GREMLIN Database
Q9HSG2 - Uncharacterized protein
UniProt: Q9HSG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (292)
Sequences: 146 (108)
Seq/√Len: 6.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_V180_G8.4201.00
288_A294_A6.5181.00
141_V291_A4.6990.98
23_D73_G3.5970.90
172_A214_R2.9000.77
34_V166_V2.8410.76
138_L179_A2.7660.74
138_L200_F2.7560.73
4_I105_A2.6380.70
270_D297_M2.6350.70
40_V192_T2.5560.67
105_A120_G2.4920.65
241_Y270_D2.4660.64
34_V180_G2.3700.61
214_R287_L2.3600.61
226_I259_I2.3390.60
133_V170_P2.2720.58
169_T200_F2.2700.58
223_A251_E2.2160.56
179_A200_F2.0660.50
105_A144_G2.0480.50
135_E200_F2.0260.49
226_I288_A1.9980.48
23_D70_E1.8980.44
141_V179_A1.8690.43
145_V158_I1.8660.43
145_V189_M1.8630.43
280_V295_V1.8620.43
22_A40_V1.8020.41
124_V128_D1.7880.40
4_I123_T1.7640.39
147_M295_V1.7460.39
263_V267_D1.7230.38
108_H113_P1.6910.37
60_A260_R1.6780.36
161_V277_G1.6760.36
27_R262_A1.6390.35
222_A294_A1.6260.35
34_V143_R1.6120.34
167_E291_A1.5760.33
23_D80_N1.5740.33
33_E262_A1.5720.33
168_C181_V1.5680.33
105_A123_T1.5550.32
154_F200_F1.5470.32
279_G282_P1.5420.32
45_V285_Y1.5290.32
72_T112_N1.4990.31
137_V200_F1.4940.31
286_V296_R1.4920.30
31_Q42_Q1.4840.30
276_G281_E1.4750.30
14_P17_R1.4700.30
32_H288_A1.4540.29
241_Y293_D1.4510.29
10_E122_F1.4440.29
69_V214_R1.4380.29
61_A261_D1.4360.29
137_V169_T1.4160.28
20_L300_G1.3960.28
63_D171_E1.3890.27
165_L277_G1.3840.27
141_V167_E1.3730.27
203_S282_P1.3650.27
129_S204_A1.3650.27
141_V191_R1.3540.26
157_Q229_S1.3480.26
121_D286_V1.3390.26
154_F189_M1.3350.26
66_Q218_V1.3220.25
169_T179_A1.3030.25
120_G123_T1.2950.25
154_F179_A1.2950.25
14_P35_A1.2890.25
44_A108_H1.2850.24
168_C172_A1.2820.24
25_R34_V1.2770.24
7_V70_E1.2720.24
72_T218_V1.2710.24
226_I241_Y1.2670.24
18_S284_V1.2660.24
16_F208_T1.2620.24
234_A241_Y1.2580.24
198_P285_Y1.2560.24
136_H227_A1.2480.23
149_E194_I1.2460.23
201_G282_P1.2450.23
65_V68_L1.2440.23
106_E269_V1.2410.23
40_V196_A1.2410.23
104_L257_H1.2390.23
40_V80_N1.2390.23
159_P183_G1.2370.23
67_E171_E1.2150.23
87_L139_S1.2030.22
40_V254_T1.1950.22
164_N281_E1.1910.22
208_T289_E1.1790.22
39_G45_V1.1750.22
201_G210_L1.1510.21
52_D147_M1.1450.21
96_E112_N1.1430.21
147_M288_A1.1420.21
23_D74_S1.1370.21
158_I286_V1.1350.21
141_V294_A1.1340.21
177_D272_L1.1320.21
218_V226_I1.1230.20
3_F25_R1.1160.20
46_S200_F1.1120.20
133_V301_L1.1120.20
57_D60_A1.1100.20
10_E66_Q1.1050.20
41_S177_D1.1040.20
17_R35_A1.0990.20
154_F169_T1.0960.20
245_E275_T1.0900.20
69_V213_A1.0880.20
19_L63_D1.0800.19
10_E46_S1.0720.19
35_A177_D1.0660.19
68_L139_S1.0620.19
61_A264_R1.0620.19
72_T99_T1.0610.19
166_V202_V1.0600.19
180_G221_H1.0580.19
211_L229_S1.0550.19
120_G144_G1.0530.19
29_L40_V1.0500.19
241_Y267_D1.0490.19
35_A41_S1.0490.19
178_V190_G1.0400.18
32_H40_V1.0390.18
161_V246_F1.0320.18
185_V229_S1.0310.18
168_C178_V1.0240.18
206_V247_E1.0210.18
73_G286_V1.0210.18
4_I120_G1.0190.18
80_N119_D1.0190.18
42_Q198_P1.0160.18
31_Q198_P1.0160.18
46_S137_V1.0140.18
34_V293_D1.0120.18
4_I144_G1.0100.18
40_V219_D1.0020.18
178_V240_G1.0010.18
192_T301_L0.9990.18
49_A139_S0.9980.18
87_L273_Y0.9980.18
108_H115_L0.9900.17
26_E149_E0.9870.17
78_T271_V0.9850.17
37_L248_P0.9800.17
14_P201_G0.9770.17
162_G223_A0.9750.17
221_H240_G0.9740.17
229_S232_T0.9720.17
158_I242_A0.9670.17
151_T287_L0.9640.17
197_E274_Q0.9620.17
184_R225_N0.9600.17
10_E19_L0.9580.17
87_L115_L0.9560.17
182_P200_F0.9550.17
168_C214_R0.9530.17
10_E231_D0.9500.17
230_A287_L0.9500.17
147_M283_I0.9490.17
24_L285_Y0.9470.17
226_I231_D0.9430.16
173_D300_G0.9360.16
39_G285_Y0.9340.16
18_S272_L0.9260.16
117_D233_V0.9210.16
30_T51_G0.9210.16
173_D191_R0.9170.16
41_S293_D0.9130.16
224_L286_V0.9120.16
161_V198_P0.9110.16
252_S280_V0.9090.16
18_S244_V0.9090.16
37_L270_D0.9080.16
55_T60_A0.9070.16
158_I222_A0.8990.16
102_D253_T0.8960.16
141_V165_L0.8930.15
74_S254_T0.8920.15
181_V235_A0.8910.15
101_S240_G0.8910.15
86_A89_E0.8890.15
37_L112_N0.8890.15
150_R239_A0.8820.15
75_G212_D0.8820.15
192_T294_A0.8770.15
158_I165_L0.8720.15
170_P199_E0.8710.15
42_Q285_Y0.8710.15
31_Q285_Y0.8710.15
83_Q287_L0.8700.15
241_Y297_M0.8670.15
164_N276_G0.8560.15
11_E59_I0.8530.15
147_M160_A0.8530.15
11_E56_D0.8480.15
180_G202_V0.8470.15
72_T272_L0.8450.15
223_A232_T0.8450.15
249_E260_R0.8440.15
205_Y269_V0.8410.15
41_S219_D0.8400.15
277_G285_Y0.8400.15
109_E246_F0.8350.14
259_I296_R0.8290.14
150_R252_S0.8280.14
159_P164_N0.8260.14
164_N183_G0.8260.14
145_V181_V0.8250.14
24_L31_Q0.8250.14
24_L42_Q0.8250.14
152_S176_E0.8240.14
179_A224_L0.8230.14
130_E224_L0.8150.14
286_V298_A0.8140.14
179_A225_N0.8120.14
127_A204_A0.8110.14
36_E226_I0.8070.14
87_L228_Y0.8060.14
228_Y277_G0.8050.14
93_L190_G0.8030.14
32_H251_E0.8010.14
224_L244_V0.8010.14
218_V222_A0.7990.14
293_D297_M0.7980.14
212_D294_A0.7970.14
117_D259_I0.7950.14
187_D204_A0.7900.14
173_D259_I0.7890.14
182_P198_P0.7880.14
225_N279_G0.7880.14
24_L164_N0.7790.13
161_V285_Y0.7780.13
155_A188_V0.7780.13
113_P161_V0.7770.13
81_V158_I0.7760.13
22_A196_A0.7740.13
23_D72_T0.7740.13
148_L178_V0.7710.13
51_G211_L0.7700.13
49_A120_G0.7680.13
83_Q274_Q0.7670.13
110_A254_T0.7660.13
10_E58_E0.7650.13
212_D253_T0.7650.13
274_Q287_L0.7600.13
41_S172_A0.7590.13
14_P210_L0.7540.13
74_S260_R0.7540.13
172_A210_L0.7540.13
7_V112_N0.7530.13
33_E80_N0.7520.13
18_S22_A0.7490.13
195_P291_A0.7490.13
4_I49_A0.7430.13
180_G196_A0.7420.13
99_T243_V0.7400.13
97_L275_T0.7400.13
72_T278_Y0.7400.13
25_R143_R0.7390.13
131_V137_V0.7370.13
17_R172_A0.7370.13
174_T267_D0.7360.13
87_L138_L0.7350.13
134_R215_A0.7340.13
207_A279_G0.7340.13
19_L223_A0.7310.13
83_Q152_S0.7310.13
10_E45_V0.7300.13
185_V205_Y0.7230.13
114_A226_I0.7190.12
163_A185_V0.7180.12
46_S225_N0.7150.12
178_V221_H0.7130.12
247_E280_V0.7130.12
6_E113_P0.7120.12
145_V178_V0.7120.12
228_Y289_E0.7110.12
241_Y292_P0.7110.12
6_E291_A0.7100.12
144_G203_S0.7100.12
55_T298_A0.7090.12
93_L262_A0.7080.12
253_T296_R0.7050.12
114_A185_V0.7040.12
185_V204_A0.7030.12
172_A178_V0.7020.12
186_L280_V0.7020.12
66_Q234_A0.7010.12
159_P184_R0.7010.12
241_Y271_V0.6970.12
205_Y210_L0.6970.12
29_L181_V0.6950.12
47_K200_F0.6930.12
29_L32_H0.6920.12
166_V196_A0.6900.12
42_Q45_V0.6890.12
31_Q45_V0.6890.12
144_G269_V0.6880.12
165_L168_C0.6880.12
192_T230_A0.6790.12
142_R162_G0.6760.12
183_G281_E0.6750.12
159_P281_E0.6750.12
57_D80_N0.6710.12
227_A260_R0.6660.12
122_F260_R0.6640.12
51_G217_G0.6630.12
141_V168_C0.6600.12
87_L94_V0.6550.11
208_T290_N0.6540.11
49_A105_A0.6530.11
173_D232_T0.6520.11
174_T244_V0.6510.11
90_A96_E0.6490.11
177_D181_V0.6480.11
86_A94_V0.6470.11
110_A232_T0.6470.11
24_L45_V0.6450.11
156_T196_A0.6450.11
43_S105_A0.6430.11
34_V149_E0.6420.11
152_S192_T0.6410.11
54_T80_N0.6400.11
108_H162_G0.6390.11
95_R240_G0.6390.11
65_V292_P0.6370.11
36_E138_L0.6350.11
216_A264_R0.6350.11
160_A242_A0.6320.11
22_A103_I0.6310.11
78_T234_A0.6300.11
177_D237_A0.6300.11
250_G253_T0.6300.11
34_V189_M0.6280.11
111_A284_V0.6270.11
172_A260_R0.6260.11
69_V179_A0.6240.11
149_E269_V0.6200.11
232_T260_R0.6190.11
229_S251_E0.6180.11
34_V49_A0.6170.11
146_R301_L0.6160.11
162_G206_V0.6150.11
185_V294_A0.6120.11
154_F227_A0.6110.11
30_T206_V0.6090.11
288_A301_L0.6080.11
85_Q120_G0.6080.11
27_R86_A0.6040.11
29_L254_T0.6040.11
75_G146_R0.6020.11
94_V170_P0.6020.11
33_E43_S0.6010.11
7_V20_L0.6000.11
15_T298_A0.5990.11
49_A123_T0.5980.11
113_P291_A0.5960.11
73_G101_S0.5960.11
137_V181_V0.5930.11
30_T58_E0.5920.11
70_E147_M0.5910.11
4_I287_L0.5910.11
119_D248_P0.5880.11
40_V299_R0.5870.11
178_V260_R0.5870.11
134_R188_V0.5860.10
161_V248_P0.5850.10
104_L298_A0.5840.10
137_V222_A0.5820.10
232_T273_Y0.5820.10
88_V91_E0.5730.10
43_S109_E0.5690.10
140_S167_E0.5680.10
209_V274_Q0.5680.10
16_F155_A0.5670.10
76_L218_V0.5660.10
207_A240_G0.5650.10
35_A155_A0.5640.10
56_D272_L0.5630.10
94_V243_V0.5630.10
4_I43_S0.5610.10
58_E212_D0.5600.10
120_G284_V0.5590.10
163_A251_E0.5590.10
212_D269_V0.5580.10
291_A294_A0.5540.10
14_P207_A0.5510.10
154_F204_A0.5510.10
143_R187_D0.5490.10
263_V280_V0.5490.10
120_G202_V0.5480.10
93_L301_L0.5470.10
65_V209_V0.5450.10
150_R227_A0.5430.10
149_E181_V0.5430.10
19_L76_L0.5430.10
158_I228_Y0.5410.10
19_L110_A0.5380.10
5_E258_H0.5360.10
151_T172_A0.5350.10
68_L91_E0.5340.10
204_A293_D0.5320.10
101_S146_R0.5310.10
38_L49_A0.5310.10
27_R30_T0.5300.10
57_D253_T0.5300.10
107_R157_Q0.5260.10
185_V298_A0.5260.10
7_V282_P0.5220.10
72_T110_A0.5200.10
144_G299_R0.5170.10
235_A284_V0.5160.10
93_L133_V0.5140.10
166_V292_P0.5130.10
14_P199_E0.5110.10
259_I262_A0.5100.09
180_G235_A0.5090.09
137_V173_D0.5080.09
32_H294_A0.5070.09
29_L277_G0.5060.09
38_L198_P0.5060.09
192_T215_A0.5050.09
12_F44_A0.5040.09
75_G89_E0.5040.09
121_D196_A0.5030.09
7_V36_E0.5010.09
227_A263_V0.5010.09
268_A290_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2phpA 3 0.5695 100 0.519 Contact Map
2pb9A 3 0.5596 100 0.523 Contact Map
2cw1A 1 0.2119 98.2 0.915 Contact Map
3vwbA 1 0.3841 98 0.919 Contact Map
3kxaA 4 0.2748 97.7 0.924 Contact Map
1zugA 1 0.2252 97.3 0.929 Contact Map
2w7nA 2 0.2616 97.1 0.932 Contact Map
1neqA 1 0.2318 97.1 0.932 Contact Map
2mqkA 1 0.2086 97 0.933 Contact Map
3kz3A 2 0.2649 96.9 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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