Q9HSK5 - HALSA - GREMLIN Contacts

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Q9HSK5 - Aminopeptidase homolog

UniProt:	Q9HSK5	Sequences: MDTRVRRHAEVLVDQCADVRRGDMVTIRASRQAEALVVALYEALGQRGARPSLSWSLPRATRAYARAMDEADYTTKDHELAAMEETDVVFLIGGGPNAFETSDVPPEMSQAGSRAHKPISEQRLDTRWVITTHPTAAGAQRAGMSTAAYEEFVYDAVNKDWAAQSEFQSQLVEILDPAETVHIVSGDTTDITMRVDGMRACNDDGDHNMPAGEVFTAPVPDSVAGEVYFDKPLMRQGNEIRGAALTFEDGDVVSFSAEQNEDVLAGILNTDAGARRLGELGIGMNRGIDRFTYNMLFDEKMGDTVHLAVGGAIDECVPEDCEFNDSAVHTDMIVDMSEDSFIEIDGEIVQRNGTFVFEDGFEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (350)
Sequences:	1710 (1196)
Seq/√Len:	63.9

BACSU - AMPS
HALSA - Q9HSK5 Q9HMP2 Q9HMH0 Q9HSS8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
242_G	258_E	5.534	1.00
246_T	254_S	3.984	1.00
343_E	347_E	3.710	1.00
252_V	309_V	3.613	1.00
19_V	25_V	3.524	1.00
194_R	222_S	3.511	1.00
43_A	46_Q	3.346	1.00
241_R	259_Q	3.275	1.00
29_A	37_V	3.164	1.00
261_E	265_A	3.046	1.00
10_E	43_A	3.005	1.00
230_D	336_M	2.949	1.00
224_A	249_D	2.941	1.00
180_T	192_T	2.803	1.00
10_E	14_D	2.782	1.00
269_N	275_R	2.675	1.00
12_L	131_T	2.636	1.00
165_S	206_D	2.542	1.00
340_S	351_R	2.496	1.00
66_R	104_V	2.433	1.00
226_E	246_T	2.420	1.00
6_R	43_A	2.407	1.00
13_V	40_L	2.386	1.00
13_V	47_R	2.334	1.00
120_S	124_L	2.321	1.00
247_F	277_L	2.264	1.00
348_I	351_R	2.240	1.00
285_N	290_R	2.228	1.00
182_H	190_D	2.183	1.00
285_N	354_T	2.116	1.00
14_D	47_R	2.115	1.00
140_Q	145_S	2.029	1.00
255_F	265_A	2.013	1.00
244_A	256_S	1.973	1.00
268_L	275_R	1.959	1.00
251_D	275_R	1.951	1.00
169_S	173_E	1.950	1.00
19_V	88_V	1.905	1.00
17_A	90_F	1.884	1.00
220_P	319_E	1.868	1.00
62_R	103_D	1.848	1.00
99_F	141_R	1.830	1.00
178_A	341_F	1.829	1.00
256_S	261_E	1.827	1.00
27_I	40_L	1.822	1.00
120_S	123_R	1.782	1.00
217_A	323_F	1.777	1.00
198_M	318_P	1.761	1.00
193_M	307_L	1.754	1.00
226_E	244_A	1.752	1.00
265_A	269_N	1.733	0.99
173_E	177_P	1.729	0.99
77_D	81_A	1.700	0.99
228_Y	244_A	1.685	0.99
23_D	88_V	1.684	0.99
12_L	90_F	1.662	0.99
155_D	160_D	1.656	0.99
41_Y	60_A	1.650	0.99
220_P	276_R	1.642	0.99
44_L	49_A	1.632	0.99
91_L	130_I	1.626	0.99
197_G	344_I	1.614	0.99
90_F	129_V	1.604	0.99
6_R	39_A	1.596	0.99
25_V	44_L	1.593	0.99
119_I	124_L	1.575	0.99
198_M	321_C	1.575	0.99
83_M	86_T	1.574	0.99
70_E	108_M	1.565	0.99
25_V	90_F	1.560	0.99
223_V	276_R	1.555	0.99
192_T	224_A	1.544	0.99
251_D	276_R	1.534	0.99
110_Q	114_R	1.531	0.99
194_R	219_V	1.512	0.99
157_V	209_M	1.489	0.98
117_K	123_R	1.484	0.98
235_R	240_I	1.464	0.98
36_L	40_L	1.454	0.98
24_M	50_R	1.449	0.98
80_L	84_E	1.444	0.98
255_F	261_E	1.442	0.98
6_R	42_E	1.440	0.98
187_D	338_E	1.434	0.98
217_A	312_A	1.433	0.98
305_V	334_V	1.420	0.98
132_T	297_F	1.398	0.98
165_S	204_D	1.396	0.98
290_R	354_T	1.395	0.98
219_V	222_S	1.388	0.97
268_L	274_A	1.386	0.97
117_K	121_E	1.382	0.97
252_V	268_L	1.378	0.97
40_L	90_F	1.377	0.97
312_A	323_F	1.374	0.97
248_E	253_V	1.374	0.97
227_V	307_L	1.370	0.97
217_A	316_C	1.366	0.97
68_M	73_Y	1.364	0.97
117_K	120_S	1.360	0.97
117_K	124_L	1.359	0.97
64_Y	68_M	1.357	0.97
27_I	37_V	1.325	0.97
15_Q	162_A	1.303	0.96
136_A	146_T	1.301	0.96
26_T	87_D	1.299	0.96
179_E	344_I	1.296	0.96
65_A	73_Y	1.295	0.96
46_Q	67_A	1.292	0.96
80_L	83_M	1.285	0.96
93_G	132_T	1.282	0.96
255_F	268_L	1.277	0.96
119_I	123_R	1.274	0.96
39_A	42_E	1.264	0.96
20_R	23_D	1.251	0.95
268_L	309_V	1.247	0.95
311_G	325_D	1.239	0.95
182_H	192_T	1.234	0.95
121_E	124_L	1.228	0.95
341_F	351_R	1.223	0.95
36_L	133_H	1.216	0.94
25_V	129_V	1.212	0.94
13_V	44_L	1.192	0.94
34_E	55_W	1.185	0.94
39_A	43_A	1.177	0.93
81_A	85_E	1.169	0.93
179_E	222_S	1.166	0.93
82_A	86_T	1.165	0.93
81_A	84_E	1.165	0.93
340_S	348_I	1.164	0.93
270_T	327_A	1.159	0.93
274_A	328_V	1.154	0.93
186_G	338_E	1.139	0.92
7_R	10_E	1.138	0.92
305_V	339_D	1.138	0.92
266_G	269_N	1.135	0.92
97_N	137_A	1.135	0.92
145_S	148_A	1.135	0.92
28_R	54_S	1.133	0.92
37_V	53_L	1.129	0.92
187_D	228_Y	1.128	0.92
70_E	111_A	1.127	0.92
62_R	66_R	1.125	0.92
37_V	90_F	1.121	0.92
217_A	313_I	1.120	0.92
80_L	86_T	1.112	0.91
165_S	203_D	1.110	0.91
66_R	103_D	1.110	0.91
42_E	46_Q	1.101	0.91
245_L	268_L	1.094	0.91
23_D	127_R	1.092	0.91
92_I	131_T	1.086	0.90
19_V	47_R	1.073	0.90
181_V	280_L	1.069	0.90
165_S	205_G	1.068	0.90
307_L	334_V	1.065	0.90
19_V	44_L	1.064	0.89
174_I	178_A	1.058	0.89
191_I	307_L	1.049	0.89
203_D	211_A	1.048	0.89
12_L	129_V	1.047	0.89
338_E	352_N	1.046	0.89
234_M	239_E	1.044	0.89
254_S	265_A	1.039	0.88
219_V	276_R	1.036	0.88
227_V	334_V	1.035	0.88
130_I	313_I	1.033	0.88
252_V	275_R	1.029	0.88
13_V	25_V	1.026	0.88
32_Q	135_T	1.026	0.88
180_T	342_I	1.020	0.87
193_M	223_V	1.020	0.87
118_P	123_R	1.016	0.87
105_P	108_M	1.013	0.87
111_A	115_A	1.007	0.87
166_E	170_Q	1.005	0.87
68_M	72_D	1.005	0.87
38_V	57_L	1.000	0.86
43_A	47_R	0.992	0.86
3_T	6_R	0.984	0.85
265_A	275_R	0.982	0.85
63_A	66_R	0.980	0.85
89_V	126_T	0.978	0.85
42_E	63_A	0.977	0.85
136_A	140_Q	0.974	0.85
75_T	116_H	0.974	0.85
112_G	116_H	0.964	0.84
184_V	340_S	0.960	0.84
4_R	7_R	0.960	0.84
255_F	269_N	0.959	0.84
15_Q	206_D	0.953	0.84
195_V	216_T	0.952	0.83
180_T	346_G	0.949	0.83
252_V	274_A	0.946	0.83
179_E	194_R	0.946	0.83
264_L	267_I	0.937	0.82
245_L	252_V	0.937	0.82
91_L	313_I	0.935	0.82
270_T	328_V	0.925	0.82
30_S	95_G	0.922	0.81
95_G	135_T	0.920	0.81
179_E	196_D	0.918	0.81
13_V	19_V	0.917	0.81
156_A	291_F	0.914	0.81
53_L	60_A	0.913	0.81
18_D	206_D	0.908	0.80
282_I	342_I	0.906	0.80
25_V	88_V	0.905	0.80
243_A	295_M	0.905	0.80
54_S	82_A	0.897	0.80
133_H	150_E	0.892	0.79
344_I	347_E	0.878	0.78
158_N	164_Q	0.877	0.78
172_V	204_D	0.876	0.78
171_L	349_V	0.875	0.78
134_P	150_E	0.873	0.78
119_I	122_Q	0.871	0.78
42_E	67_A	0.866	0.77
188_T	244_A	0.866	0.77
238_N	263_V	0.862	0.77
183_I	191_I	0.859	0.77
233_L	330_T	0.856	0.76
309_V	328_V	0.855	0.76
191_I	223_V	0.855	0.76
41_Y	53_L	0.855	0.76
36_L	39_A	0.851	0.76
141_R	293_Y	0.849	0.76
233_L	295_M	0.843	0.75
274_A	309_V	0.841	0.75
191_I	277_L	0.837	0.75
106_P	266_G	0.834	0.75
107_E	266_G	0.834	0.75
243_A	332_M	0.834	0.75
218_P	277_L	0.829	0.74
180_T	194_R	0.824	0.74
69_D	73_Y	0.822	0.73
244_A	254_S	0.821	0.73
165_S	169_S	0.821	0.73
69_D	72_D	0.818	0.73
178_A	343_E	0.817	0.73
152_F	156_A	0.816	0.73
184_V	190_D	0.816	0.73
341_F	346_G	0.813	0.73
317_V	321_C	0.813	0.73
162_A	165_S	0.811	0.72
107_E	111_A	0.811	0.72
4_R	154_Y	0.808	0.72
197_G	219_V	0.805	0.72
306_H	329_H	0.803	0.72
34_E	38_V	0.803	0.72
170_Q	174_I	0.795	0.71
79_E	116_H	0.793	0.71
188_T	228_Y	0.792	0.71
305_V	350_Q	0.792	0.71
79_E	82_A	0.789	0.70
240_I	264_L	0.786	0.70
61_T	101_T	0.782	0.70
279_E	306_H	0.781	0.70
132_T	135_T	0.780	0.69
11_V	158_N	0.778	0.69
183_I	193_M	0.778	0.69
30_S	33_A	0.777	0.69
162_A	166_E	0.777	0.69
4_R	160_D	0.771	0.69
12_L	130_I	0.771	0.69
203_D	206_D	0.770	0.68
40_L	92_I	0.769	0.68
4_R	151_E	0.769	0.68
262_D	266_G	0.769	0.68
279_E	329_H	0.769	0.68
160_D	270_T	0.767	0.68
311_G	314_D	0.766	0.68
183_I	280_L	0.766	0.68
97_N	140_Q	0.766	0.68
169_S	202_N	0.764	0.68
169_S	205_G	0.764	0.68
181_V	195_V	0.762	0.68
173_E	176_D	0.761	0.68
33_A	133_H	0.759	0.67
281_G	284_M	0.758	0.67
171_L	356_V	0.754	0.67
157_V	297_F	0.754	0.67
184_V	192_T	0.753	0.67
24_M	52_S	0.753	0.67
17_A	129_V	0.752	0.67
17_A	88_V	0.751	0.67
240_I	267_I	0.748	0.66
95_G	132_T	0.748	0.66
113_S	236_Q	0.746	0.66
254_S	261_E	0.744	0.66
299_E	306_H	0.743	0.66
42_E	66_R	0.742	0.66
186_G	305_V	0.739	0.65
251_D	272_A	0.738	0.65
183_I	339_D	0.738	0.65
148_A	151_E	0.737	0.65
275_R	309_V	0.736	0.65
187_D	336_M	0.736	0.65
165_S	172_V	0.736	0.65
151_E	160_D	0.734	0.65
292_T	301_M	0.732	0.65
168_Q	214_V	0.730	0.64
340_S	344_I	0.726	0.64
224_A	248_E	0.725	0.64
28_R	89_V	0.725	0.64
54_S	79_E	0.718	0.63
52_S	82_A	0.717	0.63
110_Q	266_G	0.716	0.63
21_R	48_G	0.715	0.63
215_F	315_E	0.710	0.62
3_T	7_R	0.709	0.62
172_V	176_D	0.709	0.62
284_M	289_D	0.708	0.62
28_R	91_L	0.705	0.62
68_M	108_M	0.704	0.62
252_V	255_F	0.703	0.61
273_G	326_S	0.701	0.61
8_H	131_T	0.698	0.61
14_D	43_A	0.695	0.61
243_A	264_L	0.693	0.60
35_A	59_R	0.691	0.60
186_G	334_V	0.690	0.60
79_E	83_M	0.690	0.60
242_G	259_Q	0.690	0.60
308_A	329_H	0.690	0.60
228_Y	242_G	0.689	0.60
152_F	291_F	0.689	0.60
187_D	230_D	0.687	0.60
130_I	217_A	0.687	0.60
65_A	101_T	0.685	0.59
223_V	307_L	0.683	0.59
172_V	206_D	0.682	0.59
172_V	203_D	0.682	0.59
195_V	349_V	0.680	0.59
213_E	218_P	0.680	0.59
103_D	148_A	0.680	0.59
299_E	329_H	0.678	0.59
193_M	280_L	0.677	0.59
175_L	214_V	0.676	0.58
321_C	325_D	0.673	0.58
118_P	122_Q	0.673	0.58
109_S	236_Q	0.672	0.58
42_E	59_R	0.671	0.58
194_R	224_A	0.671	0.58
17_A	25_V	0.670	0.58
343_E	346_G	0.669	0.58
27_I	163_A	0.664	0.57
308_A	331_D	0.662	0.57
117_K	122_Q	0.662	0.57
213_E	306_H	0.661	0.57
5_V	39_A	0.658	0.56
284_M	337_S	0.657	0.56
80_L	123_R	0.656	0.56
160_D	209_M	0.655	0.56
208_N	296_L	0.655	0.56
199_R	216_T	0.654	0.56
279_E	299_E	0.654	0.56
235_R	328_V	0.653	0.56
213_E	329_H	0.653	0.56
212_G	300_K	0.651	0.56
155_D	249_D	0.650	0.55
241_R	258_E	0.648	0.55
63_A	67_A	0.647	0.55
88_V	127_R	0.640	0.54
267_I	270_T	0.638	0.54
29_A	33_A	0.637	0.54
24_M	87_D	0.635	0.54
150_E	154_Y	0.635	0.54
306_H	331_D	0.634	0.54
206_D	209_M	0.629	0.53
126_T	129_V	0.628	0.53
24_M	85_E	0.628	0.53
350_Q	354_T	0.627	0.53
75_T	115_A	0.625	0.53
75_T	79_E	0.625	0.53
80_L	122_Q	0.625	0.53
348_I	352_N	0.625	0.53
88_V	316_C	0.623	0.52
213_E	299_E	0.620	0.52
343_E	348_I	0.619	0.52
61_T	112_G	0.619	0.52
101_T	104_V	0.618	0.52
28_R	56_S	0.618	0.52
146_T	150_E	0.618	0.52
312_A	325_D	0.614	0.51
320_D	344_I	0.613	0.51
96_P	234_M	0.613	0.51
289_D	337_S	0.612	0.51
29_A	92_I	0.609	0.51
37_V	55_W	0.609	0.51
3_T	137_A	0.609	0.51
33_A	95_G	0.608	0.51
245_L	332_M	0.607	0.50
169_S	203_D	0.607	0.50
259_Q	262_D	0.607	0.50
178_A	349_V	0.606	0.50
174_I	347_E	0.605	0.50
97_N	141_R	0.603	0.50
104_V	109_S	0.603	0.50
174_I	177_P	0.602	0.50
221_D	276_R	0.601	0.50
312_A	321_C	0.599	0.50
198_M	317_V	0.596	0.49
221_D	319_E	0.595	0.49
236_Q	328_V	0.593	0.49
218_P	306_H	0.590	0.49
56_S	60_A	0.590	0.49
235_R	267_I	0.589	0.48
213_E	279_E	0.588	0.48
156_A	297_F	0.586	0.48
229_F	274_A	0.586	0.48
19_V	49_A	0.585	0.48
12_L	36_L	0.584	0.48
292_T	335_D	0.584	0.48
242_G	265_A	0.583	0.48
44_L	88_V	0.582	0.48
283_G	286_R	0.582	0.48
215_F	319_E	0.580	0.47
35_A	39_A	0.579	0.47
298_D	301_M	0.579	0.47
246_T	256_S	0.578	0.47
142_A	149_Y	0.577	0.47
72_D	159_K	0.576	0.47
132_T	138_G	0.575	0.47
193_M	222_S	0.574	0.47
233_L	332_M	0.574	0.47
84_E	122_Q	0.574	0.47
295_M	332_M	0.574	0.47
255_F	275_R	0.572	0.46
284_M	354_T	0.571	0.46
221_D	249_D	0.571	0.46
179_E	219_V	0.568	0.46
50_R	72_D	0.567	0.46
98_A	141_R	0.567	0.46
4_R	159_K	0.565	0.46
78_H	88_V	0.564	0.46
184_V	342_I	0.562	0.45
349_V	356_V	0.561	0.45
5_V	8_H	0.561	0.45
299_E	331_D	0.561	0.45
52_S	78_H	0.558	0.45
32_Q	37_V	0.557	0.45
281_G	305_V	0.556	0.45
144_M	147_A	0.556	0.45
65_A	106_P	0.555	0.44
93_G	130_I	0.553	0.44
130_I	207_H	0.551	0.44
134_P	154_Y	0.550	0.44
113_S	207_H	0.548	0.44
11_V	43_A	0.548	0.44
79_E	86_T	0.548	0.44
337_S	352_N	0.548	0.44
177_P	182_H	0.546	0.43
13_V	43_A	0.546	0.43
235_R	330_T	0.545	0.43
223_V	234_M	0.545	0.43
237_G	298_D	0.545	0.43
51_P	183_I	0.543	0.43
90_F	130_I	0.542	0.43
183_I	334_V	0.542	0.43
111_A	148_A	0.541	0.43
138_G	149_Y	0.541	0.43
250_G	310_G	0.539	0.43
268_L	277_L	0.538	0.43
184_V	351_R	0.538	0.43
163_A	167_F	0.537	0.42
80_L	90_F	0.536	0.42
70_E	107_E	0.536	0.42
36_L	92_I	0.535	0.42
179_E	342_I	0.535	0.42
312_A	315_E	0.534	0.42
189_T	296_L	0.533	0.42
99_F	102_S	0.533	0.42
157_V	160_D	0.532	0.42
154_Y	157_V	0.531	0.42
101_T	108_M	0.531	0.42
93_G	96_P	0.530	0.42
244_A	261_E	0.530	0.42
151_E	155_D	0.528	0.41
157_V	217_A	0.528	0.41
121_E	325_D	0.527	0.41
26_T	89_V	0.526	0.41
341_F	344_I	0.526	0.41
295_M	333_I	0.524	0.41
76_K	114_R	0.524	0.41
22_G	71_A	0.523	0.41
54_S	60_A	0.523	0.41
16_C	209_M	0.523	0.41
262_D	265_A	0.521	0.41
227_V	305_V	0.521	0.41
223_V	247_F	0.520	0.41
230_D	304_T	0.519	0.40
110_Q	263_V	0.518	0.40
19_V	23_D	0.518	0.40
187_D	355_F	0.517	0.40
95_G	138_G	0.517	0.40
202_N	315_E	0.517	0.40
196_D	199_R	0.517	0.40
82_A	85_E	0.517	0.40
207_H	313_I	0.516	0.40
282_I	305_V	0.516	0.40
187_D	226_E	0.516	0.40
196_D	217_A	0.516	0.40
45_G	51_P	0.515	0.40
276_R	341_F	0.515	0.40
246_T	249_D	0.515	0.40
265_A	268_L	0.514	0.40
33_A	37_V	0.514	0.40
267_I	328_V	0.513	0.40
36_L	245_L	0.512	0.40
147_A	151_E	0.512	0.40
95_G	137_A	0.512	0.40
350_Q	355_F	0.510	0.39
112_G	115_A	0.510	0.39
71_A	151_E	0.510	0.39
186_G	228_Y	0.505	0.39
6_R	338_E	0.504	0.39
227_V	349_V	0.504	0.39
27_I	202_N	0.504	0.39
304_T	309_V	0.503	0.39
201_C	300_K	0.503	0.39
75_T	89_V	0.502	0.39
228_Y	241_R	0.500	0.38
4_R	155_D	0.500	0.38
11_V	209_M	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ayiA	2	0.9642	100	0.233	Contact Map
4icsA	2	0.9725	100	0.239	Contact Map
1zjcA	2	0.978	100	0.245	Contact Map
3shoA	4	0.3333	55	0.968	Contact Map
3lygA	2	0.3168	49	0.969	Contact Map
4ivnA	2	0.3333	32.8	0.972	Contact Map
1jeoA	4	0.3113	28.9	0.972	Contact Map
3cvjA	2	0.3554	25	0.973	Contact Map
1m3sA	4	0.3113	22.9	0.974	Contact Map
1vimA	4	0.3196	22.4	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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