GREMLIN Database
Q9HSK2 - Uncharacterized protein
UniProt: Q9HSK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (384)
Sequences: 767 (559)
Seq/√Len: 28.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_I150_E3.8511.00
27_R164_A3.5771.00
287_A327_T3.5011.00
31_Q34_R3.3191.00
213_I264_L3.1561.00
334_R339_E3.1541.00
63_L207_V3.1301.00
24_L95_C3.0901.00
99_L102_V3.0761.00
317_R336_R2.9641.00
69_E90_Q2.8411.00
67_V207_V2.8001.00
160_E164_A2.7951.00
10_V218_Q2.7641.00
264_L269_T2.6801.00
99_L157_V2.6521.00
64_A93_L2.5920.99
105_P111_G2.5900.99
65_K94_E2.5890.99
419_E427_P2.5610.99
43_T52_T2.5130.99
9_P48_G2.3940.99
231_R271_H2.3900.99
34_R54_F2.3680.99
20_L94_E2.3640.99
403_V406_H2.3590.99
392_R396_R2.3260.99
42_T274_S2.3100.99
104_H150_E2.1670.98
100_H208_D2.1560.98
27_R30_F2.1510.98
374_A377_A2.1230.98
158_C176_C2.1120.98
119_A149_H2.1050.97
311_T317_R2.0560.97
395_P399_D2.0130.97
250_A253_T2.0110.97
171_D174_A1.9900.96
109_H208_D1.9560.96
5_Q13_Y1.8850.95
9_P218_Q1.8800.95
415_V423_L1.8770.95
399_D402_G1.8720.95
102_V157_V1.8440.95
101_D208_D1.8350.94
154_C157_V1.8270.94
28_K160_E1.8270.94
150_E153_G1.7990.94
61_Y94_E1.7910.94
162_A166_T1.7690.93
330_T334_R1.7130.92
69_E87_D1.7070.92
153_G157_V1.6800.91
10_V222_A1.6730.91
35_H308_D1.6720.91
54_F231_R1.6290.90
151_L180_L1.6240.90
206_D209_R1.6150.89
239_H245_A1.6060.89
306_G322_D1.6040.89
60_V207_V1.5860.89
110_L274_S1.5520.87
424_E428_I1.5460.87
173_H333_E1.5300.87
109_H150_E1.5240.86
171_D179_I1.5160.86
116_D298_T1.5090.86
100_H149_H1.5040.86
264_L268_V1.5010.86
38_Q51_H1.4930.85
205_I227_F1.4910.85
311_T316_L1.4830.85
421_Q424_E1.4630.84
60_V97_A1.4600.84
93_L197_A1.4530.84
324_P329_A1.4510.84
44_L277_A1.4450.83
4_T21_V1.4340.83
6_L47_P1.4340.83
150_E208_D1.4310.83
105_P269_T1.4210.82
104_H149_H1.4170.82
402_G405_V1.4100.82
151_L155_L1.4080.82
45_V93_L1.4080.82
161_F306_G1.4070.82
58_L414_Y1.4050.82
201_L340_F1.4020.81
7_K13_Y1.3990.81
320_A325_D1.3970.81
64_A207_V1.3930.81
160_E165_I1.3870.81
393_L396_R1.3790.80
284_L335_F1.3750.80
152_F304_D1.3710.80
154_C180_L1.3620.79
284_L332_Y1.3590.79
291_M324_P1.3550.79
351_Y358_G1.3450.79
6_L16_L1.3410.78
12_G230_A1.3330.78
40_S108_S1.3300.78
205_I257_Y1.3220.77
260_G264_L1.3220.77
149_H208_D1.3200.77
153_G156_F1.3200.77
23_G167_A1.3190.77
109_H149_H1.3160.77
11_H210_L1.3070.77
53_R56_H1.3050.76
214_T229_T1.2950.76
64_A97_A1.2920.76
100_H104_H1.2830.75
176_C179_I1.2810.75
155_L159_R1.2740.75
276_F414_Y1.2640.74
322_D329_A1.2580.74
29_P159_R1.2560.74
159_R163_D1.2530.73
276_F280_L1.2530.73
104_H208_D1.2480.73
40_S278_H1.2310.72
246_L254_I1.2250.72
50_N235_S1.2190.71
104_H109_H1.2160.71
31_Q54_F1.2160.71
101_D109_H1.2140.71
58_L175_V1.2130.71
11_H271_H1.2110.71
112_E255_G1.2050.70
355_V358_G1.2030.70
227_F258_L1.2000.70
20_L95_C1.1850.69
16_L57_S1.1850.69
30_F98_L1.1750.68
28_K337_S1.1670.68
29_P163_D1.1660.68
31_Q51_H1.1600.67
36_V227_F1.1590.67
396_R399_D1.1520.67
236_Y246_L1.1490.67
213_I260_G1.1470.67
262_I266_M1.1460.66
75_P79_Q1.1450.66
70_N233_V1.1370.66
8_D11_H1.1330.66
47_P50_N1.1320.66
56_H101_D1.1310.65
231_R338_R1.1280.65
46_Y219_M1.1230.65
20_L61_Y1.1230.65
101_D149_H1.1170.64
53_R59_G1.1160.64
390_A395_P1.1150.64
45_V54_F1.1140.64
26_D271_H1.1130.64
66_T230_A1.1110.64
181_G309_D1.1110.64
25_I30_F1.0980.63
106_P413_S1.0970.63
248_D377_A1.0930.63
421_Q425_D1.0910.63
15_E234_A1.0900.63
420_P424_E1.0870.62
51_H216_D1.0850.62
108_S212_Y1.0790.62
401_L404_P1.0750.61
316_L328_L1.0720.61
156_F159_R1.0680.61
287_A325_D1.0670.61
100_H150_E1.0660.61
413_S423_L1.0650.61
104_H212_Y1.0650.61
325_D328_L1.0580.60
311_T315_R1.0550.60
392_R395_P1.0520.60
39_L220_T1.0520.60
392_R399_D1.0460.59
20_L57_S1.0460.59
206_D212_Y1.0450.59
213_I268_V1.0440.59
100_H109_H1.0360.59
40_S206_D1.0360.59
227_F265_Y1.0310.58
338_R342_E1.0300.58
56_H100_H1.0290.58
173_H177_A1.0250.58
19_A23_G1.0230.58
395_P405_V1.0140.57
216_D269_T1.0120.57
47_P55_E1.0070.56
62_H65_K1.0060.56
289_A295_P1.0010.56
312_I316_L1.0000.56
105_P304_D0.9980.56
69_E74_Q0.9970.56
67_V236_Y0.9910.55
420_P427_P0.9900.55
33_L38_Q0.9870.55
149_H153_G0.9850.55
40_S212_Y0.9830.54
379_I382_F0.9810.54
68_F90_Q0.9780.54
109_H261_R0.9780.54
327_T330_T0.9780.54
7_K46_Y0.9760.54
381_A384_D0.9740.54
422_A426_I0.9720.54
285_L334_R0.9680.53
80_D84_T0.9620.53
314_E317_R0.9600.53
273_K342_E0.9590.53
9_P219_M0.9590.53
56_H208_D0.9580.53
25_I54_F0.9540.52
94_E97_A0.9510.52
109_H212_Y0.9490.52
389_N414_Y0.9490.52
64_A200_I0.9490.52
31_Q107_F0.9480.52
321_R336_R0.9480.52
58_L254_I0.9460.52
60_V205_I0.9450.52
29_P40_S0.9390.51
48_G219_M0.9370.51
63_L387_T0.9370.51
417_E420_P0.9360.51
399_D405_V0.9350.51
220_T268_V0.9350.51
46_Y277_A0.9300.50
357_V360_T0.9270.50
420_P423_L0.9250.50
56_H59_G0.9250.50
271_H342_E0.9210.50
207_V232_M0.9210.50
91_R171_D0.9170.49
423_L427_P0.9140.49
403_V408_V0.9110.49
354_R361_T0.9110.49
367_P375_T0.9110.49
80_D83_T0.9080.49
243_G390_A0.9080.49
204_P369_D0.9060.49
110_L278_H0.9040.48
271_H338_R0.9020.48
52_T102_V0.9020.48
177_A198_A0.9010.48
62_H66_T0.9010.48
224_V264_L0.9010.48
54_F271_H0.9000.48
277_A340_F0.8980.48
104_H216_D0.8960.48
149_H212_Y0.8960.48
82_T85_E0.8960.48
79_Q83_T0.8940.48
98_L103_G0.8920.47
52_T97_A0.8890.47
107_F221_G0.8850.47
419_E422_A0.8840.47
17_D94_E0.8830.47
174_A312_I0.8820.47
399_D404_P0.8810.47
16_L30_F0.8770.46
59_G215_R0.8730.46
53_R211_D0.8720.46
170_V296_P0.8680.46
368_A371_P0.8670.46
266_M308_D0.8650.45
28_K302_V0.8640.45
45_V274_S0.8590.45
221_G228_D0.8570.45
11_H227_F0.8560.45
297_I307_I0.8520.44
26_D34_R0.8500.44
16_L58_L0.8480.44
280_L328_L0.8470.44
211_D215_R0.8440.44
69_E86_L0.8400.43
112_E259_E0.8400.43
394_E399_D0.8400.43
115_L281_L0.8400.43
61_Y272_H0.8390.43
69_E205_I0.8390.43
179_I206_D0.8390.43
103_G216_D0.8340.43
26_D338_R0.8310.43
175_V181_G0.8310.43
209_R258_L0.8310.43
421_Q427_P0.8290.43
388_G391_D0.8270.42
120_I123_R0.8260.42
102_V370_D0.8230.42
69_E73_T0.8210.42
17_D20_L0.8200.42
328_L331_L0.8180.42
24_L99_L0.8170.42
293_D302_V0.8150.42
25_I34_R0.8140.42
197_A201_L0.8110.41
235_S250_A0.8110.41
33_L309_D0.8090.41
108_S308_D0.8070.41
123_R153_G0.8040.41
101_D212_Y0.8030.41
284_L340_F0.8000.40
70_N74_Q0.7990.40
38_Q208_D0.7980.40
32_R59_G0.7960.40
390_A393_L0.7960.40
8_D33_L0.7930.40
103_G108_S0.7920.40
61_Y65_K0.7910.40
79_Q84_T0.7910.40
196_V209_R0.7840.39
280_L335_F0.7830.39
33_L57_S0.7820.39
50_N55_E0.7800.39
6_L25_I0.7790.39
112_E165_I0.7780.39
47_P97_A0.7770.39
245_A332_Y0.7770.39
265_Y304_D0.7760.39
222_A225_L0.7760.39
280_L284_L0.7750.39
8_D32_R0.7730.38
180_L191_R0.7730.38
40_S106_P0.7710.38
284_L343_T0.7680.38
201_L382_F0.7680.38
5_Q15_E0.7660.38
273_K312_I0.7640.38
418_Y427_P0.7630.38
208_D212_Y0.7620.38
58_L63_L0.7610.38
53_R109_H0.7590.37
111_G269_T0.7570.37
358_G361_T0.7530.37
369_D373_R0.7530.37
118_S413_S0.7530.37
63_L174_A0.7520.37
38_Q216_D0.7520.37
312_I342_E0.7520.37
395_P404_P0.7510.37
256_N263_A0.7490.37
280_L340_F0.7490.37
97_A283_E0.7470.37
4_T274_S0.7450.36
154_C159_R0.7440.36
196_V199_Q0.7430.36
287_A328_L0.7410.36
220_T264_L0.7410.36
34_R51_H0.7390.36
51_H268_V0.7380.36
46_Y419_E0.7360.36
119_A286_A0.7350.36
16_L25_I0.7330.36
211_D216_D0.7320.36
79_Q82_T0.7310.35
161_F164_A0.7290.35
231_R250_A0.7280.35
223_D230_A0.7270.35
6_L281_L0.7250.35
120_I149_H0.7250.35
38_Q56_H0.7250.35
167_A387_T0.7230.35
12_G226_S0.7230.35
32_R56_H0.7220.35
13_Y235_S0.7220.35
102_V156_F0.7220.35
112_E272_H0.7190.35
333_E337_S0.7170.34
196_V284_L0.7160.34
26_D31_Q0.7140.34
210_L250_A0.7140.34
212_Y216_D0.7130.34
225_L255_G0.7120.34
331_L373_R0.7070.34
38_Q101_D0.7070.34
216_D271_H0.7070.34
21_V46_Y0.7060.34
7_K41_A0.7050.34
400_A405_V0.7050.34
257_Y272_H0.7030.33
218_Q233_V0.7030.33
242_E398_A0.7030.33
280_L341_P0.7000.33
29_P201_L0.7000.33
33_L37_R0.7000.33
296_P322_D0.6990.33
87_D194_H0.6990.33
152_F155_L0.6970.33
386_L391_D0.6950.33
112_E116_D0.6940.33
55_E219_M0.6940.33
205_I246_L0.6940.33
399_D414_Y0.6930.33
393_L397_L0.6910.33
45_V271_H0.6900.33
405_V408_V0.6890.33
53_R101_D0.6880.32
14_I75_P0.6880.32
53_R215_R0.6860.32
300_D303_L0.6840.32
41_A281_L0.6840.32
56_H211_D0.6830.32
339_E360_T0.6820.32
38_Q104_H0.6820.32
105_P207_V0.6810.32
419_E425_D0.6770.32
375_T381_A0.6770.32
313_L317_R0.6770.32
51_H271_H0.6760.32
10_V245_A0.6740.32
57_S94_E0.6690.31
93_L200_I0.6680.31
38_Q212_Y0.6650.31
355_V359_D0.6610.31
279_A285_L0.6610.31
30_F237_T0.6600.31
199_Q375_T0.6600.31
346_K412_H0.6580.30
29_P164_A0.6560.30
6_L10_V0.6530.30
90_Q171_D0.6530.30
28_K164_A0.6520.30
6_L95_C0.6510.30
100_H212_Y0.6490.30
17_D26_D0.6480.30
46_Y260_G0.6470.30
108_S216_D0.6460.30
57_S221_G0.6450.30
29_P382_F0.6430.29
28_K322_D0.6430.29
106_P314_E0.6410.29
76_Y79_Q0.6390.29
369_D379_I0.6390.29
294_T352_A0.6390.29
398_A401_L0.6360.29
5_Q234_A0.6350.29
38_Q46_Y0.6340.29
96_A103_G0.6330.29
6_L21_V0.6310.29
112_E152_F0.6300.29
293_D296_P0.6290.29
150_E212_Y0.6280.29
11_H414_Y0.6270.28
28_K313_L0.6250.28
101_D150_E0.6240.28
231_R235_S0.6220.28
253_T331_L0.6200.28
262_I267_W0.6170.28
367_P371_P0.6160.28
422_A425_D0.6150.28
333_E352_A0.6150.28
298_T313_L0.6150.28
52_T379_I0.6150.28
333_E339_E0.6130.28
259_E263_A0.6120.28
36_V43_T0.6100.27
32_R53_R0.6090.27
419_E428_I0.6090.27
334_R341_P0.6080.27
24_L165_I0.6070.27
39_L42_T0.6070.27
41_A278_H0.6060.27
161_F359_D0.6010.27
255_G259_E0.6010.27
321_R337_S0.6000.27
335_F338_R0.5990.27
6_L414_Y0.5980.27
302_V324_P0.5970.27
66_T69_E0.5930.26
79_Q85_E0.5910.26
7_K14_I0.5900.26
72_R87_D0.5880.26
68_F107_F0.5870.26
331_L361_T0.5870.26
166_T169_D0.5870.26
369_D381_A0.5870.26
7_K274_S0.5860.26
222_A268_V0.5860.26
39_L205_I0.5850.26
284_L331_L0.5830.26
108_S278_H0.5830.26
268_V305_R0.5830.26
379_I385_W0.5820.26
213_I217_N0.5810.26
16_L19_A0.5810.26
44_L233_V0.5800.26
7_K217_N0.5800.26
104_H108_S0.5800.26
38_Q100_H0.5780.25
29_P237_T0.5760.25
91_R268_V0.5750.25
351_Y359_D0.5730.25
228_D250_A0.5720.25
57_S335_F0.5700.25
37_R177_A0.5670.25
56_H109_H0.5640.25
160_E163_D0.5640.25
422_A427_P0.5630.25
38_Q103_G0.5630.25
82_T358_G0.5620.25
382_F388_G0.5560.24
167_A331_L0.5560.24
46_Y410_I0.5540.24
174_A192_W0.5530.24
400_A403_V0.5530.24
236_Y313_L0.5530.24
23_G180_L0.5530.24
330_T418_Y0.5520.24
99_L209_R0.5520.24
58_L358_G0.5510.24
8_D14_I0.5510.24
26_D51_H0.5500.24
12_G277_A0.5480.24
35_H202_H0.5480.24
102_V116_D0.5470.24
247_S309_D0.5450.24
66_T113_R0.5450.24
421_Q428_I0.5440.24
255_G368_A0.5420.23
38_Q268_V0.5420.23
209_R212_Y0.5410.23
161_F354_R0.5400.23
49_A280_L0.5370.23
68_F285_L0.5360.23
57_S209_R0.5350.23
28_K102_V0.5350.23
397_L404_P0.5340.23
252_S266_M0.5330.23
161_F165_I0.5320.23
90_Q95_C0.5310.23
423_L426_I0.5310.23
59_G211_D0.5290.23
322_D326_S0.5290.23
108_S209_R0.5290.23
325_D331_L0.5290.23
55_E232_M0.5270.23
227_F267_W0.5270.23
117_R286_A0.5260.23
399_D403_V0.5230.22
158_C332_Y0.5230.22
68_F72_R0.5230.22
53_R100_H0.5230.22
259_E401_L0.5220.22
17_D207_V0.5210.22
201_L259_E0.5210.22
252_S262_I0.5210.22
389_N396_R0.5200.22
81_A84_T0.5170.22
53_R208_D0.5170.22
313_L344_C0.5170.22
29_P94_E0.5170.22
11_H214_T0.5160.22
26_D200_I0.5150.22
284_L328_L0.5140.22
201_L330_T0.5130.22
210_L217_N0.5120.22
178_H218_Q0.5110.22
210_L275_V0.5100.22
326_S398_A0.5100.22
10_V322_D0.5100.22
56_H215_R0.5090.22
263_A267_W0.5090.22
265_Y270_Q0.5080.22
267_W308_D0.5080.22
109_H211_D0.5080.22
26_D375_T0.5070.22
388_G392_R0.5060.21
412_H415_V0.5060.21
34_R38_Q0.5050.21
313_L335_F0.5050.21
375_T403_V0.5030.21
247_S343_T0.5000.21
203_S210_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz7A 4 0.8956 100 0.277 Contact Map
4lrlA 4 0.8246 100 0.377 Contact Map
2q14A 4 0.762 100 0.418 Contact Map
2hekA 4 0.7537 100 0.42 Contact Map
2pgsA 4 0.618 100 0.761 Contact Map
3bg2A 4 0.6221 100 0.763 Contact Map
2dqbA 4 0.595 100 0.773 Contact Map
4x9eA 4 0.6868 100 0.779 Contact Map
3gw7A 2 0.4175 98.4 0.925 Contact Map
2pq7A 2 0.3549 98.3 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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