GREMLIN Database
Q9HSK8 - Lipoate protein ligase
UniProt: Q9HSK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (229)
Sequences: 2612 (1846)
Seq/√Len: 122.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_D255_E4.0021.00
184_A212_E3.8711.00
209_T214_Q3.5001.00
115_T119_D2.8651.00
66_A73_V2.8221.00
26_E30_Q2.8061.00
65_A69_A2.7801.00
122_D127_D2.6471.00
69_A193_V2.5761.00
123_R232_E2.5091.00
64_A68_D2.4141.00
218_D221_D2.3941.00
242_T245_E2.3311.00
248_R251_D2.2601.00
123_R229_A2.1901.00
43_Y94_S2.1401.00
119_D232_E2.0621.00
26_E256_K2.0131.00
93_Y179_G2.0011.00
124_L225_A1.9431.00
186_D189_R1.8661.00
85_H92_S1.8521.00
74_T263_V1.8421.00
127_D159_P1.8421.00
30_Q248_R1.8401.00
78_T169_Y1.8081.00
47_P72_D1.8001.00
154_I163_I1.7981.00
252_L257_Y1.7451.00
250_R254_A1.7421.00
224_T228_R1.7361.00
65_A68_D1.6941.00
17_P20_M1.6851.00
209_T213_A1.6711.00
26_E257_Y1.6681.00
69_A192_S1.6541.00
9_R245_E1.6541.00
120_A229_A1.6531.00
119_D229_A1.6341.00
91_I219_R1.6231.00
12_R223_V1.6201.00
244_A247_A1.6151.00
40_V230_L1.5781.00
51_S85_H1.5691.00
20_M246_L1.5591.00
252_L256_K1.5521.00
91_I222_A1.5471.00
119_D122_D1.5271.00
30_Q171_R1.5071.00
31_T248_R1.5031.00
25_D178_H1.4991.00
164_S180_S1.4901.00
50_L66_A1.4851.00
85_H90_D1.4831.00
99_A173_D1.4691.00
254_A258_A1.4631.00
22_M25_D1.4291.00
63_W67_A1.4131.00
10_L227_E1.4111.00
156_A163_I1.3671.00
82_G194_F1.3651.00
65_A193_V1.3561.00
28_A39_T1.3491.00
245_E248_R1.3211.00
239_G245_E1.3031.00
111_E115_T1.2971.00
63_W73_V1.2961.00
61_V66_A1.2921.00
161_R213_A1.2911.00
21_Q46_T1.2911.00
62_D195_S1.2911.00
161_R209_T1.2861.00
192_S195_S1.2771.00
241_W249_A1.2751.00
22_M51_S1.2741.00
69_A189_R1.2721.00
118_F128_A1.2711.00
167_A178_H1.2681.00
47_P87_A1.2480.99
152_H207_H1.2280.99
46_T85_H1.2260.99
64_A67_A1.2230.99
128_A156_A1.2010.99
20_M24_L1.1980.99
90_D180_S1.1970.99
62_D65_A1.1930.99
27_I31_T1.1930.99
247_A251_D1.1900.99
227_E231_G1.1880.99
183_F222_A1.1860.99
78_T178_H1.1810.99
32_A98_P1.1790.99
91_I223_V1.1660.99
43_Y177_Q1.1570.99
189_R192_S1.1510.99
243_D247_A1.1500.99
164_S179_G1.1500.99
166_N177_Q1.1470.99
44_T219_R1.1410.99
156_A214_Q1.1330.99
21_Q85_H1.1300.99
65_A71_I1.1170.99
123_R225_A1.1150.99
200_T203_A1.1140.99
27_I249_A1.1130.99
38_R98_P1.0900.99
128_A131_T1.0860.99
166_N179_G1.0770.98
51_S83_I1.0760.98
260_D263_V1.0760.98
25_D41_R1.0700.98
18_G74_T1.0630.98
152_H199_T1.0530.98
28_A32_A1.0490.98
163_I211_I1.0320.98
220_A224_T1.0320.98
81_G164_S1.0270.98
77_Q256_K1.0250.98
9_R239_G1.0160.98
43_Y51_S1.0150.98
251_D254_A1.0110.98
128_A154_I1.0080.98
131_T155_V1.0070.98
239_G242_T0.9980.97
77_Q169_Y0.9980.97
12_R227_E0.9940.97
111_E130_F0.9900.97
50_L194_F0.9800.97
119_D233_W0.9790.97
168_Q177_Q0.9750.97
113_L116_P0.9740.97
52_M82_G0.9640.97
120_A226_V0.9610.97
71_I193_V0.9540.97
114_C166_N0.9480.97
123_R228_R0.9470.97
22_M85_H0.9430.96
42_V223_V0.9380.96
86_D189_R0.9370.96
51_S90_D0.9340.96
99_A170_R0.9320.96
247_A250_R0.9300.96
24_L249_A0.9300.96
53_G153_D0.9290.96
28_A38_R0.9290.96
22_M92_S0.9280.96
120_A225_A0.9240.96
77_Q257_Y0.9200.96
17_P72_D0.9130.96
85_H178_H0.9120.96
187_A191_L0.9080.96
261_A264_R0.9050.96
51_S92_S0.8960.95
22_M90_D0.8920.95
188_E191_L0.8860.95
131_T150_P0.8840.95
190_H208_V0.8810.95
17_P258_A0.8770.95
229_A233_W0.8740.95
225_A228_R0.8700.94
66_A71_I0.8680.94
229_A232_E0.8640.94
155_V160_G0.8640.94
29_A171_R0.8620.94
65_A192_S0.8600.94
46_T90_D0.8600.94
94_S177_Q0.8550.94
121_F222_A0.8540.94
150_P207_H0.8480.94
99_A175_V0.8470.94
244_A248_R0.8400.93
81_G153_D0.8390.93
84_Y193_V0.8340.93
16_R87_A0.8270.93
59_D202_A0.8250.93
249_A252_L0.8180.92
183_F219_R0.8130.92
83_I92_S0.8130.92
36_G39_T0.8110.92
187_A190_H0.8100.92
222_A226_V0.8100.92
110_Y151_A0.8060.92
51_S177_Q0.8030.92
183_F217_V0.7940.91
166_N178_H0.7940.91
118_F154_I0.7760.90
63_W264_R0.7730.90
121_F163_I0.7720.90
48_D189_R0.7710.90
28_A96_V0.7680.90
59_D198_D0.7670.90
44_T223_V0.7630.90
81_G180_S0.7620.89
79_G165_G0.7570.89
187_A210_T0.7560.89
189_R193_V0.7550.89
246_L250_R0.7530.89
94_S167_A0.7460.88
159_P214_Q0.7420.88
38_R97_A0.7410.88
27_I245_E0.7320.88
95_I113_L0.7310.87
51_S180_S0.7300.87
231_G237_D0.7300.87
9_R39_T0.7220.87
56_Q60_S0.7200.87
97_A175_V0.7090.86
241_W245_E0.7060.86
153_D177_Q0.7010.85
212_E216_G0.7010.85
247_A254_A0.7000.85
92_S166_N0.6970.85
201_P204_F0.6950.85
198_D201_P0.6950.85
219_R223_V0.6940.85
43_Y85_H0.6930.85
94_S178_H0.6910.84
199_T202_A0.6890.84
182_S185_L0.6850.84
191_L204_F0.6850.84
170_R175_V0.6830.84
83_I180_S0.6820.84
68_D247_A0.6780.83
241_W246_L0.6780.83
257_Y263_V0.6780.83
188_E205_R0.6750.83
152_H196_D0.6740.83
22_M257_Y0.6720.83
217_V225_A0.6720.83
94_S176_I0.6700.82
49_T72_D0.6690.82
82_G204_F0.6650.82
231_G236_A0.6630.82
163_I209_T0.6630.82
220_A237_D0.6610.82
198_D202_A0.6590.81
150_P153_D0.6580.81
50_L234_A0.6550.81
50_L61_V0.6540.81
164_S182_S0.6530.81
24_L241_W0.6470.80
43_Y90_D0.6450.80
85_H185_L0.6420.80
153_D164_S0.6420.80
186_D192_S0.6410.80
98_P174_A0.6400.80
109_T170_R0.6380.79
100_D247_A0.6330.79
18_G263_V0.6310.79
103_P112_L0.6300.78
84_Y189_R0.6280.78
29_A176_I0.6270.78
156_A159_P0.6270.78
32_A35_G0.6240.78
50_L84_Y0.6240.78
223_V227_E0.6230.78
61_V73_V0.6230.78
96_V176_I0.6170.77
83_I90_D0.6150.77
221_D225_A0.6150.77
65_A189_R0.6130.77
114_C154_I0.6110.76
168_Q175_V0.6110.76
21_Q179_G0.6100.76
260_D264_R0.6090.76
93_Y177_Q0.6010.75
94_S168_Q0.5990.75
28_A89_A0.5990.75
58_T260_D0.5970.75
116_P229_A0.5970.75
52_M73_V0.5950.74
89_A185_L0.5940.74
46_T92_S0.5930.74
154_I164_S0.5920.74
163_I230_L0.5860.73
200_T204_F0.5830.73
203_A206_E0.5780.72
201_P207_H0.5780.72
67_A260_D0.5770.72
41_R94_S0.5750.72
60_S182_S0.5750.72
221_D224_T0.5740.72
56_Q75_R0.5740.72
122_D126_I0.5730.72
13_E41_R0.5730.72
67_A240_E0.5720.72
81_G152_H0.5720.72
188_E192_S0.5680.71
248_R252_L0.5660.71
89_A210_T0.5660.71
93_Y150_P0.5650.71
183_F212_E0.5650.71
153_D208_V0.5650.71
31_T36_G0.5640.71
110_Y113_L0.5620.70
166_N169_Y0.5610.70
39_T239_G0.5570.70
13_E241_W0.5560.69
62_D68_D0.5560.69
228_R231_G0.5550.69
19_P263_V0.5540.69
12_R238_E0.5510.69
20_M250_R0.5500.69
153_D199_T0.5460.68
235_D250_R0.5450.68
186_D210_T0.5440.68
198_D203_A0.5430.68
123_R221_D0.5430.68
44_T87_A0.5420.67
25_D51_S0.5400.67
100_D173_D0.5400.67
43_Y183_F0.5400.67
49_T85_H0.5380.67
245_E249_A0.5380.67
187_A213_A0.5360.67
85_H179_G0.5360.67
42_V93_Y0.5350.66
77_Q176_I0.5350.66
220_A223_V0.5330.66
29_A169_Y0.5310.66
51_S194_F0.5290.66
25_D85_H0.5290.66
18_G51_S0.5280.65
180_S208_V0.5270.65
25_D78_T0.5240.65
129_R160_G0.5220.65
215_A221_D0.5210.64
77_Q82_G0.5170.64
67_A238_E0.5130.63
55_R169_Y0.5130.63
81_G208_V0.5130.63
22_M49_T0.5100.63
227_E238_E0.5100.63
122_D128_A0.5100.63
43_Y92_S0.5090.63
156_A209_T0.5050.62
199_T207_H0.5050.62
90_D179_G0.5050.62
117_V226_V0.5020.62
29_A174_A0.5020.62
25_D92_S0.5020.62
192_S232_E0.5020.62
82_G121_F0.5020.62
118_F121_F0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.875 100 0.274 Contact Map
2c8mA 1 0.8787 100 0.289 Contact Map
2e5aA 1 0.8676 100 0.296 Contact Map
1vqzA 1 0.8824 100 0.336 Contact Map
2p0lA 1 0.8934 100 0.38 Contact Map
2p5iA 1 0.8824 100 0.395 Contact Map
2qhsA 1 0.75 100 0.495 Contact Map
1w66A 1 0.7574 100 0.515 Contact Map
2dxuA 2 0.6875 97.5 0.893 Contact Map
3bfmA 2 0.6801 96.7 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.