GREMLIN Database
DCD - Probable deoxycytidine triphosphate deaminase
UniProt: Q9HSG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (174)
Sequences: 1827 (800)
Seq/√Len: 60.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_E127_N5.1521.00
46_E66_T4.0981.00
10_A14_D3.9371.00
36_V151_S3.6611.00
122_I130_V3.5361.00
37_R89_K3.2891.00
97_D157_E3.0471.00
19_I34_V2.6941.00
89_K147_E2.3251.00
106_S110_R2.3101.00
113_V142_V2.1491.00
9_L163_D2.0921.00
100_A155_F2.0391.00
7_D160_S1.9751.00
9_L24_D1.9381.00
41_R67_E1.9221.00
28_Q37_R1.9171.00
7_D159_T1.9071.00
39_G87_T1.8831.00
91_R127_N1.8381.00
94_V100_A1.8041.00
11_R16_D1.7200.99
101_Q156_T1.7170.99
22_L29_V1.7040.99
11_R15_G1.6890.99
87_T129_R1.6880.99
107_S183_S1.6680.99
45_F85_L1.6550.99
22_L34_V1.6050.99
11_R98_L1.5880.99
54_H145_T1.5760.99
120_G123_D1.5380.98
36_V92_V1.5250.98
7_D10_A1.5150.98
3_L7_D1.4990.98
41_R69_V1.4950.98
110_R152_Q1.4780.98
30_Q152_Q1.4630.98
127_N176_D1.4360.98
79_H82_D1.4330.98
75_E143_A1.4320.98
29_V34_V1.4270.97
122_I153_L1.4180.97
32_A124_P1.4170.97
108_L148_M1.4150.97
40_R69_V1.4130.97
94_V98_L1.3990.97
36_V153_L1.3800.97
109_G133_E1.3640.97
88_T132_L1.3620.97
4_S7_D1.3390.96
35_D105_R1.3370.96
106_S152_Q1.3370.96
39_G147_E1.3300.96
56_N145_T1.3250.96
89_K146_P1.3100.96
15_G18_A1.3000.96
129_R179_G1.2770.95
126_F177_Q1.2650.95
167_G172_S1.2560.95
84_V136_N1.2550.95
12_L22_L1.2420.94
114_V135_S1.2150.94
2_I156_T1.1950.93
42_F76_F1.1880.93
11_R95_P1.1840.93
133_E177_Q1.1640.92
7_D11_R1.1600.92
20_E91_R1.1310.91
97_D161_P1.1210.91
43_L67_E1.1180.90
23_E37_R1.1180.90
105_R128_G1.1140.90
96_R165_P1.1040.90
8_I34_V1.1000.90
95_P98_L1.0950.90
115_V151_S1.0800.89
80_P113_V1.0760.89
79_H141_P1.0730.89
4_S160_S1.0640.88
117_A141_P1.0640.88
100_A122_I1.0310.86
11_R97_D1.0080.85
30_Q35_D1.0060.85
9_L29_V1.0060.85
18_A93_E0.9780.83
107_S152_Q0.9750.83
11_R17_L0.9720.83
41_R87_T0.9670.83
8_I155_F0.9670.83
86_G104_G0.9600.82
68_T76_F0.9580.82
75_E145_T0.9580.82
85_L131_T0.9520.82
105_R149_R0.9340.81
6_Q163_D0.9310.80
77_I143_A0.9280.80
95_P128_G0.9200.79
35_D154_V0.9150.79
109_G119_A0.9010.78
96_R161_P0.8950.78
105_R152_Q0.8940.78
28_Q149_R0.8940.78
31_P152_Q0.8860.77
23_E28_Q0.8850.77
104_G177_Q0.8830.77
88_T150_I0.8830.77
16_D97_D0.8820.77
114_V137_L0.8790.76
14_D25_V0.8710.76
104_G109_G0.8690.75
3_L157_E0.8640.75
8_I16_D0.8620.75
113_V136_N0.8600.75
55_P148_M0.8590.75
126_F130_V0.8540.74
36_V88_T0.8540.74
10_A18_A0.8430.73
103_E133_E0.8360.73
24_D153_L0.8340.72
109_G116_H0.8240.72
162_A165_P0.8240.72
40_R73_G0.8200.71
105_R110_R0.8140.71
116_H120_G0.8060.70
102_V122_I0.8030.70
101_Q121_F0.7890.68
123_D174_Y0.7800.67
134_L180_P0.7710.66
4_S158_L0.7680.66
86_G134_L0.7610.65
2_I154_V0.7600.65
96_R125_G0.7600.65
123_D126_F0.7570.65
10_A13_A0.7560.65
121_F126_F0.7490.64
103_E116_H0.7480.64
71_E75_E0.7480.64
23_E132_L0.7400.63
132_L150_I0.7360.63
76_F79_H0.7280.62
94_V155_F0.7250.62
9_L13_A0.7220.61
113_V135_S0.7210.61
100_A153_L0.7190.61
36_V100_A0.7180.61
19_I22_L0.7140.60
3_L11_R0.7120.60
2_I99_V0.7110.60
78_L134_L0.7110.60
29_V54_H0.7100.60
30_Q106_S0.7100.60
38_L86_G0.7090.60
109_G172_S0.7080.60
42_F86_G0.7010.59
110_R128_G0.7000.59
32_A136_N0.6980.59
68_T72_D0.6970.59
36_V150_I0.6970.59
77_I153_L0.6920.58
38_L144_L0.6910.58
66_T69_V0.6910.58
37_R90_E0.6860.57
111_L115_V0.6770.56
99_V121_F0.6730.56
29_V167_G0.6680.55
12_L20_E0.6680.55
181_Q184_R0.6670.55
5_D8_I0.6630.55
54_H141_P0.6620.55
22_L25_V0.6610.55
103_E126_F0.6540.54
154_V158_L0.6540.54
38_L84_V0.6520.54
109_G132_L0.6520.54
4_S159_T0.6510.53
80_P141_P0.6510.53
138_G142_V0.6500.53
82_D149_R0.6500.53
63_E66_T0.6490.53
85_L113_V0.6490.53
149_R154_V0.6440.53
35_D128_G0.6420.52
11_R155_F0.6380.52
83_F135_S0.6360.52
16_D19_I0.6330.51
120_G126_F0.6330.51
65_V68_T0.6320.51
101_Q154_V0.6290.51
100_A126_F0.6270.51
42_F146_P0.6270.51
54_H143_A0.6230.50
30_Q107_S0.6180.50
175_Q179_G0.6140.49
46_E78_L0.6120.49
116_H133_E0.6110.49
171_G176_D0.6100.49
88_T130_V0.6080.49
72_D75_E0.6020.48
88_T104_G0.6010.48
100_A124_P0.5990.48
116_H121_F0.5990.48
32_A162_A0.5890.47
76_F84_V0.5880.46
167_G178_D0.5860.46
136_N142_V0.5820.46
129_R178_D0.5820.46
46_E60_E0.5810.46
92_V153_L0.5800.45
35_D155_F0.5790.45
102_V115_V0.5760.45
125_G158_L0.5720.45
99_V137_L0.5710.44
141_P151_S0.5690.44
96_R155_F0.5680.44
32_A145_T0.5670.44
18_A91_R0.5670.44
106_S128_G0.5660.44
60_E179_G0.5660.44
33_S109_G0.5660.44
109_G120_G0.5650.44
134_L144_L0.5640.44
105_R173_K0.5640.44
107_S149_R0.5630.44
2_I50_V0.5620.43
104_G116_H0.5610.43
32_A121_F0.5570.43
167_G175_Q0.5570.43
13_A22_L0.5520.42
100_A130_V0.5520.42
103_E107_S0.5480.42
12_L34_V0.5460.42
75_E144_L0.5450.42
103_E154_V0.5440.42
25_V28_Q0.5410.41
31_P104_G0.5390.41
33_S121_F0.5370.41
99_V154_V0.5340.40
9_L178_D0.5320.40
68_T146_P0.5320.40
144_L158_L0.5290.40
6_Q10_A0.5290.40
104_G130_V0.5270.40
21_P29_V0.5270.40
86_G118_T0.5260.40
13_A24_D0.5250.39
49_N84_V0.5250.39
36_V157_E0.5230.39
100_A129_R0.5190.39
158_L162_A0.5180.39
43_L76_F0.5160.38
24_D66_T0.5150.38
118_T126_F0.5140.38
30_Q109_G0.5120.38
59_D160_S0.5120.38
24_D36_V0.5120.38
20_E23_E0.5110.38
57_R60_E0.5090.38
128_G152_Q0.5070.38
52_C77_I0.5010.37
143_A146_P0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xs1A 5 0.9538 100 0.202 Contact Map
2qxxA 3 0.9641 100 0.217 Contact Map
1pkhA 5 0.8359 100 0.225 Contact Map
4xjcA 3 0.9077 100 0.25 Contact Map
3km3A 4 0.759 100 0.287 Contact Map
4dhkA 5 0.8 100 0.289 Contact Map
2r9qA 4 0.8359 100 0.303 Contact Map
2yzjA 3 0.8103 100 0.336 Contact Map
3lqwA 3 0.6359 99.9 0.624 Contact Map
1f7dA 3 0.5846 99.9 0.642 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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