GREMLIN Database
Q9HSL4 - TRK potassium uptake system protein
UniProt: Q9HSL4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (209)
Sequences: 8741 (6230)
Seq/√Len: 430.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_D57_T3.8231.00
152_V198_I3.7081.00
183_R202_D3.4641.00
69_I86_A3.2841.00
6_V52_A3.2431.00
4_I66_A3.1541.00
181_I196_T2.8421.00
33_D49_H2.7241.00
183_R199_Q2.7121.00
52_A82_V2.6971.00
164_Q195_D2.6131.00
162_T165_E2.3941.00
5_I16_I2.3881.00
167_A172_L2.3751.00
83_C112_V2.3531.00
154_D200_A2.2421.00
36_A47_V2.2141.00
209_G212_A2.1811.00
59_A64_G2.1481.00
183_R196_T2.0461.00
161_T165_E2.0111.00
62_G65_R1.9481.00
163_L178_V1.9371.00
33_D37_A1.9241.00
4_I69_I1.8961.00
104_M117_N1.8891.00
6_V69_I1.8841.00
162_T197_V1.8811.00
69_I82_V1.8411.00
160_G199_Q1.8361.00
9_G12_G1.8291.00
87_A94_I1.8281.00
30_E36_A1.8181.00
83_C96_S1.8071.00
175_D212_A1.7661.00
20_T45_C1.7561.00
4_I63_A1.7331.00
87_A113_S1.7161.00
159_A200_A1.6831.00
71_S86_A1.6691.00
8_A28_V1.6061.00
15_L70_I1.5891.00
88_E109_R1.5821.00
171_A177_L1.5681.00
71_S79_N1.5631.00
164_Q194_G1.5591.00
61_A66_A1.5321.00
160_G200_A1.5171.00
30_E47_V1.4951.00
35_R38_R1.4931.00
93_A113_S1.4881.00
55_K59_A1.4871.00
59_A89_F1.4491.00
158_V166_A1.4331.00
83_C94_I1.4311.00
48_L61_A1.4301.00
178_V206_V1.3851.00
8_A39_A1.3751.00
149_E203_L1.3631.00
50_D61_A1.3521.00
149_E205_T1.3441.00
56_D59_A1.3371.00
9_G97_V1.3291.00
193_R196_T1.3251.00
198_I204_L1.3041.00
32_D35_R1.3041.00
71_S83_C1.2981.00
6_V82_V1.2981.00
13_T39_A1.2771.00
12_G72_T1.2481.00
27_A66_A1.2431.00
73_T82_V1.1851.00
151_S203_L1.1751.00
3_L68_A1.1711.00
96_S112_V1.1701.00
199_Q202_D1.1651.00
181_I202_D1.1591.00
208_S213_N1.1481.00
123_A127_Y1.1391.00
151_S201_G1.1321.00
104_M108_E1.1071.00
8_A36_A1.1061.00
48_L57_T1.0821.00
212_A215_S1.0791.00
16_I43_Y1.0781.00
93_A114_T1.0711.00
152_V159_A1.0631.00
55_K85_L1.0521.00
15_L123_A1.0471.00
78_T82_V1.0451.00
38_R42_D1.0401.00
159_A199_Q1.0391.00
29_I61_A1.0351.00
57_T61_A1.0341.00
56_D60_D1.0331.00
39_A47_V1.0301.00
73_T78_T1.0261.00
15_L72_T1.0221.00
150_I206_V1.0161.00
94_I113_S1.0091.00
16_I28_V1.0041.00
176_V208_S1.0011.00
6_V29_I0.9941.00
146_E210_V0.9881.00
188_D191_T0.9871.00
167_A171_A0.9821.00
34_S37_A0.9731.00
167_A173_P0.9691.00
63_A90_D0.9671.00
29_I57_T0.9621.00
121_L125_Y0.9611.00
8_A30_E0.9601.00
12_G30_E0.9511.00
145_A207_Y0.9311.00
29_I50_D0.9251.00
101_P120_Q0.9121.00
11_I97_V0.9041.00
174_D212_A0.8971.00
208_S212_A0.8961.00
166_A198_I0.8951.00
69_I91_I0.8921.00
30_E35_R0.8901.00
182_E203_L0.8901.00
24_N67_D0.8821.00
192_P196_T0.8801.00
3_L24_N0.8781.00
4_I61_A0.8741.00
5_I26_V0.8731.00
14_P17_D0.8601.00
9_G30_E0.8591.00
180_A205_T0.8551.00
17_D42_D0.8511.00
164_Q193_R0.8501.00
206_V216_V0.8491.00
68_A95_L0.8491.00
34_S38_R0.8381.00
161_T166_A0.8361.00
8_A13_T0.8291.00
184_D199_Q0.8291.00
158_V216_V0.8261.00
13_T17_D0.8221.00
28_V39_A0.8191.00
5_I12_G0.8161.00
27_A61_A0.8151.00
163_L192_P0.8141.00
26_V45_C0.8091.00
104_M120_Q0.8081.00
20_T26_V0.8081.00
162_T195_D0.8051.00
72_T97_V0.8001.00
12_G16_I0.7981.00
40_A47_V0.7971.00
176_V216_V0.7971.00
63_A89_F0.7921.00
98_V107_F0.7911.00
58_L89_F0.7881.00
44_D47_V0.7831.00
9_G52_A0.7821.00
180_A189_P0.7821.00
160_G197_V0.7811.00
58_L63_A0.7801.00
75_Q78_T0.7801.00
68_A93_A0.7751.00
30_E49_H0.7741.00
24_N131_T0.7681.00
27_A48_L0.7671.00
108_E114_T0.7661.00
87_A111_G0.7661.00
86_A90_D0.7661.00
5_I28_V0.7601.00
37_A41_D0.7571.00
55_K89_F0.7551.00
13_T43_Y0.7541.00
63_A66_A0.7541.00
76_D79_N0.7481.00
77_A81_M0.7441.00
213_N217_T0.7411.00
120_Q124_E0.7381.00
12_G97_V0.7331.00
12_G52_A0.7321.00
4_I27_A0.7301.00
58_L61_A0.7281.00
191_T194_G0.7271.00
14_P18_V0.7261.00
18_V21_R0.7261.00
144_H209_G0.7251.00
189_P196_T0.7241.00
84_L121_L0.7231.00
215_S218_D0.7201.00
165_E197_V0.7201.00
28_V44_D0.7201.00
162_T166_A0.7181.00
177_L194_G0.7141.00
73_T79_N0.7041.00
163_L194_G0.7031.00
125_Y129_A0.7031.00
94_I112_V0.6991.00
147_V179_V0.6961.00
85_L89_F0.6931.00
17_D21_R0.6931.00
153_T200_A0.6921.00
19_A26_V0.6891.00
179_V207_Y0.6881.00
28_V45_C0.6861.00
79_N103_H0.6801.00
5_I15_L0.6781.00
190_I196_T0.6691.00
54_I57_T0.6671.00
3_L19_A0.6651.00
84_L88_E0.6641.00
18_V123_A0.6601.00
173_P176_V0.6580.99
20_T44_D0.6560.99
66_A69_I0.6560.99
79_N96_S0.6500.99
36_A49_H0.6500.99
59_A63_A0.6430.99
196_T199_Q0.6430.99
132_R135_I0.6380.99
16_I45_C0.6370.99
183_R189_P0.6330.99
101_P104_M0.6310.99
63_A69_I0.6290.99
29_I48_L0.6280.99
53_T78_T0.6280.99
112_V115_M0.6250.99
99_H119_Q0.6230.99
14_P123_A0.6220.99
3_L70_I0.6190.99
77_A80_I0.6140.99
114_T129_A0.6120.99
182_E189_P0.6110.99
31_R51_D0.6110.99
214_P217_T0.6100.99
152_V201_G0.6080.99
121_L124_E0.6050.99
8_A12_G0.6010.99
4_I50_D0.6010.99
82_V86_A0.6000.99
20_T43_Y0.6000.99
27_A46_L0.5970.99
131_T137_D0.5940.99
88_E105_G0.5940.99
77_A100_N0.5890.99
9_G73_T0.5870.99
18_V22_S0.5830.99
37_A40_A0.5810.99
76_D99_H0.5780.99
182_E205_T0.5770.99
175_D209_G0.5770.99
30_E52_A0.5750.99
30_E118_P0.5690.99
46_L49_H0.5670.99
71_S82_V0.5670.99
11_I72_T0.5660.98
153_T157_P0.5660.98
124_E128_R0.5640.98
11_I103_H0.5630.98
183_R201_G0.5580.98
166_A171_A0.5540.98
54_I102_E0.5530.98
55_K88_E0.5520.98
159_A198_I0.5520.98
142_G145_A0.5500.98
6_V71_S0.5490.98
77_A103_H0.5490.98
163_L198_I0.5480.98
76_D103_H0.5470.98
171_A194_G0.5470.98
120_Q123_A0.5470.98
13_T35_R0.5460.98
171_A174_D0.5440.98
100_N103_H0.5430.98
76_D122_I0.5420.98
71_S94_I0.5410.98
11_I119_Q0.5400.98
7_G12_G0.5390.98
51_D54_I0.5390.98
165_E195_D0.5380.98
13_T38_R0.5370.98
69_I94_I0.5360.98
6_V86_A0.5360.98
80_I107_F0.5350.98
17_D20_T0.5340.98
59_A62_G0.5330.98
71_S96_S0.5310.98
16_I26_V0.5310.98
3_L15_L0.5300.98
140_R146_E0.5280.98
84_L107_F0.5270.98
28_V36_A0.5250.98
84_L110_I0.5230.97
13_T42_D0.5230.97
3_L67_D0.5200.97
39_A42_D0.5200.97
206_V213_N0.5180.97
58_L86_A0.5180.97
148_F152_V0.5170.97
31_R52_A0.5160.97
148_F208_S0.5150.97
98_V117_N0.5150.97
125_Y128_R0.5140.97
57_T60_D0.5120.97
97_V122_I0.5060.97
52_A58_L0.5050.97
182_E185_G0.5030.97
105_G162_T0.5030.97
162_T167_A0.5030.97
5_I72_T0.5030.97
146_E206_V0.5020.97
124_E127_Y0.5020.97
8_A45_C0.5020.97
60_D65_R0.5020.97
185_G203_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g65A 2 0.9605 100 0.229 Contact Map
4gx0A 3 0.9211 100 0.24 Contact Map
2aefA 2 0.9561 100 0.25 Contact Map
1lnqA 6 0.943 100 0.259 Contact Map
3mt5A 5 0.9386 100 0.288 Contact Map
3l4bC 2 0.943 100 0.294 Contact Map
3nafA 3 0.9781 100 0.305 Contact Map
4hpfA 3 0.9079 100 0.335 Contact Map
4j91A 3 0.9386 100 0.362 Contact Map
3l9wA 2 0.8289 99.9 0.532 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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