GREMLIN Database
END4 - Probable endonuclease 4
UniProt: Q9HSK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (268)
Sequences: 2262 (1461)
Seq/√Len: 89.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_K225_A4.0341.00
123_A162_R3.9541.00
216_A231_H2.9931.00
110_H114_G2.7351.00
53_E57_A2.7301.00
186_E191_D2.6851.00
82_A86_D2.6431.00
157_H161_T2.6361.00
20_E25_G2.5621.00
141_S176_A2.5581.00
77_K80_L2.5501.00
136_T206_Q2.5411.00
171_I176_A2.5261.00
26_N271_R2.4821.00
194_A198_D2.4751.00
212_D228_G2.3521.00
119_L158_E2.2251.00
154_E199_V2.1641.00
189_V243_H2.1271.00
81_R125_A2.1161.00
115_V155_H2.0891.00
96_H134_D2.0811.00
116_D158_E2.0641.00
151_G155_H2.0121.00
158_E162_R1.9621.00
64_V252_V1.9431.00
177_F231_H1.9321.00
182_D185_T1.9271.00
234_E269_R1.9181.00
208_V251_L1.8961.00
263_F266_N1.8871.00
17_V54_G1.8851.00
127_D164_D1.8721.00
21_L58_D1.8721.00
196_F205_L1.8561.00
215_H221_K1.8481.00
95_A100_I1.8451.00
232_I236_G1.8321.00
120_D162_R1.7991.00
81_R121_N1.7481.00
14_D47_E1.7351.00
115_V151_G1.7321.00
20_E28_G1.7241.00
85_I128_E1.6901.00
225_A229_E1.6891.00
153_F192_T1.6801.00
195_A199_V1.6751.00
114_G117_D1.6701.00
169_V196_F1.6491.00
73_L125_A1.6451.00
195_A198_D1.6271.00
235_A238_R1.6051.00
74_C118_G1.5901.00
52_R99_G1.5861.00
160_L167_L1.5711.00
154_E195_A1.5531.00
189_V193_L1.5511.00
29_Q252_V1.5411.00
109_A147_T1.4911.00
237_M240_F1.4881.00
75_T80_L1.4640.99
193_L246_I1.4640.99
47_E50_A1.4620.99
15_N19_N1.4610.99
64_V207_Y1.4600.99
119_L149_L1.4470.99
177_F217_C1.4400.99
18_T54_G1.3900.99
102_Y206_Q1.3890.99
49_A53_E1.3880.99
109_A148_K1.3830.99
264_A268_D1.3690.99
3_V267_I1.3680.99
139_I156_L1.3550.99
2_R62_P1.3520.99
190_N194_A1.3490.99
152_D155_H1.3430.99
269_R272_D1.3360.99
163_S167_L1.3340.99
160_L204_H1.3320.99
45_A49_A1.3240.99
178_A215_H1.3220.99
167_L204_H1.3140.99
81_R85_I1.3040.99
244_D247_A1.2590.98
127_D163_S1.2530.98
156_L169_V1.2520.98
88_M105_V1.2390.98
263_F267_I1.2280.98
79_D83_K1.2250.98
160_L169_V1.2180.98
34_S37_V1.2120.98
189_V239_A1.2100.98
268_D272_D1.2070.98
95_A103_V1.1950.98
21_L54_G1.1840.98
86_D90_A1.1760.98
43_I48_A1.1630.97
110_H118_G1.1610.97
110_H115_V1.1590.97
152_D195_A1.1590.97
176_A183_L1.1510.97
14_D50_A1.1490.97
52_R56_A1.1480.97
158_E161_T1.1470.97
126_L137_V1.1470.97
54_G57_A1.1360.97
78_D82_A1.1360.97
242_N272_D1.1340.97
120_D158_E1.1340.97
45_A97_T1.1320.97
17_V28_G1.1280.97
81_R124_S1.1250.97
219_T231_H1.1170.97
17_V21_L1.1130.97
9_I30_I1.1120.97
114_G118_G1.1100.96
65_I95_A1.1090.96
65_I100_I1.1060.96
14_D54_G1.0830.96
19_N22_D1.0820.96
104_N170_C1.0770.96
133_D166_D1.0650.96
54_G58_D1.0600.95
229_E265_W1.0550.95
64_V104_N1.0520.95
186_E192_T1.0510.95
121_N124_S1.0450.95
117_D120_D1.0390.95
51_F55_T1.0350.95
33_H40_D1.0300.95
153_F196_F1.0220.94
13_V98_L1.0100.94
88_M129_L1.0090.94
120_D124_S1.0090.94
259_D262_G1.0050.94
2_R26_N1.0030.94
191_D195_A1.0020.94
32_T65_I0.9960.94
213_S231_H0.9920.94
265_W268_D0.9920.94
55_T63_W0.9870.93
27_C62_P0.9870.93
177_F232_I0.9720.93
212_D233_G0.9710.93
92_V103_V0.9710.93
25_G267_I0.9700.93
119_L162_R0.9690.93
35_P68_S0.9680.93
117_D121_N0.9640.93
31_F69_Y0.9630.92
90_A93_D0.9610.92
226_H266_N0.9580.92
177_F184_S0.9580.92
169_V200_V0.9580.92
85_I125_A0.9550.92
246_I251_L0.9490.92
50_A54_G0.9490.92
14_D18_T0.9440.92
49_A56_A0.9430.92
50_A53_E0.9420.92
33_H68_S0.9400.92
154_E157_H0.9350.91
38_W83_K0.9350.91
67_S105_V0.9270.91
41_P44_G0.9260.91
184_S217_C0.9200.91
19_N23_V0.9080.90
205_L246_I0.9050.90
168_D206_Q0.8950.89
3_V241_I0.8860.89
110_H147_T0.8850.89
193_L243_H0.8670.88
11_G19_N0.8620.88
177_F219_T0.8610.88
89_Q93_D0.8590.87
227_I241_I0.8590.87
227_I270_V0.8590.87
119_L159_V0.8530.87
153_F181_Y0.8520.87
73_L88_M0.8510.87
102_Y168_D0.8500.87
27_C252_V0.8420.86
48_A52_R0.8410.86
38_W70_L0.8400.86
118_G149_L0.8370.86
32_T94_A0.8360.86
80_L83_K0.8350.86
138_L168_D0.8330.86
226_H257_H0.8290.86
189_V236_G0.8270.85
238_R270_V0.8260.85
92_V135_V0.8230.85
71_V87_S0.8220.85
237_M270_V0.8220.85
33_H87_S0.8200.85
122_A159_V0.8190.85
2_R60_D0.8090.84
212_D230_G0.8090.84
2_R59_L0.8020.84
234_E238_R0.8010.83
67_S88_M0.7990.83
91_E103_V0.7950.83
7_V16_A0.7940.83
102_Y138_L0.7930.83
257_H263_F0.7920.83
30_I98_L0.7870.82
207_Y252_V0.7850.82
76_P111_T0.7840.82
138_L207_Y0.7800.82
196_F200_V0.7730.81
102_Y136_T0.7720.81
93_D96_H0.7710.81
116_D120_D0.7700.81
48_A97_T0.7690.81
226_H256_P0.7670.81
226_H263_F0.7670.81
216_A219_T0.7670.81
240_F246_I0.7650.81
96_H133_D0.7650.81
96_H135_V0.7650.81
226_H229_E0.7620.80
196_F201_G0.7620.80
67_S103_V0.7600.80
197_D200_V0.7590.80
118_G121_N0.7580.80
210_L240_F0.7580.80
44_G47_E0.7570.80
153_F199_V0.7560.80
96_H132_P0.7550.80
78_D121_N0.7520.79
126_L167_L0.7520.79
13_V16_A0.7510.79
53_E56_A0.7510.79
190_N243_H0.7480.79
194_A245_A0.7470.79
197_D202_L0.7420.79
151_G220_N0.7370.78
157_H199_V0.7360.78
37_V68_S0.7360.78
234_E272_D0.7350.78
20_E23_V0.7300.77
2_R61_G0.7290.77
146_G220_N0.7280.77
51_F54_G0.7270.77
184_S231_H0.7260.77
143_A178_A0.7250.77
208_V240_F0.7190.76
155_H200_V0.7190.76
46_D50_A0.7160.76
74_C122_A0.7150.76
81_R128_E0.7140.76
202_L205_L0.7120.76
28_G55_T0.7100.75
228_G233_G0.7070.75
115_V152_D0.7070.75
145_S148_K0.7050.75
7_V19_N0.7010.75
124_S128_E0.7000.74
74_C226_H0.6970.74
5_A23_V0.6930.74
157_H160_L0.6930.74
89_Q129_L0.6910.73
156_L160_L0.6870.73
68_S87_S0.6870.73
38_W84_S0.6860.73
17_V63_W0.6810.72
74_C121_N0.6800.72
171_I192_T0.6790.72
9_I16_A0.6790.72
76_P113_A0.6780.72
142_D148_K0.6770.72
186_E190_N0.6770.72
33_H37_V0.6710.71
236_G240_F0.6670.71
73_L84_S0.6660.71
267_I271_R0.6660.71
178_A217_C0.6660.71
21_L26_N0.6650.71
210_L241_I0.6630.70
171_I208_V0.6610.70
119_L155_H0.6610.70
67_S71_V0.6600.70
122_A142_D0.6590.70
18_T22_D0.6570.70
121_N125_A0.6570.70
176_A179_A0.6570.70
61_G101_P0.6540.69
225_A256_P0.6540.69
107_L142_D0.6480.69
151_G179_A0.6460.68
7_V20_E0.6450.68
238_R242_N0.6450.68
186_E239_A0.6450.68
171_I246_I0.6440.68
227_I237_M0.6440.68
5_A25_G0.6420.68
155_H158_E0.6420.68
189_V246_I0.6410.68
23_V263_F0.6380.67
13_V30_I0.6360.67
62_P101_P0.6320.67
33_H90_A0.6310.67
7_V28_G0.6260.66
177_F237_M0.6240.66
208_V245_A0.6220.65
145_S221_K0.6190.65
181_Y195_A0.6180.65
183_L189_V0.6170.65
75_T121_N0.6160.65
7_V23_V0.6160.65
55_T60_D0.6140.64
152_D179_A0.6140.64
184_S236_G0.6110.64
205_L208_V0.6100.64
159_V163_S0.6090.64
258_E261_R0.6080.64
184_S189_V0.6040.63
41_P47_E0.6040.63
232_I237_M0.6020.63
238_R269_R0.5980.62
29_Q64_V0.5960.62
64_V138_L0.5950.62
236_G239_A0.5910.62
130_D133_D0.5910.62
10_A15_N0.5910.62
64_V102_Y0.5900.61
21_L60_D0.5880.61
104_N207_Y0.5880.61
103_V135_V0.5860.61
237_M251_L0.5860.61
86_D93_D0.5860.61
25_G266_N0.5840.61
111_T147_T0.5830.61
136_T168_D0.5820.60
45_A48_A0.5790.60
90_A94_A0.5790.60
177_F236_G0.5740.59
238_R272_D0.5730.59
89_Q130_D0.5710.59
57_A198_D0.5710.59
146_G221_K0.5700.59
266_N269_R0.5700.59
7_V263_F0.5700.59
132_P166_D0.5700.59
92_V137_V0.5690.59
73_L156_L0.5680.59
15_N18_T0.5660.58
179_A218_G0.5650.58
30_I100_I0.5600.57
150_G155_H0.5600.57
113_A121_N0.5580.57
70_L84_S0.5580.57
227_I236_G0.5580.57
85_I129_L0.5570.57
68_S145_S0.5550.57
243_H246_I0.5530.57
66_H106_H0.5520.56
184_S239_A0.5490.56
161_T199_V0.5480.56
153_F197_D0.5470.56
193_L208_V0.5460.56
38_W87_S0.5420.55
25_G226_H0.5390.55
256_P259_D0.5390.55
66_H175_H0.5360.54
96_H136_T0.5360.54
116_D162_R0.5350.54
9_I13_V0.5350.54
92_V147_T0.5340.54
82_A198_D0.5330.54
137_V167_L0.5310.54
73_L143_A0.5310.54
115_V158_E0.5310.54
53_E203_D0.5310.54
37_V148_K0.5300.53
216_A221_K0.5290.53
37_V40_D0.5290.53
215_H231_H0.5270.53
93_D130_D0.5250.53
186_E194_A0.5240.53
106_H175_H0.5220.52
240_F251_L0.5210.52
227_I253_L0.5190.52
17_V51_F0.5160.51
39_Q86_D0.5150.51
70_L83_K0.5140.51
81_R113_A0.5120.51
127_D165_Q0.5120.51
112_G117_D0.5110.51
51_F63_W0.5100.51
55_T58_D0.5090.51
233_G236_G0.5080.50
184_S216_A0.5080.50
222_D230_G0.5080.50
202_L245_A0.5070.50
123_A158_E0.5070.50
8_S12_G0.5060.50
185_T191_D0.5050.50
150_G156_L0.5040.50
225_A231_H0.5010.49
257_H262_G0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tc3A 1 0.8909 100 0.542 Contact Map
1qtwA 1 0.9927 100 0.549 Contact Map
4hnoA 1 0.9964 100 0.551 Contact Map
3aalA 1 0.9927 100 0.56 Contact Map
3aamA 1 0.9636 100 0.573 Contact Map
3ayvA 2 0.8436 100 0.664 Contact Map
3wqoA 2 0.92 100 0.666 Contact Map
2j6vA 1 0.8545 100 0.681 Contact Map
3p14A 2 0.92 100 0.684 Contact Map
2zvrA 2 0.8945 100 0.685 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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