GREMLIN Database
Q9HSJ6 - Uncharacterized protein
UniProt: Q9HSJ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (300)
Sequences: 4208 (3503)
Seq/√Len: 202.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_A25_W3.6701.00
50_L253_V3.5481.00
28_G31_E3.4501.00
63_W67_R3.0331.00
290_E316_R2.9301.00
22_V26_L2.8181.00
79_I83_A2.7511.00
255_F311_A2.6801.00
57_L239_L2.6481.00
61_A240_A2.5371.00
59_G79_I2.5281.00
160_I164_F2.5001.00
231_T235_K2.4871.00
85_T103_A2.4801.00
43_L253_V2.4671.00
57_L242_A2.4411.00
33_I37_G2.4241.00
252_W256_I2.4161.00
263_P266_V2.3251.00
74_S77_S2.2781.00
46_V253_V2.2701.00
291_S295_A2.2621.00
57_L246_C2.2571.00
59_G78_A2.2521.00
56_V75_V2.2511.00
61_A129_N2.0891.00
283_P316_R2.0761.00
92_T98_G2.0671.00
62_L121_A2.0631.00
64_I235_K2.0541.00
60_T239_L2.0461.00
114_D117_T2.0431.00
89_N99_G2.0171.00
75_V79_I2.0161.00
100_E126_D2.0001.00
304_A307_L1.9461.00
220_V224_E1.9451.00
103_A125_A1.9151.00
87_F328_G1.9101.00
40_R43_L1.9091.00
274_G278_G1.9091.00
71_I113_A1.9011.00
17_A21_A1.8961.00
129_N244_L1.8841.00
289_I316_R1.8781.00
277_A292_V1.8731.00
58_Q129_N1.8571.00
140_G272_P1.8541.00
77_S111_S1.8441.00
163_A167_I1.7921.00
65_V236_V1.7681.00
73_V78_A1.7531.00
329_G333_V1.7451.00
47_A254_V1.7221.00
47_A318_G1.7181.00
255_F260_S1.6831.00
132_P240_A1.6791.00
251_M293_H1.6761.00
303_A308_V1.6641.00
211_R215_G1.6621.00
129_N240_A1.6601.00
312_V316_R1.6511.00
42_P46_V1.6451.00
59_G75_V1.6141.00
90_N324_M1.5861.00
60_T63_W1.5861.00
76_R80_L1.5781.00
308_V312_V1.5761.00
62_L103_A1.5541.00
48_G318_G1.5301.00
61_A125_A1.5081.00
18_V22_V1.4941.00
229_D232_G1.4761.00
45_V49_A1.4361.00
43_L256_I1.4311.00
81_V106_L1.4261.00
289_I315_H1.4231.00
43_L46_V1.4171.00
104_A122_I1.4131.00
53_G246_C1.4091.00
34_T37_G1.4081.00
159_G163_A1.3781.00
66_W113_A1.3681.00
293_H312_V1.3661.00
108_T115_Y1.3561.00
61_A126_D1.3421.00
125_A129_N1.3371.00
286_L316_R1.3361.00
88_A102_V1.3361.00
64_I239_L1.3351.00
47_A257_A1.3281.00
33_I36_L1.3251.00
128_L236_V1.3221.00
126_D129_N1.3191.00
290_E312_V1.3191.00
104_A118_A1.3171.00
104_A119_L1.3121.00
294_V308_V1.3111.00
159_G162_G1.2961.00
294_V309_A1.2941.00
83_A330_S1.2931.00
80_L333_V1.2791.00
270_V296_L1.2601.00
168_V172_A1.2591.00
39_A314_I1.2501.00
164_F168_V1.2431.00
254_V311_A1.2371.00
250_A315_H1.2211.00
64_I232_G1.2151.00
103_A126_D1.1971.00
39_A257_A1.1961.00
50_L246_C1.1841.00
289_I312_V1.1811.00
238_G242_A1.1811.00
16_A20_F1.1691.00
67_R72_T1.1671.00
153_R156_S1.1591.00
49_A53_G1.1581.00
100_E103_A1.1561.00
63_W78_A1.1411.00
214_A218_E1.1351.00
18_V21_A1.1341.00
13_F17_A1.1271.00
84_G106_L1.1201.00
209_P213_E1.1181.00
71_I114_D1.1031.00
31_E34_T1.0931.00
84_G88_A1.0921.00
325_T329_G1.0901.00
254_V257_A1.0861.00
295_A298_T1.0721.00
58_Q97_A1.0661.00
258_L314_I1.0641.00
173_V177_R1.0611.00
115_Y118_A1.0611.00
295_A299_A1.0571.00
274_G288_G1.0541.00
165_V169_G1.0511.00
15_A19_V1.0501.00
19_V23_L1.0391.00
148_N151_S1.0381.00
274_G285_G1.0341.00
55_I83_A1.0291.00
89_N100_E1.0271.00
274_G292_V1.0271.00
168_V175_G1.0251.00
102_V106_L1.0181.00
235_K238_G1.0161.00
82_F243_A1.0151.00
307_L310_A1.0131.00
106_L331_L1.0101.00
41_I45_V1.0031.00
255_F267_P0.9911.00
252_W267_P0.9891.00
58_Q244_L0.9871.00
118_A122_I0.9831.00
115_Y119_L0.9801.00
58_Q243_A0.9791.00
20_F24_F0.9761.00
48_G322_L0.9680.99
224_E228_A0.9630.99
97_A129_N0.9570.99
284_G289_I0.9480.99
66_W121_A0.9310.99
87_F327_G0.9300.99
278_G285_G0.9280.99
316_R319_G0.9260.99
157_V175_G0.9250.99
293_H297_L0.9210.99
174_A177_R0.9170.99
255_F303_A0.9150.99
83_A326_V0.9150.99
61_A243_A0.9140.99
100_E129_N0.9140.99
43_L47_A0.9100.99
167_I171_L0.9090.99
39_A43_L0.9030.99
274_G293_H0.8960.99
90_N94_F0.8880.99
284_G320_F0.8830.99
252_W264_I0.8790.99
92_T101_P0.8770.99
94_F289_I0.8770.99
171_L177_R0.8730.99
222_S225_R0.8690.99
51_M247_Q0.8690.99
19_V22_V0.8680.99
23_L26_L0.8670.99
42_P45_V0.8660.99
96_Q100_E0.8640.99
89_N98_G0.8610.99
221_A224_E0.8580.99
113_A118_A0.8510.99
22_V25_W0.8500.99
291_S294_V0.8470.99
117_T222_S0.8450.99
108_T118_A0.8430.99
249_I253_V0.8410.99
46_V49_A0.8380.99
250_A319_G0.8380.99
271_V275_T0.8370.99
105_L109_N0.8370.99
129_N243_A0.8280.98
297_L303_A0.8230.98
62_L126_D0.8210.98
156_S160_I0.8190.98
194_L198_A0.8140.98
313_V316_R0.8110.98
215_G218_E0.8050.98
12_G16_A0.7990.98
154_L157_V0.7940.98
21_A24_F0.7930.98
58_Q100_E0.7910.98
94_F98_G0.7880.98
103_A286_L0.7860.98
254_V315_H0.7850.98
62_L100_E0.7840.98
78_A82_F0.7830.98
40_R257_A0.7820.98
47_A250_A0.7810.98
151_S155_R0.7790.98
129_N133_S0.7780.98
195_R198_A0.7750.98
160_I167_I0.7740.98
290_E313_V0.7730.98
9_T13_F0.7720.98
256_I260_S0.7700.97
249_I264_I0.7680.97
249_I252_W0.7670.97
30_Q34_T0.7670.97
213_E217_E0.7660.97
218_E221_A0.7650.97
58_Q125_A0.7650.97
270_V297_L0.7640.97
72_T76_R0.7640.97
66_W71_I0.7610.97
116_E218_E0.7600.97
286_L315_H0.7570.97
172_A176_W0.7570.97
10_I158_V0.7570.97
39_A44_V0.7550.97
166_L170_G0.7550.97
171_L175_G0.7530.97
63_W75_V0.7530.97
136_L245_L0.7520.97
251_M311_A0.7500.97
233_V236_V0.7490.97
247_Q319_G0.7470.97
66_W107_T0.7470.97
250_A318_G0.7460.97
277_A296_L0.7430.97
81_V111_S0.7410.97
90_N320_F0.7410.97
315_H319_G0.7400.97
9_T12_G0.7390.97
94_F97_A0.7360.97
122_I126_D0.7330.97
89_N94_F0.7330.97
80_L330_S0.7320.97
18_V34_T0.7320.97
283_P289_I0.7290.96
328_G332_A0.7290.96
13_F16_A0.7220.96
140_G269_F0.7210.96
217_E220_V0.7210.96
297_L301_T0.7200.96
156_S159_G0.7190.96
88_A92_T0.7190.96
283_P312_V0.7180.96
31_E35_A0.7170.96
166_L173_V0.7140.96
125_A282_T0.7110.96
39_A47_A0.7080.96
254_V314_I0.7070.96
62_L125_A0.7050.96
90_N323_T0.7030.96
61_A103_A0.7000.96
61_A100_E0.7000.96
103_A122_I0.6980.96
286_L312_V0.6980.96
99_G129_N0.6980.96
97_A100_E0.6970.95
36_L314_I0.6960.95
157_V161_V0.6960.95
288_G291_S0.6950.95
12_G282_T0.6930.95
16_A19_V0.6930.95
211_R214_A0.6930.95
162_G165_V0.6900.95
34_T38_R0.6880.95
65_V121_A0.6850.95
293_H311_A0.6840.95
158_V162_G0.6840.95
256_I261_P0.6830.95
62_L315_H0.6830.95
81_V85_T0.6820.95
58_Q82_F0.6770.95
120_A219_F0.6740.95
37_G174_A0.6740.95
210_E214_A0.6690.94
39_A258_L0.6670.94
54_W243_A0.6660.94
253_V257_A0.6620.94
92_T100_E0.6620.94
107_T113_A0.6620.94
282_T288_G0.6610.94
81_V107_T0.6580.94
313_V317_I0.6560.94
105_L335_R0.6540.94
162_G173_V0.6530.94
58_Q98_G0.6490.93
94_F125_A0.6490.93
292_V295_A0.6470.93
267_P297_L0.6470.93
320_F323_T0.6430.93
165_V172_A0.6400.93
80_L334_L0.6390.93
74_S79_I0.6360.93
144_Y148_N0.6300.92
231_T234_L0.6290.92
61_A89_N0.6290.92
84_G334_L0.6280.92
161_V214_A0.6280.92
100_E125_A0.6270.92
43_L257_A0.6260.92
324_M330_S0.6250.92
81_V103_A0.6240.92
232_G236_V0.6200.92
29_I33_I0.6190.92
328_G331_L0.6190.92
54_W246_C0.6170.92
248_A268_L0.6160.92
97_A122_I0.6160.92
173_V176_W0.6120.91
61_A99_G0.6110.91
16_A283_P0.6100.91
107_T118_A0.6090.91
163_A173_V0.6080.91
264_I268_L0.6070.91
278_G289_I0.6060.91
326_V329_G0.6060.91
74_S111_S0.6050.91
116_E233_V0.6010.91
87_F91_I0.6000.90
12_G18_V0.5990.90
89_N103_A0.5980.90
14_G221_A0.5980.90
133_S244_L0.5980.90
96_Q128_L0.5960.90
330_S334_L0.5920.90
172_A175_G0.5920.90
82_F129_N0.5910.90
89_N126_D0.5900.90
104_A108_T0.5900.90
282_T312_V0.5890.90
86_S103_A0.5890.90
243_A247_Q0.5870.89
285_G316_R0.5870.89
240_A248_A0.5850.89
133_S137_A0.5850.89
128_L240_A0.5840.89
152_P155_R0.5830.89
169_G173_V0.5830.89
207_P211_R0.5830.89
116_E318_G0.5800.89
162_G166_L0.5780.89
87_F281_P0.5770.89
270_V274_G0.5730.88
85_T126_D0.5720.88
118_A121_A0.5700.88
89_N289_I0.5700.88
86_S323_T0.5690.88
133_S275_T0.5690.88
93_P284_G0.5680.88
12_G283_P0.5650.88
89_N96_Q0.5630.87
294_V305_A0.5620.87
156_S167_I0.5610.87
153_R157_V0.5610.87
299_A302_S0.5610.87
62_L94_F0.5600.87
293_H296_L0.5590.87
298_T308_V0.5580.87
323_T326_V0.5560.87
88_A94_F0.5560.87
125_A240_A0.5560.87
132_P241_T0.5550.87
251_M297_L0.5550.87
46_V142_A0.5540.87
10_I210_E0.5530.87
83_A327_G0.5520.86
238_G245_L0.5500.86
257_A318_G0.5480.86
316_R321_W0.5480.86
136_L272_P0.5470.86
86_S315_H0.5450.86
31_E306_P0.5430.86
278_G320_F0.5420.85
157_V176_W0.5390.85
163_A166_L0.5390.85
153_R160_I0.5380.85
51_M250_A0.5380.85
51_M55_I0.5370.85
131_V140_G0.5360.85
132_P136_L0.5350.85
159_G164_F0.5340.85
289_I327_G0.5340.85
27_I309_A0.5330.84
8_S12_G0.5310.84
120_A124_G0.5280.84
194_L249_I0.5260.84
102_V277_A0.5260.84
138_L142_A0.5250.84
58_Q85_T0.5240.83
132_P237_I0.5240.83
107_T122_I0.5240.83
250_A253_V0.5220.83
62_L85_T0.5220.83
73_V113_A0.5210.83
148_N167_I0.5210.83
154_L158_V0.5200.83
41_I332_A0.5180.83
135_G237_I0.5180.83
58_Q126_D0.5180.83
8_S16_A0.5170.83
146_I149_T0.5170.83
255_F262_I0.5160.83
56_V79_I0.5150.82
51_M318_G0.5140.82
36_L39_A0.5140.82
133_S250_A0.5130.82
151_S154_L0.5130.82
146_I197_L0.5120.82
247_Q251_M0.5120.82
91_I273_V0.5110.82
92_T296_L0.5090.82
246_C249_I0.5080.82
12_G20_F0.5070.81
13_F24_F0.5060.81
290_E317_I0.5040.81
146_I151_S0.5040.81
99_G126_D0.5040.81
164_F238_G0.5030.81
309_A312_V0.5020.81
156_S169_G0.5020.81
11_V213_E0.5020.81
155_R169_G0.5010.81
102_V331_L0.5010.81
31_E71_I0.5010.81
89_N92_T0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.8889 24.5 0.944 Contact Map
3zuxA 1 0.8304 13.6 0.95 Contact Map
2kluA 1 0.114 10.1 0.953 Contact Map
2jwaA 2 0.1111 6.8 0.957 Contact Map
4i0uA 4 0.1813 6.7 0.957 Contact Map
4ev6A 3 0.1871 6.2 0.957 Contact Map
2m20A 2 0.1023 5.9 0.958 Contact Map
2zy9A 2 0.3772 4.5 0.96 Contact Map
2l2tA 2 0.1199 4.4 0.96 Contact Map
4k0jA 3 0.4883 4.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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