GREMLIN Database
Q9HSK6 - Uncharacterized protein
UniProt: Q9HSK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (204)
Sequences: 2156 (1751)
Seq/√Len: 122.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_V76_C3.6011.00
99_A159_L3.5171.00
18_R40_P3.4281.00
40_P60_H3.2431.00
105_L109_I3.1271.00
44_L64_G3.0451.00
51_L61_R2.8801.00
24_A43_A2.8071.00
97_E100_R2.7511.00
90_E93_A2.6761.00
54_T61_R2.6541.00
43_A61_R2.5941.00
43_A54_T2.5841.00
97_E101_V2.5521.00
79_V102_S2.4321.00
20_L76_C2.4061.00
102_S159_L2.2501.00
105_L108_V2.2081.00
48_T63_A2.1671.00
51_L63_A2.1571.00
73_D97_E2.1341.00
67_T88_L2.1271.00
9_A36_E2.0531.00
23_G84_L2.0391.00
42_V76_C1.9751.00
18_R103_S1.9671.00
22_V98_F1.9501.00
64_G70_P1.9451.00
69_L101_V1.8791.00
48_T52_G1.8661.00
34_A58_A1.8511.00
23_G81_C1.8221.00
69_L97_E1.8201.00
24_A45_D1.8071.00
88_L94_A1.8061.00
77_D103_S1.8011.00
65_D68_R1.7591.00
205_G208_D1.7241.00
24_A44_L1.6861.00
73_D100_R1.6511.00
30_A41_V1.6261.00
84_L88_L1.6191.00
37_S41_V1.5951.00
92_A156_D1.5751.00
52_G55_A1.5361.00
43_A59_A1.5301.00
24_A30_A1.5171.00
42_V60_H1.5121.00
22_V66_A1.4991.00
207_A210_A1.4711.00
21_D43_A1.4481.00
16_R38_S1.4441.00
204_G207_A1.4271.00
53_H56_D1.4131.00
44_L62_V1.4121.00
98_F102_S1.3641.00
190_T193_R1.3621.00
24_A54_T1.3211.00
199_P203_A1.3201.00
14_S17_S1.3181.00
143_D149_D1.2941.00
198_R202_A1.2911.00
102_S107_A1.2881.00
81_C84_L1.2751.00
151_A155_A1.2120.99
79_V98_F1.1990.99
83_A86_I1.1980.99
74_D103_S1.1890.99
189_A193_R1.1800.99
46_A65_D1.1770.99
98_F107_A1.1680.99
18_R76_C1.1450.99
19_I33_L1.1240.99
93_A96_E1.1010.99
62_V71_V1.0880.99
190_T194_L1.0860.99
79_V101_V1.0830.99
106_V109_I1.0780.98
20_L71_V1.0650.98
199_P202_A1.0650.98
85_L95_V1.0640.98
92_A153_V1.0640.98
73_D101_V1.0630.98
30_A59_A1.0480.98
42_V71_V1.0470.98
92_A157_A1.0460.98
18_R75_A1.0350.98
70_P97_E1.0340.98
95_V154_L1.0320.98
91_P153_V1.0310.98
47_D50_L1.0300.98
84_L87_N1.0300.98
21_D41_V1.0290.98
66_A88_L1.0290.98
18_R42_V1.0190.98
52_G56_D1.0080.98
83_A87_N1.0030.98
85_L110_E0.9980.98
42_V62_V0.9970.97
36_E39_A0.9880.97
11_L33_L0.9880.97
20_L79_V0.9840.97
205_G209_S0.9800.97
82_Q86_I0.9790.97
191_A195_A0.9770.97
201_L204_G0.9770.97
71_V100_R0.9690.97
57_G60_H0.9600.97
127_A130_A0.9590.97
204_G208_D0.9590.97
193_R196_D0.9480.97
82_Q87_N0.9330.96
71_V101_V0.9310.96
85_L88_L0.9310.96
206_L209_S0.9130.96
30_A61_R0.9090.96
120_S124_A0.9080.96
206_L210_A0.9060.96
92_A96_E0.8960.95
70_P100_R0.8950.95
45_D51_L0.8910.95
33_L80_A0.8910.95
45_D50_L0.8860.95
125_E128_L0.8830.95
58_A61_R0.8800.95
129_S134_E0.8790.95
154_L159_L0.8780.95
183_D186_A0.8640.94
19_I78_L0.8620.94
16_R37_S0.8510.94
95_V153_V0.8450.94
95_V159_L0.8420.94
146_L153_V0.8410.93
105_L111_P0.8390.93
17_S106_V0.8370.93
189_A194_L0.8340.93
81_C98_F0.8260.93
87_N111_P0.8230.93
69_L100_R0.8180.92
98_F159_L0.8100.92
186_A190_T0.8070.92
176_P180_G0.8070.92
26_T87_N0.8050.92
200_E204_G0.8040.92
29_F82_Q0.8040.92
201_L205_G0.8020.92
111_P142_T0.7980.92
194_L198_R0.7980.92
194_L197_Q0.7960.91
75_A100_R0.7880.91
70_P101_V0.7830.91
26_T50_L0.7800.91
186_A193_R0.7770.90
66_A94_A0.7760.90
39_A58_A0.7750.90
186_A197_Q0.7740.90
205_G210_A0.7720.90
34_A39_A0.7700.90
136_Y139_G0.7620.90
127_A210_A0.7620.90
26_T82_Q0.7560.89
86_I110_E0.7550.89
107_A159_L0.7550.89
24_A51_L0.7540.89
85_L94_A0.7510.89
29_F80_A0.7450.89
182_L186_A0.7370.88
74_D101_V0.7330.88
91_P95_V0.7310.88
87_N110_E0.7280.87
23_G88_L0.7260.87
28_E50_L0.7240.87
71_V97_E0.7230.87
13_L19_I0.7230.87
45_D84_L0.7220.87
110_E113_N0.7180.87
131_R134_E0.7180.87
7_A80_A0.7140.86
29_F83_A0.7010.85
27_G61_R0.7010.85
175_P178_D0.6990.85
189_A192_D0.6970.85
67_T89_P0.6930.85
83_A111_P0.6920.85
155_A162_V0.6840.84
200_E203_A0.6830.84
178_D181_D0.6810.84
185_A189_A0.6810.84
31_R35_A0.6790.83
191_A194_L0.6790.83
75_A101_V0.6770.83
185_A188_K0.6760.83
102_S105_L0.6700.83
120_S123_A0.6680.82
28_E82_Q0.6670.82
31_R59_A0.6660.82
182_L189_A0.6640.82
23_G50_L0.6630.82
203_A206_L0.6610.82
48_T51_L0.6600.82
182_L185_A0.6590.82
10_D13_L0.6560.81
81_C86_I0.6550.81
198_R201_L0.6530.81
94_A98_F0.6530.81
121_T124_A0.6520.81
201_L208_D0.6520.81
19_I38_S0.6510.81
102_S154_L0.6510.81
66_A71_V0.6470.80
29_F81_C0.6370.79
93_A190_T0.6330.79
16_R36_E0.6320.79
67_T93_A0.6310.79
191_A199_P0.6280.78
110_E142_T0.6270.78
28_E87_N0.6270.78
132_A136_Y0.6260.78
20_L101_V0.6250.78
31_R57_G0.6250.78
26_T94_A0.6190.77
76_C100_R0.6170.77
188_K193_R0.6080.76
115_A118_V0.6010.75
86_I145_T0.5990.75
202_A207_A0.5960.75
13_L78_L0.5960.75
110_E115_A0.5960.75
30_A33_L0.5930.74
128_L186_A0.5900.74
16_R39_A0.5900.74
50_L86_I0.5900.74
52_G130_A0.5890.74
83_A110_E0.5870.74
196_D203_A0.5840.73
18_R38_S0.5830.73
184_A188_K0.5830.73
195_A199_P0.5820.73
126_S130_A0.5800.73
81_C109_I0.5780.73
113_N145_T0.5770.72
24_A61_R0.5760.72
111_P114_S0.5760.72
30_A43_A0.5750.72
71_V75_A0.5750.72
22_V44_L0.5720.72
33_L87_N0.5720.72
51_L55_A0.5710.72
13_L17_S0.5690.71
7_A82_Q0.5660.71
46_A84_L0.5630.71
19_I80_A0.5620.70
112_D115_A0.5600.70
46_A83_A0.5590.70
55_A60_H0.5580.70
31_R82_Q0.5580.70
113_N116_V0.5580.70
112_D148_A0.5560.70
75_A97_E0.5550.69
117_T122_V0.5550.69
23_G87_N0.5520.69
189_A197_Q0.5500.69
87_N94_A0.5490.69
16_R77_D0.5490.69
46_A116_V0.5480.69
117_T123_A0.5480.69
69_L157_A0.5470.68
186_A189_A0.5450.68
108_V169_H0.5440.68
116_V119_A0.5400.67
49_T85_L0.5400.67
189_A196_D0.5390.67
118_V121_T0.5380.67
203_A208_D0.5360.67
143_D146_L0.5350.67
88_L91_P0.5310.66
39_A94_A0.5290.66
17_S78_L0.5290.66
26_T29_F0.5280.66
192_D203_A0.5280.66
41_V77_D0.5280.66
31_R34_A0.5270.66
29_F66_A0.5270.66
29_F87_N0.5240.65
188_K192_D0.5230.65
196_D199_P0.5220.65
185_A194_L0.5210.65
50_L87_N0.5190.64
12_R17_S0.5180.64
164_T167_H0.5170.64
64_G97_E0.5170.64
149_D152_D0.5160.64
111_P116_V0.5160.64
186_A194_L0.5140.64
145_T153_V0.5130.63
19_I37_S0.5130.63
176_P179_D0.5100.63
133_R136_Y0.5090.63
67_T90_E0.5090.63
96_E127_A0.5080.63
49_T52_G0.5060.62
117_T121_T0.5060.62
193_R198_R0.5050.62
74_D199_P0.5020.62
50_L53_H0.5020.62
29_F84_L0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ineA 2 0.8549 100 0.508 Contact Map
4kriA 1 0.8549 100 0.517 Contact Map
4pneA 2 0.8431 100 0.52 Contact Map
2yqzA 1 0.898 100 0.523 Contact Map
3ccfA 1 0.9098 100 0.526 Contact Map
2o57A 2 0.8667 100 0.527 Contact Map
1vl5A 1 0.8667 100 0.529 Contact Map
3ujcA 1 0.8549 100 0.534 Contact Map
3busA 1 0.8549 100 0.539 Contact Map
3egeA 1 0.902 100 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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