GREMLIN Database
Q9HSH6 - Serine proteinase
UniProt: Q9HSH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (293)
Sequences: 8703 (5842)
Seq/√Len: 341.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_S206_D5.4641.00
307_A336_R4.2501.00
337_L346_V3.9611.00
139_T226_A3.6351.00
309_N327_T3.4271.00
88_A114_T3.1821.00
136_A206_D3.1241.00
332_T347_D2.9471.00
139_T142_P2.8471.00
135_L207_V2.8411.00
334_S345_T2.7921.00
336_R343_R2.7911.00
109_G123_V2.4811.00
63_S134_P2.4741.00
97_V111_V2.4581.00
141_S226_A2.4551.00
110_R126_T2.4301.00
334_S347_D2.3251.00
77_W210_V2.2761.00
122_A236_I2.2371.00
337_L344_R2.2201.00
191_V220_A2.1471.00
98_N106_W2.0891.00
96_T108_T2.0611.00
54_T146_T2.0181.00
306_L338_L2.0131.00
307_A310_G2.0121.00
77_W199_P1.9961.00
107_E125_V1.9571.00
307_A312_R1.9521.00
120_L210_V1.9431.00
314_H318_D1.9411.00
77_W135_L1.9321.00
137_L225_A1.9321.00
166_I185_V1.9011.00
332_T349_E1.8951.00
57_Y161_V1.8941.00
77_W207_V1.8931.00
336_R345_T1.8491.00
246_L348_V1.8461.00
85_V228_T1.8401.00
137_L229_D1.8211.00
277_S281_A1.8181.00
328_S331_D1.7781.00
238_T242_E1.7701.00
249_S273_S1.7641.00
298_V335_V1.7331.00
303_D339_R1.7241.00
234_S238_T1.7171.00
250_F316_L1.7061.00
147_E163_T1.6921.00
85_V232_V1.6911.00
233_P237_D1.6741.00
60_V201_V1.6201.00
298_V337_L1.6161.00
135_L201_V1.6141.00
327_T350_L1.6061.00
252_P316_L1.6001.00
306_L343_R1.5781.00
78_L132_A1.5691.00
199_P207_V1.5591.00
98_N108_T1.5521.00
242_E352_A1.5251.00
245_Y279_P1.5111.00
282_G351_G1.5071.00
60_V135_L1.5071.00
240_D352_A1.4941.00
53_Y147_E1.4911.00
101_F107_E1.4901.00
110_R124_T1.4891.00
327_T331_D1.4691.00
83_T124_T1.4581.00
315_T318_D1.4511.00
311_T322_L1.4391.00
306_L336_R1.4341.00
210_V228_T1.4161.00
127_D132_A1.4111.00
83_T112_R1.3941.00
339_R344_R1.3911.00
229_D233_P1.3871.00
69_T97_V1.3711.00
78_L101_F1.3691.00
267_R312_R1.3651.00
83_T236_I1.3641.00
68_R100_R1.3491.00
76_G84_L1.3461.00
80_N83_T1.3461.00
140_A226_A1.3331.00
308_V327_T1.3221.00
143_V208_V1.3101.00
52_P146_T1.3071.00
79_Y232_V1.2981.00
327_T333_V1.2801.00
170_N183_D1.2751.00
244_A329_P1.2721.00
276_P281_A1.2681.00
147_E203_L1.2681.00
63_S135_L1.2551.00
56_V201_V1.2511.00
338_L343_R1.2511.00
279_P351_G1.2491.00
75_T199_P1.2411.00
298_V346_V1.2311.00
89_H119_D1.2271.00
107_E127_D1.2171.00
89_H196_S1.2121.00
65_V84_L1.2001.00
309_N334_S1.1981.00
115_D118_S1.1961.00
113_G235_L1.1931.00
53_Y163_T1.1911.00
267_R314_H1.1771.00
271_V298_V1.1671.00
138_R225_A1.1641.00
53_Y149_V1.1631.00
150_A200_L1.1581.00
84_L125_V1.1471.00
65_V76_G1.1431.00
88_A92_G1.1421.00
245_Y275_D1.1281.00
59_D136_A1.1271.00
275_D278_G1.1241.00
144_A169_T1.1221.00
169_T185_V1.1191.00
187_T200_L1.1181.00
143_V166_I1.1171.00
143_V185_V1.1171.00
155_F216_G1.1171.00
149_V203_L1.1091.00
309_N322_L1.1051.00
56_V149_V1.0931.00
273_S301_G1.0931.00
308_V335_V1.0861.00
100_R106_W1.0751.00
67_I123_V1.0691.00
270_L302_G1.0621.00
333_V350_L1.0571.00
94_S97_V1.0521.00
83_T122_A1.0491.00
52_P55_A1.0441.00
308_V319_V1.0411.00
233_P236_I1.0321.00
200_L211_V1.0271.00
150_A211_V1.0151.00
232_V236_I1.0111.00
111_V114_T1.0091.00
254_T257_V1.0001.00
138_R143_V0.9971.00
67_I99_V0.9961.00
128_T131_A0.9941.00
101_F105_T0.9931.00
274_V278_G0.9861.00
80_N236_I0.9861.00
148_V166_I0.9831.00
117_N353_R0.9811.00
57_Y149_V0.9751.00
155_F217_D0.9571.00
252_P315_T0.9511.00
118_S231_V0.9421.00
89_H194_G0.9411.00
191_V211_V0.9411.00
153_N158_N0.9351.00
118_S243_H0.9351.00
338_L341_G0.9341.00
127_D131_A0.9341.00
271_V305_V0.9331.00
60_V151_I0.9311.00
247_G279_P0.9281.00
313_V322_L0.9271.00
74_G90_V0.9271.00
88_A116_P0.9271.00
63_S133_T0.9241.00
244_A350_L0.9201.00
161_V165_I0.9181.00
230_R234_S0.9161.00
82_T124_T0.9141.00
137_L207_V0.9081.00
56_V60_V0.9071.00
308_V333_V0.9051.00
62_D133_T0.9041.00
228_T232_V0.9031.00
115_D243_H0.9021.00
99_V125_V0.9001.00
112_R124_T0.9001.00
53_Y57_Y0.8991.00
251_T272_M0.8941.00
119_D196_S0.8771.00
299_R339_R0.8751.00
57_Y61_I0.8651.00
148_V203_L0.8621.00
310_G334_S0.8471.00
245_Y353_R0.8411.00
69_T73_Q0.8361.00
308_V323_L0.8351.00
81_D124_T0.8351.00
335_V346_V0.8341.00
175_A178_G0.8281.00
250_F269_L0.8281.00
274_V301_G0.8191.00
231_V235_L0.8181.00
101_F125_V0.8171.00
282_G297_A0.8171.00
61_I159_G0.8131.00
87_N223_I0.8081.00
92_G116_P0.8081.00
249_S275_D0.8031.00
148_V208_V0.8001.00
84_L123_V0.7991.00
99_V109_G0.7971.00
268_G304_I0.7971.00
120_L232_V0.7951.00
189_A220_A0.7941.00
274_V281_A0.7881.00
55_A59_D0.7861.00
171_R186_Q0.7831.00
66_M72_G0.7811.00
329_P351_G0.7811.00
113_G122_A0.7801.00
59_D133_T0.7781.00
143_V169_T0.7761.00
335_V348_V0.7741.00
186_Q221_F0.7711.00
269_L313_V0.7641.00
250_F319_V0.7621.00
299_R340_D0.7621.00
248_V269_L0.7581.00
79_Y122_A0.7581.00
251_T257_V0.7571.00
173_I184_A0.7541.00
275_D281_A0.7531.00
200_L222_G0.7531.00
90_V196_S0.7441.00
255_P259_D0.7420.99
246_L335_V0.7410.99
61_I102_N0.7380.99
249_S272_M0.7380.99
79_Y236_I0.7360.99
225_A229_D0.7310.99
282_G296_G0.7290.99
207_V225_A0.7250.99
66_M153_N0.7220.99
175_A184_A0.7160.99
80_N134_P0.7160.99
87_N119_D0.7150.99
122_A232_V0.7150.99
122_A235_L0.7140.99
79_Y85_V0.7120.99
253_V266_S0.7110.99
49_S52_P0.7060.99
77_W85_V0.7060.99
322_L327_T0.7050.99
64_V199_P0.7020.99
251_T270_L0.7010.99
234_S239_G0.7000.99
56_V59_D0.6990.99
49_S147_E0.6960.99
69_T72_G0.6940.99
264_T338_L0.6940.99
296_G348_V0.6930.99
339_R342_D0.6920.99
253_V263_L0.6920.99
154_P157_L0.6900.99
119_D194_G0.6880.99
307_A343_R0.6840.99
87_N90_V0.6820.99
337_L345_T0.6810.99
192_N195_N0.6800.99
87_N211_V0.6790.99
225_A228_T0.6750.99
309_N333_V0.6750.99
78_L134_P0.6710.99
138_R142_P0.6680.99
257_V260_A0.6680.99
97_V123_V0.6670.99
199_P211_V0.6660.99
244_A331_D0.6660.99
318_D322_L0.6650.99
246_L350_L0.6640.99
342_D347_D0.6640.99
125_V128_T0.6630.99
69_T94_S0.6610.99
322_L325_L0.6610.99
108_T126_T0.6600.99
78_L125_V0.6590.99
163_T188_D0.6580.99
280_S296_G0.6580.99
238_T241_Y0.6580.99
113_G231_V0.6550.99
183_D227_L0.6540.99
171_R221_F0.6490.99
252_P269_L0.6490.99
277_S282_G0.6460.99
190_A216_G0.6450.99
211_V222_G0.6450.99
155_F214_G0.6440.99
339_R346_V0.6400.99
153_N156_A0.6380.98
149_V161_V0.6370.98
68_R73_Q0.6340.98
278_G281_A0.6340.98
195_N198_G0.6340.98
234_S237_D0.6330.98
142_P226_A0.6330.98
179_Y182_P0.6300.98
273_S276_P0.6280.98
52_P147_E0.6270.98
313_V335_V0.6220.98
66_M73_Q0.6200.98
167_S186_Q0.6200.98
305_V313_V0.6200.98
56_V135_L0.6190.98
332_T350_L0.6180.98
148_V163_T0.6160.98
78_L84_L0.6120.98
234_S241_Y0.6120.98
81_D134_P0.6060.98
246_L319_V0.6040.98
146_T202_S0.6040.98
91_V114_T0.6030.98
149_V163_T0.6010.98
274_V297_A0.6000.98
174_P179_Y0.5990.98
68_R106_W0.5950.98
139_T229_D0.5950.98
140_A143_V0.5940.98
320_L323_L0.5940.98
333_V348_V0.5920.98
271_V346_V0.5910.98
91_V97_V0.5900.97
254_T258_A0.5880.97
46_D49_S0.5860.97
323_L327_T0.5860.97
68_R98_N0.5830.97
84_L132_A0.5820.97
242_E350_L0.5800.97
84_L99_V0.5800.97
250_F320_L0.5790.97
131_A134_P0.5790.97
257_V261_N0.5770.97
299_R303_D0.5760.97
175_A182_P0.5750.97
50_E54_T0.5750.97
85_V120_L0.5740.97
51_S55_A0.5720.97
87_N196_S0.5710.97
216_G219_I0.5710.97
172_A184_A0.5710.97
252_P317_E0.5700.97
148_V200_L0.5700.97
52_P203_L0.5690.97
258_A263_L0.5680.97
66_M158_N0.5670.97
137_L232_V0.5670.97
202_S208_V0.5670.97
182_P212_N0.5670.97
245_Y250_F0.5660.97
120_L225_A0.5660.97
157_L219_I0.5660.97
175_A213_S0.5640.97
318_D321_S0.5640.97
51_S54_T0.5630.97
180_R320_L0.5620.97
344_R347_D0.5610.97
69_T95_E0.5610.97
226_A229_D0.5600.97
105_T127_D0.5600.97
184_A212_N0.5590.97
310_G336_R0.5580.97
80_N124_T0.5570.96
309_N331_D0.5560.96
138_R141_S0.5560.96
107_E132_A0.5550.96
62_D102_N0.5550.96
186_Q192_N0.5540.96
92_G114_T0.5530.96
122_A170_N0.5530.96
331_D350_L0.5530.96
55_A58_R0.5520.96
162_T195_N0.5520.96
214_G217_D0.5500.96
320_L324_A0.5500.96
299_R344_R0.5500.96
235_L241_Y0.5490.96
67_I109_G0.5480.96
235_L244_A0.5470.96
209_A222_G0.5470.96
192_N218_N0.5460.96
86_T121_A0.5460.96
151_I201_V0.5460.96
118_S227_L0.5450.96
282_G349_E0.5440.96
230_R233_P0.5430.96
89_H186_Q0.5400.96
53_Y161_V0.5360.96
75_T154_P0.5350.96
87_N195_N0.5340.96
67_I76_G0.5330.95
46_D50_E0.5320.95
248_V298_V0.5320.95
258_A261_N0.5310.95
269_L316_L0.5310.95
256_T260_A0.5290.95
140_A225_A0.5270.95
77_W120_L0.5260.95
308_V322_L0.5250.95
181_I324_A0.5240.95
73_Q153_N0.5240.95
167_S192_N0.5230.95
280_S297_A0.5220.95
57_Y151_I0.5220.95
279_P296_G0.5210.95
185_V200_L0.5210.95
144_A161_V0.5200.95
258_A262_G0.5190.95
187_T222_G0.5180.95
311_T325_L0.5180.95
54_T57_Y0.5170.95
66_M159_G0.5160.95
74_G196_S0.5140.95
263_L304_I0.5140.95
79_Y137_L0.5130.94
50_E146_T0.5130.94
82_T132_A0.5130.94
316_L320_L0.5130.94
44_T47_S0.5120.94
87_N199_P0.5120.94
253_V304_I0.5120.94
90_V194_G0.5120.94
230_R325_L0.5110.94
118_S241_Y0.5100.94
61_I158_N0.5100.94
101_F132_A0.5080.94
54_T58_R0.5060.94
155_F219_I0.5060.94
167_S195_N0.5050.94
153_N213_S0.5050.94
91_V121_A0.5050.94
263_L338_L0.5030.94
274_V280_S0.5010.94
105_T131_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.8006 100 0.323 Contact Map
3pv2A 6 0.7809 100 0.338 Contact Map
3stjA 6 0.8062 100 0.34 Contact Map
4a8cA 5 0.8146 100 0.351 Contact Map
1lcyA 3 0.7781 100 0.38 Contact Map
4ic6A 4 0.8427 100 0.387 Contact Map
3qo6A 5 0.8315 100 0.388 Contact Map
4flnA 5 0.7921 100 0.395 Contact Map
4ri0A 3 0.809 100 0.396 Contact Map
1te0A 6 0.8315 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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