Q9HSL5 - HALSA - GREMLIN Contacts

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Q9HSL5 - Cationic amino acid transporter

UniProt:	Q9HSL5	Sequences: MIGAGIFVLPKIAAEQAGPASMVSFFVGGMVSLFAALSLSELATGMPKAGGSYYYVNRALGPFFGSIVGWGMWAGLTFASAFYMIGFGQYLLPGLGEYVGVLAGWGDLGITVAALAMAALLTAVNYYGVKETSALQNVIVLTLVGLVLAFLGLGAVTGPTITEFNPNGWPAVAATIGTVYVTFIGFEVIATSAEEIKNPSRNLPLAMIAAVVTPTLMYVGVMFVSTGTIDIPVLAGSDVPVALVAREIFQPLAGAVSWLPFVSVQPATAGSVGALAMIVGAVLATVSSANASILSAARVNFAMGRDKILVNWLNEVHDRFRTPYRAIAATGVITLLLIGIGVGVGTLAEVASFMYLVTYALVHVSVVVLRRANPDTYDPAFRIPAVLYPVVPVLGAAACVAVLVQMSVTFSPMTIGVASVAVVLPVTPTPVGAIGTVLVAFGIAWYYCYARARAPSQSLVGDALAPSSSPDTDTPDTYTVVVPVANPDTEHDLLRMAAASAHAHTDAHAEVIAVNVIEVPRQTSLSQDLAFEEERVERQQELLDAASAAAADLDVRLRTRAVASHDTGAAILDVIEDTAADHVLLGWGGTRRRDHVLGSTIDPVVGHASCDATLVRLGPAAAGDASDIMVLAGEGPHAPVAARRAAEFVAADETDASLTLLNVQPPADDDDDADASATERGAAVIDALAERAGIKYMTYDTEVVVSTDTEAAVIDAAADFDMVYAGATRSGPVSQAVFGSIPEAVGAGVDQTVVMARGPDNTPMSVRDAITRRFGG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	776 (661)
Sequences:	879 (606)
Seq/√Len:	23.6

HALSA - Q9HSL5 Q9HQB3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_P	226_T	7.291	1.00
83_Y	292_S	4.599	1.00
201_R	205_L	4.492	1.00
151_L	220_G	4.120	1.00
79_A	83_Y	3.923	1.00
305_R	321_R	3.775	1.00
625_A	628_I	3.585	1.00
7_F	146_L	3.532	1.00
626_S	629_M	3.515	1.00
160_T	163_E	3.404	1.00
636_P	642_A	3.314	1.00
7_F	143_L	3.165	1.00
158_G	163_E	3.103	1.00
615_V	618_G	3.074	1.00
360_A	400_V	3.047	1.00
143_L	288_S	2.871	0.99
487_P	586_G	2.847	0.99
604_V	608_A	2.831	0.99
677_A	680_R	2.830	0.99
83_Y	359_Y	2.796	0.99
642_A	646_A	2.791	0.99
479_T	510_E	2.766	0.99
83_Y	288_S	2.746	0.99
440_A	443_I	2.731	0.99
641_A	645_A	2.669	0.99
195_E	301_F	2.665	0.99
83_Y	355_Y	2.636	0.99
635_G	639_P	2.628	0.99
636_P	643_R	2.623	0.99
168_G	171_A	2.618	0.99
11_K	31_V	2.568	0.99
437_V	441_F	2.557	0.99
642_A	645_A	2.519	0.99
85_I	347_L	2.490	0.98
611_D	618_G	2.461	0.98
290_N	322_T	2.447	0.98
115_L	335_L	2.399	0.98
600_T	605_V	2.367	0.98
33_L	208_I	2.355	0.98
1_M	6_I	2.354	0.98
449_Y	453_R	2.348	0.98
159_P	163_E	2.348	0.98
32_S	186_F	2.326	0.98
73_W	330_T	2.319	0.97
482_V	497_A	2.295	0.97
14_A	21_S	2.260	0.97
158_G	161_I	2.225	0.97
7_F	128_G	2.217	0.97
476_D	582_H	2.196	0.96
627_D	633_G	2.134	0.96
494_L	513_A	2.102	0.95
636_P	645_A	2.080	0.95
622_A	625_A	2.065	0.95
61_G	65_G	2.046	0.95
222_M	226_T	2.044	0.95
44_T	284_A	2.042	0.95
364_V	396_A	2.020	0.94
707_T	712_A	2.019	0.94
300_N	304_G	2.014	0.94
145_G	584_L	2.012	0.94
52_S	187_E	1.990	0.94
184_I	359_Y	1.977	0.94
312_W	328_A	1.975	0.94
315_E	325_R	1.972	0.94
452_A	502_H	1.970	0.93
284_A	352_S	1.950	0.93
602_D	607_H	1.939	0.93
601_I	607_H	1.936	0.93
459_L	462_D	1.931	0.93
611_D	616_R	1.912	0.92
313_L	329_A	1.912	0.92
548_A	555_V	1.909	0.92
710_E	714_I	1.906	0.92
408_V	412_P	1.886	0.92
635_G	644_R	1.881	0.92
182_T	358_T	1.873	0.92
171_A	394_L	1.842	0.91
665_P	713_V	1.842	0.91
636_P	641_A	1.831	0.91
50_G	69_G	1.791	0.90
144_V	148_L	1.787	0.90
694_I	703_V	1.781	0.89
708_D	711_A	1.781	0.89
58_R	61_G	1.780	0.89
26_F	145_G	1.764	0.89
493_L	586_G	1.763	0.89
316_V	321_R	1.762	0.89
133_S	294_L	1.755	0.89
190_A	199_P	1.755	0.89
55_Y	67_I	1.754	0.89
164_F	167_N	1.736	0.88
707_T	710_E	1.732	0.88
2_I	217_M	1.715	0.88
575_I	583_V	1.699	0.87
115_L	119_A	1.697	0.87
455_P	462_D	1.689	0.87
641_A	644_R	1.686	0.87
292_S	402_V	1.683	0.87
85_I	134_A	1.675	0.86
79_A	359_Y	1.669	0.86
293_I	296_A	1.668	0.86
709_T	713_V	1.668	0.86
290_N	326_A	1.662	0.86
172_V	175_T	1.647	0.85
371_R	377_Y	1.645	0.85
39_L	44_T	1.639	0.85
598_G	602_D	1.633	0.85
238_D	241_V	1.631	0.85
22_M	223_F	1.611	0.84
138_V	413_M	1.599	0.83
676_S	680_R	1.598	0.83
494_L	555_V	1.594	0.83
25_F	222_M	1.593	0.83
497_A	511_V	1.576	0.83
74_A	143_L	1.573	0.82
143_L	291_A	1.570	0.82
125_N	290_N	1.569	0.82
5_G	13_A	1.561	0.82
211_V	292_S	1.552	0.82
14_A	380_A	1.546	0.81
447_Y	472_T	1.523	0.80
603_P	607_H	1.522	0.80
454_A	458_S	1.522	0.80
292_S	359_Y	1.518	0.80
164_F	168_G	1.512	0.80
26_F	215_T	1.504	0.79
170_P	175_T	1.504	0.79
33_L	201_R	1.503	0.79
182_T	222_M	1.502	0.79
32_S	83_Y	1.491	0.79
566_D	569_A	1.483	0.78
136_Q	287_S	1.478	0.78
44_T	61_G	1.468	0.78
640_V	644_R	1.467	0.78
187_E	295_S	1.461	0.77
284_A	287_S	1.451	0.77
601_I	614_L	1.450	0.77
612_A	618_G	1.448	0.77
645_A	648_F	1.447	0.77
1_M	83_Y	1.441	0.76
177_G	359_Y	1.441	0.76
191_T	359_Y	1.439	0.76
54_Y	57_N	1.438	0.76
516_V	713_V	1.425	0.76
681_G	689_A	1.423	0.76
636_P	639_P	1.421	0.75
629_M	641_A	1.419	0.75
120_L	336_L	1.418	0.75
628_I	637_H	1.412	0.75
684_V	689_A	1.411	0.75
497_A	584_L	1.409	0.75
167_N	171_A	1.406	0.75
182_T	355_Y	1.405	0.75
147_V	287_S	1.405	0.75
630_V	634_E	1.393	0.74
455_P	458_S	1.386	0.74
187_E	191_T	1.384	0.73
287_S	291_A	1.383	0.73
598_G	601_I	1.382	0.73
37_L	208_I	1.381	0.73
227_G	350_V	1.374	0.73
611_D	614_L	1.374	0.73
485_A	586_G	1.373	0.73
11_K	199_P	1.369	0.73
208_I	212_V	1.368	0.73
638_A	642_A	1.359	0.72
60_L	86_G	1.355	0.72
685_I	688_L	1.354	0.72
36_A	211_V	1.349	0.71
184_I	189_I	1.345	0.71
439_V	442_G	1.343	0.71
53_Y	185_G	1.342	0.71
55_Y	299_V	1.338	0.71
443_I	447_Y	1.331	0.70
600_T	607_H	1.327	0.70
715_D	723_V	1.323	0.70
120_L	380_A	1.323	0.70
90_Y	281_A	1.321	0.70
32_S	292_S	1.318	0.70
296_A	338_I	1.316	0.70
152_G	276_A	1.316	0.70
634_E	638_A	1.314	0.69
85_I	583_V	1.313	0.69
163_E	167_N	1.307	0.69
645_A	660_L	1.306	0.69
181_V	189_I	1.302	0.69
290_N	295_S	1.300	0.69
284_A	288_S	1.297	0.68
460_V	463_A	1.296	0.68
73_W	300_N	1.295	0.68
717_A	722_M	1.294	0.68
605_V	608_A	1.289	0.68
393_V	397_A	1.285	0.68
550_A	559_T	1.285	0.68
463_A	558_R	1.281	0.67
637_H	642_A	1.279	0.67
175_T	178_T	1.279	0.67
53_Y	69_G	1.274	0.67
203_L	207_M	1.273	0.67
452_A	459_L	1.273	0.67
50_G	53_Y	1.270	0.67
41_E	46_M	1.269	0.67
460_V	466_P	1.267	0.67
121_L	286_V	1.260	0.66
301_F	316_V	1.259	0.66
710_E	713_V	1.250	0.65
520_P	523_T	1.248	0.65
446_Y	449_Y	1.248	0.65
717_A	723_V	1.248	0.65
330_T	640_V	1.246	0.65
712_A	716_A	1.243	0.65
72_M	214_P	1.242	0.65
598_G	603_P	1.240	0.65
605_V	613_T	1.238	0.65
80_S	334_T	1.233	0.64
629_M	633_G	1.232	0.64
2_I	6_I	1.232	0.64
68_V	308_I	1.232	0.64
112_V	338_I	1.227	0.64
188_V	292_S	1.226	0.64
75_G	574_V	1.224	0.64
481_V	574_V	1.223	0.64
212_V	216_L	1.223	0.64
711_A	715_D	1.221	0.64
240_P	244_V	1.216	0.63
48_K	54_Y	1.214	0.63
447_Y	474_T	1.210	0.63
107_D	350_V	1.210	0.63
138_V	314_N	1.210	0.63
597_L	601_I	1.209	0.63
241_V	245_A	1.209	0.63
73_W	389_P	1.203	0.62
456_S	466_P	1.202	0.62
601_I	608_A	1.196	0.62
61_G	86_G	1.196	0.62
414_T	417_V	1.196	0.62
601_I	605_V	1.195	0.62
18_G	51_G	1.193	0.62
305_R	316_V	1.185	0.61
552_D	583_V	1.184	0.61
611_D	615_V	1.182	0.61
65_G	306_D	1.170	0.60
690_E	694_I	1.168	0.60
76_L	358_T	1.167	0.60
5_G	9_L	1.167	0.60
183_F	192_S	1.167	0.60
290_N	339_G	1.163	0.60
503_A	510_E	1.160	0.60
600_T	603_P	1.158	0.59
120_L	227_G	1.156	0.59
540_Q	594_D	1.154	0.59
28_G	358_T	1.151	0.59
13_A	441_F	1.150	0.59
4_A	10_P	1.148	0.59
27_V	312_W	1.145	0.58
116_A	571_I	1.143	0.58
155_A	419_S	1.142	0.58
114_A	694_I	1.142	0.58
458_S	462_D	1.141	0.58
635_G	642_A	1.136	0.58
44_T	65_G	1.131	0.58
298_R	301_F	1.119	0.57
184_I	210_A	1.114	0.56
29_G	215_T	1.113	0.56
203_L	214_P	1.106	0.56
487_P	494_L	1.104	0.56
717_A	720_F	1.102	0.56
57_N	66_S	1.094	0.55
44_T	58_R	1.093	0.55
712_A	717_A	1.092	0.55
347_L	493_L	1.090	0.55
437_V	440_A	1.088	0.55
188_V	295_S	1.087	0.54
377_Y	438_L	1.087	0.54
120_L	165_N	1.087	0.54
75_G	303_M	1.083	0.54
704_V	707_T	1.082	0.54
397_A	401_A	1.080	0.54
638_A	641_A	1.078	0.54
375_D	464_L	1.077	0.54
181_V	206_A	1.075	0.54
39_L	55_Y	1.074	0.54
62_P	65_G	1.074	0.54
713_V	724_Y	1.073	0.54
65_G	379_P	1.073	0.54
416_G	541_E	1.071	0.53
96_G	106_G	1.070	0.53
713_V	725_A	1.069	0.53
440_A	444_A	1.068	0.53
23_V	30_M	1.067	0.53
704_V	716_A	1.065	0.53
17_A	124_V	1.064	0.53
375_D	477_T	1.061	0.53
39_L	52_S	1.058	0.52
334_T	350_V	1.055	0.52
66_S	288_S	1.055	0.52
717_A	724_Y	1.053	0.52
183_F	298_R	1.053	0.52
170_P	177_G	1.051	0.52
40_S	187_E	1.048	0.52
148_L	160_T	1.047	0.52
525_L	565_H	1.046	0.52
44_T	379_P	1.044	0.51
28_G	83_Y	1.043	0.51
180_Y	185_G	1.042	0.51
159_P	167_N	1.040	0.51
85_I	187_E	1.038	0.51
152_G	155_A	1.038	0.51
350_V	366_V	1.034	0.51
570_A	586_G	1.025	0.50
438_L	445_W	1.022	0.50
408_V	437_V	1.021	0.50
195_E	214_P	1.021	0.50
124_V	290_N	1.020	0.50
270_G	273_G	1.019	0.50
460_V	469_S	1.018	0.50
216_L	397_A	1.016	0.49
598_G	605_V	1.016	0.49
58_R	477_T	1.016	0.49
626_S	659_T	1.016	0.49
209_A	213_T	1.015	0.49
445_W	449_Y	1.014	0.49
195_E	316_V	1.012	0.49
626_S	635_G	1.011	0.49
175_T	344_V	1.010	0.49
336_L	340_I	1.010	0.49
38_S	448_C	1.007	0.49
450_A	466_P	1.006	0.49
9_L	15_E	1.006	0.49
417_V	592_R	1.005	0.49
242_A	245_A	1.004	0.49
215_T	219_V	1.003	0.49
335_L	339_G	1.001	0.48
181_V	196_I	0.999	0.48
683_A	686_D	0.998	0.48
561_A	669_D	0.997	0.48
223_F	605_V	0.995	0.48
210_A	354_M	0.991	0.48
8_V	615_V	0.991	0.48
571_I	600_T	0.987	0.47
56_V	65_G	0.986	0.47
593_R	598_G	0.986	0.47
26_F	219_V	0.985	0.47
629_M	634_E	0.985	0.47
622_A	693_G	0.984	0.47
445_W	450_A	0.984	0.47
84_M	338_I	0.984	0.47
187_E	298_R	0.982	0.47
494_L	617_L	0.979	0.47
83_Y	291_A	0.979	0.47
322_T	330_T	0.977	0.47
594_D	598_G	0.977	0.47
720_F	724_Y	0.975	0.47
58_R	65_G	0.971	0.46
520_P	525_L	0.971	0.46
716_A	719_D	0.970	0.46
42_L	66_S	0.966	0.46
331_G	660_L	0.966	0.46
176_I	192_S	0.965	0.46
6_I	407_S	0.965	0.46
551_A	555_V	0.964	0.46
143_L	284_A	0.964	0.46
643_R	646_A	0.963	0.46
75_G	229_I	0.963	0.46
1_M	210_A	0.962	0.46
288_S	292_S	0.961	0.46
483_P	586_G	0.960	0.46
28_G	136_Q	0.956	0.45
52_S	186_F	0.954	0.45
342_V	359_Y	0.954	0.45
26_F	120_L	0.953	0.45
309_L	368_V	0.952	0.45
397_A	420_V	0.951	0.45
99_V	116_A	0.951	0.45
22_M	326_A	0.949	0.45
209_A	362_V	0.948	0.45
184_I	285_T	0.948	0.45
375_D	582_H	0.947	0.45
666_P	670_D	0.946	0.45
115_L	339_G	0.946	0.45
22_M	676_S	0.946	0.45
516_V	570_A	0.946	0.45
33_L	59_A	0.945	0.45
709_T	712_A	0.945	0.45
176_I	180_Y	0.945	0.45
403_L	407_S	0.944	0.44
49_A	59_A	0.944	0.44
540_Q	582_H	0.943	0.44
614_L	679_E	0.942	0.44
59_A	301_F	0.941	0.44
21_S	27_V	0.937	0.44
279_V	322_T	0.934	0.44
7_F	18_G	0.934	0.44
132_T	136_Q	0.933	0.44
552_D	571_I	0.933	0.44
641_A	646_A	0.933	0.44
84_M	292_S	0.932	0.44
311_N	400_V	0.932	0.44
32_S	84_M	0.932	0.44
664_Q	670_D	0.932	0.44
77_T	333_I	0.931	0.44
703_V	707_T	0.931	0.44
189_I	193_A	0.930	0.43
21_S	222_M	0.929	0.43
172_V	176_I	0.928	0.43
365_S	373_N	0.927	0.43
157_T	394_L	0.926	0.43
232_P	566_D	0.922	0.43
298_R	322_T	0.922	0.43
196_I	478_Y	0.922	0.43
301_F	322_T	0.922	0.43
461_G	556_R	0.922	0.43
403_L	411_S	0.921	0.43
108_L	111_T	0.917	0.43
515_N	542_L	0.914	0.42
68_V	584_L	0.914	0.42
708_D	714_I	0.910	0.42
308_I	509_A	0.909	0.42
613_T	677_A	0.909	0.42
495_R	549_A	0.909	0.42
189_I	194_E	0.908	0.42
4_A	32_S	0.906	0.42
635_G	645_A	0.897	0.41
121_L	183_F	0.896	0.41
366_V	374_P	0.896	0.41
74_A	333_I	0.895	0.41
564_S	570_A	0.895	0.41
416_G	562_V	0.894	0.41
585_L	614_L	0.893	0.41
124_V	213_T	0.892	0.41
12_I	16_Q	0.891	0.41
668_D	706_S	0.891	0.41
383_I	388_Y	0.887	0.41
633_G	726_G	0.886	0.40
16_Q	20_A	0.885	0.40
677_A	681_G	0.881	0.40
681_G	690_E	0.881	0.40
134_A	658_L	0.881	0.40
183_F	187_E	0.879	0.40
68_V	80_S	0.877	0.40
23_V	525_L	0.875	0.40
160_T	165_N	0.875	0.40
292_S	296_A	0.874	0.40
625_A	629_M	0.873	0.40
629_M	645_A	0.870	0.39
238_D	339_G	0.869	0.39
472_T	626_S	0.868	0.39
413_M	604_V	0.867	0.39
480_V	579_A	0.864	0.39
278_I	281_A	0.860	0.39
290_N	349_E	0.860	0.39
91_L	227_G	0.859	0.39
136_Q	284_A	0.857	0.39
516_V	586_G	0.857	0.39
198_N	722_M	0.856	0.38
72_M	479_T	0.853	0.38
217_M	271_S	0.852	0.38
25_F	42_L	0.852	0.38
637_H	645_A	0.852	0.38
68_V	193_A	0.851	0.38
436_T	440_A	0.851	0.38
139_I	283_L	0.849	0.38
89_Q	355_Y	0.849	0.38
172_V	177_G	0.849	0.38
371_R	389_P	0.849	0.38
635_G	643_R	0.849	0.38
460_V	464_L	0.848	0.38
627_D	631_L	0.848	0.38
367_V	370_R	0.847	0.38
467_S	547_S	0.847	0.38
368_V	499_A	0.846	0.38
442_G	447_Y	0.845	0.38
483_P	514_V	0.845	0.38
177_G	191_T	0.839	0.37
60_L	64_F	0.839	0.37
136_Q	289_A	0.838	0.37
195_E	298_R	0.838	0.37
487_P	585_L	0.836	0.37
381_F	548_A	0.833	0.37
546_A	550_A	0.833	0.37
184_I	292_S	0.832	0.37
689_A	692_A	0.831	0.37
80_S	288_S	0.830	0.37
53_Y	306_D	0.830	0.37
191_T	354_M	0.829	0.37
25_F	284_A	0.829	0.37
487_P	493_L	0.826	0.36
136_Q	291_A	0.826	0.36
72_M	187_E	0.825	0.36
207_M	214_P	0.825	0.36
635_G	641_A	0.824	0.36
48_K	190_A	0.824	0.36
307_K	400_V	0.824	0.36
382_R	654_T	0.824	0.36
681_G	688_L	0.822	0.36
160_T	397_A	0.821	0.36
202_N	300_N	0.819	0.36
514_V	574_V	0.818	0.36
685_I	689_A	0.814	0.36
717_A	725_A	0.814	0.36
76_L	353_F	0.810	0.35
10_P	76_L	0.809	0.35
297_A	301_F	0.809	0.35
47_P	55_Y	0.808	0.35
83_Y	399_C	0.808	0.35
189_I	206_A	0.806	0.35
281_A	342_V	0.806	0.35
330_T	543_L	0.806	0.35
32_S	296_A	0.805	0.35
716_A	721_D	0.805	0.35
1_M	297_A	0.804	0.35
486_N	489_T	0.804	0.35
13_A	21_S	0.804	0.35
704_V	711_A	0.803	0.35
188_V	193_A	0.801	0.35
665_P	669_D	0.798	0.35
50_G	185_G	0.798	0.35
306_D	375_D	0.798	0.35
82_F	347_L	0.798	0.35
65_G	86_G	0.797	0.35
193_A	196_I	0.795	0.34
485_A	490_E	0.793	0.34
84_M	186_F	0.791	0.34
598_G	610_C	0.791	0.34
707_T	713_V	0.789	0.34
205_L	548_A	0.787	0.34
128_G	143_L	0.786	0.34
195_E	326_A	0.785	0.34
134_A	382_R	0.785	0.34
288_S	321_R	0.785	0.34
196_I	359_Y	0.784	0.34
79_A	288_S	0.784	0.34
547_S	551_A	0.782	0.34
183_F	354_M	0.782	0.34
224_V	229_I	0.780	0.34
309_L	442_G	0.776	0.33
7_F	283_L	0.776	0.33
683_A	687_A	0.776	0.33
347_L	412_P	0.775	0.33
76_L	402_V	0.775	0.33
80_S	133_S	0.775	0.33
197_K	660_L	0.774	0.33
625_A	632_A	0.773	0.33
61_G	379_P	0.772	0.33
8_V	55_Y	0.771	0.33
116_A	393_V	0.771	0.33
637_H	641_A	0.771	0.33
32_S	214_P	0.770	0.33
189_I	207_M	0.768	0.33
202_N	206_A	0.768	0.33
38_S	44_T	0.768	0.33
81_A	329_A	0.768	0.33
464_L	558_R	0.767	0.33
443_I	451_R	0.767	0.33
598_G	606_G	0.766	0.33
45_G	68_V	0.764	0.33
22_M	26_F	0.762	0.32
195_E	320_F	0.760	0.32
705_V	711_A	0.760	0.32
70_W	177_G	0.760	0.32
708_D	712_A	0.760	0.32
36_A	81_A	0.759	0.32
81_A	402_V	0.756	0.32
413_M	417_V	0.754	0.32
594_D	600_T	0.754	0.32
168_G	174_A	0.752	0.32
26_F	138_V	0.752	0.32
146_L	213_T	0.752	0.32
404_V	411_S	0.751	0.32
643_R	652_D	0.750	0.32
14_A	406_M	0.749	0.32
186_F	193_A	0.748	0.32
148_L	694_I	0.746	0.31
190_A	285_T	0.745	0.31
626_S	634_E	0.745	0.31
68_V	143_L	0.744	0.31
610_C	618_G	0.741	0.31
205_L	336_L	0.741	0.31
443_I	446_Y	0.739	0.31
299_V	355_Y	0.739	0.31
178_T	195_E	0.737	0.31
145_G	413_M	0.737	0.31
39_L	350_V	0.737	0.31
129_V	293_I	0.737	0.31
721_D	724_Y	0.736	0.31
415_I	697_M	0.736	0.31
172_V	585_L	0.736	0.31
3_G	51_G	0.735	0.31
604_V	611_D	0.735	0.31
712_A	715_D	0.734	0.31
158_G	416_G	0.734	0.31
18_G	35_A	0.730	0.30
464_L	470_P	0.729	0.30
312_W	325_R	0.727	0.30
83_Y	354_M	0.725	0.30
633_G	637_H	0.725	0.30
125_N	178_T	0.724	0.30
568_G	600_T	0.723	0.30
452_A	456_S	0.722	0.30
42_L	188_V	0.720	0.30
182_T	333_I	0.720	0.30
500_S	686_D	0.720	0.30
721_D	726_G	0.720	0.30
665_P	715_D	0.720	0.30
642_A	648_F	0.719	0.30
340_I	417_V	0.719	0.30
183_F	194_E	0.718	0.30
121_L	132_T	0.717	0.30
57_N	477_T	0.717	0.30
636_P	644_R	0.716	0.30
685_I	692_A	0.716	0.30
277_M	559_T	0.712	0.29
691_R	694_I	0.709	0.29
598_G	608_A	0.709	0.29
323_P	326_A	0.707	0.29
219_V	223_F	0.707	0.29
74_A	177_G	0.706	0.29
239_V	242_A	0.706	0.29
635_G	640_V	0.705	0.29
396_A	399_C	0.705	0.29
38_S	363_H	0.703	0.29
3_G	65_G	0.702	0.29
13_A	41_E	0.702	0.29
630_V	635_G	0.701	0.29
2_I	337_L	0.700	0.29
200_S	496_M	0.699	0.29
222_M	355_Y	0.699	0.29
397_A	679_E	0.698	0.29
328_A	594_D	0.697	0.29
400_V	615_V	0.697	0.29
463_A	467_S	0.696	0.28
402_V	407_S	0.694	0.28
42_L	48_K	0.694	0.28
165_N	397_A	0.694	0.28
602_D	605_V	0.694	0.28
55_Y	191_T	0.693	0.28
382_R	391_V	0.693	0.28
4_A	183_F	0.692	0.28
89_Q	342_V	0.692	0.28
694_I	716_A	0.689	0.28
678_T	681_G	0.689	0.28
449_Y	455_P	0.688	0.28
225_S	229_I	0.687	0.28
49_A	150_F	0.687	0.28
229_I	270_G	0.685	0.28
709_T	714_I	0.685	0.28
19_P	222_M	0.684	0.28
35_A	378_D	0.684	0.28
439_V	443_I	0.683	0.28
136_Q	140_V	0.682	0.28
602_D	610_C	0.681	0.28
15_E	378_D	0.681	0.28
181_V	195_E	0.681	0.28
183_F	193_A	0.681	0.28
419_S	694_I	0.680	0.28
8_V	146_L	0.678	0.27
55_Y	215_T	0.677	0.27
4_A	354_M	0.677	0.27
83_Y	183_F	0.676	0.27
629_M	653_E	0.676	0.27
285_T	398_A	0.675	0.27
120_L	655_D	0.674	0.27
218_Y	323_P	0.672	0.27
181_V	351_A	0.671	0.27
220_G	462_D	0.670	0.27
32_S	211_V	0.670	0.27
709_T	723_V	0.670	0.27
202_N	205_L	0.669	0.27
443_I	456_S	0.669	0.27
360_A	380_A	0.668	0.27
234_L	509_A	0.666	0.27
667_A	670_D	0.666	0.27
342_V	351_A	0.666	0.27
115_L	409_T	0.665	0.27
391_V	463_A	0.664	0.27
13_A	179_V	0.664	0.27
82_F	277_M	0.663	0.27
227_G	583_V	0.662	0.27
629_M	632_A	0.662	0.27
605_V	609_S	0.662	0.27
1_M	32_S	0.661	0.27
126_Y	496_M	0.659	0.26
184_I	202_N	0.659	0.26
483_P	575_I	0.657	0.26
126_Y	357_V	0.657	0.26
269_A	273_G	0.657	0.26
345_G	348_A	0.656	0.26
366_V	653_E	0.656	0.26
435_G	439_V	0.656	0.26
635_G	638_A	0.654	0.26
119_A	687_A	0.653	0.26
332_V	336_L	0.650	0.26
305_R	525_L	0.648	0.26
114_A	129_V	0.648	0.26
15_E	35_A	0.647	0.26
519_V	523_T	0.646	0.26
217_M	309_L	0.646	0.26
600_T	618_G	0.645	0.26
66_S	188_V	0.644	0.26
319_R	339_G	0.644	0.26
205_L	209_A	0.644	0.26
450_A	500_S	0.642	0.25
49_A	188_V	0.641	0.25
280_G	378_D	0.639	0.25
484_V	490_E	0.639	0.25
17_A	78_F	0.639	0.25
719_D	724_Y	0.639	0.25
407_S	410_F	0.638	0.25
664_Q	703_V	0.638	0.25
138_V	352_S	0.638	0.25
145_G	272_V	0.638	0.25
203_L	362_V	0.636	0.25
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128_G	283_L	0.635	0.25
79_A	350_V	0.634	0.25
474_T	494_L	0.634	0.25
608_A	612_A	0.633	0.25
53_Y	58_R	0.633	0.25
148_L	274_A	0.633	0.25
665_P	670_D	0.631	0.25
12_I	81_A	0.630	0.25
322_T	331_G	0.630	0.25
157_T	657_S	0.629	0.25
144_V	273_G	0.629	0.25
379_P	395_G	0.629	0.25
558_R	659_T	0.627	0.25
23_V	524_S	0.625	0.25
70_W	155_A	0.625	0.25
683_A	715_D	0.624	0.25
143_L	289_A	0.623	0.24
516_V	556_R	0.623	0.24
63_F	557_L	0.623	0.24
99_V	205_L	0.623	0.24
143_L	283_L	0.623	0.24
478_Y	581_D	0.622	0.24
716_A	723_V	0.622	0.24
68_V	85_I	0.620	0.24
480_V	586_G	0.619	0.24
448_C	472_T	0.619	0.24
352_S	406_M	0.619	0.24
288_S	296_A	0.618	0.24
70_W	554_D	0.617	0.24
1_M	77_T	0.616	0.24
194_E	301_F	0.616	0.24
198_N	485_A	0.613	0.24
216_L	612_A	0.613	0.24
630_V	643_R	0.613	0.24
128_G	479_T	0.613	0.24
315_E	655_D	0.612	0.24
336_L	339_G	0.611	0.24
639_P	644_R	0.610	0.24
66_S	377_Y	0.610	0.24
446_Y	453_R	0.610	0.24
452_A	455_P	0.609	0.24
663_V	671_D	0.609	0.24
69_G	185_G	0.608	0.24
85_I	334_T	0.608	0.24
10_P	25_F	0.608	0.24
414_T	633_G	0.608	0.24
132_T	290_N	0.607	0.24
139_I	287_S	0.606	0.24
83_Y	296_A	0.606	0.24
186_F	189_I	0.604	0.24
335_L	365_S	0.604	0.24
367_V	393_V	0.604	0.24
157_T	420_V	0.604	0.24
632_A	642_A	0.604	0.24
118_A	335_L	0.604	0.24
76_L	182_T	0.603	0.23
546_A	723_V	0.602	0.23
6_I	9_L	0.602	0.23
682_A	691_R	0.602	0.23
668_D	681_G	0.601	0.23
710_E	721_D	0.601	0.23
146_L	277_M	0.599	0.23
23_V	565_H	0.599	0.23
707_T	711_A	0.598	0.23
208_I	339_G	0.594	0.23
548_A	583_V	0.594	0.23
711_A	717_A	0.592	0.23
15_E	210_A	0.592	0.23
628_I	659_T	0.592	0.23
46_M	61_G	0.592	0.23
211_V	359_Y	0.592	0.23
42_L	191_T	0.591	0.23
58_R	306_D	0.591	0.23
218_Y	359_Y	0.590	0.23
454_A	457_Q	0.589	0.23
641_A	648_F	0.588	0.23
627_D	634_E	0.586	0.23
466_P	514_V	0.586	0.23
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152_G	166_P	0.584	0.23
598_G	611_D	0.584	0.23
561_A	640_V	0.584	0.23
44_T	143_L	0.583	0.22
129_V	377_Y	0.583	0.22
343_G	417_V	0.583	0.22
626_S	639_P	0.582	0.22
334_T	352_S	0.581	0.22
627_D	639_P	0.579	0.22
183_F	351_A	0.579	0.22
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186_F	479_T	0.579	0.22
66_S	438_L	0.579	0.22
201_R	544_D	0.578	0.22
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280_G	285_T	0.578	0.22
451_R	457_Q	0.578	0.22
483_P	571_I	0.578	0.22
352_S	691_R	0.577	0.22
547_S	579_A	0.574	0.22
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158_G	227_G	0.571	0.22
635_G	646_A	0.571	0.22
568_G	572_L	0.571	0.22
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86_G	306_D	0.569	0.22
198_N	417_V	0.569	0.22
276_A	597_L	0.569	0.22
288_S	300_N	0.568	0.22
458_S	466_P	0.567	0.22
65_G	348_A	0.567	0.22
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470_P	638_A	0.565	0.22
591_R	596_V	0.565	0.22
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308_I	328_A	0.563	0.21
364_V	368_V	0.563	0.21
706_S	711_A	0.563	0.21
79_A	82_F	0.562	0.21
29_G	47_P	0.561	0.21
629_M	640_V	0.561	0.21
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197_K	404_V	0.559	0.21
443_I	448_C	0.558	0.21
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61_G	306_D	0.558	0.21
665_P	728_T	0.557	0.21
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285_T	291_A	0.556	0.21
179_V	183_F	0.556	0.21
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450_A	454_A	0.556	0.21
13_A	149_A	0.556	0.21
596_V	657_S	0.555	0.21
162_T	168_G	0.555	0.21
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107_D	111_T	0.553	0.21
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198_N	655_D	0.553	0.21
116_A	564_S	0.553	0.21
657_S	691_R	0.552	0.21
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21_S	89_Q	0.551	0.21
148_L	220_G	0.551	0.21
151_L	569_A	0.551	0.21
76_L	173_A	0.550	0.21
9_L	24_S	0.550	0.21
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676_S	679_E	0.549	0.21
277_M	342_V	0.548	0.21
559_T	587_W	0.548	0.21
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280_G	288_S	0.547	0.21
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660_L	669_D	0.547	0.21
82_F	556_R	0.547	0.21
110_I	167_N	0.546	0.21
571_I	575_I	0.546	0.21
279_V	419_S	0.546	0.21
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52_S	83_Y	0.544	0.21
322_T	643_R	0.543	0.21
455_P	459_L	0.543	0.21
32_S	354_M	0.542	0.21
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705_V	708_D	0.541	0.20
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704_V	712_A	0.541	0.20
21_S	152_G	0.540	0.20
602_D	619_P	0.540	0.20
79_A	292_S	0.540	0.20
461_G	464_L	0.539	0.20
546_A	559_T	0.539	0.20
712_A	719_D	0.539	0.20
411_S	477_T	0.537	0.20
9_L	196_I	0.537	0.20
389_P	410_F	0.537	0.20
483_P	516_V	0.537	0.20
458_S	464_L	0.536	0.20
516_V	687_A	0.536	0.20
179_V	186_F	0.536	0.20
454_A	461_G	0.536	0.20
54_Y	306_D	0.536	0.20
130_K	482_V	0.536	0.20
9_L	41_E	0.536	0.20
122_T	331_G	0.535	0.20
51_G	69_G	0.535	0.20
195_E	334_T	0.534	0.20
709_T	716_A	0.533	0.20
35_A	57_N	0.532	0.20
125_N	179_V	0.532	0.20
79_A	299_V	0.531	0.20
191_T	299_V	0.531	0.20
309_L	600_T	0.531	0.20
98_Y	397_A	0.531	0.20
515_N	561_A	0.530	0.20
332_V	416_G	0.530	0.20
121_L	150_F	0.530	0.20
293_I	397_A	0.529	0.20
184_I	191_T	0.529	0.20
82_F	445_W	0.528	0.20
134_A	686_D	0.528	0.20
52_S	77_T	0.527	0.20
133_S	405_Q	0.527	0.20
91_L	407_S	0.526	0.20
585_L	594_D	0.525	0.20
3_G	298_R	0.525	0.20
60_L	63_F	0.525	0.20
58_R	379_P	0.524	0.20
377_Y	384_P	0.524	0.20
134_A	325_R	0.523	0.20
709_T	715_D	0.523	0.20
123_A	357_V	0.523	0.20
5_G	181_V	0.523	0.20
30_M	141_L	0.523	0.20
454_A	463_A	0.523	0.20
639_P	642_A	0.522	0.20
578_T	726_G	0.522	0.20
200_S	380_A	0.521	0.20
59_A	139_I	0.521	0.20
416_G	470_P	0.521	0.20
181_V	352_S	0.520	0.20
585_L	595_H	0.520	0.20
290_N	294_L	0.520	0.20
184_I	206_A	0.519	0.19
83_Y	184_I	0.518	0.19
74_A	337_L	0.518	0.19
41_E	557_L	0.517	0.19
149_A	345_G	0.517	0.19
194_E	207_M	0.517	0.19
234_L	395_G	0.517	0.19
140_V	292_S	0.517	0.19
145_G	480_V	0.517	0.19
120_L	691_R	0.517	0.19
704_V	708_D	0.516	0.19
179_V	193_A	0.516	0.19
30_M	360_A	0.515	0.19
644_R	661_L	0.515	0.19
624_D	645_A	0.514	0.19
22_M	393_V	0.513	0.19
177_G	289_A	0.513	0.19
26_F	583_V	0.513	0.19
689_A	703_V	0.513	0.19
299_V	358_T	0.512	0.19
273_G	287_S	0.512	0.19
177_G	575_I	0.512	0.19
619_P	678_T	0.512	0.19
128_G	227_G	0.511	0.19
239_V	243_L	0.510	0.19
66_S	477_T	0.510	0.19
87_F	286_V	0.509	0.19
318_D	328_A	0.509	0.19
324_Y	364_V	0.508	0.19
325_R	329_A	0.507	0.19
624_D	629_M	0.507	0.19
625_A	659_T	0.507	0.19
692_A	719_D	0.506	0.19
183_F	191_T	0.505	0.19
447_Y	626_S	0.504	0.19
138_V	141_L	0.503	0.19
55_Y	80_S	0.503	0.19
80_S	222_M	0.503	0.19
83_Y	285_T	0.502	0.19
314_N	325_R	0.502	0.19
353_F	403_L	0.502	0.19
153_L	629_M	0.502	0.19
297_A	398_A	0.501	0.19
452_A	467_S	0.501	0.19
307_K	393_V	0.501	0.19
181_V	478_Y	0.500	0.19
280_G	581_D	0.500	0.19
397_A	419_S	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l1lA	2	0.5129	100	0.752	Contact Map
3giaA	1	0.5193	100	0.766	Contact Map
3g40A	2	0.3093	100	0.769	Contact Map
4djkA	2	0.5193	100	0.781	Contact Map
4r2kA	2	0.3673	99.9	0.891	Contact Map
3cisA	4	0.3544	99.9	0.892	Contact Map
3mt0A	1	0.3466	99.9	0.894	Contact Map
3loqA	1	0.3389	99.9	0.895	Contact Map
4wy2A	2	0.3621	99.9	0.896	Contact Map
3ab8A	2	0.3235	99.9	0.899	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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