GREMLIN Database
Q9HSH7 - Methanol dehydrogenase regulatory protein
UniProt: Q9HSH7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (275)
Sequences: 20959 (12159)
Seq/√Len: 733.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_R273_D3.9121.00
204_D207_R3.8991.00
178_D181_G3.4561.00
102_A105_V2.7571.00
18_A25_R2.7231.00
266_R270_V2.6911.00
87_N94_E2.4091.00
245_V249_G2.3701.00
129_Q138_A2.3511.00
110_I147_A2.3321.00
187_A225_R2.2041.00
170_V256_A2.1791.00
76_L79_D2.1401.00
27_F54_T2.1061.00
31_V58_V2.0931.00
16_E19_A2.0121.00
207_R210_A1.9451.00
235_T238_H1.9441.00
66_F70_Q1.9121.00
210_A213_R1.9061.00
106_L148_T1.8891.00
14_V29_E1.8841.00
184_E187_A1.8781.00
33_V260_R1.8331.00
184_E188_R1.8261.00
209_R212_R1.8241.00
34_G41_V1.8231.00
128_G142_P1.8031.00
209_R213_R1.7951.00
30_T280_S1.7721.00
278_A282_L1.7401.00
228_M232_A1.7311.00
124_A139_L1.7201.00
222_S225_R1.7041.00
212_R215_S1.6951.00
231_V234_A1.6891.00
260_R276_G1.6841.00
55_A146_I1.6751.00
220_V224_L1.6581.00
53_L57_S1.6571.00
233_R237_E1.6491.00
232_A235_T1.6321.00
87_N90_S1.6191.00
270_V273_D1.6001.00
187_A222_S1.5871.00
220_V254_F1.5801.00
260_R264_A1.5781.00
213_R216_E1.5761.00
67_S70_Q1.5721.00
219_R222_S1.5611.00
226_E230_A1.5581.00
210_A214_A1.5441.00
183_R187_A1.5431.00
183_R226_E1.5301.00
179_A230_A1.4961.00
29_E260_R1.4951.00
212_R216_E1.4941.00
206_E209_R1.4911.00
95_F132_I1.4891.00
211_L215_S1.4891.00
231_V235_T1.4771.00
241_V247_P1.4731.00
75_L79_D1.4551.00
189_R193_D1.4491.00
276_G279_G1.4471.00
31_V54_T1.4401.00
179_A183_R1.4261.00
189_R194_A1.4251.00
235_T239_P1.4251.00
221_G224_L1.4211.00
254_F258_R1.4211.00
63_G66_F1.4191.00
31_V41_V1.4141.00
29_E276_G1.4051.00
189_R192_R1.4021.00
191_S194_A1.4001.00
229_V232_A1.4001.00
204_D208_V1.3991.00
20_A57_S1.3911.00
224_L228_M1.3801.00
190_A193_D1.3671.00
81_L120_A1.3461.00
107_A145_V1.3431.00
277_L285_R1.3331.00
220_V223_D1.3211.00
284_H288_L1.3181.00
152_V156_G1.3041.00
251_Q255_E1.3011.00
281_V288_L1.2981.00
34_G170_V1.2861.00
211_L214_A1.2751.00
89_R92_E1.2701.00
247_P250_T1.2511.00
206_E210_A1.2491.00
279_G283_A1.2421.00
228_M231_V1.2381.00
225_R229_V1.2331.00
190_A194_A1.2261.00
147_A168_F1.2251.00
182_E212_R1.2121.00
16_E61_A1.2051.00
232_A236_R1.2051.00
27_F174_I1.2031.00
257_A269_V1.2001.00
68_R71_F1.1991.00
44_E171_S1.1911.00
274_V278_A1.1851.00
56_R127_E1.1821.00
277_L280_S1.1761.00
203_L207_R1.1741.00
197_P200_D1.1701.00
111_N149_Q1.1661.00
13_V61_A1.1641.00
24_D27_F1.1611.00
100_V130_V1.1581.00
264_A273_D1.1541.00
249_G252_R1.1531.00
71_F107_A1.1531.00
25_R181_G1.1521.00
183_R229_V1.1461.00
202_V205_D1.1421.00
42_L110_I1.1421.00
207_R214_A1.1401.00
269_V273_D1.1221.00
114_P164_Q1.1131.00
276_G280_S1.1091.00
214_A262_V1.1041.00
218_V221_G1.1001.00
222_S226_E1.0991.00
245_V248_R1.0971.00
207_R213_R1.0861.00
281_V284_H1.0841.00
254_F257_A1.0821.00
273_D277_L1.0781.00
278_A284_H1.0711.00
169_V252_R1.0711.00
218_V222_S1.0621.00
66_F106_L1.0581.00
207_R211_L1.0571.00
97_P101_F1.0541.00
211_L216_E1.0531.00
258_R262_V1.0531.00
234_A237_E1.0531.00
249_G256_A1.0511.00
169_V256_A1.0451.00
202_V206_E1.0441.00
269_V274_V1.0431.00
274_V277_L1.0431.00
131_T138_A1.0411.00
208_V211_L1.0341.00
205_D209_R1.0271.00
232_A250_T1.0261.00
255_E259_A1.0161.00
274_V281_V1.0001.00
244_G247_P0.9991.00
256_A260_R0.9971.00
271_P275_K0.9961.00
219_R223_D0.9901.00
123_E127_E0.9901.00
152_V158_F0.9891.00
153_D156_G0.9881.00
208_V212_R0.9791.00
273_D276_G0.9781.00
86_F91_R0.9761.00
236_R239_P0.9751.00
35_F62_L0.9671.00
92_E96_R0.9641.00
181_G184_E0.9611.00
88_E91_R0.9571.00
185_L188_R0.9551.00
229_V233_R0.9521.00
97_P137_M0.9461.00
30_T33_V0.9431.00
152_V157_T0.9421.00
84_H133_D0.9381.00
255_E258_R0.9371.00
230_A234_A0.9351.00
128_G141_E0.9321.00
30_T172_A0.9291.00
14_V18_A0.9271.00
224_L227_Y0.9221.00
177_P181_G0.9191.00
27_F30_T0.9111.00
36_L263_V0.9101.00
97_P100_V0.9101.00
274_V284_H0.9091.00
66_F69_V0.9041.00
35_F58_V0.9021.00
267_E271_P0.8991.00
284_H287_V0.8941.00
103_N142_P0.8931.00
220_V227_Y0.8921.00
75_L80_V0.8911.00
199_V202_V0.8891.00
221_G227_Y0.8851.00
74_D79_D0.8791.00
63_G67_S0.8751.00
260_R277_L0.8701.00
283_A287_V0.8701.00
282_L285_R0.8701.00
221_G225_R0.8681.00
277_L284_H0.8651.00
278_A281_V0.8621.00
41_V146_I0.8491.00
277_L281_V0.8441.00
109_E150_N0.8421.00
234_A238_H0.8331.00
119_A122_L0.8331.00
202_V209_R0.8301.00
33_V170_V0.8281.00
65_E102_A0.8281.00
29_E264_A0.8271.00
219_R224_L0.8251.00
98_G101_F0.8221.00
13_V32_L0.8211.00
256_A259_A0.8191.00
267_E270_V0.8181.00
248_R252_R0.8181.00
245_V282_L0.8161.00
223_D226_E0.8141.00
224_L232_A0.8131.00
64_L71_F0.8101.00
152_V155_E0.8081.00
33_V256_A0.8041.00
231_V236_R0.8041.00
203_L236_R0.8031.00
252_R256_A0.7991.00
210_A215_S0.7981.00
153_D157_T0.7981.00
177_P182_E0.7981.00
217_D222_S0.7971.00
286_L289_T0.7931.00
283_A286_L0.7911.00
226_E229_V0.7911.00
210_A216_E0.7901.00
232_A238_H0.7901.00
257_A274_V0.7871.00
265_G269_V0.7851.00
95_F99_P0.7811.00
228_M235_T0.7801.00
208_V215_S0.7781.00
110_I164_Q0.7771.00
211_L262_V0.7701.00
233_R236_R0.7661.00
13_V203_L0.7661.00
208_V214_A0.7651.00
285_R289_T0.7641.00
114_P117_T0.7621.00
95_F137_M0.7621.00
83_T91_R0.7611.00
246_S249_G0.7601.00
67_S102_A0.7581.00
230_A233_R0.7571.00
21_V57_S0.7551.00
220_V225_R0.7551.00
68_R99_P0.7531.00
28_L32_L0.7501.00
281_V285_R0.7451.00
213_R217_D0.7441.00
257_A261_A0.7441.00
25_R28_L0.7431.00
65_E70_Q0.7431.00
227_Y231_V0.7391.00
98_G102_A0.7381.00
180_A184_E0.7361.00
223_D227_Y0.7361.00
90_S94_E0.7241.00
217_D220_V0.7211.00
14_V25_R0.7201.00
234_A239_P0.7201.00
244_G248_R0.7161.00
280_S284_H0.7131.00
203_L208_V0.7131.00
275_K279_G0.7081.00
221_G232_A0.7071.00
138_A141_E0.7061.00
217_D221_G0.7041.00
26_E30_T0.7011.00
207_R212_R0.7001.00
57_S61_A0.6981.00
179_A233_R0.6971.00
257_A263_V0.6961.00
203_L211_L0.6901.00
37_A259_A0.6831.00
186_L189_R0.6831.00
30_T170_V0.6811.00
257_A260_R0.6771.00
268_Y271_P0.6761.00
21_V54_T0.6761.00
204_D210_A0.6741.00
253_L278_A0.6731.00
206_E215_S0.6691.00
27_F172_A0.6691.00
22_I188_R0.6681.00
207_R216_E0.6681.00
22_I184_E0.6671.00
119_A161_P0.6651.00
100_V105_V0.6641.00
88_E92_E0.6611.00
77_P81_L0.6561.00
252_R255_E0.6491.00
27_F43_L0.6481.00
262_V266_R0.6441.00
42_L149_Q0.6421.00
274_V288_L0.6401.00
207_R215_S0.6391.00
214_A217_D0.6381.00
76_L80_V0.6351.00
76_L81_L0.6311.00
188_R191_S0.6281.00
272_A275_K0.6271.00
229_V234_A0.6271.00
45_D50_G0.6201.00
217_D225_R0.6191.00
282_L286_L0.6171.00
228_M254_F0.6161.00
259_A263_V0.6151.00
118_Q164_Q0.6131.00
18_A60_T0.6131.00
29_E32_L0.6131.00
43_L174_I0.6081.00
95_F139_L0.6071.00
242_E246_S0.6071.00
222_S227_Y0.6041.00
52_T56_R0.6041.00
45_D175_G0.6031.00
228_M234_A0.6021.00
38_D141_E0.6011.00
94_E98_G0.6011.00
49_T174_I0.6011.00
100_V124_A0.6001.00
83_T92_E0.5991.00
218_V224_L0.5981.00
272_A276_G0.5951.00
17_V57_S0.5951.00
202_V207_R0.5951.00
266_R269_V0.5931.00
56_R60_T0.5911.00
259_A262_V0.5901.00
99_P102_A0.5881.00
219_R227_Y0.5881.00
32_L36_L0.5871.00
183_R225_R0.5861.00
231_V239_P0.5861.00
236_R240_R0.5851.00
250_T254_F0.5841.00
218_V223_D0.5821.00
247_P251_Q0.5811.00
221_G228_M0.5801.00
104_V144_F0.5801.00
280_S283_A0.5741.00
33_V37_A0.5721.00
66_F71_F0.5691.00
227_Y230_A0.5691.00
198_T201_A0.5671.00
206_E213_R0.5671.00
21_V24_D0.5651.00
63_G70_Q0.5651.00
44_E173_A0.5651.00
95_F101_F0.5631.00
237_E240_R0.5631.00
218_V231_V0.5621.00
265_G273_D0.5621.00
205_D212_R0.5601.00
87_N91_R0.5581.00
246_S254_F0.5571.00
168_F171_S0.5571.00
270_V277_L0.5571.00
241_V244_G0.5531.00
105_V108_D0.5521.00
73_P120_A0.5511.00
208_V213_R0.5501.00
33_V277_L0.5501.00
205_D208_V0.5481.00
46_V49_T0.5471.00
179_A216_E0.5471.00
163_A167_R0.5451.00
260_R263_V0.5451.00
249_G260_R0.5431.00
214_A218_V0.5411.00
104_V108_D0.5391.00
83_T100_V0.5391.00
75_L81_L0.5391.00
45_D173_A0.5381.00
248_R259_A0.5321.00
267_E273_D0.5301.00
188_R192_R0.5301.00
232_A239_P0.5291.00
253_L256_A0.5271.00
186_L192_R0.5251.00
38_D212_R0.5231.00
111_N160_L0.5221.00
84_H88_E0.5211.00
285_R288_L0.5191.00
215_S218_V0.5181.00
165_L171_S0.5181.00
14_V17_V0.5171.00
226_E232_A0.5161.00
224_L229_V0.5151.00
81_L132_I0.5141.00
176_Y182_E0.5131.00
216_E219_R0.5101.00
109_E167_R0.5101.00
273_D285_R0.5091.00
248_R251_Q0.5091.00
268_Y272_A0.5061.00
218_V225_R0.5061.00
103_N140_P0.5051.00
16_E60_T0.5010.99
191_S197_P0.5010.99
209_R215_S0.5010.99
182_E185_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkgA 2 0.978 100 0.383 Contact Map
4rh7A 1 0.9434 100 0.41 Contact Map
3ja83 1 0.8679 100 0.451 Contact Map
2r44A 1 0.9843 100 0.463 Contact Map
4r7yA 3 0.8899 100 0.468 Contact Map
3ja82 1 0.9371 100 0.491 Contact Map
3ja86 1 0.9057 100 0.493 Contact Map
3ja87 1 0.9057 100 0.499 Contact Map
3ja84 1 0.8836 100 0.504 Contact Map
3ja85 1 0.8994 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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