Q9HSK6 - HALSA - GREMLIN Contacts

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Q9HSK6 - Uncharacterized protein

UniProt:	Q9HSK6	Sequences: MWRDRDALADLRLSDRSRILDVGAGTGEFARVLAAESSAPVVALDADTTLLGHTADGAAHRVAGDATRLPVRDDACDLVACQALLINLPEPAAAVEEFARVSSELVAVIEPDNSAVTVASTVAAESALSARAREFYVDGVHTDVTLGADAADVLADAGLRDVSTTRHEHVRVTEPPYDDGDLDAAARKATADRLADQRPELAAGGLADSAYDELRAAWREMGRDVVAQMQAGEYVRRETVPFYVTVGRLPDDDTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	255 (204)
Sequences:	2156 (1751)
Seq/√Len:	122.6

ECOLI - TAM UBIE BIOC YJHP SMTA UBIG
BACSU - YCGJ YODH YXBB MENG YBAJ
HALSA - Q9HSK6 ARSM Q9HR81 Q9HRX3 Q9HND6 Q9HR63 Q9HMT2
SULSO - Q97ZU8 Q97XD7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_V	76_C	3.601	1.00
99_A	159_L	3.517	1.00
18_R	40_P	3.428	1.00
40_P	60_H	3.243	1.00
105_L	109_I	3.127	1.00
44_L	64_G	3.045	1.00
51_L	61_R	2.880	1.00
24_A	43_A	2.807	1.00
97_E	100_R	2.751	1.00
90_E	93_A	2.676	1.00
54_T	61_R	2.654	1.00
43_A	61_R	2.594	1.00
43_A	54_T	2.584	1.00
97_E	101_V	2.552	1.00
79_V	102_S	2.432	1.00
20_L	76_C	2.406	1.00
102_S	159_L	2.250	1.00
105_L	108_V	2.208	1.00
48_T	63_A	2.167	1.00
51_L	63_A	2.157	1.00
73_D	97_E	2.134	1.00
67_T	88_L	2.127	1.00
9_A	36_E	2.053	1.00
23_G	84_L	2.039	1.00
42_V	76_C	1.975	1.00
18_R	103_S	1.967	1.00
22_V	98_F	1.950	1.00
64_G	70_P	1.945	1.00
69_L	101_V	1.879	1.00
48_T	52_G	1.866	1.00
34_A	58_A	1.851	1.00
23_G	81_C	1.822	1.00
69_L	97_E	1.820	1.00
24_A	45_D	1.807	1.00
88_L	94_A	1.806	1.00
77_D	103_S	1.801	1.00
65_D	68_R	1.759	1.00
205_G	208_D	1.724	1.00
24_A	44_L	1.686	1.00
73_D	100_R	1.651	1.00
30_A	41_V	1.626	1.00
84_L	88_L	1.619	1.00
37_S	41_V	1.595	1.00
92_A	156_D	1.575	1.00
52_G	55_A	1.536	1.00
43_A	59_A	1.530	1.00
24_A	30_A	1.517	1.00
42_V	60_H	1.512	1.00
22_V	66_A	1.499	1.00
207_A	210_A	1.471	1.00
21_D	43_A	1.448	1.00
16_R	38_S	1.444	1.00
204_G	207_A	1.427	1.00
53_H	56_D	1.413	1.00
44_L	62_V	1.412	1.00
98_F	102_S	1.364	1.00
190_T	193_R	1.362	1.00
24_A	54_T	1.321	1.00
199_P	203_A	1.320	1.00
14_S	17_S	1.318	1.00
143_D	149_D	1.294	1.00
198_R	202_A	1.291	1.00
102_S	107_A	1.288	1.00
81_C	84_L	1.275	1.00
151_A	155_A	1.212	0.99
79_V	98_F	1.199	0.99
83_A	86_I	1.198	0.99
74_D	103_S	1.189	0.99
189_A	193_R	1.180	0.99
46_A	65_D	1.177	0.99
98_F	107_A	1.168	0.99
18_R	76_C	1.145	0.99
19_I	33_L	1.124	0.99
93_A	96_E	1.101	0.99
62_V	71_V	1.088	0.99
190_T	194_L	1.086	0.99
79_V	101_V	1.083	0.99
106_V	109_I	1.078	0.98
20_L	71_V	1.065	0.98
199_P	202_A	1.065	0.98
85_L	95_V	1.064	0.98
92_A	153_V	1.064	0.98
73_D	101_V	1.063	0.98
30_A	59_A	1.048	0.98
42_V	71_V	1.047	0.98
92_A	157_A	1.046	0.98
18_R	75_A	1.035	0.98
70_P	97_E	1.034	0.98
95_V	154_L	1.032	0.98
91_P	153_V	1.031	0.98
47_D	50_L	1.030	0.98
84_L	87_N	1.030	0.98
21_D	41_V	1.029	0.98
66_A	88_L	1.029	0.98
18_R	42_V	1.019	0.98
52_G	56_D	1.008	0.98
83_A	87_N	1.003	0.98
85_L	110_E	0.998	0.98
42_V	62_V	0.997	0.97
36_E	39_A	0.988	0.97
11_L	33_L	0.988	0.97
20_L	79_V	0.984	0.97
205_G	209_S	0.980	0.97
82_Q	86_I	0.979	0.97
191_A	195_A	0.977	0.97
201_L	204_G	0.977	0.97
71_V	100_R	0.969	0.97
57_G	60_H	0.960	0.97
127_A	130_A	0.959	0.97
204_G	208_D	0.959	0.97
193_R	196_D	0.948	0.97
82_Q	87_N	0.933	0.96
71_V	101_V	0.931	0.96
85_L	88_L	0.931	0.96
206_L	209_S	0.913	0.96
30_A	61_R	0.909	0.96
120_S	124_A	0.908	0.96
206_L	210_A	0.906	0.96
92_A	96_E	0.896	0.95
70_P	100_R	0.895	0.95
45_D	51_L	0.891	0.95
33_L	80_A	0.891	0.95
45_D	50_L	0.886	0.95
125_E	128_L	0.883	0.95
58_A	61_R	0.880	0.95
129_S	134_E	0.879	0.95
154_L	159_L	0.878	0.95
183_D	186_A	0.864	0.94
19_I	78_L	0.862	0.94
16_R	37_S	0.851	0.94
95_V	153_V	0.845	0.94
95_V	159_L	0.842	0.94
146_L	153_V	0.841	0.93
105_L	111_P	0.839	0.93
17_S	106_V	0.837	0.93
189_A	194_L	0.834	0.93
81_C	98_F	0.826	0.93
87_N	111_P	0.823	0.93
69_L	100_R	0.818	0.92
98_F	159_L	0.810	0.92
186_A	190_T	0.807	0.92
176_P	180_G	0.807	0.92
26_T	87_N	0.805	0.92
200_E	204_G	0.804	0.92
29_F	82_Q	0.804	0.92
201_L	205_G	0.802	0.92
111_P	142_T	0.798	0.92
194_L	198_R	0.798	0.92
194_L	197_Q	0.796	0.91
75_A	100_R	0.788	0.91
70_P	101_V	0.783	0.91
26_T	50_L	0.780	0.91
186_A	193_R	0.777	0.90
66_A	94_A	0.776	0.90
39_A	58_A	0.775	0.90
186_A	197_Q	0.774	0.90
205_G	210_A	0.772	0.90
34_A	39_A	0.770	0.90
136_Y	139_G	0.762	0.90
127_A	210_A	0.762	0.90
26_T	82_Q	0.756	0.89
86_I	110_E	0.755	0.89
107_A	159_L	0.755	0.89
24_A	51_L	0.754	0.89
85_L	94_A	0.751	0.89
29_F	80_A	0.745	0.89
182_L	186_A	0.737	0.88
74_D	101_V	0.733	0.88
91_P	95_V	0.731	0.88
87_N	110_E	0.728	0.87
23_G	88_L	0.726	0.87
28_E	50_L	0.724	0.87
71_V	97_E	0.723	0.87
13_L	19_I	0.723	0.87
45_D	84_L	0.722	0.87
110_E	113_N	0.718	0.87
131_R	134_E	0.718	0.87
7_A	80_A	0.714	0.86
29_F	83_A	0.701	0.85
27_G	61_R	0.701	0.85
175_P	178_D	0.699	0.85
189_A	192_D	0.697	0.85
67_T	89_P	0.693	0.85
83_A	111_P	0.692	0.85
155_A	162_V	0.684	0.84
200_E	203_A	0.683	0.84
178_D	181_D	0.681	0.84
185_A	189_A	0.681	0.84
31_R	35_A	0.679	0.83
191_A	194_L	0.679	0.83
75_A	101_V	0.677	0.83
185_A	188_K	0.676	0.83
102_S	105_L	0.670	0.83
120_S	123_A	0.668	0.82
28_E	82_Q	0.667	0.82
31_R	59_A	0.666	0.82
182_L	189_A	0.664	0.82
23_G	50_L	0.663	0.82
203_A	206_L	0.661	0.82
48_T	51_L	0.660	0.82
182_L	185_A	0.659	0.82
10_D	13_L	0.656	0.81
81_C	86_I	0.655	0.81
198_R	201_L	0.653	0.81
94_A	98_F	0.653	0.81
121_T	124_A	0.652	0.81
201_L	208_D	0.652	0.81
19_I	38_S	0.651	0.81
102_S	154_L	0.651	0.81
66_A	71_V	0.647	0.80
29_F	81_C	0.637	0.79
93_A	190_T	0.633	0.79
16_R	36_E	0.632	0.79
67_T	93_A	0.631	0.79
191_A	199_P	0.628	0.78
110_E	142_T	0.627	0.78
28_E	87_N	0.627	0.78
132_A	136_Y	0.626	0.78
20_L	101_V	0.625	0.78
31_R	57_G	0.625	0.78
26_T	94_A	0.619	0.77
76_C	100_R	0.617	0.77
188_K	193_R	0.608	0.76
115_A	118_V	0.601	0.75
86_I	145_T	0.599	0.75
202_A	207_A	0.596	0.75
13_L	78_L	0.596	0.75
110_E	115_A	0.596	0.75
30_A	33_L	0.593	0.74
128_L	186_A	0.590	0.74
16_R	39_A	0.590	0.74
50_L	86_I	0.590	0.74
52_G	130_A	0.589	0.74
83_A	110_E	0.587	0.74
196_D	203_A	0.584	0.73
18_R	38_S	0.583	0.73
184_A	188_K	0.583	0.73
195_A	199_P	0.582	0.73
126_S	130_A	0.580	0.73
81_C	109_I	0.578	0.73
113_N	145_T	0.577	0.72
24_A	61_R	0.576	0.72
111_P	114_S	0.576	0.72
30_A	43_A	0.575	0.72
71_V	75_A	0.575	0.72
22_V	44_L	0.572	0.72
33_L	87_N	0.572	0.72
51_L	55_A	0.571	0.72
13_L	17_S	0.569	0.71
7_A	82_Q	0.566	0.71
46_A	84_L	0.563	0.71
19_I	80_A	0.562	0.70
112_D	115_A	0.560	0.70
46_A	83_A	0.559	0.70
55_A	60_H	0.558	0.70
31_R	82_Q	0.558	0.70
113_N	116_V	0.558	0.70
112_D	148_A	0.556	0.70
75_A	97_E	0.555	0.69
117_T	122_V	0.555	0.69
23_G	87_N	0.552	0.69
189_A	197_Q	0.550	0.69
87_N	94_A	0.549	0.69
16_R	77_D	0.549	0.69
46_A	116_V	0.548	0.69
117_T	123_A	0.548	0.69
69_L	157_A	0.547	0.68
186_A	189_A	0.545	0.68
108_V	169_H	0.544	0.68
116_V	119_A	0.540	0.67
49_T	85_L	0.540	0.67
189_A	196_D	0.539	0.67
118_V	121_T	0.538	0.67
203_A	208_D	0.536	0.67
143_D	146_L	0.535	0.67
88_L	91_P	0.531	0.66
39_A	94_A	0.529	0.66
17_S	78_L	0.529	0.66
26_T	29_F	0.528	0.66
192_D	203_A	0.528	0.66
41_V	77_D	0.528	0.66
31_R	34_A	0.527	0.66
29_F	66_A	0.527	0.66
29_F	87_N	0.524	0.65
188_K	192_D	0.523	0.65
196_D	199_P	0.522	0.65
185_A	194_L	0.521	0.65
50_L	87_N	0.519	0.64
12_R	17_S	0.518	0.64
164_T	167_H	0.517	0.64
64_G	97_E	0.517	0.64
149_D	152_D	0.516	0.64
111_P	116_V	0.516	0.64
186_A	194_L	0.514	0.64
145_T	153_V	0.513	0.63
19_I	37_S	0.513	0.63
176_P	179_D	0.510	0.63
133_R	136_Y	0.509	0.63
67_T	90_E	0.509	0.63
96_E	127_A	0.508	0.63
49_T	52_G	0.506	0.62
117_T	121_T	0.506	0.62
193_R	198_R	0.505	0.62
74_D	199_P	0.502	0.62
50_L	53_H	0.502	0.62
29_F	84_L	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ineA	2	0.8549	100	0.508	Contact Map
4kriA	1	0.8549	100	0.517	Contact Map
4pneA	2	0.8431	100	0.52	Contact Map
2yqzA	1	0.898	100	0.523	Contact Map
3ccfA	1	0.9098	100	0.526	Contact Map
2o57A	2	0.8667	100	0.527	Contact Map
1vl5A	1	0.8667	100	0.529	Contact Map
3ujcA	1	0.8549	100	0.534	Contact Map
3busA	1	0.8549	100	0.539	Contact Map
3egeA	1	0.902	100	0.543	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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