Q9HSH7 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HSH7 - Methanol dehydrogenase regulatory protein

UniProt:	Q9HSH7	Sequences: MDASSVRDGCSAVVDEVAAAVIADREFLETVLVGFLADGHVLLEDVPGTGKTLTARSVATALGLEFSRVQFTPDLLPTDVLGTHVFNERSREFEFRPGPVFANVVLADEINRAPPKTQAALLEAMEEGQVTIDGETMALPEPFFVIATQNPVDQEGTFPLPEAQLDRFVVSAAIGYPDAAGERELLARRASRDARSPTVDAVLDDERVRALRRASEDVRVGSDLREYMVAVARATREHPRVEVGVSPRGTQRLFEAARARAVVAGREYVVPADVKGLAGSVLAHRLVLTPDAAVENVAKGGIVEGVLDEVPVPTVDAA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	318 (275)
Sequences:	20959 (12159)
Seq/√Len:	733.2

ECOLI - RAVA YEHL RUVB RARA
BACSU - YEAC RUVB YRVN YOJN
HALSA - Q9HSH7 GVPN2 RFCS GVPN1 Q9HPM3 RFCL Q9HPV0
SULSO - Q97W74 RFCS RFCL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
266_R	273_D	3.912	1.00
204_D	207_R	3.899	1.00
178_D	181_G	3.456	1.00
102_A	105_V	2.757	1.00
18_A	25_R	2.723	1.00
266_R	270_V	2.691	1.00
87_N	94_E	2.409	1.00
245_V	249_G	2.370	1.00
129_Q	138_A	2.351	1.00
110_I	147_A	2.332	1.00
187_A	225_R	2.204	1.00
170_V	256_A	2.179	1.00
76_L	79_D	2.140	1.00
27_F	54_T	2.106	1.00
31_V	58_V	2.093	1.00
16_E	19_A	2.012	1.00
207_R	210_A	1.945	1.00
235_T	238_H	1.944	1.00
66_F	70_Q	1.912	1.00
210_A	213_R	1.906	1.00
106_L	148_T	1.889	1.00
14_V	29_E	1.884	1.00
184_E	187_A	1.878	1.00
33_V	260_R	1.833	1.00
184_E	188_R	1.826	1.00
209_R	212_R	1.824	1.00
34_G	41_V	1.823	1.00
128_G	142_P	1.803	1.00
209_R	213_R	1.795	1.00
30_T	280_S	1.772	1.00
278_A	282_L	1.740	1.00
228_M	232_A	1.731	1.00
124_A	139_L	1.720	1.00
222_S	225_R	1.704	1.00
212_R	215_S	1.695	1.00
231_V	234_A	1.689	1.00
260_R	276_G	1.684	1.00
55_A	146_I	1.675	1.00
220_V	224_L	1.658	1.00
53_L	57_S	1.657	1.00
233_R	237_E	1.649	1.00
232_A	235_T	1.632	1.00
87_N	90_S	1.619	1.00
270_V	273_D	1.600	1.00
187_A	222_S	1.587	1.00
220_V	254_F	1.580	1.00
260_R	264_A	1.578	1.00
213_R	216_E	1.576	1.00
67_S	70_Q	1.572	1.00
219_R	222_S	1.561	1.00
226_E	230_A	1.558	1.00
210_A	214_A	1.544	1.00
183_R	187_A	1.543	1.00
183_R	226_E	1.530	1.00
179_A	230_A	1.496	1.00
29_E	260_R	1.495	1.00
212_R	216_E	1.494	1.00
206_E	209_R	1.491	1.00
95_F	132_I	1.489	1.00
211_L	215_S	1.489	1.00
231_V	235_T	1.477	1.00
241_V	247_P	1.473	1.00
75_L	79_D	1.455	1.00
189_R	193_D	1.449	1.00
276_G	279_G	1.447	1.00
31_V	54_T	1.440	1.00
179_A	183_R	1.426	1.00
189_R	194_A	1.425	1.00
235_T	239_P	1.425	1.00
221_G	224_L	1.421	1.00
254_F	258_R	1.421	1.00
63_G	66_F	1.419	1.00
31_V	41_V	1.414	1.00
29_E	276_G	1.405	1.00
189_R	192_R	1.402	1.00
191_S	194_A	1.400	1.00
229_V	232_A	1.400	1.00
204_D	208_V	1.399	1.00
20_A	57_S	1.391	1.00
224_L	228_M	1.380	1.00
190_A	193_D	1.367	1.00
81_L	120_A	1.346	1.00
107_A	145_V	1.343	1.00
277_L	285_R	1.333	1.00
220_V	223_D	1.321	1.00
284_H	288_L	1.318	1.00
152_V	156_G	1.304	1.00
251_Q	255_E	1.301	1.00
281_V	288_L	1.298	1.00
34_G	170_V	1.286	1.00
211_L	214_A	1.275	1.00
89_R	92_E	1.270	1.00
247_P	250_T	1.251	1.00
206_E	210_A	1.249	1.00
279_G	283_A	1.242	1.00
228_M	231_V	1.238	1.00
225_R	229_V	1.233	1.00
190_A	194_A	1.226	1.00
147_A	168_F	1.225	1.00
182_E	212_R	1.212	1.00
16_E	61_A	1.205	1.00
232_A	236_R	1.205	1.00
27_F	174_I	1.203	1.00
257_A	269_V	1.200	1.00
68_R	71_F	1.199	1.00
44_E	171_S	1.191	1.00
274_V	278_A	1.185	1.00
56_R	127_E	1.182	1.00
277_L	280_S	1.176	1.00
203_L	207_R	1.174	1.00
197_P	200_D	1.170	1.00
111_N	149_Q	1.166	1.00
13_V	61_A	1.164	1.00
24_D	27_F	1.161	1.00
100_V	130_V	1.158	1.00
264_A	273_D	1.154	1.00
249_G	252_R	1.153	1.00
71_F	107_A	1.153	1.00
25_R	181_G	1.152	1.00
183_R	229_V	1.146	1.00
202_V	205_D	1.142	1.00
42_L	110_I	1.142	1.00
207_R	214_A	1.140	1.00
269_V	273_D	1.122	1.00
114_P	164_Q	1.113	1.00
276_G	280_S	1.109	1.00
214_A	262_V	1.104	1.00
218_V	221_G	1.100	1.00
222_S	226_E	1.099	1.00
245_V	248_R	1.097	1.00
207_R	213_R	1.086	1.00
281_V	284_H	1.084	1.00
254_F	257_A	1.082	1.00
273_D	277_L	1.078	1.00
278_A	284_H	1.071	1.00
169_V	252_R	1.071	1.00
218_V	222_S	1.062	1.00
66_F	106_L	1.058	1.00
207_R	211_L	1.057	1.00
97_P	101_F	1.054	1.00
211_L	216_E	1.053	1.00
258_R	262_V	1.053	1.00
234_A	237_E	1.053	1.00
249_G	256_A	1.051	1.00
169_V	256_A	1.045	1.00
202_V	206_E	1.044	1.00
269_V	274_V	1.043	1.00
274_V	277_L	1.043	1.00
131_T	138_A	1.041	1.00
208_V	211_L	1.034	1.00
205_D	209_R	1.027	1.00
232_A	250_T	1.026	1.00
255_E	259_A	1.016	1.00
274_V	281_V	1.000	1.00
244_G	247_P	0.999	1.00
256_A	260_R	0.997	1.00
271_P	275_K	0.996	1.00
219_R	223_D	0.990	1.00
123_E	127_E	0.990	1.00
152_V	158_F	0.989	1.00
153_D	156_G	0.988	1.00
208_V	212_R	0.979	1.00
273_D	276_G	0.978	1.00
86_F	91_R	0.976	1.00
236_R	239_P	0.975	1.00
35_F	62_L	0.967	1.00
92_E	96_R	0.964	1.00
181_G	184_E	0.961	1.00
88_E	91_R	0.957	1.00
185_L	188_R	0.955	1.00
229_V	233_R	0.952	1.00
97_P	137_M	0.946	1.00
30_T	33_V	0.943	1.00
152_V	157_T	0.942	1.00
84_H	133_D	0.938	1.00
255_E	258_R	0.937	1.00
230_A	234_A	0.935	1.00
128_G	141_E	0.932	1.00
30_T	172_A	0.929	1.00
14_V	18_A	0.927	1.00
224_L	227_Y	0.922	1.00
177_P	181_G	0.919	1.00
27_F	30_T	0.911	1.00
36_L	263_V	0.910	1.00
97_P	100_V	0.910	1.00
274_V	284_H	0.909	1.00
66_F	69_V	0.904	1.00
35_F	58_V	0.902	1.00
267_E	271_P	0.899	1.00
284_H	287_V	0.894	1.00
103_N	142_P	0.893	1.00
220_V	227_Y	0.892	1.00
75_L	80_V	0.891	1.00
199_V	202_V	0.889	1.00
221_G	227_Y	0.885	1.00
74_D	79_D	0.879	1.00
63_G	67_S	0.875	1.00
260_R	277_L	0.870	1.00
283_A	287_V	0.870	1.00
282_L	285_R	0.870	1.00
221_G	225_R	0.868	1.00
277_L	284_H	0.865	1.00
278_A	281_V	0.862	1.00
41_V	146_I	0.849	1.00
277_L	281_V	0.844	1.00
109_E	150_N	0.842	1.00
234_A	238_H	0.833	1.00
119_A	122_L	0.833	1.00
202_V	209_R	0.830	1.00
33_V	170_V	0.828	1.00
65_E	102_A	0.828	1.00
29_E	264_A	0.827	1.00
219_R	224_L	0.825	1.00
98_G	101_F	0.822	1.00
13_V	32_L	0.821	1.00
256_A	259_A	0.819	1.00
267_E	270_V	0.818	1.00
248_R	252_R	0.818	1.00
245_V	282_L	0.816	1.00
223_D	226_E	0.814	1.00
224_L	232_A	0.813	1.00
64_L	71_F	0.810	1.00
152_V	155_E	0.808	1.00
33_V	256_A	0.804	1.00
231_V	236_R	0.804	1.00
203_L	236_R	0.803	1.00
252_R	256_A	0.799	1.00
210_A	215_S	0.798	1.00
153_D	157_T	0.798	1.00
177_P	182_E	0.798	1.00
217_D	222_S	0.797	1.00
286_L	289_T	0.793	1.00
283_A	286_L	0.791	1.00
226_E	229_V	0.791	1.00
210_A	216_E	0.790	1.00
232_A	238_H	0.790	1.00
257_A	274_V	0.787	1.00
265_G	269_V	0.785	1.00
95_F	99_P	0.781	1.00
228_M	235_T	0.780	1.00
208_V	215_S	0.778	1.00
110_I	164_Q	0.777	1.00
211_L	262_V	0.770	1.00
233_R	236_R	0.766	1.00
13_V	203_L	0.766	1.00
208_V	214_A	0.765	1.00
285_R	289_T	0.764	1.00
114_P	117_T	0.762	1.00
95_F	137_M	0.762	1.00
83_T	91_R	0.761	1.00
246_S	249_G	0.760	1.00
67_S	102_A	0.758	1.00
230_A	233_R	0.757	1.00
21_V	57_S	0.755	1.00
220_V	225_R	0.755	1.00
68_R	99_P	0.753	1.00
28_L	32_L	0.750	1.00
281_V	285_R	0.745	1.00
213_R	217_D	0.744	1.00
257_A	261_A	0.744	1.00
25_R	28_L	0.743	1.00
65_E	70_Q	0.743	1.00
227_Y	231_V	0.739	1.00
98_G	102_A	0.738	1.00
180_A	184_E	0.736	1.00
223_D	227_Y	0.736	1.00
90_S	94_E	0.724	1.00
217_D	220_V	0.721	1.00
14_V	25_R	0.720	1.00
234_A	239_P	0.720	1.00
244_G	248_R	0.716	1.00
280_S	284_H	0.713	1.00
203_L	208_V	0.713	1.00
275_K	279_G	0.708	1.00
221_G	232_A	0.707	1.00
138_A	141_E	0.706	1.00
217_D	221_G	0.704	1.00
26_E	30_T	0.701	1.00
207_R	212_R	0.700	1.00
57_S	61_A	0.698	1.00
179_A	233_R	0.697	1.00
257_A	263_V	0.696	1.00
203_L	211_L	0.690	1.00
37_A	259_A	0.683	1.00
186_L	189_R	0.683	1.00
30_T	170_V	0.681	1.00
257_A	260_R	0.677	1.00
268_Y	271_P	0.676	1.00
21_V	54_T	0.676	1.00
204_D	210_A	0.674	1.00
253_L	278_A	0.673	1.00
206_E	215_S	0.669	1.00
27_F	172_A	0.669	1.00
22_I	188_R	0.668	1.00
207_R	216_E	0.668	1.00
22_I	184_E	0.667	1.00
119_A	161_P	0.665	1.00
100_V	105_V	0.664	1.00
88_E	92_E	0.661	1.00
77_P	81_L	0.656	1.00
252_R	255_E	0.649	1.00
27_F	43_L	0.648	1.00
262_V	266_R	0.644	1.00
42_L	149_Q	0.642	1.00
274_V	288_L	0.640	1.00
207_R	215_S	0.639	1.00
214_A	217_D	0.638	1.00
76_L	80_V	0.635	1.00
76_L	81_L	0.631	1.00
188_R	191_S	0.628	1.00
272_A	275_K	0.627	1.00
229_V	234_A	0.627	1.00
45_D	50_G	0.620	1.00
217_D	225_R	0.619	1.00
282_L	286_L	0.617	1.00
228_M	254_F	0.616	1.00
259_A	263_V	0.615	1.00
118_Q	164_Q	0.613	1.00
18_A	60_T	0.613	1.00
29_E	32_L	0.613	1.00
43_L	174_I	0.608	1.00
95_F	139_L	0.607	1.00
242_E	246_S	0.607	1.00
222_S	227_Y	0.604	1.00
52_T	56_R	0.604	1.00
45_D	175_G	0.603	1.00
228_M	234_A	0.602	1.00
38_D	141_E	0.601	1.00
94_E	98_G	0.601	1.00
49_T	174_I	0.601	1.00
100_V	124_A	0.600	1.00
83_T	92_E	0.599	1.00
218_V	224_L	0.598	1.00
272_A	276_G	0.595	1.00
17_V	57_S	0.595	1.00
202_V	207_R	0.595	1.00
266_R	269_V	0.593	1.00
56_R	60_T	0.591	1.00
259_A	262_V	0.590	1.00
99_P	102_A	0.588	1.00
219_R	227_Y	0.588	1.00
32_L	36_L	0.587	1.00
183_R	225_R	0.586	1.00
231_V	239_P	0.586	1.00
236_R	240_R	0.585	1.00
250_T	254_F	0.584	1.00
218_V	223_D	0.582	1.00
247_P	251_Q	0.581	1.00
221_G	228_M	0.580	1.00
104_V	144_F	0.580	1.00
280_S	283_A	0.574	1.00
33_V	37_A	0.572	1.00
66_F	71_F	0.569	1.00
227_Y	230_A	0.569	1.00
198_T	201_A	0.567	1.00
206_E	213_R	0.567	1.00
21_V	24_D	0.565	1.00
63_G	70_Q	0.565	1.00
44_E	173_A	0.565	1.00
95_F	101_F	0.563	1.00
237_E	240_R	0.563	1.00
218_V	231_V	0.562	1.00
265_G	273_D	0.562	1.00
205_D	212_R	0.560	1.00
87_N	91_R	0.558	1.00
246_S	254_F	0.557	1.00
168_F	171_S	0.557	1.00
270_V	277_L	0.557	1.00
241_V	244_G	0.553	1.00
105_V	108_D	0.552	1.00
73_P	120_A	0.551	1.00
208_V	213_R	0.550	1.00
33_V	277_L	0.550	1.00
205_D	208_V	0.548	1.00
46_V	49_T	0.547	1.00
179_A	216_E	0.547	1.00
163_A	167_R	0.545	1.00
260_R	263_V	0.545	1.00
249_G	260_R	0.543	1.00
214_A	218_V	0.541	1.00
104_V	108_D	0.539	1.00
83_T	100_V	0.539	1.00
75_L	81_L	0.539	1.00
45_D	173_A	0.538	1.00
248_R	259_A	0.532	1.00
267_E	273_D	0.530	1.00
188_R	192_R	0.530	1.00
232_A	239_P	0.529	1.00
253_L	256_A	0.527	1.00
186_L	192_R	0.525	1.00
38_D	212_R	0.523	1.00
111_N	160_L	0.522	1.00
84_H	88_E	0.521	1.00
285_R	288_L	0.519	1.00
215_S	218_V	0.518	1.00
165_L	171_S	0.518	1.00
14_V	17_V	0.517	1.00
226_E	232_A	0.516	1.00
224_L	229_V	0.515	1.00
81_L	132_I	0.514	1.00
176_Y	182_E	0.513	1.00
216_E	219_R	0.510	1.00
109_E	167_R	0.510	1.00
273_D	285_R	0.509	1.00
248_R	251_Q	0.509	1.00
268_Y	272_A	0.506	1.00
218_V	225_R	0.506	1.00
103_N	140_P	0.505	1.00
16_E	60_T	0.501	0.99
191_S	197_P	0.501	0.99
209_R	215_S	0.501	0.99
182_E	185_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3vkgA	2	0.978	100	0.383	Contact Map
4rh7A	1	0.9434	100	0.41	Contact Map
3ja83	1	0.8679	100	0.451	Contact Map
2r44A	1	0.9843	100	0.463	Contact Map
4r7yA	3	0.8899	100	0.468	Contact Map
3ja82	1	0.9371	100	0.491	Contact Map
3ja86	1	0.9057	100	0.493	Contact Map
3ja87	1	0.9057	100	0.499	Contact Map
3ja84	1	0.8836	100	0.504	Contact Map
3ja85	1	0.8994	100	0.509	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.