Q9HSJ6 - HALSA - GREMLIN Contacts

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Q9HSJ6 - Uncharacterized protein

UniProt:	Q9HSJ6	Sequences: MNTARVWSTIVGFGAAAVVFAVLFWLIGIQEIITALGRARIPLVVVAGALMLGWIVLQGTALWIVWRILDITVSVRSAILVFAGTSFANNITPFGQAGGEPVAALLTTNVSDADYETALAAIAGADALNFVPSIGLALTGTAAYAIVNTVSPRLRSVVGIVGAFVLIVGGLAVAGWRLRTTIQAAVVRVATPALRWLARVLPRVPVPSPERIEAGIEEFVASVERLAADRTGVLKVIGLATAALLCQAIAMWVVFIALGSPIPIYVPLFVVPVGTMAGIGPTPGGLGGIESVHVALLTALTSAAAPLVAAAVVIHRIGGFWLTMTVGGGSLAVLRAGGSDAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	342 (300)
Sequences:	4208 (3503)
Seq/√Len:	202.2

ECOLI - YBHN
HALSA - Q9HSJ6 Q9HS48

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
21_A	25_W	3.670	1.00
50_L	253_V	3.548	1.00
28_G	31_E	3.450	1.00
63_W	67_R	3.033	1.00
290_E	316_R	2.930	1.00
22_V	26_L	2.818	1.00
79_I	83_A	2.751	1.00
255_F	311_A	2.680	1.00
57_L	239_L	2.648	1.00
61_A	240_A	2.537	1.00
59_G	79_I	2.528	1.00
160_I	164_F	2.500	1.00
231_T	235_K	2.487	1.00
85_T	103_A	2.480	1.00
43_L	253_V	2.467	1.00
57_L	242_A	2.441	1.00
33_I	37_G	2.424	1.00
252_W	256_I	2.416	1.00
263_P	266_V	2.325	1.00
74_S	77_S	2.278	1.00
46_V	253_V	2.270	1.00
291_S	295_A	2.262	1.00
57_L	246_C	2.257	1.00
59_G	78_A	2.252	1.00
56_V	75_V	2.251	1.00
61_A	129_N	2.089	1.00
283_P	316_R	2.076	1.00
92_T	98_G	2.067	1.00
62_L	121_A	2.063	1.00
64_I	235_K	2.054	1.00
60_T	239_L	2.046	1.00
114_D	117_T	2.043	1.00
89_N	99_G	2.017	1.00
75_V	79_I	2.016	1.00
100_E	126_D	2.000	1.00
304_A	307_L	1.946	1.00
220_V	224_E	1.945	1.00
103_A	125_A	1.915	1.00
87_F	328_G	1.910	1.00
40_R	43_L	1.909	1.00
274_G	278_G	1.909	1.00
71_I	113_A	1.901	1.00
17_A	21_A	1.896	1.00
129_N	244_L	1.884	1.00
289_I	316_R	1.878	1.00
277_A	292_V	1.873	1.00
58_Q	129_N	1.857	1.00
140_G	272_P	1.854	1.00
77_S	111_S	1.844	1.00
163_A	167_I	1.792	1.00
65_V	236_V	1.768	1.00
73_V	78_A	1.753	1.00
329_G	333_V	1.745	1.00
47_A	254_V	1.722	1.00
47_A	318_G	1.718	1.00
255_F	260_S	1.683	1.00
132_P	240_A	1.679	1.00
251_M	293_H	1.676	1.00
303_A	308_V	1.664	1.00
211_R	215_G	1.662	1.00
129_N	240_A	1.660	1.00
312_V	316_R	1.651	1.00
42_P	46_V	1.645	1.00
59_G	75_V	1.614	1.00
90_N	324_M	1.586	1.00
60_T	63_W	1.586	1.00
76_R	80_L	1.578	1.00
308_V	312_V	1.576	1.00
62_L	103_A	1.554	1.00
48_G	318_G	1.530	1.00
61_A	125_A	1.508	1.00
18_V	22_V	1.494	1.00
229_D	232_G	1.476	1.00
45_V	49_A	1.436	1.00
43_L	256_I	1.431	1.00
81_V	106_L	1.426	1.00
289_I	315_H	1.423	1.00
43_L	46_V	1.417	1.00
104_A	122_I	1.413	1.00
53_G	246_C	1.409	1.00
34_T	37_G	1.408	1.00
159_G	163_A	1.378	1.00
66_W	113_A	1.368	1.00
293_H	312_V	1.366	1.00
108_T	115_Y	1.356	1.00
61_A	126_D	1.342	1.00
125_A	129_N	1.337	1.00
286_L	316_R	1.336	1.00
88_A	102_V	1.336	1.00
64_I	239_L	1.335	1.00
47_A	257_A	1.328	1.00
33_I	36_L	1.325	1.00
128_L	236_V	1.322	1.00
126_D	129_N	1.319	1.00
290_E	312_V	1.319	1.00
104_A	118_A	1.317	1.00
104_A	119_L	1.312	1.00
294_V	308_V	1.311	1.00
159_G	162_G	1.296	1.00
294_V	309_A	1.294	1.00
83_A	330_S	1.293	1.00
80_L	333_V	1.279	1.00
270_V	296_L	1.260	1.00
168_V	172_A	1.259	1.00
39_A	314_I	1.250	1.00
164_F	168_V	1.243	1.00
254_V	311_A	1.237	1.00
250_A	315_H	1.221	1.00
64_I	232_G	1.215	1.00
103_A	126_D	1.197	1.00
39_A	257_A	1.196	1.00
50_L	246_C	1.184	1.00
289_I	312_V	1.181	1.00
238_G	242_A	1.181	1.00
16_A	20_F	1.169	1.00
67_R	72_T	1.167	1.00
153_R	156_S	1.159	1.00
49_A	53_G	1.158	1.00
100_E	103_A	1.156	1.00
63_W	78_A	1.141	1.00
214_A	218_E	1.135	1.00
18_V	21_A	1.134	1.00
13_F	17_A	1.127	1.00
84_G	106_L	1.120	1.00
209_P	213_E	1.118	1.00
71_I	114_D	1.103	1.00
31_E	34_T	1.093	1.00
84_G	88_A	1.092	1.00
325_T	329_G	1.090	1.00
254_V	257_A	1.086	1.00
295_A	298_T	1.072	1.00
58_Q	97_A	1.066	1.00
258_L	314_I	1.064	1.00
173_V	177_R	1.061	1.00
115_Y	118_A	1.061	1.00
295_A	299_A	1.057	1.00
274_G	288_G	1.054	1.00
165_V	169_G	1.051	1.00
15_A	19_V	1.050	1.00
19_V	23_L	1.039	1.00
148_N	151_S	1.038	1.00
274_G	285_G	1.034	1.00
55_I	83_A	1.029	1.00
89_N	100_E	1.027	1.00
274_G	292_V	1.027	1.00
168_V	175_G	1.025	1.00
102_V	106_L	1.018	1.00
235_K	238_G	1.016	1.00
82_F	243_A	1.015	1.00
307_L	310_A	1.013	1.00
106_L	331_L	1.010	1.00
41_I	45_V	1.003	1.00
255_F	267_P	0.991	1.00
252_W	267_P	0.989	1.00
58_Q	244_L	0.987	1.00
118_A	122_I	0.983	1.00
115_Y	119_L	0.980	1.00
58_Q	243_A	0.979	1.00
20_F	24_F	0.976	1.00
48_G	322_L	0.968	0.99
224_E	228_A	0.963	0.99
97_A	129_N	0.957	0.99
284_G	289_I	0.948	0.99
66_W	121_A	0.931	0.99
87_F	327_G	0.930	0.99
278_G	285_G	0.928	0.99
316_R	319_G	0.926	0.99
157_V	175_G	0.925	0.99
293_H	297_L	0.921	0.99
174_A	177_R	0.917	0.99
255_F	303_A	0.915	0.99
83_A	326_V	0.915	0.99
61_A	243_A	0.914	0.99
100_E	129_N	0.914	0.99
43_L	47_A	0.910	0.99
167_I	171_L	0.909	0.99
39_A	43_L	0.903	0.99
274_G	293_H	0.896	0.99
90_N	94_F	0.888	0.99
284_G	320_F	0.883	0.99
252_W	264_I	0.879	0.99
92_T	101_P	0.877	0.99
94_F	289_I	0.877	0.99
171_L	177_R	0.873	0.99
222_S	225_R	0.869	0.99
51_M	247_Q	0.869	0.99
19_V	22_V	0.868	0.99
23_L	26_L	0.867	0.99
42_P	45_V	0.866	0.99
96_Q	100_E	0.864	0.99
89_N	98_G	0.861	0.99
221_A	224_E	0.858	0.99
113_A	118_A	0.851	0.99
22_V	25_W	0.850	0.99
291_S	294_V	0.847	0.99
117_T	222_S	0.845	0.99
108_T	118_A	0.843	0.99
249_I	253_V	0.841	0.99
46_V	49_A	0.838	0.99
250_A	319_G	0.838	0.99
271_V	275_T	0.837	0.99
105_L	109_N	0.837	0.99
129_N	243_A	0.828	0.98
297_L	303_A	0.823	0.98
62_L	126_D	0.821	0.98
156_S	160_I	0.819	0.98
194_L	198_A	0.814	0.98
313_V	316_R	0.811	0.98
215_G	218_E	0.805	0.98
12_G	16_A	0.799	0.98
154_L	157_V	0.794	0.98
21_A	24_F	0.793	0.98
58_Q	100_E	0.791	0.98
94_F	98_G	0.788	0.98
103_A	286_L	0.786	0.98
254_V	315_H	0.785	0.98
62_L	100_E	0.784	0.98
78_A	82_F	0.783	0.98
40_R	257_A	0.782	0.98
47_A	250_A	0.781	0.98
151_S	155_R	0.779	0.98
129_N	133_S	0.778	0.98
195_R	198_A	0.775	0.98
160_I	167_I	0.774	0.98
290_E	313_V	0.773	0.98
9_T	13_F	0.772	0.98
256_I	260_S	0.770	0.97
249_I	264_I	0.768	0.97
249_I	252_W	0.767	0.97
30_Q	34_T	0.767	0.97
213_E	217_E	0.766	0.97
218_E	221_A	0.765	0.97
58_Q	125_A	0.765	0.97
270_V	297_L	0.764	0.97
72_T	76_R	0.764	0.97
66_W	71_I	0.761	0.97
116_E	218_E	0.760	0.97
286_L	315_H	0.757	0.97
172_A	176_W	0.757	0.97
10_I	158_V	0.757	0.97
39_A	44_V	0.755	0.97
166_L	170_G	0.755	0.97
171_L	175_G	0.753	0.97
63_W	75_V	0.753	0.97
136_L	245_L	0.752	0.97
251_M	311_A	0.750	0.97
233_V	236_V	0.749	0.97
247_Q	319_G	0.747	0.97
66_W	107_T	0.747	0.97
250_A	318_G	0.746	0.97
277_A	296_L	0.743	0.97
81_V	111_S	0.741	0.97
90_N	320_F	0.741	0.97
315_H	319_G	0.740	0.97
9_T	12_G	0.739	0.97
94_F	97_A	0.736	0.97
122_I	126_D	0.733	0.97
89_N	94_F	0.733	0.97
80_L	330_S	0.732	0.97
18_V	34_T	0.732	0.97
283_P	289_I	0.729	0.96
328_G	332_A	0.729	0.96
13_F	16_A	0.722	0.96
140_G	269_F	0.721	0.96
217_E	220_V	0.721	0.96
297_L	301_T	0.720	0.96
156_S	159_G	0.719	0.96
88_A	92_T	0.719	0.96
283_P	312_V	0.718	0.96
31_E	35_A	0.717	0.96
166_L	173_V	0.714	0.96
125_A	282_T	0.711	0.96
39_A	47_A	0.708	0.96
254_V	314_I	0.707	0.96
62_L	125_A	0.705	0.96
90_N	323_T	0.703	0.96
61_A	103_A	0.700	0.96
61_A	100_E	0.700	0.96
103_A	122_I	0.698	0.96
286_L	312_V	0.698	0.96
99_G	129_N	0.698	0.96
97_A	100_E	0.697	0.95
36_L	314_I	0.696	0.95
157_V	161_V	0.696	0.95
288_G	291_S	0.695	0.95
12_G	282_T	0.693	0.95
16_A	19_V	0.693	0.95
211_R	214_A	0.693	0.95
162_G	165_V	0.690	0.95
34_T	38_R	0.688	0.95
65_V	121_A	0.685	0.95
293_H	311_A	0.684	0.95
158_V	162_G	0.684	0.95
256_I	261_P	0.683	0.95
62_L	315_H	0.683	0.95
81_V	85_T	0.682	0.95
58_Q	82_F	0.677	0.95
120_A	219_F	0.674	0.95
37_G	174_A	0.674	0.95
210_E	214_A	0.669	0.94
39_A	258_L	0.667	0.94
54_W	243_A	0.666	0.94
253_V	257_A	0.662	0.94
92_T	100_E	0.662	0.94
107_T	113_A	0.662	0.94
282_T	288_G	0.661	0.94
81_V	107_T	0.658	0.94
313_V	317_I	0.656	0.94
105_L	335_R	0.654	0.94
162_G	173_V	0.653	0.94
58_Q	98_G	0.649	0.93
94_F	125_A	0.649	0.93
292_V	295_A	0.647	0.93
267_P	297_L	0.647	0.93
320_F	323_T	0.643	0.93
165_V	172_A	0.640	0.93
80_L	334_L	0.639	0.93
74_S	79_I	0.636	0.93
144_Y	148_N	0.630	0.92
231_T	234_L	0.629	0.92
61_A	89_N	0.629	0.92
84_G	334_L	0.628	0.92
161_V	214_A	0.628	0.92
100_E	125_A	0.627	0.92
43_L	257_A	0.626	0.92
324_M	330_S	0.625	0.92
81_V	103_A	0.624	0.92
232_G	236_V	0.620	0.92
29_I	33_I	0.619	0.92
328_G	331_L	0.619	0.92
54_W	246_C	0.617	0.92
248_A	268_L	0.616	0.92
97_A	122_I	0.616	0.92
173_V	176_W	0.612	0.91
61_A	99_G	0.611	0.91
16_A	283_P	0.610	0.91
107_T	118_A	0.609	0.91
163_A	173_V	0.608	0.91
264_I	268_L	0.607	0.91
278_G	289_I	0.606	0.91
326_V	329_G	0.606	0.91
74_S	111_S	0.605	0.91
116_E	233_V	0.601	0.91
87_F	91_I	0.600	0.90
12_G	18_V	0.599	0.90
89_N	103_A	0.598	0.90
14_G	221_A	0.598	0.90
133_S	244_L	0.598	0.90
96_Q	128_L	0.596	0.90
330_S	334_L	0.592	0.90
172_A	175_G	0.592	0.90
82_F	129_N	0.591	0.90
89_N	126_D	0.590	0.90
104_A	108_T	0.590	0.90
282_T	312_V	0.589	0.90
86_S	103_A	0.589	0.90
243_A	247_Q	0.587	0.89
285_G	316_R	0.587	0.89
240_A	248_A	0.585	0.89
133_S	137_A	0.585	0.89
128_L	240_A	0.584	0.89
152_P	155_R	0.583	0.89
169_G	173_V	0.583	0.89
207_P	211_R	0.583	0.89
116_E	318_G	0.580	0.89
162_G	166_L	0.578	0.89
87_F	281_P	0.577	0.89
270_V	274_G	0.573	0.88
85_T	126_D	0.572	0.88
118_A	121_A	0.570	0.88
89_N	289_I	0.570	0.88
86_S	323_T	0.569	0.88
133_S	275_T	0.569	0.88
93_P	284_G	0.568	0.88
12_G	283_P	0.565	0.88
89_N	96_Q	0.563	0.87
294_V	305_A	0.562	0.87
156_S	167_I	0.561	0.87
153_R	157_V	0.561	0.87
299_A	302_S	0.561	0.87
62_L	94_F	0.560	0.87
293_H	296_L	0.559	0.87
298_T	308_V	0.558	0.87
323_T	326_V	0.556	0.87
88_A	94_F	0.556	0.87
125_A	240_A	0.556	0.87
132_P	241_T	0.555	0.87
251_M	297_L	0.555	0.87
46_V	142_A	0.554	0.87
10_I	210_E	0.553	0.87
83_A	327_G	0.552	0.86
238_G	245_L	0.550	0.86
257_A	318_G	0.548	0.86
316_R	321_W	0.548	0.86
136_L	272_P	0.547	0.86
86_S	315_H	0.545	0.86
31_E	306_P	0.543	0.86
278_G	320_F	0.542	0.85
157_V	176_W	0.539	0.85
163_A	166_L	0.539	0.85
153_R	160_I	0.538	0.85
51_M	250_A	0.538	0.85
51_M	55_I	0.537	0.85
131_V	140_G	0.536	0.85
132_P	136_L	0.535	0.85
159_G	164_F	0.534	0.85
289_I	327_G	0.534	0.85
27_I	309_A	0.533	0.84
8_S	12_G	0.531	0.84
120_A	124_G	0.528	0.84
194_L	249_I	0.526	0.84
102_V	277_A	0.526	0.84
138_L	142_A	0.525	0.84
58_Q	85_T	0.524	0.83
132_P	237_I	0.524	0.83
107_T	122_I	0.524	0.83
250_A	253_V	0.522	0.83
62_L	85_T	0.522	0.83
73_V	113_A	0.521	0.83
148_N	167_I	0.521	0.83
154_L	158_V	0.520	0.83
41_I	332_A	0.518	0.83
135_G	237_I	0.518	0.83
58_Q	126_D	0.518	0.83
8_S	16_A	0.517	0.83
146_I	149_T	0.517	0.83
255_F	262_I	0.516	0.83
56_V	79_I	0.515	0.82
51_M	318_G	0.514	0.82
36_L	39_A	0.514	0.82
133_S	250_A	0.513	0.82
151_S	154_L	0.513	0.82
146_I	197_L	0.512	0.82
247_Q	251_M	0.512	0.82
91_I	273_V	0.511	0.82
92_T	296_L	0.509	0.82
246_C	249_I	0.508	0.82
12_G	20_F	0.507	0.81
13_F	24_F	0.506	0.81
290_E	317_I	0.504	0.81
146_I	151_S	0.504	0.81
99_G	126_D	0.504	0.81
164_F	238_G	0.503	0.81
309_A	312_V	0.502	0.81
156_S	169_G	0.502	0.81
11_V	213_E	0.502	0.81
155_R	169_G	0.501	0.81
102_V	331_L	0.501	0.81
31_E	71_I	0.501	0.81
89_N	92_T	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wdoA	1	0.8889	24.5	0.944	Contact Map
3zuxA	1	0.8304	13.6	0.95	Contact Map
2kluA	1	0.114	10.1	0.953	Contact Map
2jwaA	2	0.1111	6.8	0.957	Contact Map
4i0uA	4	0.1813	6.7	0.957	Contact Map
4ev6A	3	0.1871	6.2	0.957	Contact Map
2m20A	2	0.1023	5.9	0.958	Contact Map
2zy9A	2	0.3772	4.5	0.96	Contact Map
2l2tA	2	0.1199	4.4	0.96	Contact Map
4k0jA	3	0.4883	4.3	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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