Q9HSL0 - HALSA - GREMLIN Contacts

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Q9HSL0 - Uncharacterized protein

UniProt:	Q9HSL0	Sequences: MVRNVADEIAALDPEDFHLLSGVEHGMRFSEWVSREKLPEFSRLTPQEVDYRLDRMLDREFLERKTIQYEGVQLTFAGYDVLALHTFAERDSVEGFGAPLGVGKESDVYEVQSFRPMALKFHREGYTQFREVHRGRDYTSEKEHTSWQYTARKAAEREYDALEALYPTVNVPRPVDHNRHAIVMEKVSGTELSNAKLNPEQASGVLDLILREVAAAYREGYVHADVSEYNVFVDSDGVVLFDWPQATPTDHENARELLARDVENIVQYFRQKYPSDVPAVDHDAVVGAVADDAFASVTEH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	300 (244)
Sequences:	956 (603)
Seq/√Len:	38.6

HALSA - Q9HSL0 Q9HN65
SULSO - Q980T1 Q97W63

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
231_V	240_L	5.387	1.00
173_R	185_E	4.177	1.00
212_E	240_L	3.890	1.00
208_L	237_G	3.821	1.00
170_N	237_G	3.365	1.00
100_L	118_A	3.083	1.00
231_V	238_V	3.027	1.00
166_Y	173_R	2.929	1.00
170_N	212_E	2.893	1.00
165_L	216_A	2.854	1.00
187_V	239_V	2.782	1.00
255_R	259_A	2.743	1.00
216_A	240_L	2.699	1.00
209_I	238_V	2.664	1.00
213_V	226_V	2.477	1.00
166_Y	174_P	2.413	1.00
213_V	286_V	2.343	1.00
177_H	180_H	2.280	1.00
216_A	243_W	2.219	0.99
210_L	282_H	2.219	0.99
131_E	135_G	2.192	0.99
119_L	183_V	2.151	0.99
121_F	181_A	2.101	0.99
90_R	176_D	2.063	0.99
131_E	134_R	1.950	0.99
205_V	233_V	1.934	0.98
214_A	218_R	1.912	0.98
209_I	231_V	1.910	0.98
263_E	267_Q	1.902	0.98
283_D	287_G	1.848	0.98
83_A	179_R	1.825	0.98
205_V	238_V	1.798	0.97
102_V	107_D	1.776	0.97
268_Y	272_K	1.740	0.97
88_A	96_F	1.722	0.97
201_Q	204_G	1.717	0.97
91_D	112_Q	1.686	0.96
213_V	262_V	1.674	0.96
234_D	239_V	1.672	0.96
146_S	149_Y	1.663	0.96
117_M	175_V	1.637	0.96
122_H	182_I	1.627	0.95
110_E	116_P	1.588	0.95
227_S	264_N	1.568	0.94
189_G	232_F	1.539	0.94
215_A	219_E	1.524	0.93
159_Y	174_P	1.503	0.93
92_S	176_D	1.486	0.93
175_V	229_Y	1.471	0.92
76_F	108_V	1.466	0.92
232_F	241_F	1.451	0.92
79_Y	179_R	1.448	0.92
165_L	169_V	1.420	0.91
211_R	215_A	1.392	0.90
111_V	117_M	1.391	0.90
125_G	147_W	1.383	0.90
281_D	284_A	1.371	0.89
82_L	179_R	1.366	0.89
206_L	266_V	1.350	0.88
99_P	109_Y	1.347	0.88
93_V	121_F	1.342	0.88
191_E	194_N	1.340	0.88
115_R	173_R	1.340	0.88
119_L	229_Y	1.338	0.88
170_N	208_L	1.334	0.88
108_V	131_E	1.318	0.87
213_V	265_I	1.308	0.87
139_T	144_H	1.301	0.86
110_E	186_K	1.299	0.86
204_G	208_L	1.290	0.86
214_A	285_V	1.286	0.86
165_L	243_W	1.282	0.86
205_V	209_I	1.258	0.85
101_G	243_W	1.250	0.84
78_G	125_G	1.244	0.84
157_R	228_E	1.234	0.83
157_R	221_Y	1.228	0.83
125_G	128_Q	1.194	0.81
222_V	257_L	1.186	0.81
161_A	221_Y	1.176	0.80
224_A	257_L	1.166	0.80
266_V	282_H	1.152	0.79
82_L	93_V	1.147	0.79
84_L	182_I	1.143	0.78
212_E	226_V	1.143	0.78
102_V	180_H	1.121	0.77
87_F	182_I	1.106	0.76
117_M	183_V	1.101	0.76
97_G	110_E	1.100	0.76
69_Y	125_G	1.099	0.75
87_F	92_S	1.091	0.75
161_A	246_A	1.085	0.75
123_R	131_E	1.084	0.74
189_G	235_S	1.077	0.74
43_R	47_Q	1.075	0.74
213_V	263_E	1.071	0.74
108_V	256_E	1.068	0.73
238_V	265_I	1.066	0.73
96_F	119_L	1.065	0.73
88_A	174_P	1.051	0.72
132_V	248_P	1.050	0.72
133_H	142_K	1.049	0.72
81_V	84_L	1.048	0.72
124_E	132_V	1.047	0.72
78_G	136_R	1.045	0.72
128_Q	136_R	1.033	0.71
74_L	126_Y	1.032	0.71
94_E	265_I	1.031	0.71
156_E	177_H	1.027	0.70
85_H	89_E	1.025	0.70
161_A	227_S	1.025	0.70
87_F	181_A	1.024	0.70
111_V	183_V	1.024	0.70
117_M	205_V	1.020	0.70
202_A	208_L	1.019	0.70
135_G	154_A	1.015	0.69
53_L	62_L	1.013	0.69
110_E	123_R	1.007	0.69
169_V	212_E	1.005	0.69
217_Y	258_L	0.994	0.68
46_P	49_V	0.994	0.68
43_R	46_P	0.992	0.68
71_G	124_E	0.991	0.68
212_E	215_A	0.982	0.67
156_E	164_A	0.982	0.67
111_V	162_L	0.969	0.66
157_R	161_A	0.968	0.66
75_T	264_N	0.967	0.66
44_L	47_Q	0.959	0.65
260_R	264_N	0.956	0.65
65_K	224_A	0.948	0.64
152_R	180_H	0.946	0.64
133_H	137_D	0.944	0.64
204_G	278_P	0.944	0.64
49_V	224_A	0.939	0.63
54_D	185_E	0.932	0.63
92_S	117_M	0.931	0.63
232_F	245_Q	0.931	0.63
263_E	279_A	0.927	0.62
43_R	50_D	0.926	0.62
71_G	125_G	0.924	0.62
88_A	200_E	0.923	0.62
221_Y	268_Y	0.922	0.62
278_P	281_D	0.921	0.62
203_S	275_S	0.917	0.61
213_V	283_D	0.916	0.61
217_Y	286_V	0.915	0.61
58_D	108_V	0.911	0.61
122_H	138_Y	0.911	0.61
43_R	64_R	0.905	0.60
121_F	253_N	0.905	0.60
187_V	234_D	0.904	0.60
210_L	262_V	0.902	0.60
151_A	154_A	0.896	0.60
69_Y	155_A	0.892	0.59
87_F	183_V	0.891	0.59
64_R	67_I	0.889	0.59
116_P	189_G	0.877	0.58
151_A	180_H	0.877	0.58
183_V	236_D	0.872	0.58
187_V	268_Y	0.868	0.57
55_R	59_R	0.864	0.57
222_V	274_P	0.863	0.57
210_L	266_V	0.861	0.57
222_V	256_E	0.853	0.56
48_E	55_R	0.852	0.56
45_T	48_E	0.850	0.56
82_L	152_R	0.847	0.55
171_V	185_E	0.843	0.55
96_F	111_V	0.841	0.55
149_Y	152_R	0.832	0.54
136_R	244_P	0.831	0.54
148_Q	178_N	0.830	0.54
92_S	204_G	0.828	0.54
227_S	258_L	0.821	0.53
44_L	48_E	0.811	0.52
241_F	245_Q	0.809	0.52
109_Y	131_E	0.808	0.52
94_E	240_L	0.807	0.52
57_L	60_E	0.801	0.51
105_E	129_F	0.801	0.51
169_V	219_E	0.800	0.51
101_G	229_Y	0.799	0.51
157_R	247_T	0.799	0.51
159_Y	163_E	0.797	0.51
179_R	260_R	0.796	0.51
165_L	254_A	0.783	0.50
84_L	119_L	0.782	0.50
173_R	286_V	0.778	0.49
77_A	154_A	0.777	0.49
49_V	60_E	0.776	0.49
81_V	258_L	0.776	0.49
206_L	210_L	0.772	0.49
62_L	65_K	0.770	0.48
79_Y	149_Y	0.770	0.48
127_T	147_W	0.766	0.48
196_K	270_R	0.765	0.48
224_A	249_T	0.762	0.48
175_V	187_V	0.760	0.48
116_P	194_N	0.753	0.47
152_R	171_V	0.751	0.47
169_V	258_L	0.749	0.47
203_S	207_D	0.746	0.46
276_D	279_A	0.744	0.46
76_F	148_Q	0.744	0.46
79_Y	152_R	0.740	0.46
80_D	101_G	0.738	0.46
197_L	233_V	0.737	0.45
163_E	167_P	0.737	0.45
137_D	220_G	0.735	0.45
154_A	161_A	0.732	0.45
200_E	207_D	0.719	0.44
282_H	287_G	0.719	0.44
51_Y	54_D	0.718	0.44
136_R	151_A	0.717	0.44
85_H	88_A	0.715	0.44
262_V	282_H	0.713	0.43
270_R	276_D	0.712	0.43
200_E	278_P	0.711	0.43
173_R	284_A	0.711	0.43
91_D	201_Q	0.711	0.43
197_L	240_L	0.709	0.43
65_K	118_A	0.708	0.43
104_K	120_K	0.707	0.43
192_L	209_I	0.707	0.43
123_R	216_A	0.705	0.43
271_Q	278_P	0.702	0.42
100_L	115_R	0.701	0.42
159_Y	215_A	0.697	0.42
79_Y	125_G	0.697	0.42
194_N	268_Y	0.693	0.42
277_V	282_H	0.692	0.41
92_S	180_H	0.692	0.41
196_K	254_A	0.691	0.41
48_E	51_Y	0.691	0.41
122_H	244_P	0.690	0.41
53_L	56_M	0.690	0.41
208_L	212_E	0.690	0.41
123_R	180_H	0.690	0.41
166_Y	185_E	0.686	0.41
254_A	267_Q	0.684	0.41
122_H	178_N	0.684	0.41
64_R	205_V	0.682	0.41
131_E	250_D	0.679	0.40
87_F	211_R	0.678	0.40
165_L	244_P	0.678	0.40
223_H	230_N	0.676	0.40
125_G	136_R	0.676	0.40
198_N	201_Q	0.675	0.40
74_L	123_R	0.673	0.40
206_L	275_S	0.670	0.40
175_V	215_A	0.670	0.40
142_K	153_K	0.669	0.39
208_L	238_V	0.665	0.39
226_V	264_N	0.664	0.39
124_E	130_R	0.663	0.39
264_N	287_G	0.662	0.39
76_F	156_E	0.657	0.38
148_Q	182_I	0.653	0.38
93_V	265_I	0.652	0.38
210_L	213_V	0.649	0.38
155_A	177_H	0.649	0.38
107_D	138_Y	0.648	0.38
110_E	136_R	0.643	0.37
99_P	193_S	0.639	0.37
123_R	147_W	0.639	0.37
227_S	246_A	0.639	0.37
98_A	157_R	0.638	0.37
126_Y	147_W	0.637	0.37
51_Y	55_R	0.632	0.36
87_F	176_D	0.625	0.36
64_R	185_E	0.622	0.36
71_G	148_Q	0.621	0.35
71_G	99_P	0.621	0.35
189_G	220_G	0.616	0.35
209_I	281_D	0.616	0.35
53_L	64_R	0.613	0.35
84_L	121_F	0.612	0.35
75_T	138_Y	0.611	0.35
185_E	267_Q	0.610	0.35
283_D	286_V	0.610	0.35
110_E	224_A	0.608	0.34
47_Q	50_D	0.608	0.34
90_R	208_L	0.608	0.34
282_H	286_V	0.608	0.34
161_A	243_W	0.607	0.34
255_R	284_A	0.606	0.34
109_Y	226_V	0.601	0.34
67_I	183_V	0.599	0.34
222_V	273_Y	0.596	0.33
80_D	180_H	0.595	0.33
133_H	136_R	0.593	0.33
119_L	175_V	0.593	0.33
94_E	112_Q	0.590	0.33
105_E	225_D	0.590	0.33
122_H	154_A	0.586	0.33
107_D	123_R	0.584	0.32
138_Y	157_R	0.584	0.32
218_R	280_V	0.581	0.32
49_V	54_D	0.580	0.32
168_T	286_V	0.578	0.32
222_V	251_H	0.574	0.32
278_P	282_H	0.567	0.31
124_E	227_S	0.567	0.31
114_F	271_Q	0.564	0.31
93_V	119_L	0.563	0.31
118_A	188_S	0.563	0.31
198_N	202_A	0.563	0.31
228_E	268_Y	0.560	0.31
116_P	271_Q	0.559	0.31
275_S	279_A	0.558	0.30
243_W	246_A	0.555	0.30
175_V	249_T	0.554	0.30
184_M	246_A	0.554	0.30
183_V	282_H	0.554	0.30
85_H	257_L	0.554	0.30
125_G	244_P	0.554	0.30
162_L	181_A	0.554	0.30
50_D	268_Y	0.551	0.30
109_Y	259_A	0.551	0.30
221_Y	246_A	0.551	0.30
123_R	248_P	0.550	0.30
280_V	283_D	0.549	0.30
178_N	193_S	0.548	0.30
50_D	271_Q	0.547	0.30
202_A	229_Y	0.546	0.30
74_L	244_P	0.544	0.29
225_D	230_N	0.537	0.29
181_A	273_Y	0.531	0.28
75_T	109_Y	0.531	0.28
115_R	265_I	0.530	0.28
165_L	209_I	0.530	0.28
210_L	271_Q	0.529	0.28
73_Q	109_Y	0.528	0.28
50_D	162_L	0.526	0.28
74_L	78_G	0.526	0.28
64_R	139_T	0.526	0.28
113_S	222_V	0.523	0.28
64_R	238_V	0.521	0.28
93_V	117_M	0.520	0.28
135_G	157_R	0.520	0.28
235_S	270_R	0.518	0.27
119_L	176_D	0.518	0.27
164_A	193_S	0.517	0.27
50_D	206_L	0.515	0.27
100_L	186_K	0.514	0.27
141_E	150_T	0.513	0.27
107_D	127_T	0.513	0.27
156_E	160_D	0.513	0.27
240_L	276_D	0.512	0.27
95_G	117_M	0.509	0.27
45_T	192_L	0.509	0.27
61_F	243_W	0.508	0.27
176_D	262_V	0.508	0.27
61_F	235_S	0.507	0.27
143_E	229_Y	0.505	0.27
259_A	280_V	0.504	0.26
261_D	269_F	0.504	0.26
128_Q	147_W	0.504	0.26
57_L	62_L	0.504	0.26
80_D	83_A	0.503	0.26
169_V	226_V	0.503	0.26
254_A	260_R	0.503	0.26
103_G	245_Q	0.501	0.26
201_Q	224_A	0.501	0.26
197_L	210_L	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zarA	1	0.8833	100	0.477	Contact Map
4gyiA	1	0.98	100	0.493	Contact Map
1zthA	1	0.7767	100	0.673	Contact Map
4otpA	1	0.6467	100	0.711	Contact Map
4pedA	1	0.9133	99.6	0.843	Contact Map
2zmdA	2	0.59	99.5	0.852	Contact Map
2y7jA	3	0.69	99.5	0.853	Contact Map
4lrjA	1	0.52	99.4	0.855	Contact Map
4q5eA	1	0.53	99.4	0.855	Contact Map
4bvuA	1	0.5367	99.4	0.859	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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