GREMLIN Database
RL15E - 50S ribosomal protein L15e
UniProt: Q9HSL2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (190)
Sequences: 351 (201)
Seq/√Len: 14.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_V148_L4.4071.00
83_R86_R3.6750.99
140_G144_N3.6050.99
64_V110_Y3.4720.99
183_G186_P3.2890.99
38_I66_V3.0030.98
75_K169_R2.7470.96
112_N138_E2.6870.95
4_S7_S2.5320.94
178_G183_G2.3040.90
62_V113_L2.2410.89
178_G186_P2.1430.86
177_R186_P2.1380.86
9_I47_L2.0840.85
180_G186_P2.0800.84
29_K122_G2.0760.84
177_R185_R2.0680.84
4_S11_E2.0510.84
180_G183_G2.0510.84
175_Q183_G2.0210.83
77_R89_V1.9960.82
59_Q139_H1.9920.82
53_L117_N1.9350.80
181_T184_L1.9190.79
107_S160_V1.8480.76
59_Q141_A1.8260.75
178_G185_R1.7910.74
177_R183_G1.7890.74
94_R101_I1.7630.73
177_R180_G1.6970.70
145_D149_N1.6650.68
72_T92_I1.6290.67
100_R104_E1.6250.66
165_T172_R1.5830.64
68_V130_F1.5710.64
182_E186_P1.5680.63
66_V106_A1.5570.63
85_K193_R1.5560.63
48_D156_H1.5450.62
149_N152_C1.4980.60
107_S161_F1.4780.59
145_D148_L1.4700.58
155_S164_K1.4470.57
130_F170_R1.4470.57
96_K104_E1.4410.57
176_N186_P1.3950.54
10_K14_E1.3780.53
180_G185_R1.3690.53
28_R33_R1.3480.52
175_Q185_R1.3480.52
100_R171_A1.3400.51
94_R100_R1.3330.51
70_K73_A1.3270.50
175_Q178_G1.3110.50
98_L130_F1.3030.49
74_R80_A1.2850.48
109_K164_K1.2820.48
23_E27_Q1.2660.47
104_E168_G1.2660.47
12_A21_L1.2630.47
21_L49_K1.2560.47
58_K145_D1.2540.46
182_E185_R1.2440.46
85_K97_N1.2390.46
178_G181_T1.2320.45
16_P19_G1.2310.45
35_E39_E1.2240.45
13_W46_R1.2060.44
99_Q167_A1.2000.43
62_V110_Y1.1900.43
175_Q186_P1.1820.42
176_N185_R1.1800.42
68_V115_T1.1580.41
123_E128_K1.1550.41
113_L134_L1.1480.41
177_R181_T1.1240.39
90_N105_R1.1240.39
176_N184_L1.1140.39
44_P71_G1.1090.39
4_S74_R1.0990.38
40_R89_V1.0990.38
44_P57_A1.0970.38
15_D18_D1.0910.38
182_E191_D1.0840.37
117_N133_I1.0750.37
46_R65_R1.0720.37
183_G191_D1.0640.36
115_T134_L1.0620.36
186_P190_A1.0510.36
6_Y46_R1.0360.35
159_R162_R1.0240.34
186_P191_D1.0200.34
114_R157_K1.0200.34
174_L187_S1.0090.33
37_A45_T1.0080.33
49_K52_E1.0070.33
45_T121_V1.0030.33
28_R45_T0.9950.33
112_N122_G0.9930.33
117_N151_I0.9830.32
159_R172_R0.9810.32
19_G135_L0.9790.32
72_T76_S0.9720.32
174_L181_T0.9700.32
10_K147_D0.9580.31
108_R147_D0.9500.31
163_G172_R0.9480.31
187_S190_A0.9410.30
46_R69_R0.9370.30
31_D35_E0.9310.30
14_E132_A0.9230.29
165_T173_G0.9170.29
85_K181_T0.9170.29
99_Q184_L0.9160.29
31_D144_N0.9140.29
153_D156_H0.9140.29
63_V148_L0.9070.29
124_D150_W0.8940.28
114_R160_V0.8900.28
135_L148_L0.8890.28
49_K53_L0.8810.27
99_Q147_D0.8560.26
100_R160_V0.8540.26
43_R73_A0.8500.26
47_L193_R0.8470.26
37_A67_S0.8460.26
91_R184_L0.8400.26
38_I144_N0.8400.26
176_N181_T0.8380.26
58_K61_V0.8280.25
190_A193_R0.8250.25
122_G129_W0.8110.25
19_G70_K0.8100.24
11_E14_E0.8070.24
48_D100_R0.8030.24
45_T125_G0.8030.24
13_W122_G0.7950.24
176_N183_G0.7940.24
5_F25_Q0.7920.24
26_W40_R0.7920.24
8_H25_Q0.7860.23
128_K172_R0.7820.23
15_D35_E0.7780.23
14_E48_D0.7770.23
85_K95_A0.7750.23
66_V127_Q0.7720.23
134_L168_G0.7690.23
49_K154_D0.7670.23
126_S143_Q0.7640.23
16_P23_E0.7640.23
162_R172_R0.7600.22
9_I68_V0.7590.22
68_V167_A0.7570.22
141_A144_N0.7520.22
36_G83_R0.7510.22
97_N179_K0.7480.22
123_E127_Q0.7470.22
17_D26_W0.7460.22
26_W30_Q0.7460.22
187_S191_D0.7430.22
126_S129_W0.7430.22
130_F154_D0.7410.22
40_R150_W0.7400.22
81_G85_K0.7360.22
122_G138_E0.7340.21
63_V110_Y0.7310.21
33_R135_L0.7220.21
101_I127_Q0.7170.21
78_F127_Q0.7150.21
178_G182_E0.7150.21
39_E47_L0.7120.21
181_T191_D0.7100.21
65_R120_W0.7090.21
120_W150_W0.7040.20
86_R191_D0.7030.20
77_R80_A0.7020.20
106_A110_Y0.6980.20
41_V101_I0.6950.20
9_I183_G0.6930.20
33_R162_R0.6910.20
170_R175_Q0.6910.20
176_N180_G0.6890.20
122_G167_A0.6890.20
166_S175_Q0.6870.20
39_E106_A0.6860.20
91_R191_D0.6860.20
175_Q181_T0.6800.20
185_R191_D0.6750.19
127_Q151_I0.6730.19
43_R108_R0.6680.19
9_I129_W0.6610.19
33_R172_R0.6600.19
111_V158_N0.6520.19
122_G149_N0.6520.19
140_G180_G0.6510.19
139_H146_D0.6480.18
81_G86_R0.6470.18
4_S17_D0.6460.18
85_K175_Q0.6440.18
107_S127_Q0.6400.18
108_R137_P0.6380.18
179_K182_E0.6380.18
61_V85_K0.6340.18
110_Y129_W0.6330.18
6_Y105_R0.6320.18
99_Q187_S0.6280.18
33_R70_K0.6270.18
9_I26_W0.6260.18
65_R121_V0.6240.18
149_N157_K0.6230.18
59_Q146_D0.6220.18
73_A94_R0.6210.18
5_F17_D0.6170.17
97_N174_L0.6170.17
175_Q179_K0.6160.17
89_V164_K0.6160.17
6_Y101_I0.6120.17
96_K101_I0.6100.17
37_A184_L0.6040.17
33_R50_A0.5980.17
91_R186_P0.5970.17
42_D112_N0.5960.17
164_K169_R0.5950.17
11_E139_H0.5940.17
135_L147_D0.5940.17
120_W178_G0.5900.17
188_T191_D0.5890.17
88_G149_N0.5890.17
31_D114_R0.5880.17
107_S114_R0.5870.17
73_A92_I0.5860.16
42_D148_L0.5860.16
100_R168_G0.5850.16
30_Q84_T0.5840.16
16_P22_A0.5820.16
31_D36_G0.5820.16
50_A137_P0.5810.16
109_K148_L0.5790.16
87_Q108_R0.5780.16
13_W45_T0.5780.16
177_R182_E0.5780.16
65_R105_R0.5770.16
44_P112_N0.5750.16
116_L124_D0.5740.16
112_N152_C0.5710.16
50_A131_E0.5680.16
34_K114_R0.5670.16
112_N135_L0.5660.16
26_W67_S0.5630.16
48_D98_L0.5610.16
159_R173_G0.5590.16
4_S75_K0.5590.16
75_K137_P0.5570.16
164_K193_R0.5560.16
25_Q129_W0.5530.15
67_S127_Q0.5530.15
57_A135_L0.5500.15
43_R98_L0.5500.15
40_R65_R0.5490.15
82_R91_R0.5460.15
25_Q123_E0.5430.15
46_R70_K0.5430.15
7_S36_G0.5360.15
46_R72_T0.5320.15
11_E17_D0.5300.15
4_S34_K0.5300.15
61_V135_L0.5300.15
109_K122_G0.5290.15
5_F31_D0.5280.15
16_P192_K0.5230.15
37_A106_A0.5200.15
141_A153_D0.5150.14
68_V123_E0.5140.14
109_K134_L0.5140.14
28_R172_R0.5140.14
101_I161_F0.5130.14
77_R82_R0.5100.14
5_F19_G0.5090.14
90_N97_N0.5090.14
123_E181_T0.5080.14
38_I73_A0.5060.14
142_I179_K0.5050.14
77_R125_G0.5010.14
99_Q166_S0.5000.14
12_A16_P0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zf7Q 1 0.9847 100 0.031 Contact Map
1vq8M 1 0.9898 100 0.034 Contact Map
3j21M 1 0.9898 100 0.037 Contact Map
3j39N 1 0.9847 100 0.038 Contact Map
3j61N 1 0.9796 100 0.04 Contact Map
4a17L 1 0.9847 100 0.042 Contact Map
1vx7P 1 0.9847 100 0.045 Contact Map
4ujrA 1 0.9796 100 0.048 Contact Map
1ffkI 1 0.9847 100 0.048 Contact Map
1eigA 1 0.3673 4.4 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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