GREMLIN Database
Q9HSH8 - Uncharacterized protein
UniProt: Q9HSH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (375)
Sequences: 2611 (2089)
Seq/√Len: 107.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_A259_E5.1081.00
59_R92_D4.8701.00
210_D223_V4.6361.00
56_S79_T4.4831.00
92_D121_Y4.3901.00
129_D157_T4.3011.00
199_E219_E4.1021.00
73_D120_T4.0081.00
59_R121_Y3.9741.00
265_A299_L3.7711.00
384_R400_D3.6621.00
79_T116_S3.5651.00
75_T118_T3.4941.00
71_E122_T3.4621.00
214_L220_L3.3521.00
129_D305_C3.2601.00
71_E124_E3.1671.00
235_A265_A3.1521.00
58_E77_T3.1371.00
74_V121_Y3.0601.00
65_A301_A2.8881.00
276_G289_P2.8871.00
77_T118_T2.8661.00
206_L209_V2.7341.00
66_P72_V2.7251.00
75_T120_T2.6941.00
264_V340_C2.6511.00
73_D122_T2.5821.00
235_A340_C2.4531.00
233_A268_L2.4121.00
237_V257_G2.4051.00
58_E79_T2.2941.00
262_G300_E2.2361.00
235_A275_V2.1871.00
16_S35_G2.1571.00
9_W12_A2.0771.00
60_S75_T2.0591.00
138_I149_R2.0561.00
234_V276_G2.0481.00
60_S77_T2.0441.00
258_V303_L2.0441.00
199_E221_A2.0441.00
84_F110_A2.0291.00
238_D243_A1.9881.00
234_V335_A1.9231.00
112_R115_K1.8501.00
140_R147_E1.8431.00
198_R204_D1.8121.00
134_P151_T1.7871.00
127_R255_E1.7721.00
11_G15_L1.7641.00
389_R393_A1.7411.00
232_T276_G1.7371.00
388_V392_R1.7101.00
19_V22_A1.7031.00
77_T116_S1.6771.00
210_D213_R1.6761.00
131_E157_T1.6631.00
194_F197_T1.6601.00
56_S81_D1.6511.00
164_F266_S1.6491.00
111_L115_K1.6291.00
138_I147_E1.6201.00
23_G32_L1.6131.00
367_P400_D1.5661.00
164_F263_G1.5431.00
208_R225_F1.5361.00
235_A261_A1.5211.00
244_H253_A1.5101.00
352_V396_V1.5031.00
388_V398_V1.4661.00
91_I136_A1.4611.00
72_V158_L1.4581.00
20_I24_A1.4521.00
67_A70_D1.4511.00
260_A340_C1.4371.00
269_L275_V1.4341.00
197_T221_A1.4341.00
244_H254_V1.4251.00
23_G35_G1.4231.00
389_R392_R1.4141.00
234_V278_A1.4131.00
266_S296_R1.4121.00
31_V35_G1.4021.00
23_G27_R1.3981.00
165_P263_G1.3961.00
253_A342_P1.3871.00
391_L396_V1.3771.00
388_V400_D1.3761.00
383_A387_R1.3761.00
167_L263_G1.3701.00
32_L35_G1.3661.00
28_V31_V1.3631.00
236_V278_A1.3541.00
55_L80_N1.3531.00
197_T223_V1.3391.00
392_R398_V1.3320.99
136_A149_R1.3250.99
18_A22_A1.3090.99
134_P153_P1.3060.99
295_H298_R1.3010.99
267_A271_A1.2950.99
106_R109_T1.2950.99
165_P259_E1.2940.99
393_A404_G1.2860.99
136_A151_T1.2710.99
217_D221_A1.2690.99
59_R74_V1.2670.99
264_V338_V1.2640.99
159_T304_A1.2610.99
382_V401_W1.2600.99
303_L306_D1.2380.99
10_R18_A1.2380.99
292_G295_H1.2270.99
214_L217_D1.2220.99
127_R215_A1.2150.99
70_D163_D1.2070.99
134_P154_A1.1850.99
385_A402_Q1.1820.99
80_N113_A1.1610.99
276_G295_H1.1580.99
61_V158_L1.1580.99
261_A277_V1.1500.98
379_F383_A1.1420.98
279_S306_D1.1390.98
163_D259_E1.1350.98
194_F225_F1.1300.98
10_R19_V1.1290.98
194_F223_V1.1250.98
215_A261_A1.1210.98
254_V258_V1.1150.98
10_R14_A1.1140.98
234_V289_P1.1100.98
140_R144_G1.1070.98
265_A275_V1.1030.98
16_S39_V1.0930.98
111_L117_A1.0880.98
80_N111_L1.0880.98
352_V361_P1.0760.98
341_S348_A1.0710.98
268_L275_V1.0700.98
12_A16_S1.0580.97
269_L295_H1.0540.97
237_V258_V1.0470.97
88_L110_A1.0460.97
239_T279_S1.0400.97
290_G298_R1.0400.97
181_G189_G1.0360.97
290_G295_H1.0360.97
265_A269_L1.0300.97
386_V390_S1.0270.97
10_R24_A1.0230.97
14_A18_A1.0230.97
207_S222_T1.0170.97
387_R393_A1.0170.97
191_G228_E1.0160.97
256_Y259_E1.0130.97
239_T254_V1.0090.97
257_G340_C1.0090.97
255_E262_G1.0080.97
383_A392_R1.0050.96
42_A197_T1.0040.96
97_T100_V0.9970.96
26_T29_P0.9960.96
234_V286_W0.9940.96
277_V302_L0.9930.96
209_V220_L0.9920.96
258_V306_D0.9890.96
209_V212_T0.9890.96
95_P98_L0.9890.96
238_D341_S0.9870.96
74_V123_V0.9860.96
127_R258_V0.9850.96
213_R221_A0.9750.96
238_D280_L0.9670.96
193_A226_R0.9670.96
266_S299_L0.9650.96
287_L302_L0.9590.95
393_A402_Q0.9570.95
204_D222_T0.9490.95
58_E155_A0.9430.95
161_V301_A0.9420.95
339_F352_V0.9420.95
197_T217_D0.9390.95
15_L31_V0.9380.95
44_Y48_F0.9370.95
379_F382_V0.9330.95
386_V393_A0.9330.95
261_A340_C0.9330.95
92_D95_P0.9320.95
385_A389_R0.9310.95
45_A141_D0.9300.95
54_S82_G0.9290.95
134_P218_G0.9290.95
280_L320_S0.9220.94
27_R160_C0.9150.94
193_A228_E0.9130.94
319_L322_L0.9110.94
28_V35_G0.9090.94
76_L119_V0.9070.94
184_P187_T0.9020.94
392_R395_S0.8960.93
131_E155_A0.8940.93
359_G363_T0.8920.93
50_P85_L0.8920.93
390_S393_A0.8910.93
55_L59_R0.8880.93
89_R147_E0.8880.93
384_R398_V0.8860.93
98_L123_V0.8840.93
129_D159_T0.8760.93
142_I209_V0.8730.92
237_V254_V0.8710.92
20_I35_G0.8680.92
57_V135_V0.8670.92
94_V123_V0.8650.92
254_V308_G0.8630.92
110_A113_A0.8620.92
80_N112_R0.8600.92
38_G41_G0.8580.92
170_F299_L0.8580.92
385_A397_R0.8530.92
392_R402_Q0.8490.91
336_Q363_T0.8450.91
269_L296_R0.8410.91
384_R401_W0.8400.91
272_G292_G0.8400.91
20_I23_G0.8390.91
9_W15_L0.8370.91
277_V303_L0.8350.91
331_L335_A0.8290.90
9_W16_S0.8280.90
41_G143_S0.8280.90
268_L273_N0.8280.90
296_R303_L0.8270.90
178_Q181_G0.8250.90
26_T31_V0.8250.90
128_G303_L0.8240.90
400_D403_A0.8240.90
280_L322_L0.8230.90
385_A388_V0.8230.90
382_V389_R0.8210.90
159_T305_C0.8200.90
181_G194_F0.8200.90
319_L327_L0.8190.90
21_A58_E0.8180.90
45_A48_F0.8180.90
189_G228_E0.8100.89
264_V268_L0.8020.89
189_G273_N0.8010.89
382_V390_S0.8000.89
92_D132_F0.7990.89
87_D140_R0.7980.89
19_V118_T0.7980.89
9_W13_V0.7950.88
269_L291_L0.7950.88
40_A89_R0.7940.88
213_R216_R0.7920.88
348_A352_V0.7900.88
160_C216_R0.7880.88
19_V34_L0.7870.88
21_A108_A0.7870.88
384_R387_R0.7860.88
326_R332_P0.7830.88
66_P125_A0.7810.88
194_F229_R0.7770.87
278_A286_W0.7750.87
359_G362_V0.7730.87
216_R268_L0.7730.87
21_A25_T0.7720.87
181_G273_N0.7690.87
59_R127_R0.7650.86
57_V152_V0.7630.86
17_L34_L0.7610.86
52_A139_A0.7590.86
54_S89_R0.7590.86
116_S218_G0.7570.86
386_V392_R0.7570.86
213_R276_G0.7560.86
181_G191_G0.7530.86
12_A38_G0.7510.85
341_S364_V0.7510.85
232_T319_L0.7480.85
16_S38_G0.7470.85
388_V397_R0.7460.85
70_D265_A0.7460.85
74_V92_D0.7450.85
9_W222_T0.7440.85
67_A164_F0.7430.85
210_D216_R0.7380.84
27_R31_V0.7370.84
10_R15_L0.7330.84
167_L266_S0.7330.84
234_V327_L0.7320.84
12_A19_V0.7260.83
56_S146_H0.7250.83
10_R22_A0.7250.83
244_H342_P0.7250.83
23_G28_V0.7240.83
181_G238_D0.7230.83
127_R143_S0.7220.83
27_R39_V0.7220.83
27_R35_G0.7200.83
399_I404_G0.7180.83
98_L106_R0.7180.83
21_A27_R0.7140.82
93_G136_A0.7120.82
186_P276_G0.7090.82
12_A27_R0.7090.82
89_R108_A0.7080.82
323_V327_L0.7080.82
19_V81_D0.7080.82
236_V352_V0.7070.82
141_D263_G0.7060.82
142_I304_A0.7040.82
47_L330_H0.7010.81
61_V64_D0.6980.81
383_A386_V0.6960.81
40_A83_S0.6960.81
133_D153_P0.6940.81
22_A25_T0.6930.81
135_V206_L0.6910.80
156_T160_C0.6900.80
77_T80_N0.6880.80
67_A72_V0.6870.80
34_L37_L0.6870.80
289_P292_G0.6840.80
59_R132_F0.6810.79
13_V35_G0.6800.79
199_E217_D0.6800.79
24_A32_L0.6800.79
198_R224_Q0.6760.79
66_P132_F0.6750.79
61_V121_Y0.6750.79
394_A402_Q0.6740.79
13_V16_S0.6720.79
133_D154_A0.6710.78
112_R117_A0.6710.78
346_D351_Y0.6710.78
141_D146_H0.6680.78
232_T274_Q0.6670.78
55_L137_V0.6640.78
85_L111_L0.6630.78
388_V393_A0.6630.78
79_T110_A0.6620.77
258_V300_E0.6620.77
67_A161_V0.6610.77
343_L369_V0.6610.77
332_P335_A0.6600.77
351_Y354_R0.6590.77
200_Y204_D0.6590.77
161_V304_A0.6580.77
72_V132_F0.6570.77
127_R304_A0.6550.77
249_D404_G0.6520.76
196_A224_Q0.6520.76
98_L236_V0.6520.76
223_V302_L0.6510.76
392_R397_R0.6490.76
274_Q291_L0.6490.76
336_Q361_P0.6480.76
383_A403_A0.6470.76
276_G292_G0.6460.76
240_R243_A0.6460.76
386_V394_A0.6450.76
105_P109_T0.6440.76
56_S73_D0.6440.76
339_F348_A0.6430.75
391_L398_V0.6430.75
83_S97_T0.6410.75
384_R390_S0.6400.75
328_R358_S0.6400.75
255_E260_A0.6390.75
363_T366_S0.6390.75
127_R213_R0.6390.75
53_P152_V0.6380.75
202_S255_E0.6370.75
35_G42_A0.6340.74
379_F397_R0.6320.74
105_P108_A0.6310.74
339_F349_A0.6310.74
59_R156_T0.6300.74
47_L50_P0.6300.74
260_A264_V0.6300.74
28_V84_F0.6290.74
41_G145_S0.6290.74
370_T379_F0.6290.74
22_A26_T0.6290.74
197_T230_A0.6290.74
382_V385_A0.6290.74
212_T245_V0.6280.74
34_L38_G0.6280.74
15_L25_T0.6260.73
288_A292_G0.6250.73
117_A123_V0.6240.73
320_S333_D0.6220.73
12_A216_R0.6220.73
189_G238_D0.6210.73
214_L221_A0.6200.73
40_A43_G0.6200.73
191_G229_R0.6180.73
269_L299_L0.6180.73
262_G303_L0.6170.72
213_R223_V0.6160.72
350_E354_R0.6150.72
385_A392_R0.6140.72
57_V61_V0.6130.72
157_T305_C0.6120.72
95_P130_H0.6100.72
299_L302_L0.6100.72
386_V389_R0.6100.72
215_A263_G0.6090.71
15_L20_I0.6090.71
350_E353_R0.6090.71
279_S303_L0.6080.71
33_V287_L0.6070.71
28_V34_L0.6060.71
85_L142_I0.6060.71
326_R330_H0.6040.71
383_A388_V0.6040.71
29_P33_V0.6030.71
78_V90_L0.6020.71
356_E361_P0.6020.71
257_G342_P0.6020.71
21_A24_A0.6020.71
71_E389_R0.6020.71
60_S69_G0.6010.70
227_A231_A0.6000.70
240_R262_G0.5970.70
283_H346_D0.5970.70
164_F259_E0.5960.70
397_R401_W0.5950.70
183_T273_N0.5950.70
213_R336_Q0.5940.70
54_S58_E0.5940.70
316_R345_D0.5940.70
283_H329_T0.5910.69
159_T299_L0.5900.69
162_P395_S0.5900.69
29_P44_Y0.5890.69
384_R388_V0.5880.69
215_A255_E0.5870.69
243_A342_P0.5860.69
338_V365_V0.5850.68
378_R382_V0.5840.68
63_E187_T0.5830.68
397_R404_G0.5830.68
14_A56_S0.5810.68
9_W46_T0.5810.68
65_A159_T0.5780.67
276_G288_A0.5770.67
387_R397_R0.5760.67
210_D368_D0.5750.67
389_R400_D0.5750.67
42_A46_T0.5750.67
289_P295_H0.5750.67
366_S400_D0.5740.67
161_V228_E0.5730.67
197_T233_A0.5730.67
126_T305_C0.5700.66
64_D90_L0.5690.66
287_L295_H0.5690.66
379_F385_A0.5690.66
188_G199_E0.5680.66
16_S20_I0.5670.66
92_D127_R0.5670.66
11_G24_A0.5660.66
56_S154_A0.5660.66
384_R399_I0.5650.66
109_T112_R0.5640.66
296_R300_E0.5610.65
157_T271_A0.5590.65
346_D350_E0.5590.65
36_V85_L0.5580.65
163_D300_E0.5570.65
379_F386_V0.5550.64
195_H213_R0.5550.64
14_A21_A0.5550.64
322_L326_R0.5540.64
130_H210_D0.5540.64
15_L158_L0.5540.64
141_D144_G0.5540.64
66_P122_T0.5540.64
35_G39_V0.5540.64
196_A212_T0.5530.64
137_V196_A0.5490.64
302_L306_D0.5480.63
55_L352_V0.5480.63
164_F262_G0.5480.63
170_F177_T0.5480.63
73_D118_T0.5470.63
26_T398_V0.5470.63
92_D123_V0.5460.63
228_E273_N0.5450.63
240_R345_D0.5440.63
76_L92_D0.5440.63
12_A50_P0.5420.63
385_A400_D0.5420.63
308_G346_D0.5420.63
19_V23_G0.5420.63
389_R397_R0.5410.62
90_L119_V0.5410.62
14_A44_Y0.5400.62
383_A404_G0.5400.62
135_V154_A0.5360.62
30_A35_G0.5340.61
160_C163_D0.5330.61
389_R403_A0.5320.61
167_L206_L0.5320.61
12_A18_A0.5320.61
25_T43_G0.5320.61
15_L77_T0.5320.61
41_G58_E0.5310.61
113_A316_R0.5300.61
210_D218_G0.5290.61
49_A68_A0.5290.61
164_F167_L0.5280.61
42_A203_G0.5280.61
48_F143_S0.5270.60
180_A276_G0.5260.60
367_P384_R0.5260.60
232_T318_F0.5260.60
122_T153_P0.5250.60
382_V386_V0.5240.60
390_S394_A0.5230.60
347_T350_E0.5230.60
387_R404_G0.5230.60
338_V361_P0.5200.59
229_R336_Q0.5190.59
181_G229_R0.5180.59
142_I145_S0.5170.59
167_L225_F0.5170.59
16_S22_A0.5170.59
126_T252_N0.5160.59
356_E359_G0.5160.59
104_T108_A0.5160.59
388_V399_I0.5160.59
35_G78_V0.5150.59
82_G200_Y0.5150.59
189_G255_E0.5150.59
22_A31_V0.5140.59
344_V368_D0.5140.59
365_V368_D0.5130.58
95_P121_Y0.5130.58
79_T131_E0.5120.58
84_F404_G0.5110.58
88_L112_R0.5100.58
85_L88_L0.5090.58
88_L111_L0.5090.58
282_P357_A0.5080.58
379_F394_A0.5070.57
257_G328_R0.5070.57
232_T275_V0.5070.57
367_P379_F0.5050.57
158_L162_P0.5050.57
379_F401_W0.5050.57
206_L225_F0.5040.57
260_A345_D0.5020.57
93_G171_P0.5020.57
191_G273_N0.5020.57
359_G365_V0.5010.57
78_V369_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nvoA 2 0.8214 99.3 0.828 Contact Map
1yvrA 1 0.7667 99.1 0.844 Contact Map
2x31A 2 0.3905 98.2 0.884 Contact Map
4bj3A 1 0.3952 98.1 0.888 Contact Map
1atzA 1 0.4095 98 0.89 Contact Map
4jduA 1 0.4238 97.9 0.893 Contact Map
4wfqA 1 0.4167 97.9 0.894 Contact Map
4cr2W 1 0.419 97.6 0.899 Contact Map
2x5nA 1 0.4071 97.6 0.899 Contact Map
4rckA 2 0.4357 97.6 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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