GREMLIN Database
GUAAA - GMP synthase [glutamine-hydrolyzing] subunit A
UniProt: Q9HSH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (169)
Sequences: 11987 (6569)
Seq/√Len: 505.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_A128_V3.2101.00
80_I156_L2.8321.00
56_D82_D2.5001.00
24_M176_E2.4871.00
5_L32_T2.4481.00
138_T150_G2.3781.00
81_A149_M2.3721.00
115_A170_E2.3571.00
151_D154_R2.3381.00
37_P40_D2.3221.00
21_L47_V2.3121.00
23_D172_E2.3001.00
136_T152_T2.2861.00
136_T150_G2.2281.00
137_I146_V2.1311.00
170_E173_A2.0211.00
20_L172_E1.9301.00
6_V18_H1.8871.00
139_A148_A1.8551.00
77_H158_G1.8331.00
87_R130_A1.8281.00
9_N48_L1.7961.00
151_D155_D1.7881.00
119_R169_E1.7781.00
89_E127_E1.7521.00
61_R79_L1.7121.00
118_T170_E1.7091.00
176_E180_A1.6751.00
173_A176_E1.6631.00
150_G157_Y1.6041.00
149_M158_G1.5641.00
134_G153_D1.4921.00
96_Y125_A1.4741.00
128_V149_M1.4581.00
137_I140_E1.4561.00
80_I158_G1.4551.00
99_V121_W1.4521.00
17_E73_V1.4491.00
114_L118_T1.4271.00
6_V47_V1.4121.00
27_V179_V1.4001.00
32_T36_T1.3841.00
30_D43_A1.3781.00
45_G178_F1.3741.00
4_I45_G1.3681.00
56_D87_R1.3591.00
62_E65_T1.3401.00
101_V119_R1.3101.00
10_H35_T1.3091.00
127_E145_G1.3041.00
84_L156_L1.3031.00
92_D145_G1.2941.00
134_G152_T1.2811.00
100_T117_D1.2671.00
47_V71_L1.2571.00
81_A86_G1.2551.00
89_E129_V1.2511.00
121_W167_H1.2421.00
101_V117_D1.2361.00
111_V148_A1.2111.00
77_H128_V1.2081.00
24_M175_F1.1691.00
88_I128_V1.1661.00
118_T174_V1.1571.00
102_S120_V1.1421.00
17_E175_F1.1361.00
4_I27_V1.1281.00
135_F149_M1.1261.00
135_F151_D1.1151.00
140_E144_C1.1091.00
20_L23_D1.1061.00
48_L70_I1.1021.00
103_I140_E1.1011.00
36_T40_D1.0951.00
67_D154_R1.0891.00
65_T154_R1.0721.00
91_G127_E1.0671.00
99_V119_R1.0661.00
61_R65_T1.0631.00
109_P157_Y1.0591.00
16_L19_R1.0461.00
74_C162_H1.0421.00
5_L41_I1.0331.00
18_H22_R1.0281.00
71_L159_V1.0281.00
9_N34_N1.0271.00
134_G151_D1.0141.00
65_T156_L1.0061.00
81_A132_P1.0051.00
24_M172_E1.0051.00
141_S145_G1.0031.00
102_S117_D1.0011.00
37_P41_I1.0001.00
77_H149_M0.9991.00
131_V137_I0.9951.00
46_L68_V0.9921.00
84_L135_F0.9891.00
6_V13_F0.9841.00
152_T155_D0.9811.00
86_G132_P0.9671.00
131_V146_V0.9671.00
161_W174_V0.9631.00
54_M57_I0.9581.00
5_L43_A0.9531.00
102_S140_E0.9521.00
22_R29_V0.9501.00
115_A169_E0.9471.00
109_P150_G0.9281.00
120_V168_T0.9281.00
7_V32_T0.9261.00
63_Y66_L0.9181.00
90_A94_G0.9181.00
53_T57_I0.9131.00
73_V159_V0.9091.00
61_R83_E0.9021.00
19_R22_R0.8991.00
114_L170_E0.8941.00
138_T157_Y0.8891.00
93_Y143_I0.8821.00
45_G179_V0.8811.00
138_T148_A0.8771.00
63_Y67_D0.8771.00
139_A161_W0.8731.00
103_I117_D0.8721.00
24_M179_V0.8671.00
10_H33_D0.8671.00
84_L151_D0.8461.00
159_V163_P0.8301.00
110_L157_Y0.8271.00
150_G177_N0.8261.00
61_R64_L0.8251.00
21_L27_V0.8181.00
13_F18_H0.8111.00
115_A118_T0.8071.00
100_T142_D0.8041.00
39_A63_Y0.8031.00
54_M126_D0.8021.00
21_L179_V0.7971.00
157_Y178_F0.7971.00
66_L154_R0.7951.00
4_I21_L0.7941.00
86_G130_A0.7911.00
6_V21_L0.7861.00
32_T40_D0.7771.00
118_T171_G0.7761.00
43_A68_V0.7761.00
56_D88_I0.7751.00
122_A147_E0.7721.00
74_C78_Q0.7721.00
21_L175_F0.7691.00
172_E176_E0.7681.00
38_P41_I0.7671.00
114_L173_A0.7671.00
111_V161_W0.7591.00
26_G29_V0.7591.00
113_S177_N0.7531.00
51_G75_L0.7411.00
62_E66_L0.7401.00
130_A133_D0.7391.00
14_T31_L0.7391.00
15_H18_H0.7321.00
54_M90_A0.7321.00
8_D14_T0.7301.00
18_H31_L0.7241.00
84_L154_R0.7231.00
47_V178_F0.7221.00
5_L30_D0.7211.00
100_T119_R0.7201.00
111_V177_N0.7181.00
19_R23_D0.7161.00
27_V45_G0.7061.00
7_V41_I0.7051.00
46_L70_I0.7021.00
94_G125_A0.7001.00
86_G128_V0.6951.00
16_L20_L0.6941.00
151_D156_L0.6931.00
33_D36_T0.6891.00
103_I116_P0.6881.00
103_I142_D0.6851.00
109_P112_G0.6811.00
6_V49_S0.6781.00
82_D87_R0.6761.00
14_T49_S0.6731.00
6_V14_T0.6611.00
38_P63_Y0.6531.00
54_M82_D0.6491.00
159_V174_V0.6461.00
36_T41_I0.6451.00
71_L174_V0.6401.00
6_V29_V0.6401.00
53_T56_D0.6391.00
112_G180_A0.6381.00
98_D121_W0.6361.00
88_I126_D0.6351.00
118_T173_A0.6321.00
61_R67_D0.6321.00
79_L83_E0.6291.00
111_V139_A0.6271.00
45_G71_L0.6231.00
113_S173_A0.6141.00
70_I80_I0.6121.00
96_Y123_S0.6050.99
161_W171_G0.6050.99
121_W165_V0.6040.99
7_V37_P0.6030.99
20_L175_F0.5970.99
62_E83_E0.5960.99
9_N79_L0.5950.99
123_S126_D0.5940.99
7_V36_T0.5930.99
61_R66_L0.5900.99
133_D152_T0.5900.99
65_T84_L0.5860.99
176_E179_V0.5840.99
54_M88_I0.5810.99
173_A177_N0.5790.99
78_Q160_Q0.5780.99
95_G141_S0.5730.99
50_G74_C0.5670.99
61_R70_I0.5650.99
46_L63_Y0.5650.99
146_V149_M0.5630.99
35_T60_C0.5600.99
34_N60_C0.5600.99
121_W168_T0.5550.99
57_I60_C0.5550.99
29_V47_V0.5550.99
29_V32_T0.5510.99
121_W169_E0.5490.99
58_G79_L0.5470.99
42_D68_V0.5460.99
45_G69_P0.5430.99
132_P149_M0.5410.99
131_V135_F0.5400.99
177_N180_A0.5380.99
133_D136_T0.5290.99
80_I149_M0.5290.99
127_E144_C0.5260.99
95_G98_D0.5250.99
101_V142_D0.5240.99
109_P138_T0.5200.98
7_V34_N0.5200.98
127_E143_I0.5170.98
95_G100_T0.5160.98
38_P60_C0.5110.98
87_R129_V0.5110.98
111_V115_A0.5090.98
112_G115_A0.5080.98
91_G94_G0.5070.98
71_L157_Y0.5040.98
101_V139_A0.5040.98
129_V132_P0.5010.98
38_P62_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqiA 3 0.929 100 0.21 Contact Map
2ywbA 4 0.9563 100 0.215 Contact Map
1gpmA 3 0.9891 100 0.217 Contact Map
2vxoA 2 0.9672 100 0.229 Contact Map
3uowA 2 0.9836 100 0.257 Contact Map
3r75A 2 0.9727 100 0.309 Contact Map
2vpiA 1 0.9344 100 0.318 Contact Map
1i1qB 1 0.9454 100 0.322 Contact Map
1a9xB 1 0.9454 100 0.322 Contact Map
1qdlB 2 0.9781 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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