Q9HSL3 - HALSA - GREMLIN Contacts

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Q9HSL3 - Uncharacterized protein

UniProt:	Q9HSL3	Sequences: MSDTAETELAFDHDDQKRLYNYVERHGECTYDDLEAAMPLSPRGIRHHVAILQRDGFLRVDDEAVTVAFDADVAAETHRSDGIEVVVRPARQGDLSGLVGAIRQVADDRTYIEAESVADIVDHEEVLLRHNDVEERMFFVATVDEAVVGWVHLVGSELAKLAHTATLTVGVIDAHQGHGIGGYLLERGLEWAASRGYEKLYNSVPATNDAAIGFLESRGWEREARRADHYQLDEAYVDEVMMAYRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	246 (209)
Sequences:	1053 (793)
Seq/√Len:	54.8

BACSU - YBFA YWNH
HALSA - Q9HSL3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_A	73_V	4.897	1.00
64_A	72_D	4.785	1.00
102_I	116_S	4.159	1.00
73_V	76_E	3.948	1.00
70_D	73_V	3.426	1.00
182_G	217_S	3.205	1.00
64_A	76_E	2.978	1.00
64_A	70_D	2.876	1.00
101_A	172_I	2.790	1.00
66_T	73_V	2.737	1.00
100_G	104_Q	2.536	1.00
72_D	76_E	2.515	1.00
88_R	142_T	2.389	1.00
17_K	20_Y	2.364	1.00
66_T	72_D	2.271	1.00
102_I	170_G	2.257	1.00
146_A	174_A	2.251	1.00
156_S	166_T	2.221	1.00
70_D	76_E	2.202	1.00
85_V	180_I	2.197	1.00
23_V	29_C	2.195	1.00
189_L	200_L	2.147	1.00
66_T	76_E	2.126	1.00
202_N	215_L	2.118	1.00
122_D	126_V	2.072	1.00
213_G	216_E	1.935	1.00
187_R	190_E	1.832	0.99
18_R	21_N	1.773	0.99
189_L	220_W	1.758	0.99
202_N	211_A	1.737	0.99
63_E	73_V	1.730	0.99
41_S	47_H	1.703	0.99
138_F	152_H	1.697	0.99
64_A	67_V	1.651	0.99
183_Y	187_R	1.637	0.99
88_R	94_D	1.636	0.99
53_Q	60_V	1.616	0.98
33_D	36_A	1.595	0.98
122_D	129_R	1.561	0.98
151_V	169_V	1.545	0.98
65_V	73_V	1.539	0.98
211_A	215_L	1.510	0.98
105_V	109_R	1.500	0.97
16_Q	20_Y	1.495	0.97
62_D	73_V	1.491	0.97
148_V	175_H	1.487	0.97
171_V	180_I	1.484	0.97
102_I	106_A	1.459	0.97
143_V	148_V	1.458	0.97
216_E	222_R	1.455	0.97
141_A	180_I	1.455	0.97
191_W	195_R	1.448	0.97
98_L	105_V	1.438	0.97
93_G	96_S	1.396	0.96
44_G	48_H	1.366	0.96
151_V	220_W	1.312	0.94
139_F	191_W	1.308	0.94
103_R	107_D	1.299	0.94
67_V	73_V	1.294	0.94
67_V	70_D	1.271	0.93
147_V	170_G	1.265	0.93
101_A	105_V	1.252	0.93
40_L	44_G	1.237	0.92
204_V	208_N	1.224	0.92
66_T	70_D	1.223	0.92
185_L	214_F	1.222	0.92
30_T	35_E	1.211	0.92
151_V	188_G	1.210	0.92
187_R	194_S	1.208	0.92
59_R	74_A	1.201	0.91
150_W	170_G	1.200	0.91
85_V	183_Y	1.186	0.91
70_D	74_A	1.183	0.91
106_A	112_I	1.183	0.91
166_T	201_Y	1.150	0.89
90_A	138_F	1.148	0.89
153_L	167_L	1.145	0.89
31_Y	49_V	1.142	0.89
153_L	200_L	1.136	0.89
97_G	147_V	1.134	0.89
67_V	72_D	1.130	0.89
123_H	127_L	1.125	0.88
106_A	109_R	1.119	0.88
102_I	105_V	1.117	0.88
169_V	185_L	1.117	0.88
17_K	21_N	1.105	0.87
61_D	71_A	1.099	0.87
122_D	125_E	1.086	0.86
206_A	209_D	1.086	0.86
116_S	120_I	1.082	0.86
182_G	186_E	1.077	0.86
112_I	117_V	1.075	0.86
171_V	192_A	1.051	0.85
182_G	218_R	1.049	0.85
100_G	147_V	1.044	0.84
124_E	127_L	1.038	0.84
69_F	73_V	1.020	0.83
48_H	52_L	1.005	0.82
191_W	194_S	1.002	0.82
63_E	76_E	0.996	0.81
141_A	148_V	0.995	0.81
74_A	77_T	0.994	0.81
16_Q	51_I	0.989	0.81
204_V	215_L	0.987	0.81
113_E	116_S	0.986	0.81
204_V	211_A	0.983	0.80
89_P	137_M	0.954	0.78
94_D	142_T	0.953	0.78
43_R	60_V	0.953	0.78
94_D	140_V	0.951	0.78
19_L	34_L	0.944	0.78
214_F	218_R	0.943	0.78
26_H	33_D	0.942	0.78
20_Y	57_F	0.926	0.76
167_L	188_G	0.926	0.76
86_V	144_D	0.917	0.76
98_L	102_I	0.917	0.76
136_R	155_G	0.916	0.76
50_A	54_R	0.915	0.75
43_R	46_R	0.914	0.75
205_P	228_D	0.912	0.75
126_V	130_H	0.905	0.75
97_G	100_G	0.898	0.74
58_L	70_D	0.895	0.74
120_I	123_H	0.891	0.73
18_R	44_G	0.887	0.73
18_R	43_R	0.879	0.72
30_T	33_D	0.870	0.72
95_L	99_V	0.867	0.71
145_E	179_G	0.862	0.71
94_D	97_G	0.848	0.70
26_H	37_A	0.844	0.69
69_F	194_S	0.841	0.69
186_E	218_R	0.841	0.69
98_L	106_A	0.840	0.69
85_V	143_V	0.838	0.69
202_N	220_W	0.836	0.69
64_A	74_A	0.834	0.68
30_T	43_R	0.834	0.68
86_V	89_P	0.832	0.68
157_E	164_T	0.831	0.68
98_L	152_H	0.823	0.67
37_A	190_E	0.822	0.67
73_V	77_T	0.822	0.67
63_E	72_D	0.818	0.67
120_I	127_L	0.817	0.67
105_V	108_D	0.815	0.67
105_V	113_E	0.809	0.66
19_L	185_L	0.805	0.66
79_R	82_G	0.804	0.66
135_E	195_R	0.799	0.65
51_I	54_R	0.799	0.65
97_G	101_A	0.797	0.65
27_G	33_D	0.781	0.63
83_I	198_E	0.780	0.63
84_E	144_D	0.779	0.63
150_W	166_T	0.776	0.63
114_A	118_A	0.775	0.63
62_D	72_D	0.770	0.62
94_D	98_L	0.769	0.62
44_G	52_L	0.766	0.62
31_Y	70_D	0.765	0.62
63_E	74_A	0.760	0.61
45_I	201_Y	0.747	0.60
28_E	61_D	0.746	0.60
121_V	127_L	0.744	0.60
79_R	83_I	0.744	0.60
175_H	178_H	0.742	0.59
41_S	165_A	0.735	0.59
78_H	83_I	0.735	0.59
41_S	44_G	0.725	0.58
65_V	70_D	0.724	0.57
141_A	171_V	0.724	0.57
110_T	208_N	0.721	0.57
59_R	71_A	0.718	0.57
29_C	34_L	0.714	0.56
205_P	208_N	0.711	0.56
33_D	45_I	0.703	0.55
71_A	80_S	0.700	0.55
31_Y	35_E	0.697	0.55
19_L	61_D	0.696	0.55
120_I	124_E	0.694	0.54
132_D	213_G	0.693	0.54
32_D	36_A	0.691	0.54
183_Y	186_E	0.690	0.54
90_A	130_H	0.683	0.53
203_S	208_N	0.681	0.53
164_T	199_K	0.681	0.53
203_S	212_I	0.680	0.53
96_S	100_G	0.674	0.52
22_Y	47_H	0.674	0.52
178_H	200_L	0.668	0.52
62_D	70_D	0.666	0.51
103_R	116_S	0.662	0.51
167_L	211_A	0.660	0.51
31_Y	60_V	0.659	0.51
142_T	145_E	0.656	0.50
49_V	54_R	0.654	0.50
151_V	167_L	0.654	0.50
93_G	117_V	0.653	0.50
165_A	197_Y	0.650	0.50
149_G	184_L	0.650	0.50
45_I	141_A	0.646	0.49
188_G	191_W	0.645	0.49
102_I	150_W	0.643	0.49
153_L	188_G	0.643	0.49
151_V	206_A	0.642	0.49
116_S	119_D	0.639	0.48
18_R	22_Y	0.636	0.48
186_E	190_E	0.635	0.48
81_D	186_E	0.632	0.48
71_A	76_E	0.632	0.48
84_E	89_P	0.628	0.47
141_A	149_G	0.627	0.47
131_N	136_R	0.625	0.47
40_L	210_A	0.622	0.47
148_V	174_A	0.622	0.47
34_L	39_P	0.622	0.47
167_L	215_L	0.621	0.46
19_L	128_L	0.620	0.46
25_R	40_L	0.616	0.46
146_A	172_I	0.616	0.46
158_L	174_A	0.613	0.46
68_A	73_V	0.612	0.46
119_D	168_T	0.610	0.45
53_Q	57_F	0.609	0.45
65_V	72_D	0.605	0.45
208_N	211_A	0.604	0.45
102_I	109_R	0.600	0.44
63_E	66_T	0.598	0.44
95_L	102_I	0.597	0.44
65_V	76_E	0.597	0.44
98_L	114_A	0.595	0.44
74_A	78_H	0.590	0.43
202_N	208_N	0.590	0.43
99_V	109_R	0.589	0.43
117_V	127_L	0.587	0.43
95_L	124_E	0.586	0.43
109_R	176_Q	0.585	0.43
190_E	194_S	0.582	0.42
23_V	58_L	0.581	0.42
80_S	84_E	0.581	0.42
80_S	90_A	0.580	0.42
58_L	83_I	0.580	0.42
191_W	197_Y	0.580	0.42
59_R	78_H	0.579	0.42
43_R	47_H	0.577	0.42
108_D	173_D	0.576	0.42
92_Q	227_A	0.575	0.42
64_A	71_A	0.575	0.42
156_S	221_E	0.574	0.42
105_V	110_T	0.573	0.41
155_G	159_A	0.572	0.41
31_Y	45_I	0.571	0.41
102_I	112_I	0.569	0.41
19_L	48_H	0.565	0.41
113_E	117_V	0.565	0.41
60_V	87_V	0.564	0.40
93_G	107_D	0.563	0.40
119_D	123_H	0.560	0.40
89_P	92_Q	0.560	0.40
109_R	113_E	0.560	0.40
126_V	129_R	0.556	0.40
118_A	148_V	0.555	0.40
47_H	204_V	0.555	0.40
165_A	170_G	0.554	0.39
53_Q	159_A	0.552	0.39
68_A	72_D	0.550	0.39
209_D	217_S	0.550	0.39
115_E	119_D	0.550	0.39
22_Y	34_L	0.549	0.39
62_D	68_A	0.549	0.39
100_G	108_D	0.548	0.39
74_A	190_E	0.548	0.39
159_A	190_E	0.547	0.39
48_H	134_E	0.546	0.39
57_F	60_V	0.546	0.39
112_I	116_S	0.545	0.39
159_A	194_S	0.543	0.38
36_A	81_D	0.540	0.38
79_R	104_Q	0.540	0.38
135_E	155_G	0.539	0.38
123_H	168_T	0.537	0.38
122_D	153_L	0.537	0.38
74_A	83_I	0.534	0.37
46_R	76_E	0.533	0.37
22_Y	38_M	0.532	0.37
101_A	147_V	0.529	0.37
43_R	53_Q	0.529	0.37
35_E	42_P	0.528	0.37
194_S	223_E	0.528	0.37
67_V	76_E	0.528	0.37
117_V	121_V	0.526	0.37
118_A	121_V	0.525	0.37
95_L	138_F	0.525	0.37
16_Q	48_H	0.525	0.37
74_A	79_R	0.523	0.36
17_K	34_L	0.523	0.36
125_E	145_E	0.521	0.36
61_D	213_G	0.521	0.36
185_L	218_R	0.521	0.36
99_V	113_E	0.518	0.36
129_R	158_L	0.516	0.36
19_L	22_Y	0.516	0.36
51_I	55_D	0.514	0.35
67_V	71_A	0.510	0.35
82_G	221_E	0.509	0.35
19_L	23_V	0.508	0.35
71_A	79_R	0.508	0.35
49_V	109_R	0.505	0.35
26_H	62_D	0.503	0.34
154_V	166_T	0.503	0.34
31_Y	41_S	0.502	0.34
123_H	126_V	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j8mA	2	0.6585	100	0.558	Contact Map
3dr6A	2	0.6585	100	0.561	Contact Map
4h89A	2	0.6707	99.9	0.575	Contact Map
4j3gA	2	0.6626	99.9	0.584	Contact Map
1gheA	1	0.6585	99.9	0.605	Contact Map
2i79A	2	0.6748	99.9	0.608	Contact Map
1s7kA	2	0.6138	99.9	0.609	Contact Map
3r9fA	1	0.7033	99.9	0.611	Contact Map
1vhsA	1	0.6545	99.9	0.611	Contact Map
2ge3A	2	0.6626	99.9	0.613	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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