GREMLIN Database
Q9HSI7 - Uncharacterized protein
UniProt: Q9HSI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (269)
Sequences: 33774 (27129)
Seq/√Len: 1654.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
309_T327_R4.9651.00
79_N82_H3.4041.00
189_L252_L3.1691.00
178_G308_F2.8431.00
73_R82_H2.6711.00
236_R328_G2.6231.00
174_Q301_S2.6101.00
90_H104_R2.5731.00
197_R245_R2.5621.00
300_T303_F2.5581.00
308_F326_M2.5521.00
181_A302_H2.2801.00
200_Q237_M2.2471.00
169_A251_Y2.1351.00
40_E58_R2.1231.00
188_K262_W2.1161.00
174_Q184_V2.1081.00
87_I105_L1.9861.00
151_S154_E1.9801.00
176_K241_D1.9751.00
245_R249_L1.9551.00
60_S107_Y1.9411.00
188_K272_Q1.9381.00
188_K261_P1.9191.00
114_Y118_D1.9001.00
319_N322_L1.8871.00
36_F61_F1.8611.00
321_E324_K1.8431.00
58_R62_R1.8271.00
199_V203_Y1.7911.00
63_Q104_R1.7821.00
60_S103_N1.7491.00
312_W318_L1.7161.00
308_F312_W1.7141.00
179_L184_V1.7081.00
198_D237_M1.6921.00
167_D281_I1.6871.00
329_D335_N1.6371.00
234_K330_T1.6281.00
78_P112_Y1.6081.00
181_A185_C1.6051.00
313_R323_I1.6011.00
193_H196_N1.5961.00
152_V311_Y1.5801.00
168_R172_L1.5791.00
240_L245_R1.5791.00
239_P326_M1.5781.00
172_L247_A1.5761.00
188_K191_E1.5711.00
83_I130_I1.5581.00
36_F111_A1.5141.00
183_E236_R1.5041.00
181_A275_K1.5001.00
170_I278_V1.5001.00
320_R336_L1.4901.00
53_T57_Y1.4861.00
99_G103_N1.4811.00
111_A115_W1.4691.00
155_L175_L1.4651.00
189_L263_L1.4481.00
312_W323_I1.4421.00
35_P115_W1.4381.00
159_V172_L1.4251.00
324_K332_G1.4171.00
91_R101_I1.4101.00
321_E325_Y1.3931.00
170_I184_V1.3881.00
182_T186_N1.3841.00
169_A250_R1.3841.00
327_R335_N1.3841.00
194_L249_L1.3671.00
33_I37_E1.3591.00
74_H77_C1.3531.00
231_K234_K1.3361.00
175_L311_Y1.3221.00
150_L307_R1.3181.00
154_E157_G1.3131.00
67_F89_Y1.2911.00
163_T168_R1.2791.00
51_D55_E1.2781.00
169_A247_A1.2661.00
155_L311_Y1.2611.00
176_K244_L1.2601.00
55_E59_R1.2531.00
52_S55_E1.2451.00
266_S269_T1.2391.00
105_L109_N1.2341.00
150_L299_I1.2331.00
175_L304_G1.2281.00
262_W272_Q1.2271.00
334_A337_K1.2241.00
277_G280_E1.2091.00
38_L42_N1.2001.00
190_S261_P1.1991.00
40_E54_V1.1991.00
309_T323_I1.1961.00
35_P114_Y1.1921.00
281_I284_S1.1911.00
87_I91_R1.1891.00
332_G336_L1.1881.00
86_F90_H1.1821.00
121_F127_Y1.1771.00
191_E202_H1.1651.00
116_Q121_F1.1551.00
279_N283_K1.1521.00
57_Y107_Y1.1431.00
197_R242_D1.1381.00
86_F104_R1.1311.00
176_K243_E1.1311.00
165_I254_I1.1251.00
60_S104_R1.1241.00
181_A279_N1.1211.00
162_I285_A1.1211.00
56_E59_R1.1181.00
149_R307_R1.1151.00
202_H235_P1.1151.00
54_V58_R1.1051.00
170_I264_F1.1021.00
46_S54_V1.1001.00
307_R311_Y1.0881.00
84_T88_K1.0871.00
157_G161_E1.0861.00
112_Y121_F1.0781.00
333_S336_L1.0701.00
113_Q131_D1.0651.00
168_R247_A1.0631.00
193_H198_D1.0631.00
31_T34_D1.0601.00
100_T104_R1.0561.00
276_Q279_N1.0511.00
35_P75_P1.0501.00
275_K279_N1.0481.00
115_W120_A1.0461.00
33_I66_E1.0371.00
150_L158_K1.0361.00
331_A337_K1.0361.00
189_L255_R1.0351.00
80_E84_T1.0311.00
154_E297_R1.0281.00
64_W67_F1.0221.00
56_E60_S1.0221.00
274_T277_G1.0181.00
333_S337_K1.0091.00
73_R77_C1.0081.00
286_F299_I1.0061.00
282_W286_F1.0031.00
152_V316_Q1.0021.00
39_Y110_Q1.0011.00
173_M244_L1.0011.00
334_A338_D0.9981.00
156_R160_E0.9981.00
241_D244_L0.9961.00
112_Y129_P0.9951.00
331_A334_A0.9891.00
152_V156_R0.9871.00
318_L322_L0.9871.00
49_L54_V0.9841.00
119_A127_Y0.9831.00
324_K335_N0.9771.00
180_R302_H0.9711.00
96_N104_R0.9701.00
113_Q128_N0.9601.00
109_N113_Q0.9601.00
59_R63_Q0.9571.00
80_E117_D0.9551.00
175_L307_R0.9531.00
91_R98_V0.9531.00
52_S56_E0.9531.00
67_F86_F0.9501.00
185_C275_K0.9491.00
172_L243_E0.9471.00
103_N106_M0.9461.00
173_M264_F0.9431.00
56_E103_N0.9331.00
310_T340_G0.9311.00
51_D54_V0.9251.00
309_T313_R0.9251.00
308_F327_R0.9231.00
97_S100_T0.9171.00
29_I76_A0.9171.00
243_E246_R0.9101.00
194_L245_R0.9081.00
187_I199_V0.9071.00
50_S53_T0.9071.00
84_T118_D0.9061.00
230_N234_K0.9061.00
161_E292_E0.8981.00
283_K298_G0.8931.00
165_I250_R0.8861.00
64_W112_Y0.8831.00
33_I72_G0.8821.00
162_I171_V0.8811.00
150_L154_E0.8791.00
179_L201_D0.8781.00
68_M89_Y0.8771.00
85_G89_Y0.8671.00
242_D246_R0.8611.00
187_I192_I0.8611.00
285_A292_E0.8601.00
61_F66_E0.8531.00
90_H101_I0.8511.00
36_F40_E0.8501.00
116_Q127_Y0.8501.00
306_H340_G0.8491.00
311_Y315_E0.8451.00
148_P303_F0.8441.00
96_N100_T0.8441.00
49_L57_Y0.8371.00
62_R66_E0.8351.00
90_H96_N0.8341.00
112_Y130_I0.8341.00
190_S260_E0.8291.00
116_Q128_N0.8271.00
82_H85_G0.8231.00
262_W265_L0.8211.00
165_I169_A0.8191.00
279_N301_S0.8131.00
38_L120_A0.8121.00
240_L244_L0.8091.00
281_I285_A0.8081.00
165_I168_R0.8051.00
321_E336_L0.8041.00
283_K287_Q0.7931.00
37_E58_R0.7931.00
280_E284_S0.7881.00
266_S271_E0.7871.00
38_L114_Y0.7871.00
152_V315_E0.7841.00
29_I74_H0.7831.00
102_K106_M0.7821.00
193_H200_Q0.7811.00
324_K336_L0.7791.00
277_G281_I0.7761.00
116_Q131_D0.7761.00
284_S292_E0.7761.00
173_M184_V0.7741.00
185_C278_V0.7721.00
322_L326_M0.7711.00
169_A264_F0.7681.00
278_V301_S0.7651.00
99_G102_K0.7651.00
117_D134_K0.7651.00
30_E34_D0.7601.00
313_R340_G0.7501.00
158_K171_V0.7421.00
35_P111_A0.7421.00
282_W304_G0.7401.00
128_N131_D0.7371.00
161_E293_T0.7351.00
115_W121_F0.7341.00
96_N101_I0.7341.00
113_Q116_Q0.7281.00
105_L130_I0.7261.00
117_D132_L0.7231.00
102_K140_T0.7221.00
109_N130_I0.7181.00
181_A301_S0.7161.00
88_K91_R0.7151.00
162_I168_R0.7141.00
187_I263_L0.7141.00
166_R251_Y0.7141.00
78_P83_I0.7131.00
37_E41_E0.7101.00
30_E38_L0.7081.00
149_R310_T0.7081.00
67_F85_G0.7071.00
181_A278_V0.7051.00
155_L307_R0.7041.00
200_Q235_P0.7031.00
33_I65_R0.6961.00
247_A250_R0.6941.00
244_L247_A0.6931.00
38_L41_E0.6901.00
83_I108_L0.6891.00
177_L238_L0.6881.00
251_Y255_R0.6871.00
299_I303_F0.6851.00
81_S118_D0.6821.00
320_R332_G0.6811.00
69_D86_F0.6811.00
64_W69_D0.6801.00
89_Y93_E0.6791.00
87_I101_I0.6771.00
116_Q132_L0.6731.00
32_E111_A0.6731.00
59_R62_R0.6701.00
249_L252_L0.6671.00
86_F108_L0.6651.00
89_Y94_R0.6651.00
110_Q114_Y0.6651.00
81_S85_G0.6641.00
171_V304_G0.6631.00
80_E119_A0.6601.00
88_K92_D0.6591.00
178_G327_R0.6591.00
202_H233_R0.6591.00
172_L176_K0.6561.00
32_E36_F0.6551.00
39_Y114_Y0.6511.00
148_P297_R0.6501.00
194_L199_V0.6501.00
98_V102_K0.6481.00
34_D38_L0.6461.00
163_T172_L0.6441.00
249_L253_L0.6441.00
157_G160_E0.6441.00
169_A248_L0.6431.00
313_R321_E0.6401.00
313_R320_R0.6381.00
42_N114_Y0.6361.00
61_F111_A0.6361.00
173_M199_V0.6351.00
282_W301_S0.6351.00
152_V307_R0.6321.00
167_D285_A0.6311.00
116_Q126_D0.6301.00
166_R169_A0.6261.00
35_P118_D0.6251.00
158_K286_F0.6241.00
67_F70_Q0.6241.00
147_P300_T0.6201.00
161_E285_A0.6191.00
252_L255_R0.6171.00
65_R69_D0.6141.00
64_W93_E0.6121.00
64_W108_L0.6101.00
80_E132_L0.6091.00
309_T335_N0.6081.00
66_E70_Q0.6081.00
186_N272_Q0.6061.00
153_D157_G0.6001.00
155_L159_V0.6001.00
243_E247_A0.5971.00
192_I263_L0.5971.00
61_F65_R0.5971.00
173_M248_L0.5971.00
302_H306_H0.5961.00
109_N131_D0.5951.00
194_L197_R0.5941.00
121_F126_D0.5911.00
172_L244_L0.5901.00
57_Y60_S0.5901.00
33_I70_Q0.5861.00
246_R250_R0.5861.00
173_M179_L0.5851.00
149_R340_G0.5851.00
63_Q94_R0.5841.00
84_T87_I0.5831.00
171_V282_W0.5831.00
153_D156_R0.5821.00
255_R265_L0.5811.00
169_A244_L0.5811.00
31_T74_H0.5801.00
174_Q181_A0.5771.00
62_R65_R0.5751.00
174_Q304_G0.5731.00
283_K286_F0.5721.00
119_A132_L0.5711.00
293_T296_Y0.5711.00
116_Q119_A0.5701.00
192_I248_L0.5691.00
35_P120_A0.5691.00
86_F89_Y0.5661.00
331_A336_L0.5591.00
260_E265_L0.5581.00
177_L241_D0.5581.00
61_F107_Y0.5561.00
37_E66_E0.5561.00
90_H94_R0.5541.00
287_Q292_E0.5541.00
105_L133_A0.5511.00
313_R319_N0.5511.00
64_W68_M0.5501.00
108_L130_I0.5471.00
189_L248_L0.5451.00
246_R249_L0.5451.00
45_A48_D0.5431.00
161_E164_H0.5431.00
83_I133_A0.5431.00
64_W86_F0.5421.00
49_L53_T0.5411.00
112_Y116_Q0.5411.00
318_L323_I0.5401.00
75_P112_Y0.5391.00
110_Q113_Q0.5381.00
194_L240_L0.5381.00
93_E96_N0.5361.00
276_Q280_E0.5361.00
150_L303_F0.5351.00
111_A114_Y0.5261.00
173_M187_I0.5211.00
309_T329_D0.5211.00
276_Q283_K0.5201.00
158_K282_W0.5171.00
312_W326_M0.5151.00
75_P115_W0.5131.00
179_L187_I0.5081.00
42_N84_T0.5081.00
183_E230_N0.5061.00
159_V168_R0.5041.00
36_F65_R0.5021.00
112_Y128_N0.5011.00
252_L256_P0.5011.00
183_E328_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.7355 100 0.243 Contact Map
1z1bA 3 0.8576 100 0.251 Contact Map
2a3vA 3 0.7762 100 0.262 Contact Map
1z19A 3 0.7733 100 0.275 Contact Map
1xo0A 3 0.8169 100 0.288 Contact Map
4a8eA 2 0.7297 100 0.311 Contact Map
3nkhA 2 0.5436 100 0.434 Contact Map
1ae9A 4 0.4448 100 0.51 Contact Map
1aihA 2 0.4331 99.9 0.553 Contact Map
4e0gA 2 0.7442 99.9 0.556 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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