.65
334_A402_R0.5580.65
368_R378_D0.5580.65
279_D282_A0.5580.65
142_A243_A0.5580.65
493_K513_E0.5580.65
211_D225_Y0.5570.65
830_A833_G0.5570.65
578_A603_R0.5570.65
729_D751_L0.5560.65
107_D111_G0.5560.65
332_I647_Q0.5550.65
132_L161_S0.5550.65
629_M670_G0.5550.65
369_V382_L0.5550.65
18_L21_M0.5550.65
24_Q55_A0.5550.65
23_S67_E0.5540.64
685_E688_E0.5540.64
289_F319_T0.5540.64
215_P219_R0.5530.64
25_Y28_L0.5520.64
43_D46_E0.5520.64
111_G483_S0.5520.64
425_I438_V0.5520.64
220_E223_A0.5510.64
518_P521_K0.5500.64
472_T503_Y0.5500.64
225_Y245_L0.5490.64
547_E550_A0.5490.64
588_G658_E0.5490.64
576_A651_F0.5490.64
159_D601_V0.5490.64
98_A118_T0.5480.64
315_R571_S0.5480.64
738_A774_V0.5480.64
407_L566_V0.5480.64
692_I702_V0.5480.64
167_A238_L0.5470.63
488_Y524_E0.5460.63
126_V138_N0.5450.63
319_T323_R0.5450.63
597_R601_V0.5450.63
78_V88_E0.5450.63
50_A359_V0.5440.63
103_V113_V0.5440.63
643_V647_Q0.5440.63
313_L563_L0.5440.63
139_F193_G0.5440.63
276_L371_R0.5440.63
454_E534_A0.5430.63
372_G550_A0.5430.63
104_Q116_A0.5430.63
140_V189_V0.5420.63
41_V75_M0.5420.63
159_D744_L0.5420.63
459_Q462_D0.5420.63
180_L188_L0.5420.63
352_L395_L0.5410.63
342_L569_L0.5410.63
215_P239_R0.5400.62
143_L395_L0.5400.62
296_G301_A0.5400.62
630_S804_L0.5400.62
166_Y183_F0.5390.62
197_D698_D0.5380.62
224_D249_E0.5380.62
108_E113_V0.5380.62
41_V87_I0.5380.62
236_A343_V0.5380.62
507_Q514_R0.5380.62
235_T239_R0.5370.62
613_T645_L0.5370.62
745_T787_V0.5370.62
233_P695_A0.5360.62
160_V248_A0.5360.62
276_L655_A0.5360.62
644_V648_A0.5360.62
590_G658_E0.5350.62
42_G46_E0.5350.62
478_K482_N0.5350.62
218_A225_Y0.5350.62
285_S304_D0.5350.62
143_L153_F0.5350.62
17_D20_P0.5340.62
383_A440_R0.5340.62
436_G538_E0.5330.61
439_I447_L0.5330.61
135_A303_V0.5330.61
334_A403_K0.5330.61
57_R62_T0.5330.61
209_D212_A0.5330.61
32_Y100_A0.5320.61
39_F112_V0.5320.61
417_I556_M0.5310.61
639_V642_I0.5310.61
55_A89_A0.5310.61
475_D613_T0.5310.61
287_E290_E0.5310.61
571_S814_G0.5310.61
360_Y365_L0.5300.61
347_L350_E0.5300.61
351_E355_H0.5300.61
506_R516_V0.5290.61
524_E528_V0.5290.61
63_L66_R0.5290.61
376_A542_F0.5290.61
166_Y270_Y0.5290.61
417_I545_I0.5290.61
57_R276_L0.5280.61
465_E479_V0.5280.61
581_Y641_V0.5280.61
17_D70_T0.5280.61
708_G782_S0.5280.61
646_A652_V0.5270.61
126_V679_R0.5270.61
404_L566_V0.5270.61
305_V309_T0.5270.61
713_T784_G0.5260.60
472_T489_I0.5260.60
287_E291_Q0.5260.60
581_Y603_R0.5260.60
139_F183_F0.5250.60
67_E112_V0.5250.60
525_E588_G0.5250.60
749_D753_D0.5250.60
679_R684_V0.5240.60
139_F142_A0.5240.60
655_A658_E0.5240.60
432_E535_Q0.5240.60
136_D536_D0.5230.60
41_V99_V0.5230.60
823_D839_R0.5230.60
392_V566_V0.5230.60
218_A222_V0.5230.60
226_F265_N0.5220.60
236_A239_R0.5220.60
359_V388_V0.5220.60
759_F786_E0.5220.60
61_V64_T0.5220.60
370_S550_A0.5210.60
716_G720_A0.5200.60
305_V676_A0.5200.60
457_G523_R0.5190.59
636_M640_A0.5190.59
384_D422_D0.5190.59
279_D666_F0.5190.59
308_E574_A0.5190.59
214_E218_A0.5190.59
213_F239_R0.5180.59
601_V608_F0.5180.59
106_P109_V0.5180.59
336_H659_L0.5180.59
585_V592_H0.5180.59
300_T604_T0.5180.59
383_A387_A0.5180.59
156_A167_A0.5180.59
623_V724_T0.5180.59
21_M112_V0.5180.59
19_T28_L0.5170.59
391_E419_G0.5170.59
168_T659_L0.5170.59
382_L385_T0.5170.59
67_E71_G0.5170.59
504_Q516_V0.5160.59
389_V413_D0.5160.59
83_A97_V0.5160.59
590_G620_R0.5160.59
119_R636_M0.5160.59
629_M713_T0.5160.59
373_R674_D0.5150.59
450_L533_R0.5150.59
58_I704_L0.5150.59
745_T779_A0.5150.59
292_R669_V0.5150.59
22_M72_Q0.5140.59
43_D48_F0.5140.59
298_D304_D0.5140.59
113_V484_V0.5140.59
352_L356_L0.5140.59
379_L383_A0.5140.59
814_G817_G0.5130.59
722_A820_P0.5130.59
593_I643_V0.5130.59
242_G245_L0.5130.59
60_E360_Y0.5120.58
18_L73_Y0.5120.58
53_E61_V0.5120.58
499_V515_Y0.5110.58
391_E395_L0.5110.58
434_T535_Q0.5110.58
830_A836_A0.5110.58
704_L715_D0.5100.58
311_C675_I0.5100.58
139_F162_T0.5100.58
601_V642_I0.5090.58
414_L786_E0.5090.58
412_D418_R0.5090.58
306_L322_L0.5090.58
405_Q409_E0.5090.58
100_A301_A0.5080.58
225_Y249_E0.5080.58
645_L703_L0.5080.58
461_V476_S0.5080.58
170_L175_R0.5080.58
403_K406_S0.5080.58
630_S778_A0.5070.58
482_N507_Q0.5070.58
99_V121_V0.5070.58
490_E629_M0.5070.58
346_P655_A0.5070.58
241_C267_V0.5070.58
721_R747_D0.5070.58
369_V564_A0.5060.58
719_I757_L0.5060.58
402_R405_Q0.5060.58
279_D721_R0.5060.58
329_S647_Q0.5050.57
56_A61_V0.5050.57
104_Q113_V0.5050.57
61_V497_D0.5040.57
30_R95_Y0.5040.57
56_A76_A0.5030.57
18_L67_E0.5030.57
61_V786_E0.5030.57
571_S578_A0.5030.57
32_Y427_A0.5030.57
263_Y267_V0.5020.57
131_L278_M0.5020.57
126_V161_S0.5020.57
389_V485_H0.5020.57
301_A724_T0.5020.57
613_T736_L0.5010.57
572_F767_G0.5010.57
485_H521_K0.5010.57
570_A574_A0.5010.57
838_L843_V0.5010.57
468_E502_D0.5010.57
490_E514_R0.5010.57
346_P577_A0.5010.57
400_D405_Q0.5000.57
91_L336_H0.5000.57
687_T707_V0.5000.57
463_D466_A0.5000.57
198_R699_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wb9A 2 0.905 100 0.243 Contact Map
3thxA 1 0.92 100 0.255 Contact Map
2o8bB 1 0.9096 100 0.262 Contact Map
3thxB 1 0.9258 100 0.272 Contact Map
1ewqA 2 0.8702 100 0.289 Contact Map
4hseA 1 0.3082 99.1 0.948 Contact Map
2px0A 4 0.2851 98.9 0.953 Contact Map
4uxhA 3 0.1889 98.8 0.955 Contact Map
2i3bA 1 0.153 98.7 0.955 Contact Map
2r8rA 1 0.2271 98.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0194 seconds.