GREMLIN Database
PFDB - Prefoldin subunit beta
UniProt: Q9HSH0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 125 (114)
Sequences: 178 (131)
Seq/√Len: 12.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_E71_N2.9970.96
48_G77_D2.6890.93
23_A97_V2.4030.88
103_S107_E2.3300.86
52_E69_Y2.2070.83
11_E32_Q2.1460.81
85_V99_E2.0160.76
26_V73_H1.9360.73
57_Y87_V1.9290.73
41_E80_V1.9280.73
67_T72_A1.9040.72
15_Q95_D1.8060.68
13_L81_S1.7970.67
24_Q94_E1.7760.66
6_P100_Q1.7450.65
17_Q86_R1.6230.59
4_N25_N1.5710.56
70_D75_D1.5620.56
44_L73_H1.5440.55
46_A89_T1.5420.55
16_L101_F1.5190.54
5_L18_D1.5120.53
97_V114_G1.5060.53
106_E110_D1.4820.52
46_A49_D1.4730.51
54_T110_D1.4470.50
13_L37_L1.4330.49
42_T45_D1.4040.48
10_Q78_E1.3870.47
21_E24_Q1.3460.45
4_N18_D1.3390.45
88_E92_K1.3200.44
13_L77_D1.3140.43
16_L43_A1.3130.43
11_E100_Q1.3130.43
75_D89_T1.3120.43
70_D74_D1.3040.43
5_L70_D1.3040.43
44_L76_L1.2970.43
8_E107_E1.2950.42
17_Q105_Q1.2930.42
5_L74_D1.2840.42
56_M80_V1.2800.42
107_E111_M1.2560.41
73_H98_Q1.2260.39
48_G73_H1.2190.39
9_A99_E1.1880.37
29_Q86_R1.1830.37
28_T85_V1.1660.36
24_Q29_Q1.1590.36
15_Q66_E1.1500.35
37_L64_L1.1460.35
55_T66_E1.1220.34
16_L111_M1.1160.34
71_N109_Q1.1160.34
58_R103_S1.1160.34
26_V90_L1.1140.34
26_V75_D1.1050.33
10_Q17_Q1.0870.33
58_R75_D1.0860.33
91_Q95_D1.0830.32
20_Q23_A1.0630.32
92_K104_L1.0550.31
43_A96_R1.0510.31
12_K39_E1.0470.31
81_S99_E1.0410.31
20_Q24_Q1.0320.30
11_E101_F0.9970.29
34_E57_Y0.9930.29
30_K94_E0.9820.28
12_K18_D0.9780.28
65_V82_D0.9750.28
12_K22_K0.9750.28
27_A75_D0.9750.28
84_E88_E0.9620.27
48_G99_E0.9440.27
23_A96_R0.9420.26
26_V114_G0.9330.26
12_K21_E0.9230.26
29_Q100_Q0.9200.26
40_A110_D0.9190.26
51_E63_L0.9060.25
12_K107_E0.8990.25
39_E93_Q0.8920.25
45_D79_K0.8840.24
65_V72_A0.8800.24
86_R105_Q0.8760.24
29_Q32_Q0.8700.24
51_E77_D0.8650.24
27_A98_Q0.8570.23
66_E74_D0.8430.23
32_Q38_S0.8050.21
46_A91_Q0.8050.21
16_L60_V0.8020.21
40_A43_A0.8000.21
7_P34_E0.7800.21
22_K89_T0.7710.20
15_Q89_T0.7660.20
50_I68_E0.7590.20
46_A58_R0.7540.20
39_E106_E0.7500.20
34_E87_V0.7450.19
36_Q87_V0.7410.19
30_K92_K0.7400.19
59_E81_S0.7400.19
45_D77_D0.7360.19
45_D82_D0.7340.19
50_I53_S0.7330.19
36_Q79_K0.7230.19
25_N92_K0.7220.19
20_Q94_E0.7210.19
28_T77_D0.7190.19
16_L55_T0.7120.18
17_Q20_Q0.7070.18
49_D56_M0.6970.18
22_K38_S0.6960.18
103_S111_M0.6950.18
46_A66_E0.6930.18
31_Q43_A0.6910.18
64_L75_D0.6890.18
8_E21_E0.6860.18
60_V108_L0.6860.18
85_V89_T0.6820.18
44_L57_Y0.6760.17
4_N29_Q0.6730.17
7_P107_E0.6610.17
87_V111_M0.6600.17
13_L99_E0.6580.17
12_K26_V0.6510.17
7_P104_L0.6460.16
20_Q86_R0.6440.16
24_Q43_A0.6400.16
9_A108_L0.6380.16
23_A27_A0.6310.16
7_P16_L0.6240.16
47_L50_I0.6010.15
23_A98_Q0.5940.15
33_A83_L0.5920.15
34_E117_G0.5850.15
9_A110_D0.5810.15
9_A14_E0.5780.15
95_D100_Q0.5780.15
16_L63_L0.5730.15
44_L47_L0.5680.14
45_D78_E0.5640.14
84_E99_E0.5600.14
56_M79_K0.5590.14
88_E99_E0.5580.14
30_K117_G0.5560.14
15_Q85_V0.5520.14
42_T49_D0.5500.14
16_L79_K0.5470.14
30_K78_E0.5460.14
30_K43_A0.5460.14
6_P95_D0.5430.14
16_L104_L0.5420.14
75_D87_V0.5380.14
31_Q94_E0.5380.14
40_A65_V0.5350.14
12_K112_L0.5330.14
11_E96_R0.5250.13
13_L17_Q0.5240.13
94_E98_Q0.5240.13
95_D99_E0.5230.13
50_I55_T0.5170.13
15_Q29_Q0.5160.13
28_T99_E0.5120.13
84_E104_L0.5080.13
63_L73_H0.5020.13
55_T81_S0.5000.13
50_I106_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zqmA 5 0.912 99.8 0.519 Contact Map
1fxkA 2 0.856 99.8 0.541 Contact Map
3aeiA 3 0.752 99.7 0.568 Contact Map
2zdiC 2 0.976 99.5 0.639 Contact Map
1fxkC 2 0.88 99.2 0.687 Contact Map
4q4gX 1 0.008 84.8 0.886 Contact Map
4cgkA 3 0.64 81.7 0.89 Contact Map
1l8dA 2 0.832 72.1 0.899 Contact Map
2dfsA 2 0.696 70.7 0.9 Contact Map
3ghgA 2 0.912 68.5 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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