GREMLIN Database
Q9HSH2 - Uncharacterized protein
UniProt: Q9HSH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (188)
Sequences: 16096 (12081)
Seq/√Len: 881.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_T163_A4.6101.00
39_E69_D3.9751.00
73_V84_L3.7461.00
70_R96_Y3.1431.00
72_L164_Y2.7551.00
150_H167_E2.5981.00
99_E141_V2.5171.00
94_P138_R2.2911.00
145_D148_G2.2781.00
151_A162_V2.2631.00
43_V74_T2.2451.00
41_T70_R2.2391.00
195_D198_A2.2001.00
166_H169_L2.1991.00
32_Y217_C2.1521.00
149_F166_H2.0991.00
101_D160_G2.0961.00
151_A164_Y2.0791.00
35_V40_T2.0511.00
96_Y138_R2.0371.00
70_R94_P2.0251.00
170_S214_E1.9561.00
145_D150_H1.9481.00
98_H162_V1.9121.00
98_H153_H1.8791.00
142_D205_S1.8561.00
171_V217_C1.8271.00
40_T63_V1.7691.00
150_H165_V1.7411.00
141_V144_D1.7121.00
32_Y173_F1.7041.00
55_R90_A1.6611.00
102_A106_A1.6281.00
161_H175_G1.5831.00
163_A172_A1.5731.00
57_G60_T1.5661.00
43_V173_F1.5271.00
96_Y140_V1.5221.00
165_V172_A1.5211.00
88_T137_I1.4881.00
39_E70_R1.4771.00
40_T68_I1.4651.00
55_R59_H1.4511.00
57_G61_A1.4411.00
68_I93_A1.4181.00
152_Y165_V1.4061.00
205_S208_R1.4011.00
198_A201_S1.4001.00
99_E139_A1.3981.00
35_V63_V1.3891.00
140_V162_V1.3751.00
165_V170_S1.3571.00
41_T72_L1.3571.00
201_S204_R1.3411.00
84_L95_V1.3211.00
102_A139_A1.3141.00
74_T175_G1.2981.00
45_A71_V1.2971.00
154_T202_S1.2941.00
43_V164_Y1.2871.00
204_R208_R1.2691.00
185_L188_T1.2621.00
97_V101_D1.2461.00
165_V214_E1.2301.00
51_E86_R1.2131.00
85_A89_P1.2041.00
42_L68_I1.2011.00
56_D59_H1.1851.00
138_R144_D1.1751.00
56_D60_T1.1731.00
163_A206_L1.1691.00
174_L216_A1.1551.00
39_E64_E1.1501.00
177_L206_L1.1421.00
158_T161_H1.1391.00
215_Y223_P1.1281.00
154_T161_H1.1251.00
40_T69_D1.1251.00
143_G150_H1.1081.00
101_D158_T1.1061.00
51_E55_R1.1041.00
197_A201_S1.0781.00
156_G202_S1.0611.00
85_A88_T1.0551.00
196_A200_E1.0501.00
41_T149_F1.0501.00
33_V40_T1.0491.00
152_Y205_S1.0281.00
100_R103_P1.0171.00
100_R153_H1.0121.00
184_R187_P1.0081.00
86_R90_A1.0061.00
36_D39_E1.0051.00
155_P202_S1.0051.00
73_V95_V0.9981.00
52_Q56_D0.9981.00
55_R91_L0.9961.00
88_T95_V0.9931.00
45_A84_L0.9781.00
72_L162_V0.9681.00
51_E83_T0.9581.00
34_V43_V0.9571.00
216_A224_L0.9521.00
142_D153_H0.9511.00
43_V72_L0.9411.00
103_P107_G0.9371.00
50_D53_T0.9371.00
163_A177_L0.9191.00
165_V213_F0.9171.00
203_V207_C0.9161.00
170_S213_F0.9161.00
165_V209_R0.9151.00
53_T57_G0.9111.00
68_I91_L0.9101.00
31_A54_V0.9091.00
204_R207_C0.9081.00
167_E170_S0.9071.00
152_Y163_A0.9041.00
74_T164_Y0.9041.00
42_L45_A0.8901.00
171_V215_Y0.8811.00
71_V93_A0.8791.00
126_Y129_R0.8781.00
154_T177_L0.8771.00
71_V84_L0.8771.00
200_E204_R0.8711.00
140_V164_Y0.8691.00
99_E103_P0.8661.00
32_Y219_G0.8631.00
59_H90_A0.8591.00
76_Y97_V0.8431.00
125_L128_R0.8431.00
71_V95_V0.8361.00
107_G110_L0.8351.00
150_H209_R0.8341.00
218_P221_G0.8261.00
172_A209_R0.8261.00
76_Y101_D0.8231.00
206_L226_D0.8211.00
33_V42_L0.8191.00
199_V203_V0.8161.00
215_Y225_P0.8121.00
97_V105_V0.8051.00
53_T56_D0.8051.00
216_A226_D0.8041.00
30_N221_G0.7921.00
99_E102_A0.7831.00
124_R127_Y0.7781.00
140_V144_D0.7741.00
184_R188_T0.7731.00
134_D137_I0.7621.00
101_D104_Y0.7601.00
180_G222_P0.7571.00
89_P132_L0.7481.00
177_L199_V0.7461.00
80_H176_D0.7411.00
94_P137_I0.7391.00
196_A199_V0.7351.00
172_A216_A0.7341.00
148_G168_D0.7311.00
35_V57_G0.7301.00
179_Y182_G0.7261.00
42_L58_L0.7181.00
97_V102_A0.7161.00
205_S209_R0.7101.00
73_V81_V0.7071.00
217_C223_P0.7011.00
103_P106_A0.7001.00
159_P198_A0.7001.00
52_Q55_R0.7001.00
152_Y209_R0.6971.00
140_V151_A0.6961.00
83_T86_R0.6931.00
31_A46_G0.6921.00
131_D135_L0.6911.00
201_S205_S0.6901.00
145_D167_E0.6891.00
212_A227_G0.6861.00
58_L68_I0.6811.00
29_P46_G0.6801.00
177_L202_S0.6781.00
72_L149_F0.6771.00
78_A82_G0.6761.00
140_V146_I0.6741.00
125_L129_R0.6731.00
45_A83_T0.6731.00
161_H177_L0.6691.00
69_D94_P0.6691.00
40_T58_L0.6691.00
183_D186_K0.6671.00
33_V58_L0.6631.00
108_D111_P0.6601.00
86_R89_P0.6561.00
148_G167_E0.6551.00
149_F164_Y0.6511.00
59_H62_G0.6511.00
109_R112_P0.6501.00
84_L88_T0.6491.00
173_F217_C0.6491.00
31_A45_A0.6461.00
35_V61_A0.6461.00
182_G188_T0.6411.00
144_D151_A0.6411.00
42_L54_V0.6401.00
174_L218_P0.6401.00
58_L63_V0.6401.00
75_H176_D0.6381.00
104_Y159_P0.6371.00
34_V166_H0.6371.00
209_R213_F0.6211.00
126_Y130_L0.6201.00
110_L113_W0.6191.00
192_T195_D0.6161.00
71_V87_L0.6151.00
127_Y130_L0.6151.00
70_R138_R0.6141.00
85_A132_L0.6091.00
88_T92_D0.6041.00
29_P32_Y0.6031.00
26_L29_P0.6011.00
100_R159_P0.6011.00
90_A93_A0.6011.00
170_S212_A0.6001.00
34_V149_F0.5991.00
30_N219_G0.5951.00
185_L189_G0.5941.00
183_D188_T0.5921.00
209_R212_A0.5901.00
33_V57_G0.5901.00
213_F216_A0.5881.00
79_D220_H0.5841.00
133_P136_P0.5831.00
59_H64_E0.5811.00
179_Y221_G0.5781.00
54_V83_T0.5741.00
193_S196_A0.5741.00
174_L178_A0.5721.00
106_A135_L0.5711.00
166_H171_V0.5681.00
32_Y35_V0.5651.00
96_Y144_D0.5641.00
36_D41_T0.5601.00
140_V143_G0.5581.00
216_A220_H0.5541.00
159_P193_S0.5541.00
98_H101_D0.5521.00
182_G187_P0.5481.00
184_R189_G0.5471.00
76_Y81_V0.5451.00
70_R73_V0.5451.00
47_W50_D0.5451.00
143_G153_H0.5441.00
178_A203_V0.5421.00
143_G205_S0.5411.00
126_Y131_D0.5411.00
193_S199_V0.5391.00
25_T29_P0.5391.00
44_D75_H0.5391.00
38_N62_G0.5341.00
194_S197_A0.5331.00
108_D112_P0.5301.00
34_V41_T0.5281.00
41_T69_D0.5261.00
81_V105_V0.5251.00
198_A202_S0.5231.00
64_E69_D0.5231.00
30_N218_P0.5221.00
44_D176_D0.5211.00
81_V84_L0.5171.00
40_T62_G0.5161.00
37_D40_T0.5151.00
157_H160_G0.5131.00
59_H91_L0.5111.00
125_L130_L0.5101.00
152_Y172_A0.5101.00
207_C212_A0.5071.00
101_D105_V0.5071.00
42_L87_L0.5061.00
172_A214_E0.5051.00
163_A202_S0.5051.00
77_D80_H0.5011.00
179_Y183_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9237 100 0.316 Contact Map
2cfuA 2 0.9661 100 0.343 Contact Map
2yheA 3 0.9831 100 0.345 Contact Map
4nurA 2 0.9831 100 0.35 Contact Map
2fhxA 2 0.9449 100 0.362 Contact Map
4pdxA 2 0.9619 100 0.366 Contact Map
2vw8A 2 0.9576 100 0.374 Contact Map
1k07A 1 0.9322 100 0.377 Contact Map
3iogA 1 0.9025 100 0.38 Contact Map
3q6vA 1 0.9068 100 0.383 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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