GREMLIN Database
Q9HSL3 - Uncharacterized protein
UniProt: Q9HSL3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (209)
Sequences: 1053 (793)
Seq/√Len: 54.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_A73_V4.8971.00
64_A72_D4.7851.00
102_I116_S4.1591.00
73_V76_E3.9481.00
70_D73_V3.4261.00
182_G217_S3.2051.00
64_A76_E2.9781.00
64_A70_D2.8761.00
101_A172_I2.7901.00
66_T73_V2.7371.00
100_G104_Q2.5361.00
72_D76_E2.5151.00
88_R142_T2.3891.00
17_K20_Y2.3641.00
66_T72_D2.2711.00
102_I170_G2.2571.00
146_A174_A2.2511.00
156_S166_T2.2211.00
70_D76_E2.2021.00
85_V180_I2.1971.00
23_V29_C2.1951.00
189_L200_L2.1471.00
66_T76_E2.1261.00
202_N215_L2.1181.00
122_D126_V2.0721.00
213_G216_E1.9351.00
187_R190_E1.8320.99
18_R21_N1.7730.99
189_L220_W1.7580.99
202_N211_A1.7370.99
63_E73_V1.7300.99
41_S47_H1.7030.99
138_F152_H1.6970.99
64_A67_V1.6510.99
183_Y187_R1.6370.99
88_R94_D1.6360.99
53_Q60_V1.6160.98
33_D36_A1.5950.98
122_D129_R1.5610.98
151_V169_V1.5450.98
65_V73_V1.5390.98
211_A215_L1.5100.98
105_V109_R1.5000.97
16_Q20_Y1.4950.97
62_D73_V1.4910.97
148_V175_H1.4870.97
171_V180_I1.4840.97
102_I106_A1.4590.97
143_V148_V1.4580.97
216_E222_R1.4550.97
141_A180_I1.4550.97
191_W195_R1.4480.97
98_L105_V1.4380.97
93_G96_S1.3960.96
44_G48_H1.3660.96
151_V220_W1.3120.94
139_F191_W1.3080.94
103_R107_D1.2990.94
67_V73_V1.2940.94
67_V70_D1.2710.93
147_V170_G1.2650.93
101_A105_V1.2520.93
40_L44_G1.2370.92
204_V208_N1.2240.92
66_T70_D1.2230.92
185_L214_F1.2220.92
30_T35_E1.2110.92
151_V188_G1.2100.92
187_R194_S1.2080.92
59_R74_A1.2010.91
150_W170_G1.2000.91
85_V183_Y1.1860.91
70_D74_A1.1830.91
106_A112_I1.1830.91
166_T201_Y1.1500.89
90_A138_F1.1480.89
153_L167_L1.1450.89
31_Y49_V1.1420.89
153_L200_L1.1360.89
97_G147_V1.1340.89
67_V72_D1.1300.89
123_H127_L1.1250.88
106_A109_R1.1190.88
102_I105_V1.1170.88
169_V185_L1.1170.88
17_K21_N1.1050.87
61_D71_A1.0990.87
122_D125_E1.0860.86
206_A209_D1.0860.86
116_S120_I1.0820.86
182_G186_E1.0770.86
112_I117_V1.0750.86
171_V192_A1.0510.85
182_G218_R1.0490.85
100_G147_V1.0440.84
124_E127_L1.0380.84
69_F73_V1.0200.83
48_H52_L1.0050.82
191_W194_S1.0020.82
63_E76_E0.9960.81
141_A148_V0.9950.81
74_A77_T0.9940.81
16_Q51_I0.9890.81
204_V215_L0.9870.81
113_E116_S0.9860.81
204_V211_A0.9830.80
89_P137_M0.9540.78
94_D142_T0.9530.78
43_R60_V0.9530.78
94_D140_V0.9510.78
19_L34_L0.9440.78
214_F218_R0.9430.78
26_H33_D0.9420.78
20_Y57_F0.9260.76
167_L188_G0.9260.76
86_V144_D0.9170.76
98_L102_I0.9170.76
136_R155_G0.9160.76
50_A54_R0.9150.75
43_R46_R0.9140.75
205_P228_D0.9120.75
126_V130_H0.9050.75
97_G100_G0.8980.74
58_L70_D0.8950.74
120_I123_H0.8910.73
18_R44_G0.8870.73
18_R43_R0.8790.72
30_T33_D0.8700.72
95_L99_V0.8670.71
145_E179_G0.8620.71
94_D97_G0.8480.70
26_H37_A0.8440.69
69_F194_S0.8410.69
186_E218_R0.8410.69
98_L106_A0.8400.69
85_V143_V0.8380.69
202_N220_W0.8360.69
64_A74_A0.8340.68
30_T43_R0.8340.68
86_V89_P0.8320.68
157_E164_T0.8310.68
98_L152_H0.8230.67
37_A190_E0.8220.67
73_V77_T0.8220.67
63_E72_D0.8180.67
120_I127_L0.8170.67
105_V108_D0.8150.67
105_V113_E0.8090.66
19_L185_L0.8050.66
79_R82_G0.8040.66
135_E195_R0.7990.65
51_I54_R0.7990.65
97_G101_A0.7970.65
27_G33_D0.7810.63
83_I198_E0.7800.63
84_E144_D0.7790.63
150_W166_T0.7760.63
114_A118_A0.7750.63
62_D72_D0.7700.62
94_D98_L0.7690.62
44_G52_L0.7660.62
31_Y70_D0.7650.62
63_E74_A0.7600.61
45_I201_Y0.7470.60
28_E61_D0.7460.60
121_V127_L0.7440.60
79_R83_I0.7440.60
175_H178_H0.7420.59
41_S165_A0.7350.59
78_H83_I0.7350.59
41_S44_G0.7250.58
65_V70_D0.7240.57
141_A171_V0.7240.57
110_T208_N0.7210.57
59_R71_A0.7180.57
29_C34_L0.7140.56
205_P208_N0.7110.56
33_D45_I0.7030.55
71_A80_S0.7000.55
31_Y35_E0.6970.55
19_L61_D0.6960.55
120_I124_E0.6940.54
132_D213_G0.6930.54
32_D36_A0.6910.54
183_Y186_E0.6900.54
90_A130_H0.6830.53
203_S208_N0.6810.53
164_T199_K0.6810.53
203_S212_I0.6800.53
96_S100_G0.6740.52
22_Y47_H0.6740.52
178_H200_L0.6680.52
62_D70_D0.6660.51
103_R116_S0.6620.51
167_L211_A0.6600.51
31_Y60_V0.6590.51
142_T145_E0.6560.50
49_V54_R0.6540.50
151_V167_L0.6540.50
93_G117_V0.6530.50
165_A197_Y0.6500.50
149_G184_L0.6500.50
45_I141_A0.6460.49
188_G191_W0.6450.49
102_I150_W0.6430.49
153_L188_G0.6430.49
151_V206_A0.6420.49
116_S119_D0.6390.48
18_R22_Y0.6360.48
186_E190_E0.6350.48
81_D186_E0.6320.48
71_A76_E0.6320.48
84_E89_P0.6280.47
141_A149_G0.6270.47
131_N136_R0.6250.47
40_L210_A0.6220.47
148_V174_A0.6220.47
34_L39_P0.6220.47
167_L215_L0.6210.46
19_L128_L0.6200.46
25_R40_L0.6160.46
146_A172_I0.6160.46
158_L174_A0.6130.46
68_A73_V0.6120.46
119_D168_T0.6100.45
53_Q57_F0.6090.45
65_V72_D0.6050.45
208_N211_A0.6040.45
102_I109_R0.6000.44
63_E66_T0.5980.44
95_L102_I0.5970.44
65_V76_E0.5970.44
98_L114_A0.5950.44
74_A78_H0.5900.43
202_N208_N0.5900.43
99_V109_R0.5890.43
117_V127_L0.5870.43
95_L124_E0.5860.43
109_R176_Q0.5850.43
190_E194_S0.5820.42
23_V58_L0.5810.42
80_S84_E0.5810.42
80_S90_A0.5800.42
58_L83_I0.5800.42
191_W197_Y0.5800.42
59_R78_H0.5790.42
43_R47_H0.5770.42
108_D173_D0.5760.42
92_Q227_A0.5750.42
64_A71_A0.5750.42
156_S221_E0.5740.42
105_V110_T0.5730.41
155_G159_A0.5720.41
31_Y45_I0.5710.41
102_I112_I0.5690.41
19_L48_H0.5650.41
113_E117_V0.5650.41
60_V87_V0.5640.40
93_G107_D0.5630.40
119_D123_H0.5600.40
89_P92_Q0.5600.40
109_R113_E0.5600.40
126_V129_R0.5560.40
118_A148_V0.5550.40
47_H204_V0.5550.40
165_A170_G0.5540.39
53_Q159_A0.5520.39
68_A72_D0.5500.39
209_D217_S0.5500.39
115_E119_D0.5500.39
22_Y34_L0.5490.39
62_D68_A0.5490.39
100_G108_D0.5480.39
74_A190_E0.5480.39
159_A190_E0.5470.39
48_H134_E0.5460.39
57_F60_V0.5460.39
112_I116_S0.5450.39
159_A194_S0.5430.38
36_A81_D0.5400.38
79_R104_Q0.5400.38
135_E155_G0.5390.38
123_H168_T0.5370.38
122_D153_L0.5370.38
74_A83_I0.5340.37
46_R76_E0.5330.37
22_Y38_M0.5320.37
101_A147_V0.5290.37
43_R53_Q0.5290.37
35_E42_P0.5280.37
194_S223_E0.5280.37
67_V76_E0.5280.37
117_V121_V0.5260.37
118_A121_V0.5250.37
95_L138_F0.5250.37
16_Q48_H0.5250.37
74_A79_R0.5230.36
17_K34_L0.5230.36
125_E145_E0.5210.36
61_D213_G0.5210.36
185_L218_R0.5210.36
99_V113_E0.5180.36
129_R158_L0.5160.36
19_L22_Y0.5160.36
51_I55_D0.5140.35
67_V71_A0.5100.35
82_G221_E0.5090.35
19_L23_V0.5080.35
71_A79_R0.5080.35
49_V109_R0.5050.35
26_H62_D0.5030.34
154_V166_T0.5030.34
31_Y41_S0.5020.34
123_H126_V0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j8mA 2 0.6585 100 0.558 Contact Map
3dr6A 2 0.6585 100 0.561 Contact Map
4h89A 2 0.6707 99.9 0.575 Contact Map
4j3gA 2 0.6626 99.9 0.584 Contact Map
1gheA 1 0.6585 99.9 0.605 Contact Map
2i79A 2 0.6748 99.9 0.608 Contact Map
1s7kA 2 0.6138 99.9 0.609 Contact Map
3r9fA 1 0.7033 99.9 0.611 Contact Map
1vhsA 1 0.6545 99.9 0.611 Contact Map
2ge3A 2 0.6626 99.9 0.613 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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