Q9HSI7 - HALSA - GREMLIN Contacts

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Q9HSI7 - Uncharacterized protein

UniProt:	Q9HSI7	Sequences: MPESDPRQELADAFGRELDPLAQFEETFIETEIDPFELYEENRLASKDLSDSTVEEYRRSFRQWREFMDQQGRHPACPNESHITGFIKYHRDERGNSVGTIKNRLMYLNQAYQYWQDDAAFPHPQDYNPIDLAKATADLTHEGPKEPPRLSVDELRGKVEEITHIRDRAIVLMQLKLGLRATEVCNIKLSEIHLSNRDVQDHYDSMGEAKALKERNRKHAVYIPHERDGNKSRKPRMLPLDDELRRALLRYLLIRPDNGEPWLFLSQTTREQMTKQGVNEIWKSAFQPEYAETEDYRGITSHFGRHRFTTYWRVEQDLNRELIKYMRGDTAGSANLKDRGAIRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (269)
Sequences:	33774 (27129)
Seq/√Len:	1654.1

ECOLI - INTQ INTR INTD INTF INTB INTZ XERC INTA INTS XERD INTE FIMB FIME
BACSU - INT YOMM XERC XERD YOPP YOEC
HALSA - Q9HSI7 Q9HR66 Q9HQV5 O54590 O52010
SULSO - Q980D9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
309_T	327_R	4.965	1.00
79_N	82_H	3.404	1.00
189_L	252_L	3.169	1.00
178_G	308_F	2.843	1.00
73_R	82_H	2.671	1.00
236_R	328_G	2.623	1.00
174_Q	301_S	2.610	1.00
90_H	104_R	2.573	1.00
197_R	245_R	2.562	1.00
300_T	303_F	2.558	1.00
308_F	326_M	2.552	1.00
181_A	302_H	2.280	1.00
200_Q	237_M	2.247	1.00
169_A	251_Y	2.135	1.00
40_E	58_R	2.123	1.00
188_K	262_W	2.116	1.00
174_Q	184_V	2.108	1.00
87_I	105_L	1.986	1.00
151_S	154_E	1.980	1.00
176_K	241_D	1.975	1.00
245_R	249_L	1.955	1.00
60_S	107_Y	1.941	1.00
188_K	272_Q	1.938	1.00
188_K	261_P	1.919	1.00
114_Y	118_D	1.900	1.00
319_N	322_L	1.887	1.00
36_F	61_F	1.861	1.00
321_E	324_K	1.843	1.00
58_R	62_R	1.827	1.00
199_V	203_Y	1.791	1.00
63_Q	104_R	1.782	1.00
60_S	103_N	1.749	1.00
312_W	318_L	1.716	1.00
308_F	312_W	1.714	1.00
179_L	184_V	1.708	1.00
198_D	237_M	1.692	1.00
167_D	281_I	1.687	1.00
329_D	335_N	1.637	1.00
234_K	330_T	1.628	1.00
78_P	112_Y	1.608	1.00
181_A	185_C	1.605	1.00
313_R	323_I	1.601	1.00
193_H	196_N	1.596	1.00
152_V	311_Y	1.580	1.00
168_R	172_L	1.579	1.00
240_L	245_R	1.579	1.00
239_P	326_M	1.578	1.00
172_L	247_A	1.576	1.00
188_K	191_E	1.571	1.00
83_I	130_I	1.558	1.00
36_F	111_A	1.514	1.00
183_E	236_R	1.504	1.00
181_A	275_K	1.500	1.00
170_I	278_V	1.500	1.00
320_R	336_L	1.490	1.00
53_T	57_Y	1.486	1.00
99_G	103_N	1.481	1.00
111_A	115_W	1.469	1.00
155_L	175_L	1.465	1.00
189_L	263_L	1.448	1.00
312_W	323_I	1.442	1.00
35_P	115_W	1.438	1.00
159_V	172_L	1.425	1.00
324_K	332_G	1.417	1.00
91_R	101_I	1.410	1.00
321_E	325_Y	1.393	1.00
170_I	184_V	1.388	1.00
182_T	186_N	1.384	1.00
169_A	250_R	1.384	1.00
327_R	335_N	1.384	1.00
194_L	249_L	1.367	1.00
33_I	37_E	1.359	1.00
74_H	77_C	1.353	1.00
231_K	234_K	1.336	1.00
175_L	311_Y	1.322	1.00
150_L	307_R	1.318	1.00
154_E	157_G	1.313	1.00
67_F	89_Y	1.291	1.00
163_T	168_R	1.279	1.00
51_D	55_E	1.278	1.00
169_A	247_A	1.266	1.00
155_L	311_Y	1.261	1.00
176_K	244_L	1.260	1.00
55_E	59_R	1.253	1.00
52_S	55_E	1.245	1.00
266_S	269_T	1.239	1.00
105_L	109_N	1.234	1.00
150_L	299_I	1.233	1.00
175_L	304_G	1.228	1.00
262_W	272_Q	1.227	1.00
334_A	337_K	1.224	1.00
277_G	280_E	1.209	1.00
38_L	42_N	1.200	1.00
190_S	261_P	1.199	1.00
40_E	54_V	1.199	1.00
309_T	323_I	1.196	1.00
35_P	114_Y	1.192	1.00
281_I	284_S	1.191	1.00
87_I	91_R	1.189	1.00
332_G	336_L	1.188	1.00
86_F	90_H	1.182	1.00
121_F	127_Y	1.177	1.00
191_E	202_H	1.165	1.00
116_Q	121_F	1.155	1.00
279_N	283_K	1.152	1.00
57_Y	107_Y	1.143	1.00
197_R	242_D	1.138	1.00
86_F	104_R	1.131	1.00
176_K	243_E	1.131	1.00
165_I	254_I	1.125	1.00
60_S	104_R	1.124	1.00
181_A	279_N	1.121	1.00
162_I	285_A	1.121	1.00
56_E	59_R	1.118	1.00
149_R	307_R	1.115	1.00
202_H	235_P	1.115	1.00
54_V	58_R	1.105	1.00
170_I	264_F	1.102	1.00
46_S	54_V	1.100	1.00
307_R	311_Y	1.088	1.00
84_T	88_K	1.087	1.00
157_G	161_E	1.086	1.00
112_Y	121_F	1.078	1.00
333_S	336_L	1.070	1.00
113_Q	131_D	1.065	1.00
168_R	247_A	1.063	1.00
193_H	198_D	1.063	1.00
31_T	34_D	1.060	1.00
100_T	104_R	1.056	1.00
276_Q	279_N	1.051	1.00
35_P	75_P	1.050	1.00
275_K	279_N	1.048	1.00
115_W	120_A	1.046	1.00
33_I	66_E	1.037	1.00
150_L	158_K	1.036	1.00
331_A	337_K	1.036	1.00
189_L	255_R	1.035	1.00
80_E	84_T	1.031	1.00
154_E	297_R	1.028	1.00
64_W	67_F	1.022	1.00
56_E	60_S	1.022	1.00
274_T	277_G	1.018	1.00
333_S	337_K	1.009	1.00
73_R	77_C	1.008	1.00
286_F	299_I	1.006	1.00
282_W	286_F	1.003	1.00
152_V	316_Q	1.002	1.00
39_Y	110_Q	1.001	1.00
173_M	244_L	1.001	1.00
334_A	338_D	0.998	1.00
156_R	160_E	0.998	1.00
241_D	244_L	0.996	1.00
112_Y	129_P	0.995	1.00
331_A	334_A	0.989	1.00
152_V	156_R	0.987	1.00
318_L	322_L	0.987	1.00
49_L	54_V	0.984	1.00
119_A	127_Y	0.983	1.00
324_K	335_N	0.977	1.00
180_R	302_H	0.971	1.00
96_N	104_R	0.970	1.00
113_Q	128_N	0.960	1.00
109_N	113_Q	0.960	1.00
59_R	63_Q	0.957	1.00
80_E	117_D	0.955	1.00
175_L	307_R	0.953	1.00
91_R	98_V	0.953	1.00
52_S	56_E	0.953	1.00
67_F	86_F	0.950	1.00
185_C	275_K	0.949	1.00
172_L	243_E	0.947	1.00
103_N	106_M	0.946	1.00
173_M	264_F	0.943	1.00
56_E	103_N	0.933	1.00
310_T	340_G	0.931	1.00
51_D	54_V	0.925	1.00
309_T	313_R	0.925	1.00
308_F	327_R	0.923	1.00
97_S	100_T	0.917	1.00
29_I	76_A	0.917	1.00
243_E	246_R	0.910	1.00
194_L	245_R	0.908	1.00
187_I	199_V	0.907	1.00
50_S	53_T	0.907	1.00
84_T	118_D	0.906	1.00
230_N	234_K	0.906	1.00
161_E	292_E	0.898	1.00
283_K	298_G	0.893	1.00
165_I	250_R	0.886	1.00
64_W	112_Y	0.883	1.00
33_I	72_G	0.882	1.00
162_I	171_V	0.881	1.00
150_L	154_E	0.879	1.00
179_L	201_D	0.878	1.00
68_M	89_Y	0.877	1.00
85_G	89_Y	0.867	1.00
242_D	246_R	0.861	1.00
187_I	192_I	0.861	1.00
285_A	292_E	0.860	1.00
61_F	66_E	0.853	1.00
90_H	101_I	0.851	1.00
36_F	40_E	0.850	1.00
116_Q	127_Y	0.850	1.00
306_H	340_G	0.849	1.00
311_Y	315_E	0.845	1.00
148_P	303_F	0.844	1.00
96_N	100_T	0.844	1.00
49_L	57_Y	0.837	1.00
62_R	66_E	0.835	1.00
90_H	96_N	0.834	1.00
112_Y	130_I	0.834	1.00
190_S	260_E	0.829	1.00
116_Q	128_N	0.827	1.00
82_H	85_G	0.823	1.00
262_W	265_L	0.821	1.00
165_I	169_A	0.819	1.00
279_N	301_S	0.813	1.00
38_L	120_A	0.812	1.00
240_L	244_L	0.809	1.00
281_I	285_A	0.808	1.00
165_I	168_R	0.805	1.00
321_E	336_L	0.804	1.00
283_K	287_Q	0.793	1.00
37_E	58_R	0.793	1.00
280_E	284_S	0.788	1.00
266_S	271_E	0.787	1.00
38_L	114_Y	0.787	1.00
152_V	315_E	0.784	1.00
29_I	74_H	0.783	1.00
102_K	106_M	0.782	1.00
193_H	200_Q	0.781	1.00
324_K	336_L	0.779	1.00
277_G	281_I	0.776	1.00
116_Q	131_D	0.776	1.00
284_S	292_E	0.776	1.00
173_M	184_V	0.774	1.00
185_C	278_V	0.772	1.00
322_L	326_M	0.771	1.00
169_A	264_F	0.768	1.00
278_V	301_S	0.765	1.00
99_G	102_K	0.765	1.00
117_D	134_K	0.765	1.00
30_E	34_D	0.760	1.00
313_R	340_G	0.750	1.00
158_K	171_V	0.742	1.00
35_P	111_A	0.742	1.00
282_W	304_G	0.740	1.00
128_N	131_D	0.737	1.00
161_E	293_T	0.735	1.00
115_W	121_F	0.734	1.00
96_N	101_I	0.734	1.00
113_Q	116_Q	0.728	1.00
105_L	130_I	0.726	1.00
117_D	132_L	0.723	1.00
102_K	140_T	0.722	1.00
109_N	130_I	0.718	1.00
181_A	301_S	0.716	1.00
88_K	91_R	0.715	1.00
162_I	168_R	0.714	1.00
187_I	263_L	0.714	1.00
166_R	251_Y	0.714	1.00
78_P	83_I	0.713	1.00
37_E	41_E	0.710	1.00
30_E	38_L	0.708	1.00
149_R	310_T	0.708	1.00
67_F	85_G	0.707	1.00
181_A	278_V	0.705	1.00
155_L	307_R	0.704	1.00
200_Q	235_P	0.703	1.00
33_I	65_R	0.696	1.00
247_A	250_R	0.694	1.00
244_L	247_A	0.693	1.00
38_L	41_E	0.690	1.00
83_I	108_L	0.689	1.00
177_L	238_L	0.688	1.00
251_Y	255_R	0.687	1.00
299_I	303_F	0.685	1.00
81_S	118_D	0.682	1.00
320_R	332_G	0.681	1.00
69_D	86_F	0.681	1.00
64_W	69_D	0.680	1.00
89_Y	93_E	0.679	1.00
87_I	101_I	0.677	1.00
116_Q	132_L	0.673	1.00
32_E	111_A	0.673	1.00
59_R	62_R	0.670	1.00
249_L	252_L	0.667	1.00
86_F	108_L	0.665	1.00
89_Y	94_R	0.665	1.00
110_Q	114_Y	0.665	1.00
81_S	85_G	0.664	1.00
171_V	304_G	0.663	1.00
80_E	119_A	0.660	1.00
88_K	92_D	0.659	1.00
178_G	327_R	0.659	1.00
202_H	233_R	0.659	1.00
172_L	176_K	0.656	1.00
32_E	36_F	0.655	1.00
39_Y	114_Y	0.651	1.00
148_P	297_R	0.650	1.00
194_L	199_V	0.650	1.00
98_V	102_K	0.648	1.00
34_D	38_L	0.646	1.00
163_T	172_L	0.644	1.00
249_L	253_L	0.644	1.00
157_G	160_E	0.644	1.00
169_A	248_L	0.643	1.00
313_R	321_E	0.640	1.00
313_R	320_R	0.638	1.00
42_N	114_Y	0.636	1.00
61_F	111_A	0.636	1.00
173_M	199_V	0.635	1.00
282_W	301_S	0.635	1.00
152_V	307_R	0.632	1.00
167_D	285_A	0.631	1.00
116_Q	126_D	0.630	1.00
166_R	169_A	0.626	1.00
35_P	118_D	0.625	1.00
158_K	286_F	0.624	1.00
67_F	70_Q	0.624	1.00
147_P	300_T	0.620	1.00
161_E	285_A	0.619	1.00
252_L	255_R	0.617	1.00
65_R	69_D	0.614	1.00
64_W	93_E	0.612	1.00
64_W	108_L	0.610	1.00
80_E	132_L	0.609	1.00
309_T	335_N	0.608	1.00
66_E	70_Q	0.608	1.00
186_N	272_Q	0.606	1.00
153_D	157_G	0.600	1.00
155_L	159_V	0.600	1.00
243_E	247_A	0.597	1.00
192_I	263_L	0.597	1.00
61_F	65_R	0.597	1.00
173_M	248_L	0.597	1.00
302_H	306_H	0.596	1.00
109_N	131_D	0.595	1.00
194_L	197_R	0.594	1.00
121_F	126_D	0.591	1.00
172_L	244_L	0.590	1.00
57_Y	60_S	0.590	1.00
33_I	70_Q	0.586	1.00
246_R	250_R	0.586	1.00
173_M	179_L	0.585	1.00
149_R	340_G	0.585	1.00
63_Q	94_R	0.584	1.00
84_T	87_I	0.583	1.00
171_V	282_W	0.583	1.00
153_D	156_R	0.582	1.00
255_R	265_L	0.581	1.00
169_A	244_L	0.581	1.00
31_T	74_H	0.580	1.00
174_Q	181_A	0.577	1.00
62_R	65_R	0.575	1.00
174_Q	304_G	0.573	1.00
283_K	286_F	0.572	1.00
119_A	132_L	0.571	1.00
293_T	296_Y	0.571	1.00
116_Q	119_A	0.570	1.00
192_I	248_L	0.569	1.00
35_P	120_A	0.569	1.00
86_F	89_Y	0.566	1.00
331_A	336_L	0.559	1.00
260_E	265_L	0.558	1.00
177_L	241_D	0.558	1.00
61_F	107_Y	0.556	1.00
37_E	66_E	0.556	1.00
90_H	94_R	0.554	1.00
287_Q	292_E	0.554	1.00
105_L	133_A	0.551	1.00
313_R	319_N	0.551	1.00
64_W	68_M	0.550	1.00
108_L	130_I	0.547	1.00
189_L	248_L	0.545	1.00
246_R	249_L	0.545	1.00
45_A	48_D	0.543	1.00
161_E	164_H	0.543	1.00
83_I	133_A	0.543	1.00
64_W	86_F	0.542	1.00
49_L	53_T	0.541	1.00
112_Y	116_Q	0.541	1.00
318_L	323_I	0.540	1.00
75_P	112_Y	0.539	1.00
110_Q	113_Q	0.538	1.00
194_L	240_L	0.538	1.00
93_E	96_N	0.536	1.00
276_Q	280_E	0.536	1.00
150_L	303_F	0.535	1.00
111_A	114_Y	0.526	1.00
173_M	187_I	0.521	1.00
309_T	329_D	0.521	1.00
276_Q	283_K	0.520	1.00
158_K	282_W	0.517	1.00
312_W	326_M	0.515	1.00
75_P	115_W	0.513	1.00
179_L	187_I	0.508	1.00
42_N	84_T	0.508	1.00
183_E	230_N	0.506	1.00
159_V	168_R	0.504	1.00
36_F	65_R	0.502	1.00
112_Y	128_N	0.501	1.00
252_L	256_P	0.501	1.00
183_E	328_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a0pA	1	0.7355	100	0.243	Contact Map
1z1bA	3	0.8576	100	0.251	Contact Map
2a3vA	3	0.7762	100	0.262	Contact Map
1z19A	3	0.7733	100	0.275	Contact Map
1xo0A	3	0.8169	100	0.288	Contact Map
4a8eA	2	0.7297	100	0.311	Contact Map
3nkhA	2	0.5436	100	0.434	Contact Map
1ae9A	4	0.4448	100	0.51	Contact Map
1aihA	2	0.4331	99.9	0.553	Contact Map
4e0gA	2	0.7442	99.9	0.556	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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