GREMLIN Database
Q9HSK5 - Aminopeptidase homolog
UniProt: Q9HSK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (350)
Sequences: 1710 (1196)
Seq/√Len: 63.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_G258_E5.5341.00
246_T254_S3.9841.00
343_E347_E3.7101.00
252_V309_V3.6131.00
19_V25_V3.5241.00
194_R222_S3.5111.00
43_A46_Q3.3461.00
241_R259_Q3.2751.00
29_A37_V3.1641.00
261_E265_A3.0461.00
10_E43_A3.0051.00
230_D336_M2.9491.00
224_A249_D2.9411.00
180_T192_T2.8031.00
10_E14_D2.7821.00
269_N275_R2.6751.00
12_L131_T2.6361.00
165_S206_D2.5421.00
340_S351_R2.4961.00
66_R104_V2.4331.00
226_E246_T2.4201.00
6_R43_A2.4071.00
13_V40_L2.3861.00
13_V47_R2.3341.00
120_S124_L2.3211.00
247_F277_L2.2641.00
348_I351_R2.2401.00
285_N290_R2.2281.00
182_H190_D2.1831.00
285_N354_T2.1161.00
14_D47_R2.1151.00
140_Q145_S2.0291.00
255_F265_A2.0131.00
244_A256_S1.9731.00
268_L275_R1.9591.00
251_D275_R1.9511.00
169_S173_E1.9501.00
19_V88_V1.9051.00
17_A90_F1.8841.00
220_P319_E1.8681.00
62_R103_D1.8481.00
99_F141_R1.8301.00
178_A341_F1.8291.00
256_S261_E1.8271.00
27_I40_L1.8221.00
120_S123_R1.7821.00
217_A323_F1.7771.00
198_M318_P1.7611.00
193_M307_L1.7541.00
226_E244_A1.7521.00
265_A269_N1.7330.99
173_E177_P1.7290.99
77_D81_A1.7000.99
228_Y244_A1.6850.99
23_D88_V1.6840.99
12_L90_F1.6620.99
155_D160_D1.6560.99
41_Y60_A1.6500.99
220_P276_R1.6420.99
44_L49_A1.6320.99
91_L130_I1.6260.99
197_G344_I1.6140.99
90_F129_V1.6040.99
6_R39_A1.5960.99
25_V44_L1.5930.99
119_I124_L1.5750.99
198_M321_C1.5750.99
83_M86_T1.5740.99
70_E108_M1.5650.99
25_V90_F1.5600.99
223_V276_R1.5550.99
192_T224_A1.5440.99
251_D276_R1.5340.99
110_Q114_R1.5310.99
194_R219_V1.5120.99
157_V209_M1.4890.98
117_K123_R1.4840.98
235_R240_I1.4640.98
36_L40_L1.4540.98
24_M50_R1.4490.98
80_L84_E1.4440.98
255_F261_E1.4420.98
6_R42_E1.4400.98
187_D338_E1.4340.98
217_A312_A1.4330.98
305_V334_V1.4200.98
132_T297_F1.3980.98
165_S204_D1.3960.98
290_R354_T1.3950.98
219_V222_S1.3880.97
268_L274_A1.3860.97
117_K121_E1.3820.97
252_V268_L1.3780.97
40_L90_F1.3770.97
312_A323_F1.3740.97
248_E253_V1.3740.97
227_V307_L1.3700.97
217_A316_C1.3660.97
68_M73_Y1.3640.97
117_K120_S1.3600.97
117_K124_L1.3590.97
64_Y68_M1.3570.97
27_I37_V1.3250.97
15_Q162_A1.3030.96
136_A146_T1.3010.96
26_T87_D1.2990.96
179_E344_I1.2960.96
65_A73_Y1.2950.96
46_Q67_A1.2920.96
80_L83_M1.2850.96
93_G132_T1.2820.96
255_F268_L1.2770.96
119_I123_R1.2740.96
39_A42_E1.2640.96
20_R23_D1.2510.95
268_L309_V1.2470.95
311_G325_D1.2390.95
182_H192_T1.2340.95
121_E124_L1.2280.95
341_F351_R1.2230.95
36_L133_H1.2160.94
25_V129_V1.2120.94
13_V44_L1.1920.94
34_E55_W1.1850.94
39_A43_A1.1770.93
81_A85_E1.1690.93
179_E222_S1.1660.93
82_A86_T1.1650.93
81_A84_E1.1650.93
340_S348_I1.1640.93
270_T327_A1.1590.93
274_A328_V1.1540.93
186_G338_E1.1390.92
7_R10_E1.1380.92
305_V339_D1.1380.92
266_G269_N1.1350.92
97_N137_A1.1350.92
145_S148_A1.1350.92
28_R54_S1.1330.92
37_V53_L1.1290.92
187_D228_Y1.1280.92
70_E111_A1.1270.92
62_R66_R1.1250.92
37_V90_F1.1210.92
217_A313_I1.1200.92
80_L86_T1.1120.91
165_S203_D1.1100.91
66_R103_D1.1100.91
42_E46_Q1.1010.91
245_L268_L1.0940.91
23_D127_R1.0920.91
92_I131_T1.0860.90
19_V47_R1.0730.90
181_V280_L1.0690.90
165_S205_G1.0680.90
307_L334_V1.0650.90
19_V44_L1.0640.89
174_I178_A1.0580.89
191_I307_L1.0490.89
203_D211_A1.0480.89
12_L129_V1.0470.89
338_E352_N1.0460.89
234_M239_E1.0440.89
254_S265_A1.0390.88
219_V276_R1.0360.88
227_V334_V1.0350.88
130_I313_I1.0330.88
252_V275_R1.0290.88
13_V25_V1.0260.88
32_Q135_T1.0260.88
180_T342_I1.0200.87
193_M223_V1.0200.87
118_P123_R1.0160.87
105_P108_M1.0130.87
111_A115_A1.0070.87
166_E170_Q1.0050.87
68_M72_D1.0050.87
38_V57_L1.0000.86
43_A47_R0.9920.86
3_T6_R0.9840.85
265_A275_R0.9820.85
63_A66_R0.9800.85
89_V126_T0.9780.85
42_E63_A0.9770.85
136_A140_Q0.9740.85
75_T116_H0.9740.85
112_G116_H0.9640.84
184_V340_S0.9600.84
4_R7_R0.9600.84
255_F269_N0.9590.84
15_Q206_D0.9530.84
195_V216_T0.9520.83
180_T346_G0.9490.83
252_V274_A0.9460.83
179_E194_R0.9460.83
264_L267_I0.9370.82
245_L252_V0.9370.82
91_L313_I0.9350.82
270_T328_V0.9250.82
30_S95_G0.9220.81
95_G135_T0.9200.81
179_E196_D0.9180.81
13_V19_V0.9170.81
156_A291_F0.9140.81
53_L60_A0.9130.81
18_D206_D0.9080.80
282_I342_I0.9060.80
25_V88_V0.9050.80
243_A295_M0.9050.80
54_S82_A0.8970.80
133_H150_E0.8920.79
344_I347_E0.8780.78
158_N164_Q0.8770.78
172_V204_D0.8760.78
171_L349_V0.8750.78
134_P150_E0.8730.78
119_I122_Q0.8710.78
42_E67_A0.8660.77
188_T244_A0.8660.77
238_N263_V0.8620.77
183_I191_I0.8590.77
233_L330_T0.8560.76
309_V328_V0.8550.76
191_I223_V0.8550.76
41_Y53_L0.8550.76
36_L39_A0.8510.76
141_R293_Y0.8490.76
233_L295_M0.8430.75
274_A309_V0.8410.75
191_I277_L0.8370.75
106_P266_G0.8340.75
107_E266_G0.8340.75
243_A332_M0.8340.75
218_P277_L0.8290.74
180_T194_R0.8240.74
69_D73_Y0.8220.73
244_A254_S0.8210.73
165_S169_S0.8210.73
69_D72_D0.8180.73
178_A343_E0.8170.73
152_F156_A0.8160.73
184_V190_D0.8160.73
341_F346_G0.8130.73
317_V321_C0.8130.73
162_A165_S0.8110.72
107_E111_A0.8110.72
4_R154_Y0.8080.72
197_G219_V0.8050.72
306_H329_H0.8030.72
34_E38_V0.8030.72
170_Q174_I0.7950.71
79_E116_H0.7930.71
188_T228_Y0.7920.71
305_V350_Q0.7920.71
79_E82_A0.7890.70
240_I264_L0.7860.70
61_T101_T0.7820.70
279_E306_H0.7810.70
132_T135_T0.7800.69
11_V158_N0.7780.69
183_I193_M0.7780.69
30_S33_A0.7770.69
162_A166_E0.7770.69
4_R160_D0.7710.69
12_L130_I0.7710.69
203_D206_D0.7700.68
40_L92_I0.7690.68
4_R151_E0.7690.68
262_D266_G0.7690.68
279_E329_H0.7690.68
160_D270_T0.7670.68
311_G314_D0.7660.68
183_I280_L0.7660.68
97_N140_Q0.7660.68
169_S202_N0.7640.68
169_S205_G0.7640.68
181_V195_V0.7620.68
173_E176_D0.7610.68
33_A133_H0.7590.67
281_G284_M0.7580.67
171_L356_V0.7540.67
157_V297_F0.7540.67
184_V192_T0.7530.67
24_M52_S0.7530.67
17_A129_V0.7520.67
17_A88_V0.7510.67
240_I267_I0.7480.66
95_G132_T0.7480.66
113_S236_Q0.7460.66
254_S261_E0.7440.66
299_E306_H0.7430.66
42_E66_R0.7420.66
186_G305_V0.7390.65
251_D272_A0.7380.65
183_I339_D0.7380.65
148_A151_E0.7370.65
275_R309_V0.7360.65
187_D336_M0.7360.65
165_S172_V0.7360.65
151_E160_D0.7340.65
292_T301_M0.7320.65
168_Q214_V0.7300.64
340_S344_I0.7260.64
224_A248_E0.7250.64
28_R89_V0.7250.64
54_S79_E0.7180.63
52_S82_A0.7170.63
110_Q266_G0.7160.63
21_R48_G0.7150.63
215_F315_E0.7100.62
3_T7_R0.7090.62
172_V176_D0.7090.62
284_M289_D0.7080.62
28_R91_L0.7050.62
68_M108_M0.7040.62
252_V255_F0.7030.61
273_G326_S0.7010.61
8_H131_T0.6980.61
14_D43_A0.6950.61
243_A264_L0.6930.60
35_A59_R0.6910.60
186_G334_V0.6900.60
79_E83_M0.6900.60
242_G259_Q0.6900.60
308_A329_H0.6900.60
228_Y242_G0.6890.60
152_F291_F0.6890.60
187_D230_D0.6870.60
130_I217_A0.6870.60
65_A101_T0.6850.59
223_V307_L0.6830.59
172_V206_D0.6820.59
172_V203_D0.6820.59
195_V349_V0.6800.59
213_E218_P0.6800.59
103_D148_A0.6800.59
299_E329_H0.6780.59
193_M280_L0.6770.59
175_L214_V0.6760.58
321_C325_D0.6730.58
118_P122_Q0.6730.58
109_S236_Q0.6720.58
42_E59_R0.6710.58
194_R224_A0.6710.58
17_A25_V0.6700.58
343_E346_G0.6690.58
27_I163_A0.6640.57
308_A331_D0.6620.57
117_K122_Q0.6620.57
213_E306_H0.6610.57
5_V39_A0.6580.56
284_M337_S0.6570.56
80_L123_R0.6560.56
160_D209_M0.6550.56
208_N296_L0.6550.56
199_R216_T0.6540.56
279_E299_E0.6540.56
235_R328_V0.6530.56
213_E329_H0.6530.56
212_G300_K0.6510.56
155_D249_D0.6500.55
241_R258_E0.6480.55
63_A67_A0.6470.55
88_V127_R0.6400.54
267_I270_T0.6380.54
29_A33_A0.6370.54
24_M87_D0.6350.54
150_E154_Y0.6350.54
306_H331_D0.6340.54
206_D209_M0.6290.53
126_T129_V0.6280.53
24_M85_E0.6280.53
350_Q354_T0.6270.53
75_T115_A0.6250.53
75_T79_E0.6250.53
80_L122_Q0.6250.53
348_I352_N0.6250.53
88_V316_C0.6230.52
213_E299_E0.6200.52
343_E348_I0.6190.52
61_T112_G0.6190.52
101_T104_V0.6180.52
28_R56_S0.6180.52
146_T150_E0.6180.52
312_A325_D0.6140.51
320_D344_I0.6130.51
96_P234_M0.6130.51
289_D337_S0.6120.51
29_A92_I0.6090.51
37_V55_W0.6090.51
3_T137_A0.6090.51
33_A95_G0.6080.51
245_L332_M0.6070.50
169_S203_D0.6070.50
259_Q262_D0.6070.50
178_A349_V0.6060.50
174_I347_E0.6050.50
97_N141_R0.6030.50
104_V109_S0.6030.50
174_I177_P0.6020.50
221_D276_R0.6010.50
312_A321_C0.5990.50
198_M317_V0.5960.49
221_D319_E0.5950.49
236_Q328_V0.5930.49
218_P306_H0.5900.49
56_S60_A0.5900.49
235_R267_I0.5890.48
213_E279_E0.5880.48
156_A297_F0.5860.48
229_F274_A0.5860.48
19_V49_A0.5850.48
12_L36_L0.5840.48
292_T335_D0.5840.48
242_G265_A0.5830.48
44_L88_V0.5820.48
283_G286_R0.5820.48
215_F319_E0.5800.47
35_A39_A0.5790.47
298_D301_M0.5790.47
246_T256_S0.5780.47
142_A149_Y0.5770.47
72_D159_K0.5760.47
132_T138_G0.5750.47
193_M222_S0.5740.47
233_L332_M0.5740.47
84_E122_Q0.5740.47
295_M332_M0.5740.47
255_F275_R0.5720.46
284_M354_T0.5710.46
221_D249_D0.5710.46
179_E219_V0.5680.46
50_R72_D0.5670.46
98_A141_R0.5670.46
4_R159_K0.5650.46
78_H88_V0.5640.46
184_V342_I0.5620.45
349_V356_V0.5610.45
5_V8_H0.5610.45
299_E331_D0.5610.45
52_S78_H0.5580.45
32_Q37_V0.5570.45
281_G305_V0.5560.45
144_M147_A0.5560.45
65_A106_P0.5550.44
93_G130_I0.5530.44
130_I207_H0.5510.44
134_P154_Y0.5500.44
113_S207_H0.5480.44
11_V43_A0.5480.44
79_E86_T0.5480.44
337_S352_N0.5480.44
177_P182_H0.5460.43
13_V43_A0.5460.43
235_R330_T0.5450.43
223_V234_M0.5450.43
237_G298_D0.5450.43
51_P183_I0.5430.43
90_F130_I0.5420.43
183_I334_V0.5420.43
111_A148_A0.5410.43
138_G149_Y0.5410.43
250_G310_G0.5390.43
268_L277_L0.5380.43
184_V351_R0.5380.43
163_A167_F0.5370.42
80_L90_F0.5360.42
70_E107_E0.5360.42
36_L92_I0.5350.42
179_E342_I0.5350.42
312_A315_E0.5340.42
189_T296_L0.5330.42
99_F102_S0.5330.42
157_V160_D0.5320.42
154_Y157_V0.5310.42
101_T108_M0.5310.42
93_G96_P0.5300.42
244_A261_E0.5300.42
151_E155_D0.5280.41
157_V217_A0.5280.41
121_E325_D0.5270.41
26_T89_V0.5260.41
341_F344_I0.5260.41
295_M333_I0.5240.41
76_K114_R0.5240.41
22_G71_A0.5230.41
54_S60_A0.5230.41
16_C209_M0.5230.41
262_D265_A0.5210.41
227_V305_V0.5210.41
223_V247_F0.5200.41
230_D304_T0.5190.40
110_Q263_V0.5180.40
19_V23_D0.5180.40
187_D355_F0.5170.40
95_G138_G0.5170.40
202_N315_E0.5170.40
196_D199_R0.5170.40
82_A85_E0.5170.40
207_H313_I0.5160.40
282_I305_V0.5160.40
187_D226_E0.5160.40
196_D217_A0.5160.40
45_G51_P0.5150.40
276_R341_F0.5150.40
246_T249_D0.5150.40
265_A268_L0.5140.40
33_A37_V0.5140.40
267_I328_V0.5130.40
36_L245_L0.5120.40
147_A151_E0.5120.40
95_G137_A0.5120.40
350_Q355_F0.5100.39
112_G115_A0.5100.39
71_A151_E0.5100.39
186_G228_Y0.5050.39
6_R338_E0.5040.39
227_V349_V0.5040.39
27_I202_N0.5040.39
304_T309_V0.5030.39
201_C300_K0.5030.39
75_T89_V0.5020.39
228_Y241_R0.5000.38
4_R155_D0.5000.38
11_V209_M0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ayiA 2 0.9642 100 0.233 Contact Map
4icsA 2 0.9725 100 0.239 Contact Map
1zjcA 2 0.978 100 0.245 Contact Map
3shoA 4 0.3333 55 0.968 Contact Map
3lygA 2 0.3168 49 0.969 Contact Map
4ivnA 2 0.3333 32.8 0.972 Contact Map
1jeoA 4 0.3113 28.9 0.972 Contact Map
3cvjA 2 0.3554 25 0.973 Contact Map
1m3sA 4 0.3113 22.9 0.974 Contact Map
1vimA 4 0.3196 22.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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