GREMLIN Database
Q9HSK1 - Uncharacterized protein
UniProt: Q9HSK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (249)
Sequences: 2366 (1758)
Seq/√Len: 111.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_T84_E3.6931.00
67_A108_L3.0961.00
68_V230_A3.0841.00
34_V72_L2.9471.00
54_E165_K2.8681.00
261_E268_R2.7111.00
33_R225_E2.6721.00
176_A271_I2.5611.00
91_H99_D2.5341.00
223_E227_A2.4601.00
55_T86_I2.4431.00
88_L153_L2.4221.00
86_I117_E2.4151.00
86_I163_A2.4001.00
91_H102_L2.3261.00
87_A114_I2.3191.00
167_L215_A2.2981.00
173_D268_R2.2851.00
54_E164_D2.2531.00
103_D106_T2.2521.00
246_S255_E2.1771.00
60_L105_C2.1191.00
179_A275_Y2.0991.00
56_W167_L2.0891.00
122_R131_D2.0701.00
44_L215_A2.0471.00
102_L106_T2.0191.00
94_I130_D2.0011.00
43_M198_S1.9391.00
108_L112_R1.9121.00
143_C242_C1.9071.00
74_E77_F1.8571.00
57_V163_A1.8551.00
64_K230_A1.8411.00
101_S238_H1.8351.00
31_E75_E1.8321.00
58_I73_I1.7791.00
179_A271_I1.7511.00
119_V156_K1.7481.00
288_T291_A1.7101.00
94_I142_P1.7081.00
274_G278_L1.6951.00
87_A109_A1.6771.00
71_D75_E1.6711.00
106_T110_A1.6631.00
71_D233_R1.6561.00
72_L76_T1.6471.00
58_I69_L1.6241.00
70_T87_A1.6001.00
37_R220_D1.5881.00
67_A235_L1.5801.00
156_K160_E1.5781.00
181_M249_F1.5681.00
107_T111_D1.5501.00
171_N226_V1.5401.00
71_D229_Y1.5321.00
30_V72_L1.5201.00
175_E195_F1.5061.00
157_Y161_Y1.4921.00
59_G154_L1.4911.00
91_H98_R1.4911.00
34_V221_I1.4831.00
158_A166_L1.4681.00
30_V221_I1.4601.00
168_T214_R1.4401.00
71_D235_L1.4351.00
64_K239_M1.4251.00
183_I274_G1.4011.00
107_T110_A1.3671.00
259_E263_R1.3591.00
117_E160_E1.3591.00
71_D112_R1.3501.00
96_G101_S1.3491.00
38_I44_L1.3461.00
35_R80_D1.3271.00
57_V86_I1.3211.00
100_E238_H1.3130.99
73_I167_L1.3040.99
239_M244_H1.3030.99
103_D107_T1.3020.99
67_A237_V1.2970.99
60_L87_A1.2920.99
132_V149_F1.2900.99
141_A144_A1.2850.99
252_D263_R1.2730.99
37_R219_R1.2590.99
184_L260_L1.2580.99
60_L67_A1.2350.99
102_L118_L1.2120.99
109_A116_H1.2050.99
68_V218_L1.1990.99
89_T116_H1.1960.99
91_H120_T1.1930.99
270_S273_A1.1900.99
31_E229_Y1.1880.99
72_L218_L1.1610.99
57_V88_L1.1600.99
93_G120_T1.1360.99
89_T102_L1.1350.99
256_V260_L1.1320.98
68_V226_V1.1310.98
88_L154_L1.1110.98
46_P82_R1.1100.98
255_E259_E1.1100.98
151_R168_T1.1050.98
155_A213_P1.0960.98
91_H241_E1.0950.98
57_V157_Y1.0920.98
284_D288_T1.0900.98
117_E157_Y1.0740.98
296_C299_C1.0690.98
230_A237_V1.0600.98
35_R39_R1.0560.98
58_I70_T1.0530.98
117_E161_Y1.0500.98
129_M149_F1.0440.97
179_A194_H1.0440.97
175_E194_H1.0430.97
90_I121_Y1.0350.97
74_E114_I1.0340.97
218_L221_I1.0330.97
38_I43_M1.0330.97
90_I153_L1.0250.97
158_A212_I1.0100.97
249_F252_D1.0080.97
102_L120_T1.0060.97
88_L157_Y0.9990.97
35_R81_P0.9970.97
144_A148_V0.9910.97
99_D120_T0.9890.96
95_A101_S0.9870.96
109_A114_I0.9850.96
59_G168_T0.9820.96
64_K223_E0.9820.96
176_A179_A0.9780.96
45_S54_E0.9730.96
119_V157_Y0.9630.96
198_S213_P0.9610.96
90_I119_V0.9590.96
86_I161_Y0.9590.96
132_V138_L0.9580.96
176_A275_Y0.9560.96
63_G169_G0.9540.96
64_K68_V0.9530.96
152_D156_K0.9510.96
65_D174_D0.9460.95
293_V297_S0.9400.95
129_M132_V0.9370.95
193_T196_D0.9370.95
184_L256_V0.9290.95
92_E150_R0.9260.95
228_L232_L0.9220.95
150_R250_R0.9210.95
75_E233_R0.9130.94
224_K261_E0.9110.94
64_K237_V0.9090.94
44_L165_K0.9070.94
277_E281_I0.9060.94
173_D223_E0.8990.94
44_L56_W0.8950.94
168_T195_F0.8950.94
33_R221_I0.8920.94
177_E250_R0.8920.94
172_L268_R0.8920.94
172_L272_M0.8910.94
175_E182_N0.8910.94
266_G270_S0.8860.94
44_L83_V0.8840.93
46_P80_D0.8840.93
72_L221_I0.8780.93
157_Y160_E0.8760.93
170_H178_T0.8750.93
143_C146_C0.8720.93
154_L158_A0.8650.93
261_E266_G0.8610.93
178_T250_R0.8540.92
176_A272_M0.8490.92
31_E35_R0.8440.92
42_N45_S0.8430.92
175_E219_R0.8420.92
104_A238_H0.8380.92
57_V117_E0.8370.91
74_E112_R0.8290.91
267_T270_S0.8250.91
176_A268_R0.8240.91
257_L267_T0.8140.90
290_D294_G0.8110.90
121_Y149_F0.8110.90
104_A237_V0.8040.90
33_R220_D0.7990.89
129_M133_A0.7970.89
142_P248_S0.7950.89
44_L54_E0.7930.89
132_V145_Y0.7920.89
69_L218_L0.7770.88
189_T278_L0.7760.88
143_C245_A0.7680.88
77_F83_V0.7620.87
154_L166_L0.7590.87
36_R40_T0.7580.87
68_V229_Y0.7550.87
190_Q282_A0.7550.87
168_T171_N0.7510.86
70_T114_I0.7470.86
97_Y241_E0.7460.86
192_A274_G0.7440.86
259_E262_D0.7390.86
172_L222_P0.7390.86
223_E226_V0.7390.86
179_A272_M0.7370.85
37_R197_A0.7360.85
165_K215_A0.7320.85
100_E103_D0.7320.85
87_A116_H0.7280.85
98_R146_C0.7260.84
119_V153_L0.7250.84
209_D212_I0.7250.84
173_D222_P0.7230.84
60_L108_L0.7190.84
292_D296_C0.7180.84
106_T116_H0.7170.84
65_D170_H0.7170.84
44_L81_P0.7160.84
105_C116_H0.7160.84
230_A235_L0.7160.84
253_L256_V0.7100.83
132_V140_M0.7100.83
189_T281_I0.7090.83
89_T101_S0.7030.83
174_D250_R0.7010.82
271_I275_Y0.7010.82
171_N223_E0.7010.82
181_M250_R0.6980.82
251_S254_Q0.6960.82
106_T118_L0.6940.82
56_W83_V0.6940.82
43_M165_K0.6930.82
69_L167_L0.6920.82
92_E147_G0.6920.82
34_V37_R0.6910.81
87_A105_C0.6890.81
100_E241_E0.6820.81
230_A239_M0.6810.81
37_R41_D0.6810.81
69_L73_I0.6790.80
184_L264_R0.6690.79
188_V191_I0.6650.79
46_P81_P0.6640.79
155_A158_A0.6630.79
188_V277_E0.6600.78
71_D74_E0.6580.78
80_D83_V0.6550.78
99_D103_D0.6550.78
143_C147_G0.6550.78
140_M145_Y0.6530.78
195_F219_R0.6530.78
94_I143_C0.6500.77
45_S165_K0.6450.77
73_I85_L0.6440.77
92_E98_R0.6440.77
177_E254_Q0.6430.77
242_C245_A0.6410.76
256_V267_T0.6360.76
227_A239_M0.6360.76
143_C248_S0.6350.76
188_V192_A0.6340.76
288_T292_D0.6340.76
252_D256_V0.6320.75
266_G269_H0.6320.75
176_A180_L0.6310.75
44_L47_D0.6310.75
43_M197_A0.6300.75
107_T236_P0.6290.75
58_I107_T0.6270.75
165_K213_P0.6260.75
141_A145_Y0.6260.75
75_E229_Y0.6220.74
61_S66_S0.6200.74
70_T85_L0.6190.74
61_S169_G0.6160.74
260_L267_T0.6160.74
170_H174_D0.6150.73
86_I115_R0.6140.73
64_K226_V0.6140.73
104_A236_P0.6140.73
70_T109_A0.6050.72
222_P225_E0.6020.72
150_R174_D0.5970.71
65_D250_R0.5940.71
181_M253_L0.5930.71
153_L157_Y0.5930.71
240_A243_P0.5910.70
71_D108_L0.5900.70
27_L233_R0.5880.70
96_G238_H0.5850.70
30_V226_V0.5800.69
178_T181_M0.5790.69
92_E243_P0.5780.69
180_L253_L0.5740.68
27_L31_E0.5740.68
57_V158_A0.5740.68
32_R36_R0.5710.68
93_G121_Y0.5710.68
77_F85_L0.5680.67
254_Q258_L0.5680.67
59_G166_L0.5660.67
31_E71_D0.5650.67
150_R177_E0.5630.67
41_D220_D0.5620.67
171_N174_D0.5610.66
92_E240_A0.5610.66
55_T163_A0.5610.66
267_T271_I0.5610.66
291_A294_G0.5600.66
224_K231_Q0.5600.66
149_F152_D0.5590.66
229_Y235_L0.5590.66
289_D293_V0.5580.66
252_D264_R0.5560.66
63_G66_S0.5520.65
155_A214_R0.5520.65
196_D279_A0.5520.65
40_T220_D0.5510.65
229_Y233_R0.5510.65
96_G99_D0.5510.65
148_V152_D0.5500.65
36_R39_R0.5500.65
147_G242_C0.5490.65
99_D102_L0.5490.65
250_R254_Q0.5460.64
168_T182_N0.5430.64
121_Y153_L0.5430.64
104_A235_L0.5420.64
187_N191_I0.5410.64
147_G174_D0.5400.64
30_V218_L0.5400.64
185_E249_F0.5390.63
143_C151_R0.5380.63
84_E115_R0.5380.63
34_V38_I0.5360.63
67_A105_C0.5350.63
155_A211_M0.5350.63
242_C248_S0.5340.63
273_A277_E0.5340.63
174_D178_T0.5310.62
159_D211_M0.5310.62
179_A183_I0.5300.62
224_K228_L0.5260.62
269_H273_A0.5240.61
174_D254_Q0.5230.61
210_A295_E0.5220.61
39_R81_P0.5210.61
38_I165_K0.5210.61
182_N193_T0.5200.61
292_D295_E0.5200.61
182_N191_I0.5190.61
240_A251_S0.5180.60
145_Y149_F0.5150.60
74_E113_D0.5150.60
272_M276_E0.5140.60
188_V274_G0.5130.60
272_M275_Y0.5130.60
184_L190_Q0.5130.60
193_T279_A0.5110.59
45_S113_D0.5110.59
67_A230_A0.5090.59
74_E85_L0.5070.59
58_I87_A0.5060.59
47_D54_E0.5050.58
143_C243_P0.5040.58
270_S274_G0.5020.58
168_T216_K0.5000.58
93_G241_E0.5000.58
264_R270_S0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vrhA 2 0.8875 100 0.3 Contact Map
3a2kA 1 0.8375 100 0.359 Contact Map
1wy5A 4 0.8344 100 0.403 Contact Map
1ni5A 2 0.8 100 0.409 Contact Map
2derA 1 0.7562 100 0.651 Contact Map
2hmaA 2 0.7875 99.9 0.666 Contact Map
2dplA 2 0.7 99.9 0.667 Contact Map
2vxoA 2 0.8875 99.9 0.668 Contact Map
3tqiA 3 0.7063 99.9 0.672 Contact Map
4kr6A 2 0.7906 99.9 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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