GREMLIN Database
RL37A - 50S ribosomal protein L37Ae
UniProt: Q9HSG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 95 (87)
Sequences: 381 (197)
Seq/√Len: 21.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_R87_G4.0351.00
55_Q62_K2.9270.99
38_C41_C2.8680.99
46_V70_P2.8640.99
29_E32_M2.2780.96
54_W59_C2.1820.95
6_S36_H1.9800.92
3_N8_G1.9630.91
25_V29_E1.8820.89
66_G72_T1.7280.85
19_R23_R1.6620.82
37_A44_E1.6500.82
24_R28_I1.5930.79
25_V44_E1.5530.78
21_S42_G1.5250.76
9_S26_S1.4820.74
51_T68_Y1.4780.74
79_T86_L1.4710.74
24_R89_T1.4680.73
46_V49_E1.4390.72
56_C59_C1.4380.72
34_E37_A1.4380.72
73_P77_T1.4370.72
49_E55_Q1.4200.71
8_G24_R1.4170.71
38_C59_C1.3950.70
45_A57_G1.3440.67
46_V55_Q1.3070.64
16_R52_G1.2820.63
53_I59_C1.2650.62
39_P88_E1.1870.57
40_D63_Y1.1840.57
28_I82_I1.1450.54
14_G22_R1.1380.54
37_A76_K1.1120.52
27_D64_A1.1090.52
54_W66_G1.1080.52
32_M67_A1.0940.51
28_I53_I1.0530.48
19_R42_G1.0380.47
36_H74_S1.0280.46
36_H42_G1.0130.45
8_G68_Y0.9950.44
17_Y38_C0.9930.44
23_R34_E0.9920.44
4_Q7_T0.9890.44
33_N39_P0.9880.44
22_R41_C0.9870.43
9_S30_G0.9810.43
43_S47_S0.9580.42
16_R22_R0.9450.41
20_V30_G0.9420.41
7_T47_S0.9350.40
52_G56_C0.9240.39
25_V28_I0.9190.39
24_R73_P0.9180.39
20_V23_R0.9150.39
68_Y73_P0.9110.39
26_S32_M0.9110.39
8_G14_G0.8980.38
20_V42_G0.8960.38
11_G17_Y0.8920.37
24_R70_P0.8910.37
46_V89_T0.8570.35
8_G16_R0.8470.35
8_G17_Y0.8320.34
15_A24_R0.8260.33
46_V81_S0.8230.33
40_D49_E0.8110.33
53_I56_C0.8040.32
35_D74_S0.7750.30
49_E57_G0.7730.30
15_A84_T0.7620.30
9_S12_R0.7570.29
25_V58_K0.7430.29
26_S43_S0.7340.28
80_R84_T0.7300.28
32_M43_S0.7300.28
19_R73_P0.7260.28
61_Y69_Q0.7170.27
8_G22_R0.7150.27
26_S40_D0.7110.27
16_R65_G0.7110.27
11_G68_Y0.7110.27
45_A62_K0.7090.27
15_A21_S0.6860.26
50_G58_K0.6840.26
7_T71_Q0.6840.26
5_S9_S0.6820.25
15_A51_T0.6760.25
28_I39_P0.6720.25
46_V68_Y0.6660.25
76_K89_T0.6640.25
58_K70_P0.6620.24
10_A60_G0.6600.24
48_R64_A0.6480.24
61_Y71_Q0.6430.24
8_G54_W0.6340.23
46_V60_G0.6340.23
11_G65_G0.6320.23
45_A58_K0.6300.23
45_A49_E0.6260.23
27_D75_G0.6250.23
40_D61_Y0.6030.22
42_G78_V0.5980.21
26_S29_E0.5870.21
17_Y53_I0.5670.20
48_R66_G0.5660.20
63_Y70_P0.5640.20
30_G83_R0.5580.20
3_N43_S0.5530.20
21_S41_C0.5520.19
20_V75_G0.5510.19
6_S43_S0.5500.19
4_Q11_G0.5490.19
48_R67_A0.5490.19
6_S35_D0.5480.19
47_S71_Q0.5440.19
78_V83_R0.5370.19
16_R56_C0.5320.19
14_G28_I0.5310.19
45_A89_T0.5290.19
26_S84_T0.5180.18
53_I60_G0.5140.18
46_V63_Y0.5130.18
5_S69_Q0.5120.18
33_N40_D0.5040.18
55_Q83_R0.5010.17
18_G68_Y0.5010.17
81_S85_A0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a17Y 1 0.9895 100 0.108 Contact Map
1vx7h 1 0.8842 100 0.114 Contact Map
3zf7o 1 0.9474 100 0.124 Contact Map
4w20p 1 0.9579 100 0.156 Contact Map
4ujrc 1 0.9579 100 0.16 Contact Map
3cc2Z 1 0.7684 100 0.163 Contact Map
3j21i 1 0.8211 100 0.195 Contact Map
1ffkW 1 0.7684 100 0.315 Contact Map
1vq8Z 1 0.7684 100 0.346 Contact Map
3j21g 1 0.4737 98.2 0.794 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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