Q9HSK1 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HSK1 - Uncharacterized protein

UniProt:	Q9HSK1	Sequences: MDCTKCDRDAVMHAAYSGAHLCEPHFLDSVERRVRRRIRTDNMLSPDTTPDDPETWVIGLSGGKDSAVLTDLIEETFRDDPRVELIALTIHEGIAGYRDESLDACTTLAADRDIRHELVTYREEFDVAMDDVADDDPLDMAPCAYCGVFRRDLLAKYADEYDADKLLTGHNLDDEAETALMNILEGNVTQIATHFDASLGSFDDRAELDAMIPRAKPLRDIPEKEVALYAQLRDLPVHMAECPHASESFRSDLQEVLLELEDRRPGTRHSIMAGYEELAGIAADEYNTDDADVGECSDCGAPTTRDRCRKCTLVDAVTSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	320 (249)
Sequences:	2366 (1758)
Seq/√Len:	111.4

ECOLI - TTCA TILS
BACSU - TILS
HALSA - Q9HSK1
SULSO - Q7LXT2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
55_T	84_E	3.693	1.00
67_A	108_L	3.096	1.00
68_V	230_A	3.084	1.00
34_V	72_L	2.947	1.00
54_E	165_K	2.868	1.00
261_E	268_R	2.711	1.00
33_R	225_E	2.672	1.00
176_A	271_I	2.561	1.00
91_H	99_D	2.534	1.00
223_E	227_A	2.460	1.00
55_T	86_I	2.443	1.00
88_L	153_L	2.422	1.00
86_I	117_E	2.415	1.00
86_I	163_A	2.400	1.00
91_H	102_L	2.326	1.00
87_A	114_I	2.319	1.00
167_L	215_A	2.298	1.00
173_D	268_R	2.285	1.00
54_E	164_D	2.253	1.00
103_D	106_T	2.252	1.00
246_S	255_E	2.177	1.00
60_L	105_C	2.119	1.00
179_A	275_Y	2.099	1.00
56_W	167_L	2.089	1.00
122_R	131_D	2.070	1.00
44_L	215_A	2.047	1.00
102_L	106_T	2.019	1.00
94_I	130_D	2.001	1.00
43_M	198_S	1.939	1.00
108_L	112_R	1.912	1.00
143_C	242_C	1.907	1.00
74_E	77_F	1.857	1.00
57_V	163_A	1.855	1.00
64_K	230_A	1.841	1.00
101_S	238_H	1.835	1.00
31_E	75_E	1.832	1.00
58_I	73_I	1.779	1.00
179_A	271_I	1.751	1.00
119_V	156_K	1.748	1.00
288_T	291_A	1.710	1.00
94_I	142_P	1.708	1.00
274_G	278_L	1.695	1.00
87_A	109_A	1.677	1.00
71_D	75_E	1.671	1.00
106_T	110_A	1.663	1.00
71_D	233_R	1.656	1.00
72_L	76_T	1.647	1.00
58_I	69_L	1.624	1.00
70_T	87_A	1.600	1.00
37_R	220_D	1.588	1.00
67_A	235_L	1.580	1.00
156_K	160_E	1.578	1.00
181_M	249_F	1.568	1.00
107_T	111_D	1.550	1.00
171_N	226_V	1.540	1.00
71_D	229_Y	1.532	1.00
30_V	72_L	1.520	1.00
175_E	195_F	1.506	1.00
157_Y	161_Y	1.492	1.00
59_G	154_L	1.491	1.00
91_H	98_R	1.491	1.00
34_V	221_I	1.483	1.00
158_A	166_L	1.468	1.00
30_V	221_I	1.460	1.00
168_T	214_R	1.440	1.00
71_D	235_L	1.435	1.00
64_K	239_M	1.425	1.00
183_I	274_G	1.401	1.00
107_T	110_A	1.367	1.00
259_E	263_R	1.359	1.00
117_E	160_E	1.359	1.00
71_D	112_R	1.350	1.00
96_G	101_S	1.349	1.00
38_I	44_L	1.346	1.00
35_R	80_D	1.327	1.00
57_V	86_I	1.321	1.00
100_E	238_H	1.313	0.99
73_I	167_L	1.304	0.99
239_M	244_H	1.303	0.99
103_D	107_T	1.302	0.99
67_A	237_V	1.297	0.99
60_L	87_A	1.292	0.99
132_V	149_F	1.290	0.99
141_A	144_A	1.285	0.99
252_D	263_R	1.273	0.99
37_R	219_R	1.259	0.99
184_L	260_L	1.258	0.99
60_L	67_A	1.235	0.99
102_L	118_L	1.212	0.99
109_A	116_H	1.205	0.99
68_V	218_L	1.199	0.99
89_T	116_H	1.196	0.99
91_H	120_T	1.193	0.99
270_S	273_A	1.190	0.99
31_E	229_Y	1.188	0.99
72_L	218_L	1.161	0.99
57_V	88_L	1.160	0.99
93_G	120_T	1.136	0.99
89_T	102_L	1.135	0.99
256_V	260_L	1.132	0.98
68_V	226_V	1.131	0.98
88_L	154_L	1.111	0.98
46_P	82_R	1.110	0.98
255_E	259_E	1.110	0.98
151_R	168_T	1.105	0.98
155_A	213_P	1.096	0.98
91_H	241_E	1.095	0.98
57_V	157_Y	1.092	0.98
284_D	288_T	1.090	0.98
117_E	157_Y	1.074	0.98
296_C	299_C	1.069	0.98
230_A	237_V	1.060	0.98
35_R	39_R	1.056	0.98
58_I	70_T	1.053	0.98
117_E	161_Y	1.050	0.98
129_M	149_F	1.044	0.97
179_A	194_H	1.044	0.97
175_E	194_H	1.043	0.97
90_I	121_Y	1.035	0.97
74_E	114_I	1.034	0.97
218_L	221_I	1.033	0.97
38_I	43_M	1.033	0.97
90_I	153_L	1.025	0.97
158_A	212_I	1.010	0.97
249_F	252_D	1.008	0.97
102_L	120_T	1.006	0.97
88_L	157_Y	0.999	0.97
35_R	81_P	0.997	0.97
144_A	148_V	0.991	0.97
99_D	120_T	0.989	0.96
95_A	101_S	0.987	0.96
109_A	114_I	0.985	0.96
59_G	168_T	0.982	0.96
64_K	223_E	0.982	0.96
176_A	179_A	0.978	0.96
45_S	54_E	0.973	0.96
119_V	157_Y	0.963	0.96
198_S	213_P	0.961	0.96
90_I	119_V	0.959	0.96
86_I	161_Y	0.959	0.96
132_V	138_L	0.958	0.96
176_A	275_Y	0.956	0.96
63_G	169_G	0.954	0.96
64_K	68_V	0.953	0.96
152_D	156_K	0.951	0.96
65_D	174_D	0.946	0.95
293_V	297_S	0.940	0.95
129_M	132_V	0.937	0.95
193_T	196_D	0.937	0.95
184_L	256_V	0.929	0.95
92_E	150_R	0.926	0.95
228_L	232_L	0.922	0.95
150_R	250_R	0.921	0.95
75_E	233_R	0.913	0.94
224_K	261_E	0.911	0.94
64_K	237_V	0.909	0.94
44_L	165_K	0.907	0.94
277_E	281_I	0.906	0.94
173_D	223_E	0.899	0.94
44_L	56_W	0.895	0.94
168_T	195_F	0.895	0.94
33_R	221_I	0.892	0.94
177_E	250_R	0.892	0.94
172_L	268_R	0.892	0.94
172_L	272_M	0.891	0.94
175_E	182_N	0.891	0.94
266_G	270_S	0.886	0.94
44_L	83_V	0.884	0.93
46_P	80_D	0.884	0.93
72_L	221_I	0.878	0.93
157_Y	160_E	0.876	0.93
170_H	178_T	0.875	0.93
143_C	146_C	0.872	0.93
154_L	158_A	0.865	0.93
261_E	266_G	0.861	0.93
178_T	250_R	0.854	0.92
176_A	272_M	0.849	0.92
31_E	35_R	0.844	0.92
42_N	45_S	0.843	0.92
175_E	219_R	0.842	0.92
104_A	238_H	0.838	0.92
57_V	117_E	0.837	0.91
74_E	112_R	0.829	0.91
267_T	270_S	0.825	0.91
176_A	268_R	0.824	0.91
257_L	267_T	0.814	0.90
290_D	294_G	0.811	0.90
121_Y	149_F	0.811	0.90
104_A	237_V	0.804	0.90
33_R	220_D	0.799	0.89
129_M	133_A	0.797	0.89
142_P	248_S	0.795	0.89
44_L	54_E	0.793	0.89
132_V	145_Y	0.792	0.89
69_L	218_L	0.777	0.88
189_T	278_L	0.776	0.88
143_C	245_A	0.768	0.88
77_F	83_V	0.762	0.87
154_L	166_L	0.759	0.87
36_R	40_T	0.758	0.87
68_V	229_Y	0.755	0.87
190_Q	282_A	0.755	0.87
168_T	171_N	0.751	0.86
70_T	114_I	0.747	0.86
97_Y	241_E	0.746	0.86
192_A	274_G	0.744	0.86
259_E	262_D	0.739	0.86
172_L	222_P	0.739	0.86
223_E	226_V	0.739	0.86
179_A	272_M	0.737	0.85
37_R	197_A	0.736	0.85
165_K	215_A	0.732	0.85
100_E	103_D	0.732	0.85
87_A	116_H	0.728	0.85
98_R	146_C	0.726	0.84
119_V	153_L	0.725	0.84
209_D	212_I	0.725	0.84
173_D	222_P	0.723	0.84
60_L	108_L	0.719	0.84
292_D	296_C	0.718	0.84
106_T	116_H	0.717	0.84
65_D	170_H	0.717	0.84
44_L	81_P	0.716	0.84
105_C	116_H	0.716	0.84
230_A	235_L	0.716	0.84
253_L	256_V	0.710	0.83
132_V	140_M	0.710	0.83
189_T	281_I	0.709	0.83
89_T	101_S	0.703	0.83
174_D	250_R	0.701	0.82
271_I	275_Y	0.701	0.82
171_N	223_E	0.701	0.82
181_M	250_R	0.698	0.82
251_S	254_Q	0.696	0.82
106_T	118_L	0.694	0.82
56_W	83_V	0.694	0.82
43_M	165_K	0.693	0.82
69_L	167_L	0.692	0.82
92_E	147_G	0.692	0.82
34_V	37_R	0.691	0.81
87_A	105_C	0.689	0.81
100_E	241_E	0.682	0.81
230_A	239_M	0.681	0.81
37_R	41_D	0.681	0.81
69_L	73_I	0.679	0.80
184_L	264_R	0.669	0.79
188_V	191_I	0.665	0.79
46_P	81_P	0.664	0.79
155_A	158_A	0.663	0.79
188_V	277_E	0.660	0.78
71_D	74_E	0.658	0.78
80_D	83_V	0.655	0.78
99_D	103_D	0.655	0.78
143_C	147_G	0.655	0.78
140_M	145_Y	0.653	0.78
195_F	219_R	0.653	0.78
94_I	143_C	0.650	0.77
45_S	165_K	0.645	0.77
73_I	85_L	0.644	0.77
92_E	98_R	0.644	0.77
177_E	254_Q	0.643	0.77
242_C	245_A	0.641	0.76
256_V	267_T	0.636	0.76
227_A	239_M	0.636	0.76
143_C	248_S	0.635	0.76
188_V	192_A	0.634	0.76
288_T	292_D	0.634	0.76
252_D	256_V	0.632	0.75
266_G	269_H	0.632	0.75
176_A	180_L	0.631	0.75
44_L	47_D	0.631	0.75
43_M	197_A	0.630	0.75
107_T	236_P	0.629	0.75
58_I	107_T	0.627	0.75
165_K	213_P	0.626	0.75
141_A	145_Y	0.626	0.75
75_E	229_Y	0.622	0.74
61_S	66_S	0.620	0.74
70_T	85_L	0.619	0.74
61_S	169_G	0.616	0.74
260_L	267_T	0.616	0.74
170_H	174_D	0.615	0.73
86_I	115_R	0.614	0.73
64_K	226_V	0.614	0.73
104_A	236_P	0.614	0.73
70_T	109_A	0.605	0.72
222_P	225_E	0.602	0.72
150_R	174_D	0.597	0.71
65_D	250_R	0.594	0.71
181_M	253_L	0.593	0.71
153_L	157_Y	0.593	0.71
240_A	243_P	0.591	0.70
71_D	108_L	0.590	0.70
27_L	233_R	0.588	0.70
96_G	238_H	0.585	0.70
30_V	226_V	0.580	0.69
178_T	181_M	0.579	0.69
92_E	243_P	0.578	0.69
180_L	253_L	0.574	0.68
27_L	31_E	0.574	0.68
57_V	158_A	0.574	0.68
32_R	36_R	0.571	0.68
93_G	121_Y	0.571	0.68
77_F	85_L	0.568	0.67
254_Q	258_L	0.568	0.67
59_G	166_L	0.566	0.67
31_E	71_D	0.565	0.67
150_R	177_E	0.563	0.67
41_D	220_D	0.562	0.67
171_N	174_D	0.561	0.66
92_E	240_A	0.561	0.66
55_T	163_A	0.561	0.66
267_T	271_I	0.561	0.66
291_A	294_G	0.560	0.66
224_K	231_Q	0.560	0.66
149_F	152_D	0.559	0.66
229_Y	235_L	0.559	0.66
289_D	293_V	0.558	0.66
252_D	264_R	0.556	0.66
63_G	66_S	0.552	0.65
155_A	214_R	0.552	0.65
196_D	279_A	0.552	0.65
40_T	220_D	0.551	0.65
229_Y	233_R	0.551	0.65
96_G	99_D	0.551	0.65
148_V	152_D	0.550	0.65
36_R	39_R	0.550	0.65
147_G	242_C	0.549	0.65
99_D	102_L	0.549	0.65
250_R	254_Q	0.546	0.64
168_T	182_N	0.543	0.64
121_Y	153_L	0.543	0.64
104_A	235_L	0.542	0.64
187_N	191_I	0.541	0.64
147_G	174_D	0.540	0.64
30_V	218_L	0.540	0.64
185_E	249_F	0.539	0.63
143_C	151_R	0.538	0.63
84_E	115_R	0.538	0.63
34_V	38_I	0.536	0.63
67_A	105_C	0.535	0.63
155_A	211_M	0.535	0.63
242_C	248_S	0.534	0.63
273_A	277_E	0.534	0.63
174_D	178_T	0.531	0.62
159_D	211_M	0.531	0.62
179_A	183_I	0.530	0.62
224_K	228_L	0.526	0.62
269_H	273_A	0.524	0.61
174_D	254_Q	0.523	0.61
210_A	295_E	0.522	0.61
39_R	81_P	0.521	0.61
38_I	165_K	0.521	0.61
182_N	193_T	0.520	0.61
292_D	295_E	0.520	0.61
182_N	191_I	0.519	0.61
240_A	251_S	0.518	0.60
145_Y	149_F	0.515	0.60
74_E	113_D	0.515	0.60
272_M	276_E	0.514	0.60
188_V	274_G	0.513	0.60
272_M	275_Y	0.513	0.60
184_L	190_Q	0.513	0.60
193_T	279_A	0.511	0.59
45_S	113_D	0.511	0.59
67_A	230_A	0.509	0.59
74_E	85_L	0.507	0.59
58_I	87_A	0.506	0.59
47_D	54_E	0.505	0.58
143_C	243_P	0.504	0.58
270_S	274_G	0.502	0.58
168_T	216_K	0.500	0.58
93_G	241_E	0.500	0.58
264_R	270_S	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3vrhA	2	0.8875	100	0.3	Contact Map
3a2kA	1	0.8375	100	0.359	Contact Map
1wy5A	4	0.8344	100	0.403	Contact Map
1ni5A	2	0.8	100	0.409	Contact Map
2derA	1	0.7562	100	0.651	Contact Map
2hmaA	2	0.7875	99.9	0.666	Contact Map
2dplA	2	0.7	99.9	0.667	Contact Map
2vxoA	2	0.8875	99.9	0.668	Contact Map
3tqiA	3	0.7063	99.9	0.672	Contact Map
4kr6A	2	0.7906	99.9	0.672	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.