GREMLIN Database
Q9HSL0 - Uncharacterized protein
UniProt: Q9HSL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (244)
Sequences: 956 (603)
Seq/√Len: 38.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_V240_L5.3871.00
173_R185_E4.1771.00
212_E240_L3.8901.00
208_L237_G3.8211.00
170_N237_G3.3651.00
100_L118_A3.0831.00
231_V238_V3.0271.00
166_Y173_R2.9291.00
170_N212_E2.8931.00
165_L216_A2.8541.00
187_V239_V2.7821.00
255_R259_A2.7431.00
216_A240_L2.6991.00
209_I238_V2.6641.00
213_V226_V2.4771.00
166_Y174_P2.4131.00
213_V286_V2.3431.00
177_H180_H2.2801.00
216_A243_W2.2190.99
210_L282_H2.2190.99
131_E135_G2.1920.99
119_L183_V2.1510.99
121_F181_A2.1010.99
90_R176_D2.0630.99
131_E134_R1.9500.99
205_V233_V1.9340.98
214_A218_R1.9120.98
209_I231_V1.9100.98
263_E267_Q1.9020.98
283_D287_G1.8480.98
83_A179_R1.8250.98
205_V238_V1.7980.97
102_V107_D1.7760.97
268_Y272_K1.7400.97
88_A96_F1.7220.97
201_Q204_G1.7170.97
91_D112_Q1.6860.96
213_V262_V1.6740.96
234_D239_V1.6720.96
146_S149_Y1.6630.96
117_M175_V1.6370.96
122_H182_I1.6270.95
110_E116_P1.5880.95
227_S264_N1.5680.94
189_G232_F1.5390.94
215_A219_E1.5240.93
159_Y174_P1.5030.93
92_S176_D1.4860.93
175_V229_Y1.4710.92
76_F108_V1.4660.92
232_F241_F1.4510.92
79_Y179_R1.4480.92
165_L169_V1.4200.91
211_R215_A1.3920.90
111_V117_M1.3910.90
125_G147_W1.3830.90
281_D284_A1.3710.89
82_L179_R1.3660.89
206_L266_V1.3500.88
99_P109_Y1.3470.88
93_V121_F1.3420.88
191_E194_N1.3400.88
115_R173_R1.3400.88
119_L229_Y1.3380.88
170_N208_L1.3340.88
108_V131_E1.3180.87
213_V265_I1.3080.87
139_T144_H1.3010.86
110_E186_K1.2990.86
204_G208_L1.2900.86
214_A285_V1.2860.86
165_L243_W1.2820.86
205_V209_I1.2580.85
101_G243_W1.2500.84
78_G125_G1.2440.84
157_R228_E1.2340.83
157_R221_Y1.2280.83
125_G128_Q1.1940.81
222_V257_L1.1860.81
161_A221_Y1.1760.80
224_A257_L1.1660.80
266_V282_H1.1520.79
82_L93_V1.1470.79
84_L182_I1.1430.78
212_E226_V1.1430.78
102_V180_H1.1210.77
87_F182_I1.1060.76
117_M183_V1.1010.76
97_G110_E1.1000.76
69_Y125_G1.0990.75
87_F92_S1.0910.75
161_A246_A1.0850.75
123_R131_E1.0840.74
189_G235_S1.0770.74
43_R47_Q1.0750.74
213_V263_E1.0710.74
108_V256_E1.0680.73
238_V265_I1.0660.73
96_F119_L1.0650.73
88_A174_P1.0510.72
132_V248_P1.0500.72
133_H142_K1.0490.72
81_V84_L1.0480.72
124_E132_V1.0470.72
78_G136_R1.0450.72
128_Q136_R1.0330.71
74_L126_Y1.0320.71
94_E265_I1.0310.71
156_E177_H1.0270.70
85_H89_E1.0250.70
161_A227_S1.0250.70
87_F181_A1.0240.70
111_V183_V1.0240.70
117_M205_V1.0200.70
202_A208_L1.0190.70
135_G154_A1.0150.69
53_L62_L1.0130.69
110_E123_R1.0070.69
169_V212_E1.0050.69
217_Y258_L0.9940.68
46_P49_V0.9940.68
43_R46_P0.9920.68
71_G124_E0.9910.68
212_E215_A0.9820.67
156_E164_A0.9820.67
111_V162_L0.9690.66
157_R161_A0.9680.66
75_T264_N0.9670.66
44_L47_Q0.9590.65
260_R264_N0.9560.65
65_K224_A0.9480.64
152_R180_H0.9460.64
133_H137_D0.9440.64
204_G278_P0.9440.64
49_V224_A0.9390.63
54_D185_E0.9320.63
92_S117_M0.9310.63
232_F245_Q0.9310.63
263_E279_A0.9270.62
43_R50_D0.9260.62
71_G125_G0.9240.62
88_A200_E0.9230.62
221_Y268_Y0.9220.62
278_P281_D0.9210.62
203_S275_S0.9170.61
213_V283_D0.9160.61
217_Y286_V0.9150.61
58_D108_V0.9110.61
122_H138_Y0.9110.61
43_R64_R0.9050.60
121_F253_N0.9050.60
187_V234_D0.9040.60
210_L262_V0.9020.60
151_A154_A0.8960.60
69_Y155_A0.8920.59
87_F183_V0.8910.59
64_R67_I0.8890.59
116_P189_G0.8770.58
151_A180_H0.8770.58
183_V236_D0.8720.58
187_V268_Y0.8680.57
55_R59_R0.8640.57
222_V274_P0.8630.57
210_L266_V0.8610.57
222_V256_E0.8530.56
48_E55_R0.8520.56
45_T48_E0.8500.56
82_L152_R0.8470.55
171_V185_E0.8430.55
96_F111_V0.8410.55
149_Y152_R0.8320.54
136_R244_P0.8310.54
148_Q178_N0.8300.54
92_S204_G0.8280.54
227_S258_L0.8210.53
44_L48_E0.8110.52
241_F245_Q0.8090.52
109_Y131_E0.8080.52
94_E240_L0.8070.52
57_L60_E0.8010.51
105_E129_F0.8010.51
169_V219_E0.8000.51
101_G229_Y0.7990.51
157_R247_T0.7990.51
159_Y163_E0.7970.51
179_R260_R0.7960.51
165_L254_A0.7830.50
84_L119_L0.7820.50
173_R286_V0.7780.49
77_A154_A0.7770.49
49_V60_E0.7760.49
81_V258_L0.7760.49
206_L210_L0.7720.49
62_L65_K0.7700.48
79_Y149_Y0.7700.48
127_T147_W0.7660.48
196_K270_R0.7650.48
224_A249_T0.7620.48
175_V187_V0.7600.48
116_P194_N0.7530.47
152_R171_V0.7510.47
169_V258_L0.7490.47
203_S207_D0.7460.46
276_D279_A0.7440.46
76_F148_Q0.7440.46
79_Y152_R0.7400.46
80_D101_G0.7380.46
197_L233_V0.7370.45
163_E167_P0.7370.45
137_D220_G0.7350.45
154_A161_A0.7320.45
200_E207_D0.7190.44
282_H287_G0.7190.44
51_Y54_D0.7180.44
136_R151_A0.7170.44
85_H88_A0.7150.44
262_V282_H0.7130.43
270_R276_D0.7120.43
200_E278_P0.7110.43
173_R284_A0.7110.43
91_D201_Q0.7110.43
197_L240_L0.7090.43
65_K118_A0.7080.43
104_K120_K0.7070.43
192_L209_I0.7070.43
123_R216_A0.7050.43
271_Q278_P0.7020.42
100_L115_R0.7010.42
159_Y215_A0.6970.42
79_Y125_G0.6970.42
194_N268_Y0.6930.42
277_V282_H0.6920.41
92_S180_H0.6920.41
196_K254_A0.6910.41
48_E51_Y0.6910.41
122_H244_P0.6900.41
53_L56_M0.6900.41
208_L212_E0.6900.41
123_R180_H0.6900.41
166_Y185_E0.6860.41
254_A267_Q0.6840.41
122_H178_N0.6840.41
64_R205_V0.6820.41
131_E250_D0.6790.40
87_F211_R0.6780.40
165_L244_P0.6780.40
223_H230_N0.6760.40
125_G136_R0.6760.40
198_N201_Q0.6750.40
74_L123_R0.6730.40
206_L275_S0.6700.40
175_V215_A0.6700.40
142_K153_K0.6690.39
208_L238_V0.6650.39
226_V264_N0.6640.39
124_E130_R0.6630.39
264_N287_G0.6620.39
76_F156_E0.6570.38
148_Q182_I0.6530.38
93_V265_I0.6520.38
210_L213_V0.6490.38
155_A177_H0.6490.38
107_D138_Y0.6480.38
110_E136_R0.6430.37
99_P193_S0.6390.37
123_R147_W0.6390.37
227_S246_A0.6390.37
98_A157_R0.6380.37
126_Y147_W0.6370.37
51_Y55_R0.6320.36
87_F176_D0.6250.36
64_R185_E0.6220.36
71_G148_Q0.6210.35
71_G99_P0.6210.35
189_G220_G0.6160.35
209_I281_D0.6160.35
53_L64_R0.6130.35
84_L121_F0.6120.35
75_T138_Y0.6110.35
185_E267_Q0.6100.35
283_D286_V0.6100.35
110_E224_A0.6080.34
47_Q50_D0.6080.34
90_R208_L0.6080.34
282_H286_V0.6080.34
161_A243_W0.6070.34
255_R284_A0.6060.34
109_Y226_V0.6010.34
67_I183_V0.5990.34
222_V273_Y0.5960.33
80_D180_H0.5950.33
133_H136_R0.5930.33
119_L175_V0.5930.33
94_E112_Q0.5900.33
105_E225_D0.5900.33
122_H154_A0.5860.33
107_D123_R0.5840.32
138_Y157_R0.5840.32
218_R280_V0.5810.32
49_V54_D0.5800.32
168_T286_V0.5780.32
222_V251_H0.5740.32
278_P282_H0.5670.31
124_E227_S0.5670.31
114_F271_Q0.5640.31
93_V119_L0.5630.31
118_A188_S0.5630.31
198_N202_A0.5630.31
228_E268_Y0.5600.31
116_P271_Q0.5590.31
275_S279_A0.5580.30
243_W246_A0.5550.30
175_V249_T0.5540.30
184_M246_A0.5540.30
183_V282_H0.5540.30
85_H257_L0.5540.30
125_G244_P0.5540.30
162_L181_A0.5540.30
50_D268_Y0.5510.30
109_Y259_A0.5510.30
221_Y246_A0.5510.30
123_R248_P0.5500.30
280_V283_D0.5490.30
178_N193_S0.5480.30
50_D271_Q0.5470.30
202_A229_Y0.5460.30
74_L244_P0.5440.29
225_D230_N0.5370.29
181_A273_Y0.5310.28
75_T109_Y0.5310.28
115_R265_I0.5300.28
165_L209_I0.5300.28
210_L271_Q0.5290.28
73_Q109_Y0.5280.28
50_D162_L0.5260.28
74_L78_G0.5260.28
64_R139_T0.5260.28
113_S222_V0.5230.28
64_R238_V0.5210.28
93_V117_M0.5200.28
135_G157_R0.5200.28
235_S270_R0.5180.27
119_L176_D0.5180.27
164_A193_S0.5170.27
50_D206_L0.5150.27
100_L186_K0.5140.27
141_E150_T0.5130.27
107_D127_T0.5130.27
156_E160_D0.5130.27
240_L276_D0.5120.27
95_G117_M0.5090.27
45_T192_L0.5090.27
61_F243_W0.5080.27
176_D262_V0.5080.27
61_F235_S0.5070.27
143_E229_Y0.5050.27
259_A280_V0.5040.26
261_D269_F0.5040.26
128_Q147_W0.5040.26
57_L62_L0.5040.26
80_D83_A0.5030.26
169_V226_V0.5030.26
254_A260_R0.5030.26
103_G245_Q0.5010.26
201_Q224_A0.5010.26
197_L210_L0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zarA 1 0.8833 100 0.477 Contact Map
4gyiA 1 0.98 100 0.493 Contact Map
1zthA 1 0.7767 100 0.673 Contact Map
4otpA 1 0.6467 100 0.711 Contact Map
4pedA 1 0.9133 99.6 0.843 Contact Map
2zmdA 2 0.59 99.5 0.852 Contact Map
2y7jA 3 0.69 99.5 0.853 Contact Map
4lrjA 1 0.52 99.4 0.855 Contact Map
4q5eA 1 0.53 99.4 0.855 Contact Map
4bvuA 1 0.5367 99.4 0.859 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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